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| 1 | Stability analysis of liver cancer-related microRNAs显示文摘MicroRNAs (miRNAs ) 是非编码的, 22 nt 的搁浅单人赛的 RNA 并且组成在植物和动物被发现的基因管理者的一个新奇的班。几研究证明了浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。关于肝的稳定性的一些文件在浆液的癌症相关的 miRNAs 是可得到的。在浆液的 miRNA 的稳定性的全身的分析是相当必要的。这研究的目的是在不同试验性的条件下面从三不同来源,有教养的肝癌症 Huh-7 房间行,临床的肝癌症,和浆液评估 miRNAs 的稳定性,包括不同温度,时间持续时间, pH 价值, RNase A 消化, DNase 我消化,并且各种各样的 freezethaw 骑车。qRT-PCR 分析表明了癌症相关的 miRNAs 是的那个肝在每测试条件下面可检测,显示 miRNAs 在严厉环境条件下面对破坏和降级极其稳定、抵抗。然而, ribosomal RNA 由在非生理的测试条件下面表明相对表示的锋利的减少易碎、容易降级。我们也极大地为浆液 RNA 抽取建立了一个柔韧的过程,它是不仅为介绍研究的 miRNA 而且为疾病预后重要基于反常 miRNA 表示。 | Yan Li Zhenggang Jiang Lijian Xu Hu Yao Jiangfeng Guo Xianfeng Ding | 2011 | Acta Biochimica et Biophysica Sinica2011，43，1： | 12 |
| 2 | Synthesis of a novel triple-site diphosphinoamine (PNP) ligand and its applications in ethylene tetramerization显示文摘A novel triple-site diphosphinoamine (PNP) ligand was synthesized and characterized. In combination with Cr(III) and methylaluminoxane (MAO), it generated active catalytic systems for ethylene tetramerization toward 1-octene with high catalytic activity and long lifetime. The effects of reaction temperature, molar ratio of Al/Cr and molar ratio of ligand/Cr on catalytic activity and selectivity to 1-octene were studied with reaction kinetics of the catalytic system for ethylene tetramerization described. At the Al/Cr molar ratio of 100, the catalytic activity is up to 2.29×106 g·mol-1 (Cr)·h-1 and the selectivity to 1-octene is 49.65 wt%. | MAO GuoLiang NING YingNan HU WenBo LI ShanMing SONG XianFeng NIU Bo JIANG Tao | 2008 | Chinese Science Bulletin2008，53，22： | 11 |
| 3 | Carbon-coated mesoporous Co9S8 nanoparticles on reduced graphene oxide as a long-life and high-rate anode material for potassium-ion batteries显示文摘Carbon-coated mesoporous Co9S8 nanoparticles supported on reduced graphene oxide(rGO)are successfully synthesized by a simple process.This composite makes full use of the protection of the carbon layer on the surface,the good conductivity and three-dimensional(3D)structure of rGO,the mesoporous structure and nanoscale size of Co9S8,thereby presenting the excellent electrochemical performances in potassium-ion batteries,407.9 mAh·g^−1 after 100 cycles at 0.2 A·g^−1 and 215.1 mAh·g^−1 at 5 A·g^−1 in rate performances.After 1,200 cycles at 1.0 A·g^−1,this composite still remains a capacity of 210.8 mAh·g^−1.The redox reactions for potassium storage are revealed by ex-situ transmission electron microscope(TEM)/high-resolution TEM(HRTEM)images,selected area electron diffraction(SAED)patterns and X-ray photoelectron spectroscopy(XPS)spectra.The application of this composite as the host of sulfur for Li-S batteries is also explored.It sustains a capacity of 431.8 mAh·g^−1 after 800 cycles at 3 C,leading to a degradation of 0.052%per cycle.These results confirm the wide applications of this composite for electrochemical energy storage. | Guangyao Ma Xiao Xu Zhenyu Feng Chenjing Hu Yansong Zhu Xianfeng Yang Jian Yang Yitai Qian | 2020 | Nano Research2020，13，3： | 9 |
| 4 | Trend and Development of Semi-Solid Metal Processing显示文摘This paper reviewed the trend and development of semi-solid metal technique. The processes and mechanisms for producing slurry of SSM and its industrial applications have been summarized and discussed. Discussions on the basic rheological theory are presented for more applications. Further consideration of the development and application of SSM technique is also proposed. | Xianfeng PAN, Haifeng ZHANG, Aimin WANG, Bingzhe DING, Keqiang QIU and Zhuangqi HU (State Key Laboratory of Rapidly Solidified Nonequilibrium Alloys, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110015, China) | 2000 | Journal of Materials Science & Technology2000，16，5： | 7 |
| 5 | Building Information Modeling-Based Secondary Development System for 3D Modeling of Underground Pipelines显示文摘Underground pipeline networks constitute a major component of urban infrastructure,and thus,it is imperative to have an efficient mechanism to manage them.This study introduces a secondary development system to efficiently model underground pipeline networks,using the building information modeling(BIM)-based software Revit.The system comprises separate pipe point and tubulation models.Using a Revit application programming interface(API),the spatial position and attribute data of the pipe points are extracted from a pipeline database,and the corresponding tubulation data are extracted from a tubulation database.Using the Family class in Revit API,the cluster in the self-built library of pipe point is inserted into the spatial location and the attribute data is added;in the same way,all pipeline instances in the pipeline system are created.The extension and localization of the model accelerated the modeling speed.The system was then used in a real construction project.The expansion of the model database and rapid modeling made the application of BIM technology in three-dimensional visualization of underground pipeline networks more convenient.Furthermore,it has applications in pipeline engineering construction and management. | Jun Chen Rao Hu Xianfeng Guo Feng Wu | 2020 | Computer Modeling in Engineering & Sciences2020，，5： | 2 |
| 6 | Surface Doping vs.Bulk Doping of Cathode Materials for Lithium-Ion Batteries:A Review显示文摘To address the capacity degradation,voltage fading,structural instability and adverse interface reactions in cathode materi-als of lithium-ion batteries(LIBs),numerous modification strategies have been developed,mainly including coating and doping.In particular,the important strategy of doping(surface doping and bulk doping)has been considered an effective strategy to modulate the crystal lattice structure of cathode materials.However,special insights into the mechanisms and effectiveness of the doping strategy,especially comparisons between surface doping and bulk doping in cathode materials,are still lacking.In this review,recent significant progress in surface doping and bulk doping strategies is demonstrated in detail by focusing on their inherent differences as well as effects on the structural stability,lithium-ion(Li-ion)diffusion and electrochemical properties of cathode materials from the following mechanistic insights:preventing the exposure of reactive Ni on the surface,stabilizing the Li slabs,mitigating the migration of transition metal(TM)ions,alleviating unde-sired structural transformations and adverse interface issues,enlarging the Li interslab spacing,forming three-dimensional(3D)Li-ion diffusion channels,and providing more active sites for the charge-transfer process.Moreover,insights into the correlation between the mechanisms of hybrid surface engineering strategies(doping and coating)and their influences on the electrochemical performance of cathode materials are provided by emphasizing the stabilization of the Li slabs,the enhancement of the surface chemical stability,and the alleviation of TM ion migration.Furthermore,the existing challenges and future perspectives in this promising field are indicated. | Huaming Qian Haoqi Ren Ying Zhang Xianfeng He Wenbin Li Jingjing Wang Junhua Hu Hong Yang Hirbod Maleki Kheimeh Sari Yu Chen Xifei Li | 2022 | Electrochemical Energy Reviews2022，5，4： | 2 |
| 7 | Circulating microRNA-122 as a potential biomarker for liver injury显示文摘 | Xianfeng Ding Jianv Ding Jing Ning Fan Yi Jiankui Chen Deyao Zhao Jiaping Zheng Zicai Liang Zhiyuan Hu Quan Du | 2012 | Molecular Medicine Reports2012，，6： | 1 |
| 8 | An efficient method to form heterojunction CdS/TiO2 photoelectrodes using highly ordered' TiO2 nanotube array films显示文摘 | Gao Xianfeng Sun Wentao Hu Zhudong | 2009 | J Phys Chem C2009，113，20： | 1 |
| 9 | A posterior inverted L-shaped approach for the treatment of posterior bicondylar tibial plateau fractures显示文摘 | Xianfeng He Penghan Ye Yong Hu Lei Huang Feng Zhang Guanyi Liu Yongping Ruan Congfeng Luo | 2013 | Archives of Orthopaedic and Trauma Surgery2013，，1： | 1 |
| 10 | Covalently tethering disulfonic acid moieties onto polyoxometalate boosts acid strength and catalytic performance for hydroxyalkylation/alkylation reaction显示文摘Solid acid catalysts are widely used in the production of various high-value added and industrially important chemicals.Although the use of organosilicon compounds to modify the vacancy site has been extensively studied,the covalent tethering-SO_(3)H functionalized organosilicon modified polyoxometalates(POMs)has been rarely reported.In this work,two catalysts(TBA_(4)[SiW_(11)O_(39)(O(SiC_(3)H_(6)SO_(3)H)_(2))](compound 2)and TBA_(4)[SiW_(11)O_(39)(O(SiC_(8)H_(8)SO_(3)H)_(2))](compound 3))were synthesized successfully through covalently grafting different sulfonic acid(-SO_(3)H)groups onto[SiW_(11)O_(39)]^(8−)cluster,respectively.Compound 2 was achieved by surface grafting and in situ oxidation(3-mercaptopropyl)-trimethoxysilane,while compound 3 was achieved by surface grafting of 2-(4-chlorosulfonylphenyl)ethyltrimethoxysilane.Strong Brønsted acid strength of compounds 2 and 3 can be demonstrated by different methods including potentiometric titration,pyridine adsorption studies,and the ^(31)P trimethylphosphine oxides(TMPO)nuclear magnetic resonance(NMR).The systematic investigation of the relationship among POM structures,acid strength,and electron density was carried out based on density functional theory(DFT)calculation and experimental results,which revealed that covalent modification of compounds 2 and 3 decreased the electron density of the O-H bond,and promoted the release of H^(+).When applied in hydroxyalkylation/alkylation(HAA)reaction of 2-methylfuran(2-MF)with cyclohexanone,compound 2 exhibited better catalytic performance with conversion of ~93%,monocyclic fuel precursors(1a)yield of 79.9% and selectivity of 85.7% than compound 3,which can be attributed to strong Brønsted acid and the intramolecular hydrogen-bonding interactions between the neighboring -SO_(3)H moieties in compound 2.Finally,compound 2 also showed excellent catalytic activity in the HAA reaction of 2-MF with several different aldehydes and ketones(e.g.,furfuraldehyde,5-methylfurfuraldehyde,acetone,butyraldehyde and 4-methoxybenzaldehyde).This result opens a new pathway for design and fabrication of novel solid acid catalysts. | Lifei Lian Yubing Liu Xianfeng Yi Hanbin Hu Xiang Chen Hongqiang Li Wei Chen Anming Zheng Yu-Fei Song | 2022 | Science China Chemistry2022，65，4： | 1 |
| 11 | Identification of A-to-I RNA editing profiles and their clinical relevance in lung adenocarcinoma显示文摘Adenosine-to-inosine(A-to-I)RNA editing is a widespread posttranscriptional modification that has been shown to play an important role in tumorigenesis.Here,we evaluated a total of 19,316 RNA editing sites in the tissues of 80 lung adenocarcinoma(LUAD)patients from our Nanjing Lung Cancer Cohort(NJLCC)and 486 LUAD patients from the TCGA database.The global RNA editing level was significantly increased in tumor tissues and was highly heterogeneous across patients.The high RNA editing level in tumors was attributed to both RNA(ADAR1 expression)and DNA alterations(mutation load).Consensus clustering on RNA editing sites revealed a new molecular subtype(EC3)that was associated with the poorest prognosis of LUAD patients.Importantly,the new classification was independent of classic molecular subtypes based on gene expression or DNA methylation.We further proposed a simplified model including eight RNA editing sites to accurately distinguish the EC3 subtype in our patients.The model was further validated in the TCGA dataset and had an area under the curve(AUC)of the receiver operating characteristic curve of 0.93(95%CI:0.91-0.95).In addition,we found that LUAD cell lines with the EC3 subtype were sensitive to four chemotherapy drugs.These findings highlighted the importance of RNA editing events in the tumorigenesis of LUAD and provided insight into the application of RNA editing in the molecular subtyping and clinical treatment of cancer. | Cheng Wang Mingtao Huang Congcong Chen Yuancheng Li Na Qin Zijian Ma Jingyi Fan Linnan Gong Hui Zeng Liu Yang Xianfeng Xu Jun Zhou Juncheng Dai Guangfu Jin Zhibin Hu Hongxia Ma Fengwei Tan Hongbing Shen | 2022 | Science China(Life Sciences)2022，65，1： | 1 |
| 12 | The operative treatment of complex pilon fractures: A strategy of soft tissue control显示文摘 | Xianfeng He Yong Hu Penghan Ye Lei Huang Feng Zhang Yongping Ruan | 2013 | Indian Journal of Orthopaedics2013，，5： | 1 |
| 13 | The Caspase Pathway of Linoelaidic Acid (9t, 12t-C18:2)-Induced Apoptosis in Human Umbilical Vein Endothelial Cells显示文摘 | Qiu Bin Huan Rao Jiang-Ning Hu Rong Liu Ya-Wei Fan Jing Li Ze-Yuan Deng Xianfeng Zhong Fang-Ling Du | 2013 | Lipids2013，，2： | 1 |
| 14 | Investigation of lateral spreading current in the 4H-SiC Schottky barrier diode chip显示文摘Lateral current spreading in the 4H-SiC Schottky barrier diode(SBD)chip is investigated.The 4H-SiC SBD chips with the same vertical parameters are simulated and fabricated.The results indicate that there is a fixed spreading resistance at on-state in current spreading region for a specific chip.The linear specific spreading resistance at the on-state is calculated to be 8.6Ω/cm in the fabricated chips.The proportion of the lateral spreading current in total forward current(Psp)is related to anode voltage and the chip area.Psp is increased with the increase in the anode voltage during initial on-state and then tends to a stable value.The stable values of Psp of the two fabricated chips are 32%and 54%.Combined with theoretical analysis,the proportion of the terminal region and scribing trench in a whole chip(Ksp)is also calculated and compared with Psp.The Ksp values of the two fabricated chips are calculated to be 31.94%and 57.75%.The values of Ksp and Psp are close with each other in a specific chip.The calculated Ksp can be used to predict that when the chip area of SiC SBD becomes larger than 0.5 cm2,the value of Psp would be lower than 10%. | Xi Wang Yiwen Zhong Hongbin Pu Jichao Hu Xianfeng Feng Guowen Yang | 2021 | Journal of Semiconductors2021，42，11： | 1 |
| 15 | Simultaneous enhancement of strength and ductility in friction stir processed 2205 duplex stainless steel with a bimodal structure:experiments and crystal plasticity modeling显示文摘Achieving excellent strength-ductility synergy is a long-lasting research theme for structural materials.However,attempts to enhance strength usually induce a loss of ductility,i.e.,the strength-ductility trade-off.In the present study,the strength-ductility trade-off in duplex stainless steel(DSS)was overcome by developing a bimodal structure using friction stir processing(FSP).The ultimate tensile strength and elongation were improved by 140%and 109%,respectively,compared with those of the asreceived materials.Plastic deformation and concurrent dynamic recrystallization(DRX)during FSP were responsible for the formation of bimodal structure.Incompatible deformation resulted in the accumulation of dislocations at the phase boundaries,which triggered interpenetrating nucleation between the austenite and ferrite phases during DRX,leading to a bimodal structure.The in situ mechanical responses of the bimodal structure during tensile deformation were investigated by crystal plasticity finite element modeling(CPFEM).The stress field distribution obtained from CPFEM revealed that the simultaneous enhancement of strength and ductility in a bimodal structure could be attributed to the formation of a unique dispersion-strengthened system with the austenite and ferrite phases.It is indicated that the present design of alternating fine austenite and coarse ferrite layers is a promising strategy for optimizing the mechanical properties of DSSs. | Yanying Hu Zexin Fang Yongbing Peng Weiqi Yang Xianfeng Ma Jinglong Li Yunqiang Zhao Biao Wang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，2： | 0 |
| 16 | Revealing the structure design of alloyed based electrodes for alkali metal ion batteries with in situ TEM显示文摘Alloyed based anode materials with high theoretical specific capacity and low reaction potential are considered to be highly potential high-energy density anode materials for alkali metal ion batteries(AMIBs).Thus,the design of alloyed based materials with high electrochemical performance has attracted great attention.Among the numerous characterization methods for guiding electrode materials design,in situ transmission electron microscopy(TEM)gradually plays an irreplaceable role due to its high temporal and spatial resolution in directly observing the change of morphology,crystal structure and element evolutions.Herein,we reviewed the two current research hotspots and mainly focused on the structure design of alloyed based electrode material under the guidance of in situ TEM.Specifically,various nanostructure designs of alloyed based electrode materials with guidance of in situ TEM were employed to solve the key scientific issues of the violent volume change during alloying/dealloying processes for enhanced electrochemical performances.Mainly through introducing buffer space in the electrode material to reduce volume change to improve structural stability,including porous structure(0 D),nanotube structure(1 D),simple hollow structure,yolk-shell structure and some hybrid hollow structures(3 D).Furthermore,the direct guidance of in situ TEM is expected for creating new opportunities to nextgeneration electrode material design for AMIBs. | Huawen Huang Ran Bi Jie Cui Ming-Ming Hu Li Tian Xianfeng Yang Lei Zhang | 2021 | Journal of Energy Chemistry2021，30，8： | 0 |
| 17 | Digital Twin Modeling and Simulation Optimization of Transmission Front and Middle Case Assembly Line显示文摘As the take-off of China’s macro economy,as well as the rapid development of infrastructure construction,real estate industry,and highway logistics transportation industry,the demand for heavy vehicles is increasing rapidly,the competition is becoming increasingly fierce,and the digital transformation of the production line is imminent.As one of themost important components of heavy vehicles,the transmission front andmiddle case assembly lines have a high degree of automation,which can be used as a pilot for the digital transformation of production.To ensure the visualization of digital twins(DT),consistent control logic,and real-time data interaction,this paper proposes an experimental digital twin modeling method for the transmission front and middle case assembly line.Firstly,theDT-based systemarchitecture is designed,and theDT model is created by constructing the visualization model,logic model,and data model of the assembly line.Then,a simulation experiment is carried out in a virtual space to analyze the existing problems in the current assembly line.Eventually,some improvement strategies are proposed and the effectiveness is verified by a new simulation experiment. | Xianfeng Cao Meihua Yao Yahui Zhang Xiaofeng Hu Chuanxun Wu | 2024 | Computer Modeling in Engineering & Sciences2024，139，6： | 0 |
| 18 | Frontiers of Offshore Oil Equipment and Engineering Technology显示文摘从一个世界范围的观点,近海气体和油地说明总数的 about60% 。目前,超过 100 个国家正在参加近海油和煤气的探索,超过 50 个国家在之中正在探索海洋地板。与设计技术的连续革新,油和气体将向深 waterarea.The 储备开发的潜水艇的探索被期望以后继续增加。在中国的海区域的油和气体的发现率仅仅分别地等于 18.5% 和 9.2% 。与陆地探索相比,近海探索有一个大潜力。 | Hu Xianfeng and Pan Ensheng | 2007 | China Oil & Gas2007，14，2： | 0 |
| 19 | Dynamic response and failure process of horizontal-layered fractured structure rock slope under strong earthquake显示文摘Rock slope with horizontal-layered fractured structure(HLFS)has high stability in its natural state.However,a strong earthquake can induce rock fissure expansion,ultimately leading to slope failure.In this study,the dynamic response,failure mode,and spectral characteristics of rock slope with HLFS under strong earthquake conditions were investigated based on the large-scale shaking table model test.On this basis,multiple sets of numerical calculation models were further established by UDEC discrete element program.Five influencing factors were considered in the parametric study of numerical simulations,including slope height,slope angle,bedding-plane spacing and secondary joint spacing as well as bedrock dip angle.The results showed that the failure process of rock slope with HLFS under earthquake action is mainly divided into four phases,i.e.,the tensile crack of the slope shoulder joints and shear dislocation at the top bedding plane,the extension of vertical joint cracks and increase of shear displacement,the formation of step-through sliding surfaces and the instability,and finally collapse of fractured rock mass.The acceleration response of slopes exhibits elevation amplification effect and surface effect.Numerical simulations indicate that the seismic stability of slopes with HLFS exhibits a negative correlation with slope height and angle,but a positive correlation with bedding-plane spacing,joint spacing,and bedrock dip angle.The results of this study can provide a reference for seismic stability evaluation of weathered rock slopes. | WANG Tong LIU Xianfeng HOU Zhaoxu XU Jiahang ZHANG Jun YUAN Shengyang JIANG Guanlu HU Jinshan | 2024 | Journal of Mountain Science2024，21，3： | 0 |
| 20 | Roadmap for rechargeable batteries:present and beyond显示文摘Rechargeable batteries currently hold the largest share of the electrochemical energy storage market,and they play a major role in the sustainable energy transition and industrial decarbonization to respond to global climate change.Due to the increased popularity of consumer electronics and electric vehicles,lithium-ion batteries have quickly become the most successful rechargeable batteries in the past three decades,yet growing demands in diversified application scenarios call for new types of rechargeable batteries.Tremendous efforts are made to developing the next-generation post-Li-ion rechargeable batteries,which include,but are not limited to solid-state batteries,lithium–sulfur batteries,sodium-/potassium-ion batteries,organic batteries,magnesium-/zinc-ion batteries,aqueous batteries and flow batteries.Despite the great achievements,challenges persist in precise understandings about the electrochemical reaction and charge transfer process,and optimal design of key materials and interfaces in a battery.This roadmap tends to provide an overview about the current research progress,key challenges and future prospects of various types of rechargeable batteries.New computational methods for materials development,and characterization techniques will also be discussed as they play an important role in battery research. | Sen Xin Xu Zhang Lin Wang Haijun Yu Xin Chang Yu-Ming Zhao Qinghai Meng Pan Xu Chen-Zi Zhao Jiahang Chen Huichao Lu Xirui Kong Jiulin Wang Kai Chen Gang Huang Xinbo Zhang Yu Su Yao Xiao Shu-Lei Chou Shilin Zhang Zaiping Guo Aobing Du Guanglei Cui Gaojing Yang Qing Zhao Liubing Dong Dong Zhou Feiyu Kang Hu Hong Chunyi Zhi Zhizhang Yuan Xianfeng Li Yifei Mo Yizhou Zhu Dongfang Yu Xincheng Lei Jianxiong Zhao Jiayi Wang Dong Su Yu-Guo Guo Qiang Zhang Jun Chen Li-Jun Wan | 2024 | Science China Chemistry2024，67，1： | 0 |
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