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| 1 | Urban expansion in China and its effect on cultivated land before and after initiating'Reform and Open Policy'显示文摘Urbanization in China has expanded at an unprecedented speed since the declaration of 'Reform and Open Policy'and presented many challenges. Unbalanced regional development, appearance of super megacities and concomitant problems,and conflicts between urbanization and cultivated land protection are three critical problems that Chinese urbanization has to face. To develop new plans for foreseeable future urbanization in China, it is critical to understand the evolving history of cities across China. This study maps urban expansion of 60 typical Chinese cities based on large amount of remote sensing data and the labor-intensive image interpretation method, in order to understand the history of urban expansion from the 1970 s to 2013.Results showed that area of cities expanded 5.23 times compared to their area in the 1970 s. Urban expansion in China accelerated three times(1988–1996, 1999–2006, and 2009–2011) and decelerated three times(1997–1998, 2007–2008, and 2012–2013) over the 40 years. The urban area of South China expanded most significantly 9.42 times, while the urban area in Northeast China expanded only 2.37 times. The disparity among different administrative ranks of cities was even greater than(3.81 times) the differences among different regions. Super megacities have been continuously expanding at a fast rate(8.60-fold), and have not shown obvious signs of slowing down. The proportion of cultivated land among the land sources for urban expansion decreased to a small extent in the 1990 s, but cultivated land continues to be the major land source for urban expansion. Effective future urbanization needs controlling the expansion scale of large cities and reasonably developing medium and small cities, as well as balancing regional development. | ZHANG ZengXiang WEN QingKe LIU Fang ZHAO XiaoLi LIU Bin XU JinYong YI Ling HU ShunGuang WANG Xiao ZUO LiJun LI Na LI MinMin SHI LiFeng ZENG Tian JU HongRun | 2016 | Science China Earth Sciences2016，59，10： | 12 |
| 2 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 3 | Effect of China's rapid development on its iconic giant panda显示文摘Anthropogenic factors affect biodiversity and have led to the contraction or extinction of animal populations worldwide.Here,we use historical demographic data,spanning the past 300 years,to show that a rapid distributional contraction of giant pandas took place during the 18th and 19th centuries alongside the increase in human population.Land-use also underwent a significant change across the areas where giant pandas were found because of government agricultural policy and the introduction of new crops.The impact of social development on giant pandas includes habitat loss and fragmentation,and range reductions.Our findings would facilitate the design of effective conservation strategies that seek to conserve and increase current habitats of this iconic species,especially in areas that our analysis has identified as places where pandas have suffered from high human pressure. | ZHU LiFeng HU YiBo ZHANG ZeJun WEI FuWen | 2013 | Chinese Science Bulletin2013，58，17： | 8 |
| 4 | Heterogeneous lamellar-edged Fe-Ni(OH)_(2)/Ni_(3)S_(2)nanoarray for efficient and stable seawater oxidation显示文摘Development of efficient non-precious catalysts for seawater electrolysis is of great significance but challenging due to the sluggish kinetics of oxygen evolution reaction(OER)and the impairment of chlorine electrochemistry at anode.Herein,we report a heterostructure of Ni_(3)S_(2)nanoarray with secondary Fe-Ni(OH)_(2)lamellar edges that exposes abundant active sites towards seawater oxidation.The resultant Fe-Ni(OH)_(2)/Ni_(3)S_(2)nanoarray works directly as a free-standing anodic electrode in alkaline artificial seawater.It only requires an overpotential of 269 mV to afford a current density of 10 mA·cm^(-2)and the Tafel slope is as low as 46 m V·dec^(-1).The 27-hour chronopotentiometry operated at high current density of 100 mA·cm^(-2)shows negligible deterioration,suggesting good stability of the Fe-Ni(OH)_(2)/Ni_(3)S_(2)@NF electrode.Faraday efficiency for oxygen evolution is up to〜95%,revealing decent selectivity of the catalyst in saline water.Such desirable catalytic performance could be benefitted from the introduction of Fe activator and the heterostructure that offers massive active and selective sites.The density functional theory(DFT)calculations indicate that the OER has lower theoretical overpotential than Cl_(2) evolution reaction in Fe sites,which is contrary to that of Ni sites.The experimental and theoretical study provides a strong support for the rational design of high-performance Fe-based electrodes for industrial seawater electrolysis. | Baihua Cui Zheng Hu Chang Liu Siliang Liu Fangshuai Chen Shi Hu Jinfeng Zhang Wei Zhou Yida Deng Zhenbo Qin Zhong Wu Yanan Chen Lifeng Cui Wenbin Hu | 2021 | Nano Research2021，14，4： | 7 |
| 5 | ANALYSIS OF TRANSMISSION CHARACTERISTICS OF COSINE GEAR DRIVE显示文摘Based on the mathematical model of a novel cosine gear drive,a few characteristics,such as the contact ratio,the sliding coefficient,and the contact and bending stresses,of this drive are analyzed.A comparison study of these characteristics with the involute gear drive is also carried out. The influences of design parameters including the number of teeth and the pressure angle on the contact and bending stresses are studied.The following conclusions are achieved:the contact ratio of the cosine gear drive is about 1.2 to 1.3,which is reduced by about 20% in comparison with that of the involute gear drive.The sliding coefficient of the cosine gear drive is smaller than that of the involute gear drive.The contact and bending stresses of the cosine gear drive are lower than those of the involute gear drive.The contact and bending stresses decrease with the growth of the number of teeth and the pressure angle. | WANG Jian LUO Shanming CHEN Lifeng CHEN Lei HU Huarong | 2008 | Chinese Journal of Mechanical Engineering2008，21，3： | 7 |
| 6 | Spatial Differences of Coastal Urban Expansion in China from 1970s to 2013显示文摘As the ′economic engines′ of China,coastal cities have developed and expanded considerably since the 1970 s.In this study,information on the urban expansion process of Chinese coastal cities from the 1970 s to 2013 was retrieved.Through the analysis of stage characteristics,spatial expansion modes,influences on land use,centroid shifts,and spatial morphological evolutions,the spatial differences of coastal urban expansion were revealed.Results indicate that 1) the expansion stages of southern coastal cities are more complex than those of northern coastal cities,and the expansion ranges and speeds of the former are far higher than those of the latter;2) the spatial expansion of southern coastal cities mostly adopt a single mode,whereas northern coastal cities mostly adopt a mixed mode;3) significant spatial differences in the occupations of different land sources exist between the south and the north along the coastline;4) the centroid of coastal cities tends to migrate toward the coastline,and the centroid shift distances of southern coastal cities are clearly higher than those of northern coastal cities;and 5) the spatial morphology of southern coastal cities tends to be compact,whereas that of northern coastal cities tends to be loose.Policies have a powerful significance in terms of guiding urban expansion and its spatial differences in coastal cities.Urban expansion in coastal cities will encounter new opportunities and challenges under the guidance of new types of urbanization strategies. | SHI Lifeng LIU Fang ZHANG Zengxiang ZHAO Xiaoli LIU Bin XU Jinyong WEN Qingke YI Ling HU Shunguang | 2015 | Chinese Geographical Science2015，25，4： | 7 |
| 7 | Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death显示文摘 | Lifeng Yuan Linhui Zhai Lili Qian De Huang Yi Ding Handan Xiang Xiaojing Liu J. Will Thompson Juan Liu Yong-Han He Xiao-Qiong Chen Jing Hu Qing-Peng Kong Minjia Tan Xiao-Fan Wang | 2018 | Cell Research2018，28，6： | 7 |
| 8 | Urban Expansion in China Based on Remote Sensing Technology:A Review显示文摘Urban areas and its evolution are important anthropogenic indicators and human ecological footprints, and play decisive roles in environmental change analysis, global geo-conditional monitoring, and sustainable development. China has the highest rate of urban expansion and has emerged as an urban expansion hotspot worldwide. In this paper, the progress of studies on Chinese urban expansion based on remote sensing technology are summarized and analyzed from the aspects of urban area definition, remotely sensed imagery applied in urban expansion, monitoring methods of urban expansion, and urban expansion applications. Existing issues and future directions of Chinese urban expansion are discussed and proposed. Results indicate that: 1) The fusion of multi-source remotely sensed imagery is imperative to meet the needs of urban expansion with various monitoring terms and frequencies on different scales and dimensions. 2) To guarantee the classification accuracy and efficiency and describe urban expansion and its influences on local land use simultaneously, the combination of visual interpretation and automatic classification is the tendency of future monitoring methods of urban areas. 3) Urban expansion data have become the prerequisite for recognizing the urban development process, excavating its driving forces, simulating and predicting the future development directions, and also is conducive to revealing and explaining urban ecological and environmental issues. 4) In the past decades, Chinese scholars have promoted the application of remote sensing technology in the urban expansion field, with data construction, methods and models developing from the quotation stage to improvement and innovation stage; however, an independent and consistent urban expansion data on the national scale with long-term and high-frequency(such as annual monitoring) monitoring is still lacking. | ZHANG Zengxiang LIU Fang ZHAO Xiaoli WANG Xiao SHI Lifeng XU Jinyong YU Sisi WEN Qingke ZUO Lijun YI Ling HU Shunguang LIU Bin | 2018 | Chinese Geographical Science2018，28，5： | 6 |
| 9 | Highly effective and reproducible surface-enhanced Raman scattering substrates based on Ag pyramidal arrays显示文摘 | Yandong Wang Nan Lu Wentao Wang Lingxiao Liu Lei Feng Zhoufang Zeng Haibo Li Weiqing Xu Zijian Wu Wei Hu Yanqing Lu Lifeng Chi | 2013 | Nano Research2013，6，3： | 6 |
| 10 | Extraction of Basic Trends of Urban Expansion in China over Past 40 Years from Satellite Images显示文摘If urban sprawl is to be avoided in China in the next ten years, it is not only crucial to understand the overall history, current status, and future trends of urban expansion there, but also these differences, and this is presently lacking. In this study, remotely sensed images with approximately 30 m spatial resolution were used to quantitatively assess the spatial and temporal patterns of urban expansion of 60 Chinese cities(1973–2013). Urban-expansion-process curves of the cities studied were drawn using annual expansion area as an indicator. Curve similarity analysis generated four basic process modes of urban expansion in China. These included cities that: 1) peaked around 2004 and then decelerated; 2) peaked around 2010 and then decelerated; 3) showed sustained acceleration, and 4) showed continued deceleration. Four basic process modes represented cities under different levels of development stage. Geographic location was found to be the most related characteristic to urban expansion process. Regional development policies at the national level in each region also showed highly temporal consistency with fluctuation characteristics of urban expansion process. Urban characteristic such as population size and administrative level were not found to be significantly related to urban expansion-process modes. Understanding the basic process-mode categories well is extremely important for future regional-balance planning and development of macroeconomic policies. | WEN Qingke ZHANG Zengxiang SHI Lifeng ZHAO Xiaoli LIU Fang XU Jinyong YI Ling LIU Bin WANG Xiao ZUO Lijun HU Shunguang LI Na LI Minmin | 2016 | Chinese Geographical Science2016，26，2： | 4 |
| 11 | City Size Distribution and Its Spatiotemporal Evolution in China显示文摘Based on the National Land Use/Cover Database of China(NLUD-C) in the end of the 1980s(the 1980s,hereafter), 1995, 2000, 2005, and 2010, 665 cities were selected to study the size distribution and its changes of urban lands in China. In this study, the spatiotemporal evolutions of urban land size distribution as well as the influence of administrative-level on these cities were explored by combining urban spatial positions and administrative-levels. Results indicate that: 1) City size distribution using urban lands was more practical and reasonable than using non-agricultural population. 2) In the 1980s, cities with ascending urban land rank were centralized in Eastern China, specially the Changjiang(Yangtze) River Delta, the Zhujiang(Pearl) River Delta, and Beijing-Tianjin-Hebei region. Cities in Central, Western, and Northeast China mainly indicated descending urban land rank. 3) The transfer of national development focus resulted in cities with ascending urban land rank becoming evenly distributed nationwide; however, this trend was slightly centralized around Chengdu, Chongqing, and Wuhan in different periods. 4) During the 1980s to 2010, the proportion of cities with ascending urban land rank in provincial capitals, municipalities, and special administrative regions(high-level cities, hereafter) was consistently higher than those in prefecture- and county-level cities except for 2005–2010. The ranks of the majority of the prefecture- and county-level cities were mainly descending, supported by ascending; the proportion of cities with unchanged rank is small. This study breaks through the bottleneck of traditional research in the area of city size distribution by examining urban land replacing the non-agricultural population. The current study also provides scientific explanation for the healthy and reasonable development of urban land as well as the coordinated development of population urbanization and land urbanization. | SHI Lifeng ZHANG Zengxiang LIU Fang ZHAO Xiaoli WANG Xiao LIU Bin HU Shunguang WEN Qingke ZUO Lijun YI Ling XU Jinyong | 2016 | Chinese Geographical Science2016，26，6： | 4 |
| 12 | Modeling of Isobutane/Butene Alkylation Using Solid Acid Catalysts in a Fixed Bed Reactor显示文摘A dynamic mass transfer model of isobutane/butene alkylation over solid acid catalysts in a fixed bed reactor was established. In the model, a modified equation for the relationship between point activity and effective diffusion coefficient was proposed. It is found that the simulation results fit the experimental data well and the breakthrough time of the bed layer is predicted accurately. By modeling the alkylation process, the time-space distribution of butene and point activity profiles of catalysts can be obtained. Furthermore, the reasons for the deactivation of solid acid catalysts were investigated. It indicates that the main reason for the deactivation of catalysts is the site coverage near the inlet of the reactor, while it is ascribed to the steric effect in the region far away from the inlet. | Liu Zheng Tang Xiaojin Hu Lifeng Hou Shuandi | 2016 | China Petroleum Processing & Petrochemical Technology2016，18，2： | 3 |
| 13 | FLEXURAL WAVE DISPERSION IN MULTI-WALLED CARBON NANOTUBES CONVEYING FLUIDS显示文摘Motivated by the great potential of carbon nanotubes for developing nanofluidic devices,this paper presents a nonlocal elastic,Timoshenko multi-beam model with the second order of strain gradient taken into consideration and derives the corresponding dispersion relation of flexural wave in multi-walled carbon nanotubes conveying fluids.The study shows that the moving flow reduces the phase velocity of flexural wave of the lowest branch in carbon nanotubes.The phase velocity of flexural wave of the lowest branch decreases with an increase of flow velocity.However,the effects of flow velocity on the other branches of the wave dispersion are not obvious.The effect of microstructure characterized by nonlocal elasticity on the dispersion of flexural wave becomes more and more remarkable with an increase in wave number. | Lifeng Wang Wanlin Guo Haiyan Hu | 2009 | Acta Mechanica Solida Sinica2009，22，6： | 3 |
| 14 | Development of upland rice introgression lines and identification of QTLs for basal root thickness under different water regimes显示文摘基因渗入线(IL ) 是为识别量的特点 loci (QTL ) 的珍贵材料,评估帮助的基因相互作用,和标记繁殖。包含的一套 430 IL (BC5F3 ) 在一块低地从高地分割热带装饰用的梨树栽培变种 IRAT109 适度的装饰用的梨树栽培变种 Yuefu 背景被开发。176 个多态的标记被用来识别 introgressed 片断。从 IRAT109 的片断都没在 160 根线被发现。另外的 270 根线的 Introgressed 片断盖住 99.1% 施主染色体。introgressed 施主片断的吝啬的数字与 14.4 厘米的平均长度每个人是 3.3。QTL 分析在在灌溉低地,高地和水耕法的条件下面种的 270 IL 的基础根厚度(BRT ) 上被进行。影响 BRT 的 22 QTL 的一个总数被识别,六 QTL (qBRT3.1, qBRT3.2, qBRT6.1, qBRT8.2, qBRT9.1,和 qBRT9.2 ) 一致地在至少二环境(地点和水政体) 下面被表示,并且 qBRT7.2 是在低地条件下面识别的新 BRT QTL。包含 qBRT9.1 的 IL255 在栽培变种 Yuefu 上看了 10.09% 和 7.07% BRT 的增加什么时候分别地在高地和低地条件下面成长。用 304 根 F2:3 线的一张人口源于生气 IL255 ??????? 瑡歭?? 匠 ? 彋 ????????? 僚 ?? 传敶敲灸敲獳潩吗?? | Junzhou Li Deping Wang Yan Xie Hongliang Zhang Guanglong Hu Jinjie Li Anyong Dai Lifeng Liu Zichao Li | 2011 | Journal of Genetics and Genomics2011，38，11： | 3 |
| 15 | Numerical research on evolvement of submarine sand waves in the Northern South China Sea显示文摘 | Qikun ZHOU Guanghai HU Yongfu SUN Xiaohui LIU Yupeng SONG Lifeng DONG Changming DONG | 2017 | Frontiers of Earth Science2017，11，1： | 3 |
| 16 | Adaptive data-driven parallelization of multi-view video coding on multi-core processor显示文摘Multi-view video coding (MVC) comprises rich 3D information and is widely used in new visual media,such as 3DTV and free viewpoint TV (FTV). However,even with mainstream computer manufacturers migrating to multi-core processors,the huge computational requirement of MVC currently prohibits its wide use in consumer markets. In this paper,we demonstrate the design and implementation of the first parallel MVC system on Cell Broadband EngineTM processor which is a state-of-the-art multi-core processor. We propose a task-dispatching algorithm which is adaptive data-driven on the frame level for MVC,and implement a parallel multi-view video decoder with modified H.264/AVC codec on real machine. This approach provides scalable speedup (up to 16 times on sixteen cores) through proper local store management,utilization of code locality and SIMD improvement. Decoding speed,speedup and utilization rate of cores are expressed in experimental results. | PANG Yi HU WeiDong SUN LiFeng YANG ShiQiang | 2009 | Science in China(Series F)2009，52，2： | 2 |
| 17 | EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer显示文摘Tyrosine kinase inhibitors for epidermal growth factor receptor(EGFR TKIs)greatly improved clinical outcomes of patients with non-small cell lung cancer(NSCLC).Unfortunately,primary and acquired resistance limits their clinical benefits.To overcome such resistance,new generations of EGFR TKIs have been developed by targeting newly identified mutations in EGFR.However,much less effort has been put into alternative strategies,such as targeting the intrinsic protective responses to EGFR TKIs.In this study,we found that EGFR TKIs,including gefitinib and AZD9291,impaired lysosome-dependent degradation of SQSTM1,thus compromising their anti-cancer efficiency.By accumulating in the lysosome lumen,gefitinib and AZD9291 attenuated lysosomal acidification and impaired autolysosomal degradation of SQSTM1 owing to their intrinsic alkalinity.As a result,SQSTM1 protein was stabilized in response to gefitinib and AZD9291 treatment and conferred EGFR TKI resistance.Depleting SQSTM1 significantly increased the sensitivity of NSCLC cells to gefitinib and AZD9291 both in vitro and in vivo.Furthermore,a chemically modified gefitinib analog lacking alkalinity displayed stronger inhibitory effects on NSCLC cells.Therefore,targeting accumulated SQSTM1 or chemically modified EGFR TKIs may represent new strategies to increase the effectiveness of EGFR targeted therapy. | Lixian Yang Shilong Ying Shiman Hu Xiangtong Zhao Muchun Li Miaoqin Chen Yiran Zhu Ping Song Liyuan Zhu Tingting Jiang Huimin An Neelum Aziz Yousafzai Wenxia Xu Zhiguo Zhang Xian Wang Lifeng Feng Hongchuan Jin | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 2 |
| 18 | The long-term denudation rate of granitic regolith in Qinhuangdao, North China determined from the in situ depth profile of the cosmogenic nuclides ^(26)Al and ^(10)Be显示文摘This study quantifies the surface denudation rate of granitic regolith via the application of the in situ cosmogenic26 Al and10Be depth profile in China. The concentration ranges of26 Al and10Be in the quartz along the*3-m granitic regolith profile in Qinhuangdao are(4.9–23.1) 9 105and(2.3–36.6) 9 104atoms/g, respectively. With the exception of the surface sample, both26 Al and10Be concentrations decrease exponentially with sample depth. The Chi-square best-fitting results revealed a total denudation rate of *9 m/Ma averaged over a 103–105a timescale, which is lower than the values observed in global granitic outcrops. Compared with global datasets, the flat terrain due to the lack of tectonic activities is most likely the dominant factor that controls the local denudation process.The surface sample offsets from the theoretical cosmogenic nuclide distribution implies that the denudation rate from river basin sediment could be overestimated because of the bioturbation in the surficial soil layer. | Lifeng Cui Congqiang Liu Sheng Xu Zhiqi Zhao Chenglong Tu Taoze Liu Hu Ding | 2014 | Chinese Science Bulletin2014，59，34： | 2 |
| 19 | DIW1 encoding a cladeⅠPP2C phosphatase negatively regulates drought tolerance by de-phosphorylating TaSnRK1.1 in wheat显示文摘Drought seriously impacts wheat production(Triticum aestivum L.),while the exploitation and utilization of genes for drought tolerance are insufficient.Leaf wilting is a direct reflection of drought tolerance in plants.Clade A PP2Cs are abscisic acid(ABA)co-receptors playing vital roles in the ABA signaling pathway,regulating drought response.However,the roles of other clade PP2Cs in drought tolerance,especially in wheat,remain largely unknown.Here,we identified a gain-of-function drought-induced wilting 1(DIW1)gene from the wheat Aikang 58 mutant library by map-based cloning,which encodes a cladeⅠprotein phosphatase 2C(TaPP2C158)with enhanced protein phosphatase activity.Phenotypic analysis of overexpression and CRISPR/Cas9 mutant lines demonstrated that DIW1/TaPP2C158 is a negative regulator responsible for drought resistance.We found that TaPP2C158 directly interacts with TaSnRK1.1 and de-phosphorylates it,thus inactivating the TaSnRK1.1–Ta AREB3 pathway.TaPP2C158 protein phosphatase activity is negatively correlated with ABA signaling.Association analysis suggested that C-terminal variation of TaPP2C158 changing protein phosphatase activity is highly correlated with the canopy temperature,and seedling survival rate under drought stress.Our data suggest that the favorable allele with lower phosphatase activity of TaPP2C158 has been positively selected in Chinese breeding history.This work benefits us in understanding the molecular mechanism of wheat drought tolerance,and provides elite genetic resources and molecular markers for improving wheat drought tolerance. | Jingyi Wang Chaonan Li Long Li Lifeng Gao Ge Hu Yanfei Zhang Matthew P.Reynolds Xueyong Zhang Jizeng Jia Xinguo Mao Ruilian Jing | 2023 | Journal of Integrative Plant Biology2023，65，8： | 1 |
| 20 | Endocrine pheromones couple fat rationing to dauer diapause through HNF4αnuclear receptors显示文摘Developmental diapause is a widespread strategy for animals to survive seasonal starvation and environmental harshness.Diapaused animals often ration body fat to generate a basal level of energy for enduring survival.How diapause and fat rationing are coupled,however,is poorly understood.The nematode Caenorhabditis elegans excretes pheromones to the environment to induce a diapause form called dauer larva.Through saturated forward genetic screens and CRISPR knockout,we found that dauer pheromones feed back to repress the transcription of ACOX-3,MAOC-1,DHS-28,DAF-22(peroxisomalβ-oxidation enzymes dually involved in pheromone synthesis and fat burning),ALH-4(aldehyde dehydrogenase for pheromone synthesis),PRX-10 and PRX-11(peroxisome assembly and proliferation factors).Dysfunction of these pheromone enzymes and factors relieves the repression.Surprisingly,transcription is repressed not by pheromones excreted but by pheromones endogenous to each animal.The endogenous pheromones regulate the nuclear translocation of HNF4αfamily nuclear receptor NHR-79 and its co-receptor NHR-49,and,repress transcription through the two receptors.The feedback repression maintains pheromone homeostasis,increases fat storage,decreases fat burning,and prolongs dauer lifespan.Thus,the exocrine dauer pheromones possess an unexpected endocrine function to mediate a peroxisome-nucleus crosstalk,coupling dauer diapause to fat rationing. | Cheng Gao Qi Li Jialei Yu Shiwei Li Qingpo Cui Xiao Hu Lifeng Chen Shaobing O.Zhang | 2021 | Science China(Life Sciences)2021，64，12： | 1 |
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