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| 1 | Ultrafast epitaxial growth of metre-sized single-crystal graphene on industrial Cu foil显示文摘A foundation of the modern technology that uses single-crystal silicon has been the growth of highquality single-crystal Si ingots with diameters up to 12 inches or larger. For many applications of graphene, large-area high-quality(ideally of single-crystal) material will be enabling. Since the first growth on copper foil a decade ago, inch-sized single-crystal graphene has been achieved. We present here the growth, in 20 min, of a graphene film of(5 ×50) cm^2 dimension with >99% ultra-highly oriented grains.This growth was achieved by:(1) synthesis of metre-sized single-crystal Cu(1 1 1) foil as substrate;(2)epitaxial growth of graphene islands on the Cu(1 1 1) surface;(3) seamless merging of such graphene islands into a graphene film with high single crystallinity and(4) the ultrafast growth of graphene film.These achievements were realized by a temperature-gradient-driven annealing technique to produce single-crystal Cu(1 1 1) from industrial polycrystalline Cu foil and the marvellous effects of a continuous oxygen supply from an adjacent oxide. The as-synthesized graphene film, with very few misoriented grains(if any), has a mobility up to ~23,000 cm^2 V^(-1)s^(-1)at 4 K and room temperature sheet resistance of ~230 Ω/□. It is very likely that this approach can be scaled up to achieve exceptionally large and high-quality graphene films with single crystallinity, and thus realize various industrial-level applications at a low cost. | Xiaozhi Xu Zhihong Zhang Jichen Dong Ding Yi Jingjing Niu Muhong Wu Li Lin Rongkang Yin Mingqiang Li Jingyuan Zhou Shaoxin Wang Junliang Sun Xiaojie Duan Peng Gao Ying Jiang Xiaosong Wu Hailin Peng Rodney S. Ruoff Zhongfan Liu Dapeng Yu Enge Wang Feng Ding Kaihui Liu | 2017 | Science Bulletin2017，62，15： | 40 |
| 2 | High-efficiency breeding of early-maturing rice cultivars via CRISPR/Cas9-mediated genome editing显示文摘Rice is a staple food for more than half of the human population.It has been estimated that by 2030,40%more rice needs to be produced in order to meet the growing demand(Khush,2005).One of the strategies to improve rice productivity is to enlarge rice | Xiufeng Li Wenjia Zhou Yuekun Ren Xiaojie Tian Tianxiao Lv Zhenyu Wang Jun Fang Chengcai Chu Jie Yang Qingyun Bu | 2017 | Journal of Genetics and Genomics2017，44，3： | 20 |
| 3 | Combined obeticholic acid and apoptosis inhibitor treatment alleviates liver fibrosis显示文摘Obeticholic acid(OCA), the first FXR-targeting drug, has been claimed effective in the therapy of liver fibrosis. However, recent clinical trials indicated that OCA might not be effective against liver fibrosis, possibly due to the lower dosage to reduce the incidence of the side-effect of pruritus. Here we propose a combinatory therapeutic strategy of OCA and apoptosis inhibitor for combating against liver fibrosis. CCl4-injured mice, D-galactosamine/LPS(GalN/LPS)-treated mice and cycloheximide/TNFα(CHX/TNFα)-treated HepG2 cells were employed to assess the effects of OCA, or together with IDN-6556, an apoptosis inhibitor. OCA treatment significantly inhibited hepatic stellate cell(HSC)activation/proliferation and prevented fibrosis. Elevated bile acid(BA) levels and hepatocyte apoptosis triggered the activation and proliferation of HSCs. OCA treatment reduced BA levels but could not inhibit hepatocellular apoptosis. An enhanced anti-fibrotic effect was observed when OCA was co-administrated with IDN-6556. Our study demonstrated that OCA inhibits HSCs activation/proliferation partially by regulating BA homeostasis and thereby inhibiting activation of HSCs. The findings in this study suggest that combined use of apoptosis inhibitor and OCA at lower dosage represents a novel therapeutic strategy for liver fibrosis. | Jiyu Zhou Ningning Huang Yitong Guo Shuang Cui Chaoliang Ge Qingxian He Xiaojie Pan Guangji Wang Hong Wang Haiping Hao | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 13 |
| 4 | Combinations of Hd2 and Hd4 genes determine rice adaptability to Heilongjiang Province, northern limit of China显示文摘Heading date is a key trait in rice domestication and adaption, and a number of quantitative trait loci(QTLs)have been identified. The rice(Oryza sativa L.) cultivars in the Heilongjiang Province, the northernmost region of China,have to flower extremely early to fulfill their life cycle.However, the critical genes or different gene combinations controlling early flowering in this region have not been determined. QTL and candidate gene analysis revealed that Hd2/Ghd7.1/Os PRR37 plays a major role in controlling rice distribution in Heilongjiang. Further association analysis with a collection of rice cultivars demonstrated that another three major QTL genes(Hd4/Ghd7, Hd5/DTH8/Ghd8, and Hd1)also participate in regulating heading date under natural long day(LD) conditions. Hd2/Ghd7.1/Os PRR37 and Hd4/Ghd7 are two major QTLs and function additively. With the northward rice cultivation, the Hd2/Ghd7.1/Os PRR37 and Hd4/Ghd7 haplotypes became non-functional alleles. Hd1 might be non-functional in most Heilongjiang rice varieties,implying that recessive hd1 were selected during local rice breeding. Non-functional Hd5/DTH8/Ghd8 is very rare, but constitutes a potential target for breeding extremely early flowering cultivars. Our results indicated that diverse genetic combinations of Hd1, Hd2, Hd4, and Hd5 determined the different distribution of rice varieties in this northernmost province of China. | Xiufeng Li Huazhao Liu Maoqing Wang Hualong Liu Xiaojie Tian Wenjia Zhou Tianxiao Lü Zhenyu Wang Chengcai Chu Jun Fang Qingyun Bu | 2015 | Journal of Integrative Plant Biology2015，57，8： | 13 |
| 5 | Elimination of senescent cells byβ-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice显示文摘Cellular senescence,a persistent state of cell cycle arrest,accumulates in aged organisms,contributes to tissue dysfunction,and drives age-related phenotypes.The clearance of senescent cells is expected to decrease chronic,low-grade inflammation and improve tissue repair capacity,thus attenuating the decline of physical function in aged organisms.However,selective and effective clearance of senescent cells of different cell types has proven challenging.Herein,we developed a prodrug strategy to design a new compound based on the increased activity of lysosomalβ-galactosidase(β-gal),a primary characteristic of senescent cells.Our prodrug SSK1 is specifically activated byβ-gal and eliminates mouse and human senescent cells independently of senescence inducers and cell types.In aged mice,our compound effectively cleared senescent cells in different tissues,decreased the senescence-and age-associated gene signatures,attenuated low-grade local and systemic inflammation,and restored physical function.Our results demonstrate that lysosomalβ-gal can be effectively leveraged to selectively eliminate senescent cells,providing a novel strategy to develop anti-aging interventions. | Yusheng Cai Huanhuan Zhou Yinhua Zhu Qi Sun Yin Ji Anqi Xue Yuting Wang Wenhan Chen Xiaojie Yu Longteng Wang Han Chen Cheng Li Tuoping Luo Hongkui Deng | 2020 | Cell Research2020，30，7： | 12 |
| 6 | A study of support strategies in deep soft rock:The horsehead crossing roadway in Daqiang Coal Mine显示文摘Geomechanics in deep mines becomes more complex and structural support in soft rock can be very difficult.Highly stressed soft rock subject to expansion deformation is particularly difficult to control.The Tiefa Coal Industry Group Daqiang Coal Mine is used as an example.A ventilation shaft,à550 horsehead,is located in tertiary soft rock.Analysis of the reasons for deformation shows an intumescent rock,which is easily damaged.Field observations and theoretical analysis led to a design capable of stabilizing the rock.A combination of spray,anchors,anchor bolts,and soft corner coupled truss supports allowed the deformation to be controlled.This provides a model for similar designs when support of a horsehead roadway is required. | Guo Zhibiao Yang Xiaojie Bai Yunpeng Zhou Feng Li Erqiang | 2012 | International Journal of Mining Science and Technology2012，22，5： | 11 |
| 7 | Orbit determination and prediction for Beidou GEO satellites at the time of the spring/autumn equinox显示文摘Geostationary(GEO) satellites form an indispensable component of the constellation of Beidou navigation system(BDS). The ephemerides, or predicted orbits of these GEO satellites(GEOs), are broadcast to positioning, navigation, and timing users. User equivalent ranging error(UERE) based on broadcast message is better than 1.5 m(root formal errors: RMS) for GEO satellites. However, monitoring of UERE indicates that the orbital prediction precision is significantly degraded when the Sun is close to the Earth's equatorial plane(or near spring or autumn Equinox). Error source analysis shows that the complicated solar radiation pressure on satellite buses and the simple box-wing model maybe the major contributor to the deterioration of orbital precision. With the aid of BDS' two-way frequency and time transfer between the GEOs and Beidou time(BDT, that is maintained at the master control station), we propose a new orbit determination strategy, namely three-step approach of the multi-satellite precise orbit determination(MPOD). Pseudo-range(carrier phase) data are transformed to geometric range(biased geometric range) data without clock offsets; and reasonable empirical acceleration parameters are estimated along with orbital elements to account for the error in solar radiation pressure modeling. Experiments with Beidou data show that using the proposed approach, the GEOs' UERE when near the autumn Equinox of 2012 can be improved to 1.3 m from 2.5 m(RMS), and the probability of user equivalent range error(UERE)<2.0 m can be improved from 50% to above 85%. | LI XiaoJie ZHOU JianHua HU XiaoGong LIU Li GUO Rui ZHOU ShanShi | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，8： | 8 |
| 8 | Medical expenditures for colorectal cancer diagnosis and treatment: A 10-year high-level-hospital-based multicenter retrospective survey in China, 2002-2011显示文摘Objective: Colorectal cancer(CRC) causes a substantial burden of disease in China and the evidence of economic burden triggered is fundamental for priority setting. The aim of this survey was to quantify medical expenditures and the time trends for CRC diagnosis and treatment in China.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 13 provinces across China. For each eligible CRC patient diagnosed from 2002 to 2011, clinical information and expenditure data were extracted using a uniform questionnaire. All expenditure data were reported in Chinese Yuan(CNY)using 2011 values.Results: Of the 14,536 CRC patients included, the average age at diagnosis was 58.2 years and 15.8% were stageI cases. The average medical expenditure per patient was estimated at 37,902 CNY [95 % confidence interval(95%CI): 37,282-38,522], and the annual average increase rate was 9.2% from 2002 to 2011(P for trend <0.001), with a cumulative increase of 2.4 times(from 23,275 CNY to 56,010 CNY). The expenditure per patient in stages Ⅰ, Ⅱ, Ⅲ and Ⅳ were 31,698 CNY, 37,067 CNY, 38,918 CNY and 42,614 CNY, respectively(P<0.001). Expenditure significantly differed within various subgroups. Expenses for drugs contributed the largest proportion(52.6%).Conclusions: These conservative estimates illustrated that medical expenditures for CRC diagnosis and treatment in tertiary hospitals in China were substantial and increased rapidly over the 10 years, with drugs continually being the main expense by 2011. Relatively, medical expenditures are lower for CRC in the earlier stages. These findings will facilitate the economic evaluation of CRC prevention and control in China. | Jufang Shi Guoxiang Liu Hong Wang Ayan Mao Chengcheng Liu Lanwei Guo Huiyao Huang Jiansong Ren Xianzhen Liao Yana Bai Xiaojie Sun Xinyu Zhu Jialin Wang Bingbing Song Jinyi Zhou Lin Zhu Haike Lei Yuqin Liu Yunyong Liu Lingbin Du Yutong He Kai Zhang Ni Li Wanqing Chen Min Dai Jie He | 2019 | Chinese Journal of Cancer Research2019，31，5： | 8 |
| 9 | Influence of Temperature and Salinity on Germination of Eelgrass (Zostera marina L.) Seeds显示文摘Seagrass restoration as part of ocean ecosystem protection has been launched for many years all over the world, but intensive research on this subject in China has just begun in recent years. Seed broadcasting has been widely accepted as the most potentially useful method for seagrass restoration over large areas. We examined the influence of key environmental factors on seed germination to help promote eelgrass bed restoration. Under anoxic conditions, the influence of temperature and salinity on the germination rate of eelgrass (Zostera marina L.) seeds was examined at different combinations of four temperatures (4, 9, 14, and 24℃) and nine salinities (5 to 45, increment of 5). The effect of significant interaction of temperature and salinity on germination rate was observed (ANOVA) (P<0.001). The highest germination rate (83.3 ± 3.5)% was reached in 8 weeks at 14℃ and salinity 5. Higher temperature significantly increased the germination rate at salinity 5 (P<0.001) during the whole observation period except for 24℃, while lower salinity significantly increased the germination rate at 14℃ (P<0.001). Although significant interaction was found between temperature and salinity (P<0.001), the influence of salinity was stronger than that of temperature for the germination of eelgrass seeds. These results provide useful information for the propagation of artificial seedlings for seagrass restoration in China. | PAN Jinhua JIANG Xin LI Xiaojie CONG Yizhou ZHANG Zhuangzhi LI Zhiling ZHOU Weili HAN Houwei LUO Shiju YANG Guanpin | 2011 | Journal of Ocean University of China2011，10，2： | 7 |
| 10 | The effect of LPSO on the deformation mechanism of Mg-Gd-Y-Zn-Zr magnesium alloy显示文摘The tensile deformation behavior and corresponding microstructure evolution of the Mg-4.7Gd-3.4Y-1.2Zn-0.5Zr(at.%)magnesium alloy with long period stacking structure(LPSO)are studied by electron backscatter diffraction(EBSD)and slip lines methods.The results show that less and very small size of twins is observed in the grains with high value of Schmid factor for twinning,which indicates that the growth of the{10–12}twinning deformation is prevented by the LPSO phase.The prismatic lines present in grains of which the prismatic slip Schmid factor is above 0.4.The favorable orientation and LPSO phase synergistically promote the activation of prismatic slip.The inhomogeneous rotation of the grains during deformation is the reason for the microcrack at grain boundary. | Jianbo Shao Zhiyong Chen Tao Chen Zhang Hu Xiaojie Zhou Chuming Liu | 2016 | Journal of Magnesium and Alloys2016，4，2： | 6 |
| 11 | High-precision orbit prediction and error control techniques for COMPASS navigation satellite显示文摘A new satellite orbit prediction method based on artificial neural network(ANN)model is proposed to improve the precision of orbit prediction.In order to avoid the difficulty of amending the dynamical model,it is attempted to use ANN model to learn the variation of orbit prediction error,and then the prediction result of ANN model is used to compensate the predicted orbit based on dynamic model to form a final predicted orbit.The experiment results showed that the orbit prediction error based on ANN model was less than that based on dynamical model,and the improvement effects for different satellites and different time were different.The maximum rates of improvement of predicting 8,15,30 d were respectively 80%,77.77%,85%.The orbit prediction error control technique based on the method of back overlap arc compare was brought forward to avoid the risk that the precision of predicted orbit is even worse after it is compensated by ANN model.The phenomena of failure were basically eliminated based on this technique,and the rate of failure was reduced from 30%to 5%.This technique could ensure that the engineering application of ANN model could come true. | Xiaojie Li Jianhua Zhou Rui Guo | 2014 | Chinese Science Bulletin2014，59，23： | 6 |
| 12 | Transcriptome Profiling Reveals Auxin and Cytokinin Regulating Somatic Embryogenesis in Different Sister Lines of Cotton Cultivar CCRI24显示文摘在在棉花(Gossypium hirsutum L.) 位于体的 embryogenesis (SE ) 下面的分子的机制上得到一个更宽广的看法,棉花 transcriptome 动力学的全球分析用 RNA-Seq 在在不同姐妹线的 SE 期间被执行。204349 unigenes 的一个总数被 214977462 Illumina 的汇编读的 de novo 检测。量的反向的 transcriptionpolymerase 链反应(qRT-PCR ) 大小断然与几乎所有测试基因的 RNA-Seq 结果被相关(R2=0.841,关联在 0.01 水平是重要的) 。不同植物激素(植物生长素和细胞激动素) 在媒介和在在不同姐妹线的二个阶段的这二植物激素的内长的内容变化的集中比率在棉花 SE 期间建议了植物生长素和细胞激动素的角色。根据植物激素相关的基因的全球基因规定,从所有差别的众多的基因表示了抄本涉及植物生长素和细胞激动素生合成和信号 transduction 小径。差别的分析表示了涉及揭示的这些小径的基因在在二根姐妹线之间的基因类型和丰富的实质的变化。隔离,克隆并且在棉花 SE 期间揭示了显著起来表示或下面表示的基因是的 silencing/overexpressing 重要。而且,植物生长素和细胞激动素与对方或另外的因素遗体一起在 SE,而是潜在的串音起一个主要作用不清楚。 | Zhenzhen Xu Chaojun Zhang Xueyan Zhang Chuanliang Liu Zhixia Wu Zuoren Yang Kehai Zhou Xiaojie Yang Fuguang Li | 2013 | Journal of Integrative Plant Biology2013，55，7： | 5 |
| 13 | The effect of Fe-Mn minerals and seawater interface and enrich-ment mechanism of ore-forming elements of polymetallic crusts and nodules from the South China Sea显示文摘Ferromanganese crusts and nodules are important submarine mineral resources that contain various metal elements with significant economic value. In this study, polymetallic crusts and nodules obtained from the South China Sea(SCS) were determined by using X-ray power diffraction(XRD), Raman spectroscopy(RS), Fourier transform infrared spectroscopy(FTIR), and X-ray photoelectron spectroscopy(XPS) to systematically investigate and analyze the mineralogical and spectral characteristics of the Fe-Mn minerals. XRD measurements revealed that the SCS polymetallic crusts and nodules were composed of vernadite, quartz, and plagioclase. The nodules also contained todorokite. The Fe-phase minerals of the SCS crusts and nodules were composed of amorphous Fe oxide/hydroxide, and the Mn-and Fe-phases minerals exhibited relatively poor degrees of crystallization. FTIR results showed that the Fe-Mn minerals in the crusts and nodules included a large number of surface hydroxyl groups. These surface hydroxyl groups contained protons that could provide reactive sites for complexation of ore-forming elements in seawater. XPS results indicated that the surfaces of the Fe-Mn minerals mainly contained Fe, Mn, and O. Fe was present in the trivalent oxidation state, while Mn, which may contain several bivalent oxidation state, was present in the tetravalent and trivalent oxidation states. The SCS polymetallic crusts and nodules were compared with Pacific seamount crusts, and results showed that the surface hydroxyl(-OH) groups of the SCS crusts and nodules numbered more than the lattice oxygen(O^(2-)). But the lattice oxygen of Pacific seamount crusts numbered more than the surface hydroxyl groups. This characteristic indicated that the degree of crystallization of Fe-Mn minerals from the Pacific Ocean was higher than that of minerals from the South China Sea. Comprehensive studies showed that ore-forming elements in the interface between seawater and the Fe-Mn minerals in the submarine ferromanganese crusts and nodules employed the following enrichment mechanisms:(1) the metal ion complexed with the surface hydroxyl of Fe-Mn minerals to form hydroxyl complexes, which were connected by coordination bonds or stable inner-sphere complexes that exchanged protons on the mineral surfaces;(2) the charged surfaces of the minerals and metal cations formed outer-sphere complexes, which made up the electrostatic double layer, through electrostatic adsorption; and(3) the metal cations isomorphously exchanged the Mn and Fe ions of the mineral lattice structure. | GUAN Yao SUN Xiaoming IANG Xiaodong SA Rina ZHOU Li HUANG Yi LIU Yating LI Xiaojie LU Rongfei WANG Chi | 2017 | Acta Oceanologica Sinica2017，36，6： | 4 |
| 14 | Mitochondrial fusion/fission process involved in the improvement of catalpol on high glucose- induced hepatic mitochondrial dysfunction显示文摘Catalpol, iridoid glycoside,被显示了由 rescuing mitochondrial 功能,而是详细机制遗体施加血糖过低的效果不清楚还。在这研究,在糖尿病的条件下面的肝的线粒体上的 catalpol 的效果和机制进一步被检验。catalpol 的口头的管理显著地在高脂肪的导致食谱、导致 streptozotocin 的糖尿病的老鼠减少了血葡萄糖, triglyceride,和胆固醇层次。另外, catalpol 在源于糖尿病的肝 mitochondrial ATP 内容稀释了减少。而且,拥有一种长尺寸的线粒体的数字在对待 catalpol 的老鼠被增加。有趣地, mitochondrial 功能的导致 catalpol 的恢复与减少的分裂蛋白质 1 被联系并且 dynamin 相关的蛋白质象增加的 mitofusin 一样的 1 个表达式在肝的 1 个表达式。在 HepG2 房间, catalpol 减轻了 ATP 内容和 mitochondrial 膜潜力的减少,并且反应的氧种类形成的增加由高葡萄糖导致了。当房间与 catalpol 被对待时,线粒体的管状的特征被维持的米托特拉克·格林污点表演。Catalpol 也减少了分裂蛋白质 1 并且 dynamin 相关的蛋白质 1 表情和增加的 mitofusin 在 HepG2 房间的 1 表情。现在的结果建议 catalpol 能改善在一名糖尿病患者下面的肝的 mitochondrial 机能障碍状态,和这可能与它 mitochondrial 的规定有关熔化和分裂事件。 | Zhimeng Xu Luyong Zhang Xiaojie Li Zhenzhou Jiang Lixin Sun Guolin Zhao Guohua Zhou Heran Zhang Jing Shang Tao Wang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 4 |
| 15 | Satellite-station time synchronization information based real-time orbit error monitoring and correction of navigation satellite in Beidou System显示文摘Satellite-station two-way time comparison is a typical design in Beidou System(BDS)which is significantly different from other satellite navigation systems.As a type of two-way time comparison method,BDS time synchronization is hardly influenced by satellite orbit error,atmosphere delay,tracking station coordinate error and measurement model error.Meanwhile,single-way time comparison can be realized through the method of Multi-satellite Precision Orbit Determination(MPOD)with pseudo-range and carrier phase of monitor receiver.It is proved in the constellation of 3GEO/2IGSO that the radial orbit error can be reflected in the difference between two-way time comparison and single-way time comparison,and that may lead to a substitute for orbit evaluation by SLR.In this article,the relation between orbit error and difference of two-way and single-way time comparison is illustrated based on the whole constellation of BDS.Considering the all-weather and real-time operation mode of two-way time comparison,the orbit error could be quantifiably monitored in a real-time mode through comparing two-way and single-way time synchronization.In addition,the orbit error can be predicted and corrected in a short time based on its periodic characteristic.It is described in the experiments of GEO and IGSO that the prediction accuracy of space signal can be obviously improved when the prediction orbit error is sent to the users through navigation message,and then the UERE including terminal error can be reduced from 0.1 m to 0.4 m while the average accuracy can be improved more than 27%.Though it is still hard to make accuracy improvement for Precision Orbit Determination(POD)and orbit prediction because of the confined tracking net and the difficulties in dynamic model optimization,in this paper,a practical method for orbit accuracy improvement is proposed based on two-way time comparison which can result in the reflection of orbit error. | HE Feng ZHOU ShanShi HU XiaoGong ZHOU JianHua LIU Li GUO Rui LI XiaoJie WU Shan | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，7： | 3 |
| 16 | A high-performance Mg-4.9Gd-3.2Y-1.1Zn-0.5Zr alloy via multidirectional forging after analyzing its compression behavior显示文摘A high-performance Mg-4.9Gd-3.2Y-1.1Zn-0.5Zr alloy has been fabricated by multidirectional forging(MDF)after analyzing its compression behavior.The as-homogenized alloy exhibits a high activation energy Q of deformation(~285 kJ/mol).The size of DRXed grains after compression tends to decrease as the Z-H parameter(Z)increases,showing a grain size exponent m of~4.0.Lamellar LPSO phases,kinking deformation,and bimodal microstructure are detected at the relatively low compression temperature of 350 and 400℃,while sufficient DRX can be achieved at 500℃,accompanied by the dissolution of lamellar LPSO.According to the processing maps,MDF was successfully conducted under an appropriate condition.After peak-aged at 200℃for 78 h,the MDFed billet exhibits a tensile yield strength(TYS)of 331 and 305 MPa at room temperature and 200℃,respectively.The high strength mainly results from the combination of fine grains,low Schmid factor for basal slip,sufficientβ’ageing precipitates,and directionally arranged interdendritic LPSO phases,etc.This paper provides a feasible way for the fabrication of high-performance,low-RE-content,and large-scale Mg components for industrial production. | Xiaojie Zhou Yuan Yao Jian Zhang Xiaomin Chen Weiying Huang Jing Pan Haoran Wang Maopeng Weng | 2021 | Journal of Materials Science & Technology2021，，11： | 3 |
| 17 | AN EMPIRICAL FEASIBILITY STUDY OF SOCIETAL RISK CLASSIFICATION TOWARD BBS POSTS显示文摘 | Jindong Chen Xiaoji Zhou Xijin Tang | 2018 | Journal of Systems Science and Systems Engineering2018，27，6： | 3 |
| 18 | Recent advances and potential applications of human pluripotent stem cell-derived pancreatic β cells显示文摘Diabetes mellitus is characterized by chronic high blood glucose levels resulted from deficiency and/or dysfunction of insulin-producing pancreaticβcells.Generation of large amounts of func-tional pancreaticβcells is critical for the study of pancreatic biology and treatment of diabetes.Recent advances in directed differentiation of pancreatic B-like cells from human pluripotent stem cells(hPSCs)can provide patient-specific and disease relevant target cells.With the improved differentiation protocols,it is now possible to generate large amounts of functional human pancreatic B-like cells that can response to high level of glucose both in vitro and in vivo.Combined with precise genomic editing,biomedical engineering,high throughput profiling,bioinformatics,and high throughput genetic and chemical screening,these hPSC-derived pancreaticβ-like cells will hold great potentials in disease modeling,drug discovery,and cell-based therapies.In this review,we summarize the recent progress in human pancreaticβ-like cells derived from hPSCs and discuss their potential applications. | Ziyu Zhou Xiaojie Ma Saiyong Zhu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，7： | 2 |
| 19 | Intercellular adhesion molecule-5 protects PAJU cells during in vitro ischemia following cerebral infarction显示文摘BACKGROUND: Intercellular adhesion molecule-5 (ICAM-5) relieves the damage of beta-amyloid protein to PAJU cells. However, little is known about how ICAM-5 works as a neurotrophic factor, or whether ICAM-5 lessens neuronal damage under ischemic conditions following cerebral infarction. OBJECTIVE: To investigate the effects of ICAM-5 on PAJU cells growth in serum-free medium under ischemic conditions following cerebral infarction. DESIGN, TIME AND SETTING: The cytological in vitro study was performed at the Central Laboratory, Second Xiangya Hospital, Central South University, China, in June 2009. MATERIALS: Human ICAM-5 gene transfected into PAJU-TLN cells was supplied by the Life Science College, Helsinki University, Finland. Empty vector transfected PAJU-NEO cells were established by the Gene Center, Second Xiangya Hospital, Central South University, China. METHODS: PAJU-TLN cells transfected with human ICAM-5 or empty vector were incubated in serum-free medium. MAIN OUTCOME MEASURES: Phase contrast microscopy was used to observe changes in PAJU cell morphology. 3-(4, 5-dimethylthiazolzyl)-2, 5-diphenyltetrazolium bromide was used to determine cell viability. Hoechst 33258 was used to stain cell nuclei. Flow cytometry was utilized to measure the apoptosis rate of both PAJU-TLN and PAJU-NEO cells. RESULTS: Both PAJU-TLN and PAJU-NEO cells were injured by cultivating in serum-free medium, but the survival rate of PAJU-TLN cells was significantly higher. CONCLUSION: ICAM-5 protects PAJU-TLN cells from serum deprivation-induced apoptosis, induces the outgrowth of PAJU cells, and diminishes their morphologic impairment. | Weijun Zhou Heping Yang Xiang Wang Yi Peng Dapeng WU Xiaojie Zhang Zhiping Hu | 2010 | Neural Regeneration Research2010，5，3： | 2 |
| 20 | Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma显示文摘Dear Editor,Signet-ring cell carcinoma(SRCC)is a rare subtype of colorectal cancer(CRC)characterized histologically by the accumulation of mucins in the cytoplasm and displacement of nuclei to the cellular periphery,accounting for about 1%CRC(Fig.S1A)(Borger et al.,2007).Compare to common subtypes of CRC,such as adenocarcinoma(AC)and mucinous adenocarcinoma(MAC),SRCC is associated with aggressive behaviors and younger age at presentation(Kang et al.,2005;Sung et al.,2008;Nitsche et al.,2013;Hugen et al.,2014;Inamura et al.,2015).A retrospective analysis of CRC patient's data at Fudan University Shanghai Cancer Center(FUSCC)also indicated a worse overall and disease-free survival of SRCC patients(Fig.S1B and S1C,Table S1). | Yaqi Li Jian Li Renjie Wang Long Zhang Guoxiang Fu Xueying Wang Yebin Wang Chuantao Fang Dandan Zhang Duo Du Xiaoji Ma Mengxue Pan Qiang Guo Xiaoya Xu Xiang Hu Yi Zhou Shaobo Mo Huijun Wang Jianjun Gao Shenglin Huang Yun Liu Sanjun Cai Guoqiang Hua Junjie Peng Fa-Xing Yu | 2020 | Protein & Cell2020，11，4： | 2 |
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