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| 1 | Anelasticity of twinned CuO nanowires显示文摘CuO nanowires (NW ) 的机械行为被调查由在 situ 传播电子显微镜学。在压缩期间, NW 展出了与高机械的应力联系的高弯曲的能力。有趣地,滞弹性一致地在压力版本以后被观察。进一步的调查显示滞弹性对 CuO NW 内在,尽管 electronbeam 照耀加速形状恢复被证明有能力。机制基于联系双胞胎的原子的合作运动被建议说明这现象。结果提供卓见进 CuO NW 的机械性质,它是为抑制系统的 nanoscale 的有希望的材料。 | Huaping Sheng He Zheng Fan Cao Shujing Wu Lei Li Chun Liu Dongshan Zhao Jianbo Wang | 2015 | Nano Research2015，8，11： | 9 |
| 2 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 3 | Porous surfur-doped hard carbon for excellent potassium storage显示文摘Hard carbon is promising anode for potassium-ion batteries(PIBs),however,the poor rate capability hinders its development as potential anode.To address this question,we design a sulfur-doped porous hard carbon(S-HC)for PIBs through the combination of structural design and composition adjustment.The as-designed S-HC exhibits a long cycling life with^191 mAh/g after 300 cycles at 1 A/g,and an excellent rate capability with^100 mAh/g at 5 A/g,which was attributed to its structural characteristics and compositions.The S-HC demonstrates to be promising anode in the future. | Xuan Xie Shihan Qi Daxiong Wu Huaping Wang Fang Li Xiaoxin Peng Jinfeng Cai Jiaojiao Liang Jianmin Ma | 2020 | Chinese Chemical Letters2020，31，1： | 4 |
| 4 | Systematic study on the mechanical and electric behaviors of the nonbuckling interconnect design of stretchable electronics显示文摘Recently, we developed a nonbuckling interconnect design that provides an effective approach to simultaneously achieving high elastic stretchability, easiness for encapsulation, and high electric performance for stretchable electronics. This paper aims to systematically study its mechanical and electric behaviors, including comparisons of the nonbuckling and buckling interconnect designs on stretchability, effects of the thickness on electric performance, and modeling and experimental investigations on the finite deformation mechanics. It is found that the results on stretchability depend on the layouts. Long straight segments and small arc radii for nonbuckling interconnects yield an enhancement of stretchability, which is much better than that of buckling designs. On the other hand, shorter straight segments or thicker interconnects are better to lower the resistances of interconnects.Therefore, optimization of the designs needs to balance the requirements of both the mechanical and electric performances. The finite deformation of interconnects during stretching is analyzed. The established analytic model is well validated by both the finite element modeling and experimental investigations. This work is key for providing the design guidelines for nonbucklingbased stretchable electronics. | Hao Liu RiYe Xue JianQiao Hu XueCheng Ping HuaPing Wu MingQi Huang Han Zhang Xu Guo Rui Li YuLi Chen YeWang Su | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，11： | 3 |
| 5 | Unexpected intercalation-dominated potassium storage in WS2 as a I potassium-ion battery anode显示文摘Unexpected intercalation-dominated process is observed duri ng K^+insertion in WS2 in a voltage range of 0.01-3.0 V.This is different fromthe previously reported two-dimensional(2D)transition metal dichalcogenides that undergo a conversion reaction in a low voltage rangewhen used as anodes in potassium-ion batteries.Charge/discharge processes in the K and Na cells are studied in parallel to demonstrate thedifferention storage mechanisms.The Na^+storage proceeds through intercalation and conversion reactions while the K^+storage is governedby an intercalation reaction.Owing to the reversible K^+intercalation in the van der Waals gaps,the WS2 anode exhibits a low decay rate of 0.07%per cycle,delivering a capacity of 103 mAh·g^-1 after 100 cycles at 100 mA·g^-1.It maintains 57%capacity at 800 mA·g^-1 and shows stablecyclability up to 400 cycles at 500 mA·g^-1.Kinetics study proves the facilitation of K^+transport is derived from the intercalation-dominatedmecha nism.Furthermore,the mechanismis verified by the density functional theory(DFT)calculations,showing that the progressive expansion of the interlayer space can account for the observed results. | Vuhan Wu Yang Xu Yueliang Li Pengbo Lyu Jin Wen Chenglin Zhang Min Zhou Yaoguo Fang Huaping Zhao Ute Kaiser Yong Lei | 2019 | Nano Research2019，12，12： | 3 |
| 6 | Durable and Flexible Bio-assembled RGO-BC/BC Bilayer Electrodes for Pressure Sensing显示文摘The new generation of electronics tends to be well-performed,facile and environmentally friendly.Here,we report a bio-assembled sensitive pressure senor based on reduced graphene oxide-bacterial cellulose/bacterial cellulose(RGO-BC/BC)bilayer films,integrated by bacteria in one step.The advantage of this integration is that there is strong nanofiber connection between the conductive RGO-BC and insulative highly compressible porous BC layer,which confers RGO-BC/BC film electrode with good robustness,tailorability,flexibility and wearability.Without extra bonding-interface or postprocessing,the RGO-BC/BC bilayer films could be directly assembled into pressure sensing devices.Ascribed from the good reversible compressibility of the BC layer and incorporated bilayer structure,the pressure sensor performs good sensitivity and excellent durability and bending stability.The facile sensitive capacitive sensor could monitor the human hand or finger motion in real time.The sensing array is able to detect the spatial distribution of pressure mounted in the flat plane as well as curved surface of human body,succeeding in the correction of human walking posture for health care.The e-skins are potential in wearable electronics,artificial intelligence,soft robots,healthcare etc. | Fangyi Guan Zhiliang Han Mengtian Jin Zhuotong Wu Ye Chen Shiyan Chen Huaping Wang | 2021 | Advanced Fiber Materials2021，3，2： | 2 |
| 7 | Intestinal dysbiosis exacerbates the pathogenesis of psoriasis-like phenotype through changes in fatty acid metabolism显示文摘The intestinal microbiota has been associated with host immunity as well as psoriasis;however,the mechanism of intestinal microbiota regulating psoriasis needs to be demonstrated systematically.Here,we sought to examine its role and mechanism of action in the pathogenesis of psoriasis.We found that the severity of psoriasis-like skin phenotype was accompanied by changes in the composition of the intestinal microbiota.We performed co-housing and fecal microbial transplantation(FMT)experiments using the K14-VEGF transgenic mouse model of psoriasis and demonstrated that the transfer of intestinal microbiota from mice with severe psoriasis-like skin phenotype exacerbated psoriasiform skin inflammation in mice with mild symptoms,including increasing the infiltration and differentiation of Th17,and increased the abundance of Prevotella,while decreasing that of Parabacteroides distasonis,in the colon.These alterations affected fatty acid metabolism,increasing the abundance of oleic and stearic acids.Meanwhile,gentamicin treatment significantly reduced the abundance of Prevotella and alleviated the psoriasis-like symptoms in both K14-VEGF mice and imiquimod(IMQ)-induced psoriasis-like mice.Indeed,administration of oleic and stearic acids exacerbated psoriasis-like symptoms and increased Th17 and monocyte-derived dendritic cell infiltration in the skin lesion areas in vivo,as well as increased the secretion of IL-23 by stimulating DCs in vitro.At last,we found that,treatment of PDE-4 inhibitor alleviated psoriasis-like phenotype of K14-VEGF mice accompanied by the recovery of intestinal microbiota,including the decrease of Prevotella and increase of Parabacteroides distasonis.Overall,our findings reveal that the intestinal microbiota modulates host metabolism and psoriasis-like skin inflammation in mice,suggesting a new target for the clinical diagnosis and treatment of psoriasis. | Qixiang Zhao Jiadong Yu Hong Zhou Xiaoyan Wang Chen Zhang Jing Hu Yawen Hu Huaping Zheng Fanlian Zeng Chengcheng Yue Linna Gu Zhen Wang Fulei Zhao Pei Zhou Haozhou Zhang Nongyu Huang Wenling Wu Yifan Zhou Jiong Li | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 2 |
| 8 | Removal of humic substances from landfill leachate by Fenton oxidation and coagulation显示文摘 | Yanyu Wu Shaoqi Zhou Fanghui Qin Huaping Peng Yanglan Lai Yiming Lin | 2010 | Process Safety and Environmental Protection2010，，4： | 2 |
| 9 | Quercetin inhibits the proliferation of multiple myeloma cells by upregulating PTPRR expression显示文摘Multiple myeloma (MM) is an incurable disease characterized by malignant plasma cell clonal expansion in the bone marrow;therefore, inhibiting the proliferation of plasma cells is an important approach to overcome the progression of MM. Quercetin (Que) is a promising flavonoid with broad-spectrum anti-tumor activity against various cancers, including MM;however, the underlying mechanism is not yet understood. The present study aimed to reveal the gene expression profile of Que-treated MM cells and clarify its potential mechanism. The 30% inhibitory concentration (IC30) of Que against MM cells was calculated, and the proliferation rate was significantly reduced after Que treatment. Next, 495 dysregulated genes were identified via RNA sequencing in Que-treated MM cells. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes analyses indicated that the dysregulated genes were enriched in various apoptosis-related GO terms and amino acid metabolism-related pathways. qPCR validation showed that protein tyrosine phosphatase receptor-type R (PTPRR) had the highest verified log2 FC (abs) among the top 15 dysregulated genes. Overexpression of PTPRR increased the sensitivity of MM cells against Que, significantly inhibiting their proliferation and colony formation ability;silencing of PTPRR showed the opposite results. Furthermore, bioinformatics analyses and PPI network construction of PTPRR indicated that dephosphorylation of ERK might be the potential pathway for the PTPRR-induced inhibition of MM cell proliferation. In summary, our study identified the gene expression profile in Que-treated MM cells and demonstrated that the upregulation of PTPRR was one of the important mechanisms for the Que-induced inhibition of MM cell proliferation. | Houcai Wang Dandan Yu Hui Zhang Ruye Ma Huiqun Wu Huili Zhai Huaping Wang Jingjing Li Liping Li Yingcong Wang Taofang Cheng Jumei Shi | 2021 | Acta Biochimica et Biophysica Sinica2021，53，11： | 2 |
| 10 | Structurally tunable characteristics of ionic liquids for optimizing lithium plating/stripping via electrolyte engineering显示文摘Electrolyte chemistry offers the opportunity to regulate the solid electrolyte interphase(SEI) and Li^(+)solvation,which is considered to be crucial to the growth of lithium crystals for safe lithium metal batteries(LMBs).Structurally tunable characteristics of ionic liquids(ILs) from anion type,cationic substituent chain length and cationic substituents,will contribute this field.Here,we explore the influence mechanism of imidazole-based ILs as electrolyte additives on Li+solvation and the formation of SEI.ILs can participate into the formation of efficient SEI,together with cathode electrolyte interphase(CEI).Moreover,ILs can also regulate the sheath structure of Li^(+)solvation,to fasten the kinetics of Li.Furthermore,the imidazole-based cations with long alkyl chain can form an electrostatic shield around newly formed Li nucleus,and suppress further Li plating at this site.Under the optimized condition,the 1-octyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide([OMIm]TFSI) additive shows the best ability to enhance the electrochemical performance,endowing the Li||Li symmetric cell with a stable life(over800 h) at 0.5 mA cm^(-2) and the Li||LiNi_(0.6)Mn_(0.2)Co_(0.2)O_(2)(NMC622) full cell with a high capacity of 141.7 mAh g^(-1) after 200 cycles at 0.5 C. | Shihan Qi Jiandong Liu Jian He Huaping Wang Mingguang Wu Daxiong Wu Junda Huang Fang Li Xin Li Yurong Ren Jianmin Ma | 2021 | Journal of Energy Chemistry2021，30，12： | 2 |
| 11 | Bulk growth and separation of single-walled carbon nanotubes from rhenium catalyst显示文摘Bulk synthesis of single-walled carbon nanotubes(SWNTs)using solid catalyst has been challenging,despite of recent breakthrough in the chirality-specific growth on the flat substrate surface.In this work,we propose a porous magnesia support rhenium catalyst for bulk synthesis of SWNTs.It is found that the well-dispersed catalyst with a high melting point and the optimal chemical vapor deposition reaction conditions account for the growth of SWNTs.Detailed characterizations reveal the produced SWNTs are dominant in(n,n−1)and(n,n−2)species.Furthermore,by using a multicolumn chromatography post-growth separation method,SWNTs with three defined diameter ranges were obtained.This work guides the design of porous oxide supported catalyst for bulk synthesis and diameter-dependent sorting of SWNTs,which will ultimately help harness the extraordinary properties of SWNTs. | Chen Ma Yumin Liu Lili Zhang Liu Qian Yiming Zhao Ying Tian Qianru Wu Dong Li Nan Zhao Xueting Zhang Liantao Xin Huaping Liu Pengxiang Hou Chang Liu Maoshuai He Jin Zhang | 2022 | Nano Research2022，15，7： | 2 |
| 12 | Microstructure and Property of AlN Joint Brazed with Au–Pd–Co–Ni–V Brazing Filler显示文摘An Au–Pd–Co–Ni–V brazing alloy was designed for Al N ceramic joining. Its wettability on Al N was studied with the sessile drop method. The results showed that the contact angle was decreased gradually with increasing temperature and the prolonging of holding time. Sound Al N/Al N joints were achieved with the brazing alloy at 1170 °C for 10 min. The microstructure of the Al N/Al N joints was examined by scanning electron microscopy(SEM). It was found that element V played the active role in the interfacial reaction between the ceramic and the brazing alloy. V reacted with N decomposed from Al N, resulted in the formation of V–N compound. Based on the energy-dispersive spectroscopy(EDS)and X-ray diffraction(XRD) analysis results, the V–N reaction product was verified as V2 N. The overall reaction during the brazing process can be described by the following equation: 2V + AlN + 2Pd = V2 N + Pd2 Al.The Al N/Al N joints brazed with the Au–Pd–Co–Ni–V brazing alloy exhibited three-point bend strength of 162.7 MPa at room temperature, and under the bend test the fracture of the joint occurred at the Al N ceramic substrate. | Bo Chen Huaping Xiong Yaoyong Cheng Wei Mao Shibiao Wu | 2015 | Journal of Materials Science & Technology2015，31，10： | 2 |
| 13 | Pseudo-concentrated electrolytes for lithium metal batteries显示文摘Lithium metal batteries suffer from short lifespans and low Coulombic efficiency (CE) due to the high reactivity of Li and the poor stability of the solid electrolyte interphase (SEI). Herein, we propose the concept of a pseudo-concentrated electrolyte (PCE) induced by an electron-deficient additive (4-pyridylboronic acid;4-PBA) to form a robust, LiF-rich SEI, thus addressing the above issues. Molecular dynamics simulations confirm that 4-PBA can increase the coordination number of PF6^(-) anions in the Li+ solvation sheath to achieve pseudo-concentrated LiPF6 in the electrolyte. Moreover, the 4-PBA can scavenge harmful PF5 decomposed from LiPF6 to stabilize the LiF-rich SEI. The resulting robust LiF-rich SEI promotes Li growth along the SEI/Li interface and represses the growth of Li dendrites. Thus, excellent performance is achieved, with a high CE of 97.1% for a Li||Cu cell at 1.0 mA cm^(−2), and over 950 cycles at 0.5 mA cm^(−2) for Li||Li symmetric cells with 1.0 wt% 4-PBA electrolyte. Meanwhile, the resulting stable boron-containing cathode electrolyte interphase enables Li||LiNi0·6Co0·2Mn0·2O_(2) (NCM622) cells to achieve excellent stability, with a capacity retention of 86.9% after 200 cycles. | Huaping Wang Jiandong Liu Jian He Shihan Qi Mingguang Wu Fang Li Junda Huang Yun Huang Jianmin Ma | 2022 | eScience2022，2，5： | 2 |
| 14 | A pentanor- triterpenoid with a novel carbon skeleton and a new pregnane from Trichilia connaroides 显示文摘 | Zhang Huaping Wu Shaohua Shen Yuemao | 2003 | Can J Chem2003，81，： | 1 |
| 15 | Efficient Photocatalytic Degradation of the Persistent PET Fiber‑Based Microplastics over Pt Nanoparticles Decorated N‑Doped TiO_(2) Nanoflowers显示文摘Fiber-based microplastics(FMPs)are highly persistent and ubiquitously exist in the wastewater of textile industry and urban sewage.It remains challenging to completely remove such newly emerged organic pollutants by the predominant physical techniques.In this work,we investigated a photocatalytic degradation catalyzed by TiO_(2) catalyst to demonstrate the feasibility of implementing efficient chemical protocol to fast degrading polyethylene terephthalate(PET)-FMPs(a major FMP type existing in environment).The result shows that a hydrothermal pretreatment(180℃/12 h)is necessary to induce the initial rough appearance and molecular weight reduction.With the comprehensive action of the nano-flower shaped N doped-TiO_(2) catalyst(Pt@N-TiO_(2)-1.5%)on the relatively low molecular weight intermediates,an approximate 29%weight loss was induced on the pretreated PET-FMPs,which is about 8 times superior to the untreated sample.This work not only achieves a superior degradation effect of PET-FMPs,but also provides a new inspiration for the proposal of reduction strategies in the field of environmental remediation in the future. | Dawang Zhou Hongxia Luo Fangzhou Zhang Jing Wu Jianping Yang Huaping Wang | 2022 | Advanced Fiber Materials2022，4，5： | 1 |
| 16 | Characteriza- tion of local mechanical properties of laser-cladding H13-TiC composite coatings using nanoindentation 显示文摘 | Gu Shengting Cai Guozhong Wu Huaping | 2012 | Materials & De- sign2012，39，： | 1 |
| 17 | Characterization of local mechanical properties of laser-cladding H13–TiC composite coatings using nanoindentation and finite element analysis显示文摘 | ShengTing Gu GuoZhong Chai HuaPing Wu YuMei Bao | 2012 | Materials and Design2012，，： | 1 |
| 18 | Characterization of local mechanical properties of laser-cladding H13–TiC composite coatings using nanoindentation and finite element analysis显示文摘 | ShengTing Gu GuoZhong Chai HuaPing Wu YuMei Bao | 2012 | Materials and Design2012，，： | 1 |
| 19 | Covalently immobilized gelatin gradients within three-dimensional porous scaffolds显示文摘A stable gelatin gradient providing continuous increment of signaling for cell adhesion and proliferation was fabricated within 3D poly(L-lactic acid) (PLLA) scaffolds. The porous PLLA scaffold fabricated by NaCl particle leaching was vertically fixed on a glass vial. 1,6-Hexanediamine/propanol solution was continuously injected into the vial by a micropump to aminolyze the PLLA scaffold. As a result of reaction time difference, the introduced -NH2 groups increased continuously along with the longitude of the PLLA scaffold in the z-direction. After covalent immobilization of gelatin by glutaraldehyde coupling, the gelatin gradient scaffold was thus obtained. In vitro chondrocyte culture showed that the cells had higher viability and more extending morphology in the gelatin gradient scaffold than that in the uniform gelatin control. | WU JinDan TAN HuaPing LI LinHui GAO ChangYou | 2009 | Chinese Science Bulletin2009，54，18： | 1 |
| 20 | Combined immersed boundary method and multiple-relaxation-time lattice Boltzmann flux solver for numerical simulations of incompressible flows显示文摘A method combining the immersed boundary technique and a multirelaxation-time(MRT) lattice Boltzmann flux solver(LBFS) is presented for numerical simulation of incompressible flows over circular and elliptic cylinders and NACA 0012 Airfoil. The method uses a simple Cartesian mesh to simulate flows past immersed complicated bodies. With the Chapman-Enskog expansion analysis, a transform is performed between the Navier-Stokes and lattice Boltzmann equations(LBEs). The LBFS is used to discretize the macroscopic differential equations with a finite volume method and evaluate the interface fluxes through local reconstruction of the lattice Boltzmann solution.The immersed boundary technique is used to correct the intermediate velocity around the solid boundary to satisfy the no-slip boundary condition. Agreement of simulation results with the data found in the literature shows reliability of the proposed method in simulating laminar flows on a Cartesian mesh. | Xiaodi WU Fu CHEN Huaping LIU | 2017 | Applied Mathematics and Mechanics(English Edition)2017，38，12： | 1 |
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