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| 1 | Collagen-binding basic fibroblast growth factor improves functional remodeling of scarred endometrium in uterine infertile women: a pilot study显示文摘Intrauterine adhesion(IUA) is a common cause of uterine infertility and one of the most severe clinical features is endometrial fibrosis namely endometrial scarring for which there are few cures currently. Blocked angiogenesis is the main pathological change in the scarred endometrium. The fibroblast growth factor 2(b FGF), a member of FGF family, is usually applied to promote healing of refractory ulcer and contributes to angiogenesis of tissues. In this study, the sustained-release system of b FGF100 μg was administrated around scarred endometrium guiding by ultrasound every 4 weeks in 18 patients(2–4 times). Results showed that after treatment, the menstrual blood volume, endometrial thickness and the scarred endometrial area were improved.Histological study showed blood vessel density increased obviously. Three patients(3/18) achieved pregnancy over 20 gestational weeks. Therefore, administrating the b FGF surrounding scarred endometrium may provide a new therapeutic approach for the patients with endometrial fibrosis. | Peipei Jiang Xiaoqiu Tang Huiyan Wang Chenyan Dai Jing Su Hui Zhu Minmin Song Jingyu Liu Ziqing Nan Tong Ru Yaling Li Jingmei Wang Jun Yang Bing Chen Jianwu Dai Yali Hu | 2019 | Science China(Life Sciences)2019，62，12： | 16 |
| 2 | Adaptive robust control of nonholonomic systems with stochastic disturbances显示文摘This paper deals with nonholonomic systems in chained form with unknown covariance stochastic disturbances. The objective is to design the almost global adaptive asymptotical controllers in probability u0 and u1 for the systems by using discontinuous control. A switching control law u0 is designed to almost globally asymptotically stabilize the state x0 in both the singular x0 (t0)=0 case and the non-singular x0 (t0)≠0 case. Then the state scaling technique is introduced for the discontinuous feedback into the (x1, x2, …, xn)-subsystem. Thereby, by using backstepping technique the global adaptive asymptotical control law u1 has been presented for (x1, x2, …, xn) -subsystem for both different u0 in non-singular x0 (t0)≠0 case and the singular case x0 (t0)=0. The control algorithm validity is proved by simulation. | WANG Jiang GAO Hanqiao LI Huiyan | 2006 | Science in China(Series F)2006，49，2： | 7 |
| 3 | Numerical simulation of cavitation turbulence in Francis turbine runner with splitter blades显示文摘Cavitation will reduce the turbine performance and even damage the turbine components.To verify the effects of splitter blades on improving the cavitation performance,the cavitation flow inside a Francis turbine runner with splitter blades was numerically simulated by using the Singhal cavitation model and the standard k-ε turbulence model.The distributions of static pressure and gas volume fractions on the surface of the runner blades were predicated under different conditions,and the cavitation in the flow field of the runner was analyzed.The results show that the static pressure and gas volume fractions are more uniformly distributed on the short blades than those on the long blades in Francis turbines with splitter blades,and there is almost no cavitation on the short blades;their distributions are more uniform under small flow conditions than those under large flow conditions;and large gas volume fractions are concentrated at the outlet tip near the band on the suction side of the long blade.The installation of splitter blades can improve the cavitation performance of conventional Francis turbines. | WANG Huiyan LIU Xiaobing JIANG Qifeng HUA Hong OU Shunbing | 2020 | 排灌机械工程学报2020，38，1： | 2 |
| 4 | Research and Application on Web Information Retrieval Based on Improved FP-Growth Algorithm显示文摘A kind of single linked lists named aggregative chain is introduced to the algorithm, thus improving the architecture of FP tree. The new FP tree is a one-way tree and only the pointers that point its parent at each node are kept. Route information of different nodes in a same item are compressed into aggregative chains so that the frequent patterns will be produced in aggregative chains without generating node links and conditional pattern bases. An example of | JIAO Minghai YAN Ping JIANG Huiyan | 2006 | Wuhan University Journal of Natural Sciences2006，11，5： | 2 |
| 5 | Optimization Approach of Sintering Feature Parameter Based on Fuzzy SVM 显示文摘 | Jiang Huiyan Huo Yan Zhou Xiaojie | 2008 | International Symposiums on Information Processing2008，34，2： | 1 |
| 6 | A medical image 3 D recon- struction method based on improved MC and MT algorithms 显示文摘 | Huiyan Jiang Ye Zhang Yudong Zhao | 2009 | Industrial Electronics and Applications2009，，2527： | 1 |
| 7 | A region growing vessel segmentation algor-ithm based on spectrum information显示文摘 | Jiang Huiyan He Baochun Fang Di | 2013 | Computational and Mathematical Methods in Medicine2013，2013，： | 1 |
| 8 | Highly Efficient Image Stitching Based on Energy Map显示文摘 | Yu Tang Huiyan Jiang | 2009 | IEEE CISP''092009，，： | 1 |
| 9 | Optimization Ap-proach of Sintering Feature Parameter Based on Fuzzy SVM 显示文摘 | JIANG HUIYAN HUO YAN ZHOU XIAOJIE | 2008 | International Symposiums on Information Processing2008，34，2： | 1 |
| 10 | Robust ISS-satisficing Variable Universe Indirectfuzzy Control for Chaotic Systems 显示文摘 | Wang Jiang Si Wenjie Li Huiyan | 2009 | Chaos Solitons and Fractals2009，39，： | 1 |
| 11 | Synchronization of coupled equations of Morris-Lecar model 显示文摘 | Wang Jiang Lu Meili Li Huiyan | 2008 | Communications in Nonlinear Science and Numerical Simulation2008，13，： | 1 |
| 12 | Rapid puff?cation of polysaccharides using novel radial ?ow ion-exchange by response surface methodology from Ganoderma lucidum 显示文摘 | JIANG Huiyan SUN Peilong HE Jinzhe | 2012 | Food and Bioproducts Process- ing2012，90，1： | 1 |
| 13 | Synchronization of Fitz-Hugh-Nagumo systems in EES via H∞ variable uni verse control显示文摘 | Wang Jiang Zhang Zhen Li Huiyan | 2008 | Chaos Solitons and Fractals2008，36，5： | 1 |
| 14 | Gene regulatory network inference based on causal discovery integrating with graph neural network显示文摘Gene regulatory network (GRN) inference from gene expression data is asignificant approach to understanding aspects of the biological system.Compared with generalized correlation-based methods, causality-inspiredones seem more rational to infer regulatory relationships. We proposeGRINCD, a novel GRN inference framework empowered by graph representationlearning and causal asymmetric learning, considering both linearand non-linear regulatory relationships. First, high-quality representation ofeach gene is generated using graph neural network. Then, we apply theadditive noise model to predict the causal regulation of each regulator-targetpair. Additionally, we design two channels and finally assemble them forrobust prediction. Through comprehensive comparisons of our frameworkwith state-of-the-art methods based on different principles on numerousdatasets of diverse types and scales, the experimental results show that ourframework achieves superior or comparable performance under variousevaluation metrics. Our work provides a new clue for constructing GRNs,and our proposed framework GRINCD also shows potential in identifyingkey factors affecting cancerdevelopment. | Ke Feng Hongyang Jiang Chaoyi Yin Huiyan Sun | 2023 | Quantitative Biology2023，11，4： | 0 |
| 15 | Genetic resources of lotus (Nelumbo) and their improvement显示文摘Lotus(Nelumbo)is one of the top ten flowers in China,which has high ornamental,edible and medicinal value.Lotus has a been cultivated for thousands of years.Through discovery and cultivation,more than 4,000 cultivars have been recorded.However,the information related to lotus breeding is quite scattered,and the related genetic rules and trait formation mechanisms are still poorly understood,which has caused a greater impact on lotus genetic breeding.This article systematically introduces lotus germplasm resources,including wild species and cultivated species,summarizes lotus breeding methods and breeding directions,and focuses on the latest progress in the isolation and functional identification of structural and regulatory genes related to important horticultural traits.Prospects for the protection and utilization of lotus resources,breeding and industrialization are reported. | Ping Zhou Qijiang Jin Ping Qian Yanjie Wang Xiaowen Wang Huiyan Jiang Dongrui Yao Xiaojing Liu Fengjun Liu Jun Li Yingchun Xu | 2022 | Ornamental Plant Research2022，2，1： | 0 |
| 16 | A HYBRID PSO-SA OPTIMIZING APPROACH FOR SVM MODELS IN CLASSIFICATION显示文摘 | HUIYAN JIANG LINGBO ZOU | 2013 | International Journal of Biomathematics2013，6，5： | 0 |
| 17 | Zhenxin Anshen formula(镇心安神方)ameliorates atopic der-matitis-like skin dysfunction in mice and in vitro via regulation of transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 in Neural pathways显示文摘OBJECTIVE:To investigate the efficacy of Zhenxin Anshen formula(镇心安神方,ZXAS)on atopic dermatitis(AD)by transient receptor potential vanilloid 1(TRPV1)and transient receptor potential ankyrin 1(TRPA1)signalling pathway in mice and in vitro.METHODS:AD-like lesions were induced by 1-chloro-2,4-dinitrobenzene(DNCB)to the shaved dorsal skin of BALB/c mice.BALB/c mice were divided into five groups:normal control,model control,cetirizine,low-,medium-,and high-dose of ZXAS.After ZXAS in-tervention,the skin lesions and blood samples were collected for hematoxylin and eosin-stained and measuring the concentrations of inflammatory cytokines.Immunoglobulin E(IgE),interleukin(IL)-4,IL-5,IL-13,and thymic stromal lymphopoietin(TSLP)were de-tected by Enzyme-linked immunosorbent assay(ELISA).The spinal cords were collected for measuring the expression of gastrin-releasing peptide receptor(GRPR),TRPV1,and TRPA1 by using immunohistochemistry,western blotting,and quantitative real-time polymerase chain reaction(qR T-PCR)analyses.In addition,3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide(MTT)assay,flow cytometry,ELISA,and Western blotting were conducted for analysis of primary dorsal root ganglia(DRG)neurons in vitro.RESULTS:ZXAS treatment improved DNCB-induced AD-like lesions through reducing dermatitis score,number of scratching and epidermal thickness,accompanied by the de-creased IgE and Th2 inflammatory cytokines.ZXAS also supressed the mRNA and protein expression of GRPR,TRPV1,and TRPA1 in the spinal cord.The medicated sera of ZXAS decreased capsaicin-induced Ca^(2+)influx and downregulated the expression of TRPV1,TRPA1,and phospholipase C in DRG neurons.CONCLUSIONS:The therapeutic effect of ZXAS on AD may be related to the regulation of TRPV1 and TRPA1 and inhibition of Ca^(2+)signals in neurons. | ZHAO Yiding YAN Xiaoning JIANG Shanshan LIU Yong DONG Chun CHI Huiyan MAO Chaoyi | 2023 | Journal of Traditional Chinese Medicine2023，43，5： | 0 |
| 18 | Expression of Fibroblast Growth Factor 21 in Escherichia coli Induced by Lactose显示文摘[Objective] This study aimed to investigate the expression of recombinant protein of fibroblast growth factor 21 (FGF21) in Escherichia coli induced by lactose and explore the possibility of engineering production.[Method] The effects of lactose concentration, induction duration, induction starting time, and induction temperature on expression of the recombinant product were compared, and the optimal condition for lactose induction was determined with IPTG induction as a control.[Result] As an induction agent, lactose plays an ideal role in the production of recombinant FGF21. In addition, the expression level of lactose induction product is consistent with that of IPTG induction product. Induction in a 250ml flask containing 50ml of medium at A600 0.8-1.0 using 0.5g/L lactose at 35℃ for 6h are the optimal condition.[Conclusion] Lactose can induce the expression of FGF21 gene and achieve ideal results. This study provides experimental basis and reference for the industrial production of FGF21. | Huiyan WANG Lei LIU Binbin YIN Lei WANG Lei ZHANG Yong JIANG Jianhui CAI | 2012 | Agricultural Biotechnology2012，1，5： | 0 |
| 19 | DNA methylation markers in the diagnosis and prognosis of common leukemias显示文摘The ability to identify a specific type of leukemia using minimally invasive biopsies holds great promise to improve the diagnosis,treatment selection,and prognosis prediction of patients.Using genome-wide methylation profiling and machine learning methods,we investigated the utility of CpG methylation status to differentiate blood from patients with acute lymphocytic leukemia(ALL)or acute myelogenous leukemia(AML)from normal blood.We established a CpG methylation panel that can distinguish ALL and AML blood from normal blood as well as ALL blood from AML blood with high sensitivity and specificity.We then developed a methylation-based survival classifier with 23 CpGs for ALL and 20 CpGs for AML that could successfully divide patients into high-risk and low-risk groups,with significant differences in clinical outcome in each leukemia type.Together,these findings demonstrate that methylation profiles can be highly sensitive and specific in the accurate diagnosis of ALL and AML,with implications for the prediction of prognosis and treatment selection. | Hua Jiang Zhiying Ou Yingyi He Meixing Yu Shaoqing Wu Gen Li Jie Zhu Ru Zhang Jiayi Wang Lianghong Zheng Xiaohong Zhang Wenge Hao Liya He Xiaoqiong Gu Qingli Quan Edward Zhang Huiyan Luo Wei Wei Zhihuan Li Guangxi Zang Charlotte Zhang Tina Poon Daniel Zhang Ian Ziyar Run-ze Zhang Oulan Li Linhai Cheng Taylor Shimizu Xinping Cui Jian-kang Zhu Xin Sun Kang Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 20 | Unexpected high-temperature brittleness of a Mg-Gd-Y-Ag alloy显示文摘Rare earth(RE)can produce excellent precipitation hardening in Mg alloys.However,when forming a solid solution,it also deteriorates formability,a problem that can usually be overcome by raising deformation temperature.Here we report an unexpected observation of high temperature brittleness in a Mg-Gd-Y-Ag alloy.As the temperature reached 500℃,the formability decreased drastically,leading to severe intergranular fracture under only 0.5% strain.This was caused by failure of grain boundaries,which are weakened by segregated interfacial compounds. | Lirong Xiao Xuefei Chen Huiyan Ning Ping Jiang Yi Liu Bin Chen Dongdi Yin Hao Zhou Yuntian Zhu | 2022 | Journal of Magnesium and Alloys2022，10，9： | 0 |
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