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| 1 | Uncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection显示文摘Natural killer (NK) cells are indispensable components of both the innate and adaptive immune response. However,their precise roles in the cross-talk between innate and adaptive immunity during influenza virus infection remaincontroversial. By comparing NK cell dynamics and activity under a sub-lethal dose and high dose of influenza virusinfection, we showed that influenza virus PR8 directly infected NK cells during natural infection, which wasconsistent with our previous findings obtained from an in vitro investigation of human NK cells. The impairments incytotoxicity and IFN-γ production by spleen NK cells following high-dose infection were accompanied by decreasedvirus-specific killing mediated by cytotoxic T lymphocytes (CTLs). Importantly, the weakened CTL activity could bereversed by adoptive transfer of spleen NK cells harvested from low-dose-infected mice but not healthy donors.Taken together, our data provide direct evidence supporting the contribution of NK cells to antiviral T-cellresponses. This study also indicates that a novel NK-targeted immune evasion strategy is used by influenza virusto shrink both innate and adaptive immune responses. | Yuan Liu Jian Zheng Yinping Liu Liyan Wen Lei Huang Zheng Xiang Kwok-Tai Lam Aizhen Lv Huawei Mao Yu-Lung Lau Wenwei Tu | 2018 | Cellular & Molecular Immunology2018，15，9： | 6 |
| 2 | Evolution of Pore Size Distribution and Mean Pore Size in Lotus-type Porous Magnesium Fabricated with Gasar Process显示文摘吝啬的毛孔上的压力缩放的气体的效果,孔和毛孔缩放莲花类型的分发与 Gasar 过程制作的多孔的镁被调查。理论分析和试验性的结果都显示那在那里存在到为与更狭窄的毛孔尺寸分发和更小的毛孔尺寸生产 lotus-typestructures 的氩 p_(Ar ) 的氢 p_(H_2 ) 的部分压力的最佳的比率。毛孔尺寸分发和毛孔尺寸上的团结模式的效果也被讨论。 | Yuan LIU Yanxiang LI Huawei ZHANG Jiang WAN | 2006 | Journal of Materials Science & Technology2006，22，3： | 3 |
| 3 | Risk of Lung Cancer and Occupational Exposure to Polycyclic Aromatic Hydrocarbons Among Workers Cohorts—Worldwide,1969–2022显示文摘Summary What is already known about this topic?Lung cancer has a high mortality,resulting in a severe disease burden.Polycyclic aromatic hydrocarbons(PAHs)are definitive carcinogen to human,and occupational exposure to PAHs is associated with lung cancer.What is added by this report?We analyzed the cancer cases from cohort studies on various PAHs exposed workers in China and other countries,calculated the quantitative risk of lung cancer based on meta-analyses,and confirmed the increased risk from lung cancer in selected PAHs exposed occupations.What are the implications for public health practices?There is a clear need to prevent lung cancer on a wide range of PAHs-related occupations in China and around the world.It is crucial to establish guidelines for improving the monitoring on exposure and health promotion in related working environments. | Huige Yuan Yanhua Wang Huawei Duan | 2022 | China CDC weekly2022，4，17： | 3 |
| 4 | Metal-gas eutectic growth during unidirectional solidification显示文摘 | Yuan Liu Yanxiang Li Jiang Wan Huawei Zhang | 2006 | Metallurgical and Materials Transactions A2006，，9： | 2 |
| 5 | Directional solidification of metal-gas eutectic and fabrication of regular porous metals显示文摘Directional solidification of metal-gas eutectic (Gasar) is a novel process for making regular porous metals.This process is based on a solid-gas eutectic reaction involving a gaseous medium and a metal or a ceramic phase, andallows an easy control of the porosity, such as its pore size, pore orientation and morphology in a wide range by properlyadjusting its melting and solidification conditions. The latest progress and our research work in this field are reviewed inthis paper. | Yuan LIU Huawei ZHANG Xiang CHEN Yanxiang LI | 2005 | China Foundry2005，2，3： | 2 |
| 6 | Effect of copper on magnetostriction and mechanical properties of TbDyFe alloys显示文摘The intrinsic brittleness of the TbDyFe alloy significantly decreases its mach inability and applications.This paper aims to improve the toughness of TbDyFe alloy by adding Cu. Various alloys of the type(Tb_(0.3)Dy_(0.7))_(0.37)Fe_(0.63-χ)Cu_χ(χ=0, 0,01.0.03, 0.05, 0.08, 0.1) were fabricated by an arc melting furnace under a high purity argon atmosphere. The microstructure, magnetostrictive properties and mechanical performance were studied systematically. The results show that the (Tb,Dy)Cu phase forms in these alloys upon the addition of Cu. Correspondingly, their toughness improves, attributed to the formation of a (Tb,Dy)Cu phase. Compared to the Cu-free alloy, the fracture toughness (Kic) increases 2-3 times with increasing Cu content. However, the magnetostriction performance of these alloys declines with Cu addition, due to the low-magnetic performance of the (Tb,Dy)Cu phase at room temperature. Compared with other alloys, the alloy with the addition of 1at%Cu shows the best compromise between the saturation magnetostriction and fracture toughness. | Naijuan Wang Yuan Liu Huawei Zhang Xiang Chen Yanxiang Li | 2019 | Journal of Rare Earths2019，37，1： | 2 |
| 7 | Metal-gas eutectic growth during unidirectional solidification显示文摘 | Yuan Liu Yanxiang Li Jiang Wan Huawei Zhang | 2006 | Metallurgical and Materials Transactions A2006，，9： | 1 |
| 8 | Fabrication of a bimodal micro/nanoporous metal by the Gasar and dealloying processes显示文摘 | Xingming Zhang Yanxiang Li Yuan Liu Huawei Zhang | 2013 | Materials Letters2013，，： | 1 |
| 9 | Fabrication of a three-dimensional bimodal porous metal显示文摘 | Xingming Zhang Yanxiang Li Huawei Zhang Yuan Liu | 2013 | Materials Letters2013，，： | 1 |
| 10 | Experimental study on heat transfer performance of lotus-type porous copper heat sink显示文摘 | Huawei Zhang Liutao Chen Yuan Liu Yanxiang Li | 2013 | 2013 (1-2)2013，，1： | 1 |
| 11 | Experimental study on heat transfer performance of lotus-type porous copper heat sink显示文摘 | Huawei Zhang Liutao Chen Yuan Liu Yanxiang Li | 2013 | International Journal of Heat and Mass Transfer (-)2013，，1： | 1 |
| 12 | Evaluation of porosity in lotus-type porous magnesium fabricated by metal/gas eutectic unidirectional solidification显示文摘 | Liu Yuan Li Yanxiang Wan Jiang Zhang Huawei | 2005 | Materials Science & Engineering A2005，，1： | 1 |
| 13 | Programmable deaminase-free base editors for G-to-Y conversion by engineered glycosylase显示文摘Current DNA base editors contain nuclease and DNA deaminase that enables deamination of cytosine(C)or adenine(A),but no method for guanine(G)or thymine(T)editing is available at present.Here we developed a deaminase-free glycosylase-based guanine base editor(gGBE)with G editing ability,by fusing Cas9 nickase with engineered N-methylpurine DNA glycosylase protein(MPG).By several rounds of MPG mutagenesis via unbiased and rational screening using an intron-split EGFP reporter,we demonstrated that gGBE with engineered MPG could increase G editing efficiency by more than 1500 fold.Furthermore,this gGBE exhibited high base editing efficiency(up to 81.2%)and high G-to-T or G-to-C(i.e.G-to-Y)conversion ratio(up to 0.95)in both cultured human cells and mouse embryos.Thus,we have provided a proof-of-concept of a new base editing approach by endowing the engineered DNA glycosylase the capability to selectively excise a new type of substrate. | Huawei Tong Nana Liu Yinghui Wei Yingsi Zhou Yun Li Danni Wu Ming Jin Shuna Cui Hengbin Li Guoling Li Jingxing Zhou Yuan Yuan Hainan Zhang Linyu Shi Xuan Yao Hui Yang | 2023 | National Science Review2023，10，8： | 1 |
| 14 | The p.(Pro170Leu) variant in NOG impairs noggin secretion and causes autosomal dominant congenital conductive hearing loss due to stapes ankylosis显示文摘Conductive hearing loss is the impairment in the mechanical transduction of sound wave through the external ear and the middle ear.Although most cases are sporadic due to acquired causes such as infections(otitis media and otitis externa),cerumen obstruction,and injuries,congenital structural defects are uncommon for significant etiologies to recognize.Stapes ankylosis is characterized by conductive hearing loss.It may be difficult to differentiate from otosclerosis,the most common cause of progressive conductive hearing loss,by audiologic evaluation,when the diagnosis is delayed.Skeletal anomalies may be subtle,such that the syndrome may not be recognized(Brown et al.,2002). | Yilai Shu Lijun Wang Xiaoting Cheng Chayada Tangshewinsirikul Weili Shi Yasheng Yuan Zhiqiang Yan Huawei Li Jun Shen Bing Chen Weiguo Zou | 2019 | Journal of Genetics and Genomics2019，46，9： | 1 |
| 15 | Experimental study on heat transfer performance of lotus-type porous copper heat sink显示文摘 | Huawei Zhang Liutao Chen Yuan Liu Yanxiang Li | 2013 | International Journal of Heat and Mass Transfer (-)2013，，1： | 1 |
| 16 | Functional Mutation of SMAC / DIABLO , Encoding a Mitochondrial Proapoptotic Protein, Causes Human Progressive Hearing Loss DFNA64显示文摘 | Jing Cheng Yuhua Zhu Sudan He Yanping Lu Jing Chen Bing Han Marco Petrillo Kazimierz O. Wrzeszczynski Shiming Yang Pu Dai Suoqiang Zhai Dongyi Han Michael Q. Zhang Wei Li Xuezhong Liu Huawei Li Zheng-Yi Chen Huijun Yuan | 2011 | The American Journal of Human Genetics2011，，1： | 1 |
| 17 | Review of studies on target acquisition in virtual reality based on the crossing paradigm显示文摘Crossing is a fundamental paradigm for target selection in human-computer interaction systems.This paradigm was first introduced to virtual reality(VR)interactions by Tu et al.,who investigated its performance in comparison to pointing,and concluded that crossing is generally no less effective than pointing and has unique advantages.However,owing to the characteristics of VR interactions,there are still many factors to consider when applying crossing to a VR environment.Thus,this review summarizes the main techniques for object selection in VR and crossing-related studies.Then,factors that may affect crossing interactions are analyzed from the perspectives of the input space and visual space.The aim of this study is to provide a reference for future studies on target selection based on the crossing paradigm in virtual reality. | Susu HUANG Daqing QI Jiabin YUAN Huawei TU | 2019 | Virtual Reality & Intelligent Hardware2019，1，3： | 1 |
| 18 | Multi-omics reveals the mechanisms underlying Lactiplantibacillus plantarum P8-mediated attenuation of oxidative stress in broilers challenged with dexamethasone显示文摘Oxidative stress is a common phenomenon in poultry production.Several molecules,including antioxidant genes,miRNAs,and gut microbiota metabolites,have been reported to participate in redox regulation.Lactiplantibacillus plantarum P8(P8)was shown to improve the antioxidant capacity of chickens,but the specific molecular mechanisms remain unclear.In this study,400 broilers were allocated to 4treatment groups:control diet(Con group),control diet+dexamethasone injection(DEX group),control diet containing 1×108CFU/g P8(P8 group),and control diet containing 1×108CFU/g P8+DEX injection(DEX_P8 group).Integrated analysis of the microbiome,metabolomics,and miRNAomics was conducted to investigate the roles of P8 in oxidative stress in broilers.Results demonstrated that P8supplementation significantly improved growth performance,jejunal morphology,and antioxidant function in DEX-treated broilers.Analysis of the gut microbiota revealed a higher abundance of Barnesiella(P=0.01)and Erysipelatoclostridium(P=0.05)in the DEX_P8 group than in the DEX group.Functional prediction indicated that certain pathways,including the phenylacetate degradation pathway,were enriched in the DEX_P8 group compared to the DEX group.Metabolites in the cecal contents were distinct between the groups.P8 supplementation increased the content of metabolites with antioxidant capacity,e.g.,urobilinogen(P<0.01),and decreased that of metabolites related to oxidative stress,e.g.,genistein(P<0.01).Functional prediction indicated that metabolites that differed between the DEX_P8and DEX groups were enriched in pathways including“tryptophan metabolism”and“primary bile acid biosynthesis”.The miRNAomics analysis further showed that,compared to the DEX group,several miRNAs in the jejunum,such as gga-miR-21-3p(P=0.03),were increased,whereas gga-miR-455-3p(P=0.02)was decreased in the DEX_P8 group.The PI3K-Akt,Ras,and Rap1 signaling pathways were enriched in the DEX_P8 group compared to the DEX group through KEGG analysis.Correlation analysis revealed potential interactions between growth performance,oxidation/antioxidation,jejunal morphology,gut microbiota,cecal content metabolites,and jejunal miRNAs.Overall,our results indicate that P8 supplementation may improve the growth performance,jejunal morphology and antioxidant capacity of DEX-treated broilers by regulating gut microbiota,its metabolites,and intestinal miRNAs. | Jinshan Zhao Fan Zhao Xuemin Li Junmeng Yuan Kai Zhang Huawei Liu Yang Wang | 2023 | Animal Nutrition2023，，3： | 0 |
| 19 | Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing in Chinese patients显示文摘Primary central nervous system lymphoma(PCNSL)is an uncommon non-Hodgkin’s lymphoma with poor prognosis.This study aimed to depict the genetic landscape of Chinese PCNSLs.Whole-genome sequencing was performed on 68 newly diagnosed Chinese PCNSL samples,whose genomic characteristics and clinicopathologic features were also analyzed.Structural variations were identified in all patients with a mean of 349,which did not significantly influence prognosis.Copy loss occurred in all samples,while gains were detected in 77.9%of the samples.The high level of copy number variations was significantly associated with poor progression-free survival(PFS)and overall survival(OS).A total of 263 genes mutated in coding regions were identified,including 6 newly discovered genes(ROBO2,KMT2C,CXCR4,MYOM2,BCLAF1,and NRXN3)detected in≥10%of the cases.CD79B mutation was significantly associated with lower PFS,TMSB4X mutation and high expression of TMSB4X protein was associated with lower OS.A prognostic risk scoring system was also established for PCNSL,which included Karnofsky performance status and six mutated genes(BRD4,EBF1,BTG1,CCND3,STAG2,and TMSB4X).Collectively,this study comprehensively reveals the genomic landscape of newly diagnosed Chinese PCNSLs,thereby enriching the present understanding of the genetic mechanisms of PCNSL. | Xianggui Yuan Teng Yu Jianzhi Zhao Huawei Jiang Yuanyuan Hao Wen Lei Yun Liang Baizhou Li Wenbin Qian | 2023 | Frontiers of Medicine2023，17，5： | 0 |
| 20 | Fabrication of lotus-type porous micro-channel copper by single-mold Gasar technique显示文摘A single-mold Gasar technique was developed to produce lotus-type porous micro-channel copper with uniform porous structure. In this paper the effect of withdrawal rate on the solid/liquid interface morphology and the corresponding porous structure was systematically investigated, especially the pore morphology, pore growth direction, porosity, and pore diameter of porous copper ingots. In addition, a temperature fi eld simulation was carried out based on Pro Cast software to investigate the shape and movement velocity of the solidifying solid/liquid interface. The experimental results show that the solidifi cation interface changes from convex to planar, then to concave shape with an increase in withdrawal rate. The average porosities of copper ingots are constant and independent of the withdrawal rate. The average pore diameter decreases with an increase in withdrawal rate. | Liu Yuan Zhuo Weijia Zhang Huawei Li Yanxiang | 2014 | China Foundry2014，11，6： | 0 |
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