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| 1 | Factor analysis identifies subgroups of constipation显示文摘AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic dysfunction.METHODS:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport questionnaire.One hundred of these patients had colonic transit measured scintigraphically.Factor analysis determined whether constipation-related symptoms grouped into distinct aspects of symptomatology.Cluster analysis was used to determine whether indi-vidual patients naturally group into distinct subtypes.RESULTS:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main descriptors.Amongst all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool frequency.The majority of patients with these characteristics also reported regular laxative use.CONCLUSION:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated population.However,clear stratification into clinically identifiable groups remains imprecise. | Philip G Dinning Mike Jones Linda Hunt Sergio E Fuentealba Jamshid Kalanter Denis W King David Z Lubowski Nicholas J Talley Ian J Cook | 2011 | World Journal of Gastroenterology2011，17，11： | 3 |
| 2 | 传统路面与透水混凝土路面砖路面隐含碳量的评价显示文摘本文介绍用路面砖铺地时所用材料的隐含碳量的数据。隐含碳量系指在材料开采、生产制造和运输过程中所排放CO2的总重量。给出混凝土路面砖、沥青、现浇混凝土、土工布和集料等产品的隐含碳量水平,并以此提出用于计算单位面积路面所产生的总CO2量方法。并给出一个住宅小区内用透水混凝土路面砖铺设路面的总CO2隐含量数据。把这些数据应用于一个典型的中等规模的住宅小区项目中,先假定采用透水混凝土路面砖铺设的路面,再假定路面采用传统路面的表面排水系统。得出的结论是:用透水混凝土路面砖替代传统的地面排水系统,CO2排放量大约减少50%。考虑到植树来'中和'路面建材产品的隐含碳量的可能性,本文得出结论:通过种植足够数量的树,可使铺设透水混凝土路面砖路面实现碳排放量的'中和';这种方法对很多透水混凝土路面砖路面项目来说,是一件简单的事情。在所列举的住宅小区项目中,通过种植一定数量的树木、以最少的建设费用,提高了项目的品质。因为不同树龄的树吸收CO2的水平不同,加上路面材料在产生过程中所排放CO2都属于'预先释放',所以在项目的初期是呈'碳亏空'状态(CO2净排放),但五十年后,路面与树木的共同作用将对CO2排放量产生积极贡献。本文得出结论:无论在何处,采用透水混凝土路面砖的设计方案中,都应包含长期的碳中和要求,或尽可能考虑如何多抵消在材料生产过程中的碳排放。 | Cook Ian Knapton John 崔玉忠 | 2012 | 建筑砌块与砌块建筑2012，，3： | 2 |
| 3 | Inter-observer agreement for Crohn’s disease sub-phenotypes using the Montreal Classification: How good are we? A multi-centre Australasian study显示文摘 | Krupa Krishnaprasad Jane M. Andrews Ian C. Lawrance Timothy Florin Richard B. Gearry Rupert W.L. Leong Gillian Mahy Peter Bampton Ruth Prosser Peta Leach Laurie Chitti Charles Cock Rachel Grafton Anthony R. Croft Sharon Cooke James D. Doecke Graham L. Rad | 2011 | Journal of Crohn’s and Colitis2011，，3： | 2 |
| 4 | The Tubulin-Binding Agent Combretastatin A-4-Phosphate Arrests Endothelial Cells in Mitosis and Induces Mitotic Cell Death显示文摘 | Chryso Kanthou Olga Greco Anna Stratford Ian Cook Richard Knight Omar Benzakour Gillian Tozer | 2004 | The American Journal of Pathology2004，，4： | 1 |
| 5 | Geographies of food: ’Afters’显示文摘 | Cook Ian Hobson Kersty Hallett Lucius Guthman Julie Murphy Andrew Hulme Alison Sheller Mimi Crewe Louise Nally David Roe Emma Mather Charles Kingsbury Paul Slocum Rachel Imai Shoko Duruz Jean Philo Chris Buller Henry Goodman Mike Hayes-C | 2011 | Progress in Human Geography2011，，1： | 1 |
| 6 | Upper esophageal sphincter tone and reactivity to stress in patients with a history of globus sensation显示文摘 | Ian J Cook | 1989 | Diges tire Diseasis and Sciences1989，34，6： | 1 |
| 7 | Development of whole body adiposity in preterm infants显示文摘 | Ian J. Griffin Richard J. Cooke | 2012 | Early Human Development2012，，： | 1 |
| 8 | Reducing ventilator-associated pneumonia in intensive care: Impact of implementing a care bundle显示文摘 | Andrew Conway Morris Alasdair W. Hay David G. Swann Kirsty Everingham Corrienne McCulloch Jane McNulty Odette Brooks Ian F. Laurenson Brian Cook Timothy S. Walsh | 2011 | Critical Care Medicine2011，，10： | 1 |
| 9 | Crohn’s disease and smoking: Is it ever too late to quit?显示文摘 | Ian C. Lawrance Kevin Murray Birol Batman Richard B. Gearry Rachel Grafton Krupa Krishnaprasad Jane M. Andrews Ruth Prosser Peter A. Bampton Sharon E. Cooke Gillian Mahy Graham Radford-Smith Anthony Croft Katherine Hanigan | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
| 10 | Discrepancies in the Measurement of UVC-Induced 8-Oxo-2′-deoxyguanosine: Implications for the Analysis of Oxidative DNA Damage显示文摘 | Mark D. Evans Marcus S. Cooke Ian D. Podmore Qinguo Zheng Karl E. Herbert Joseph Lunec | 1999 | Biochemical and Biophysical Research Communications1999，，2： | 1 |
| 11 | Management of esophageal perforation after pneumatic dilation for achalasia显示文摘 | David R. Hunt Vanessa L. Wills Beatrix Weiss John O. Jorgensen David J. DeCarle Ian J. Cook | 2000 | Journal of Gastrointestinal Surgery2000，，4： | 1 |
| 12 | Upper esophageal sphincter tone and reactivity to stress in patients with a history of globus sensation显示文摘 | Dr. Ian J. Cook MD Dr. John Dent MD Stephen M. Collins MD | 1989 | Digestive Diseases and Sciences1989，，5： | 1 |
| 13 | Timing of videofluoroscopic, manometric events, and bolus transit during the oral and pharyngeal phases of swallowing显示文摘 | Ian J. Cook M.D. Wylie J. Dodds M.D. Roberto O. Dantas M.D. Mark K. Kern M.S. Benson T. Massey M.D. Reza Shaker M.D. Walter J. Hogan M.D | 1989 | Dysphagia1989，，1： | 1 |
| 14 | Immunofluorescence Techniques 显示文摘 | Ian D O Cook D | 2013 | Journal of Investigative Dermatology2013，133，1： | 1 |
| 15 | Multimillion year thermal history of a porphyry copper deposit: application of U–Pb, 40 Ar/ 39 Ar and (U–Th)/He chronometers, Bajo de la Alumbrera copper–gold deposit, Argentina显示文摘 | Anthony C. Harris W. James Dunlap Peter W. Reiners Charlotte M. Allen David R. Cooke Noel C. White Ian H. Campbell Suzanne D. Golding | 2008 | Mineralium Deposita2008，，3： | 1 |
| 16 | Effectiveness of a quantitative electroencephalographic biomarker for predicting differential response or remission with escitalopram and bupropion in major depressive disorder显示文摘 | Andrew F. Leuchter Ian A. Cook William S. Gilmer Lauren B. Marangell Karl S. Burgoyne Robert H. Howland Madhukar H. Trivedi Sidney Zisook Rakesh Jain Maurizio Fava Dan Iosifescu Scott Greenwald | 2009 | Psychiatry Research2009，，2： | 1 |
| 17 | Atrioventricular septal defects diagnosed in fetal life: associated cardiac and extra-cardiac abnormalities and outcome显示文摘 | Ian C Huggon Andrew C Cook Nigel C Smeeton Alan G Magee Gurleen K Sharland | 2000 | Journal of the American College of Cardiology2000，，： | 1 |
| 18 | Private Sector Involvement in Urban Gov- ernance: The Case of Business Improvement Districts and Town Centre Management Partnerships in Eng- land显示文摘 | Ian Cook | 2009 | Geoforum2009，，5： | 1 |
| 19 | EBM分析:全科医学 循证医学与机器学习:志同道合的伙伴显示文摘循证医学起源于流行病学之时便已经形成了一系列严格的方法。这些方法可用于评估基于假设的实证研究在评价诊断试验、结局预测工具和干预措施方面的有效性、影响力和适用性。机器学习是人工智能的一部分,它使用计算机程序识别海量数据集中的模式和关联,然后将这些模式和关联整合到用于辅助诊断和预测结局(包括对治疗的反应)的算法中。这两个领域如何相互关联?他们有何异同,如何各有千秋?两者可否相互借鉴和补充以使临床决策更为明智和有效? | Ian Scott David Cook Enrico Coiera 王红剑(译) 孟玲慧(审校) | 2020 | 英国医学杂志中文版2020，23，12： | 0 |
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