|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | MicroRNA-21 in the pathogenesis of acute kidney injury显示文摘Acute kidney injury(AKI),associated with significant mor-bidity and mortality,is widely known to involve epithelial apoptosis,excessive inflammation,and fibrosis in re-sponse to ischemia or reperfusion injury,which results in either chronic pathological changes or death.Therefore,it is imperative that investigations are conducted in order to fi nd effective,early diagnoses,and therapeutic targets needed to help prevent and treat AKI.However,the mech-anisms modulating the pathogenesis of AKI still remain largely undetermined.MicroRNAs(miRNAs),small non-coding RNA molecules,play an important role in several fundamental biological and pathological processes by a post transcriptional regulatory function of gene expres-sion.MicroRNA-21(miR-21)is a recently identifi ed,typi-cal miRNA that is functional as a regulator known to be involved in apoptosis as well as inflammatory and fi brotic signaling pathways in AKI.As a result,miR-21 is now considered a novel biomarker when diagnosing and treat-ing AKI.This article reviews the correlative literature and research progress regarding the roles of miR-21 in AKI. | Ya-Feng Li Ying Jing Jielu Hao Nathan C Frankfort Xiaoshuang Zhou Bing Shen Xinyan Liu Lihua Wang Rongshan Li | 2013 | Protein & Cell2013，4，11： | 18 |
| 2 | Value of magnetic resonance imaging including dynamic contrast-enhanced magnetic resonance imaging in differentiation between inverted papilloma and malignant tumors in the nasal cavity显示文摘 | Wang Xinyan Zhang Zhengyu Chen Xiaoli Li Jing Xian Junfang | 2014 | Chinese Medical Journal2014，，9： | 13 |
| 3 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 4 | Effect of QPQ nitriding time on wear and corrosion behavior of 45 carbon steel显示文摘 | Wei Cai Fanna Meng Xinyan Gao Jing Hu | 2012 | Applied Surface Science2012，，： | 3 |
| 5 | Effect of QPQ nitriding time on wear and corrosion behavior of 45 carbon steel显示文摘 | Wei Cai Fanna Meng Xinyan Gao Jing Hu | 2012 | Applied Surface Science2012，，： | 1 |
| 6 | The effect of lipid metabolism on biological characteristics of hepatic stellate cell显示文摘Hepatic stellate cells(HSCs) are a kind of fat-storing cells, the lipid droplets are rich in the Cytoplasm, in which retinyl ester accounts for 42%, triglyceride occupies 28%, cholesterol(total) occupies 13%, phospholipids occupies 4% respectively. Studies have confirmed that thetransforms of HSC phenotype follows the changing of the cell lipid. After the activation of HSC, with HSC phenotype changing from fat-storing cells into myofibroblast, the lipid droplets decreased or disappeared gradually, which means HSCs are under the differentiating process of removing adipose, meawhile triglyceride, and the main content of lipid droplets, also obviously reduced. It was ever declined that during the process of HSC re-fating, the activated HSC would turn into quiescent state. Therefore this shows HSCs fat metabolism is closely related to the biological activity. | JING Xinyan YANG Xuefeng | 2013 | Journal of Medical Colleges of PLA(China)2013，28，5： | 1 |
| 7 | In situ Raman spectroscopy of topological insulator Bi2Te3 films with varying thickness显示文摘拓扑的绝缘体(TI ) 大批是有乐队差距的量物质的一个新状态,进行表面说。在这个工作,分子的横梁取向附生(MBE ) 准备的拓扑的绝缘体 Bi2Te3 电影的拉曼系列被测量了由一在里面 situ 超离频真空(UHV )-MBE-Raman 光谱学系统。Bi2Te3 的厚度什么时候拍摄,减少从 40 五倍层(QL ) 到 1 QL,光谱大批出现的一些拉曼模式的特征 Bi2Te3 变化并且一个新震动的模式出现,它没在以前的研究被报导并且可能与量尺寸效果并且对称碎有关。另外,当一个迪拉克锥形成了时,一个明显的变化在 3 QL 被观察。这些结果在 TI 的新奇的量状态附近为一些提供新信息。 | Chunxiao Wang Xiegang Zhu Louis Nilsson Jing Wen GuangWang Xinyan Shan Qing Zhang Shulin Zhang Jinfeng Jia Qikun Xue | 2013 | Nano Research2013，6，9： | 1 |
| 8 | Sensitivity of Near Real-time MODIS Gross Primary Productivity in Terrestrial Forests Based on Eddy Covariance Measurements显示文摘As an important product of Moderate Resolution Imaging Spectroradiometer(MODIS), MOD17A2 provides dramatic improvements in our ability to accurately and continuously monitor global terrestrial primary production, which is also significant in effort to advance scientific research and eco-environmental management. Over the past decades, forests have moderated climate change by sequestrating about one-quarter of the carbon emitted by human activities through fossil fuels burning and land use/land cover change. Thus, the carbon uptake by forests reduces the rate at which carbon accumulates in the atmosphere. However, the sensitivity of near real-time MODIS gross primary productivity(GPP) product is directly constrained by uncertainties in the modeling process, especially in complicated forest ecosystems. Although there have been plenty of studies to verify MODIS GPP with ground-based measurements using the eddy covariance(EC) technique, few have comprehensively validated the performance of MODIS estimates(Collection 5) across diverse forest types. Therefore, the present study examined the degree of correspondence between MODIS-derived GPP and EC-measured GPP at seasonal and interannual time scales for the main forest ecosystems, including evergreen broadleaf forest(EBF), evergreen needleleaf forest(ENF), deciduous broadleaf forest(DBF), and mixed forest(MF) relying on 16 flux towers with a total of 68 site-year datasets. Overall, site-specific evaluation of multi-year mean annual GPP estimates indicates that the current MOD17A2 product works highly effectively for MF and DBF, moderately effectively for ENF, and ineffectively for EBF. Except for tropical forest, MODIS estimates could capture the broad trends of GPP at 8-day time scale for all other sites surveyed. On the annual time scale, the best performance was observed in MF, followed by ENF, DBF, and EBF. Trend analyses also revealed the poor performance of MODIS GPP product in EBF and DBF. Thus, improvements in the sensitivity of MOD17A2 to forest productivity require continued efforts. | TANG Xuguang LI Hengpeng LIU Guihua LI Xinyan YAO Li XIE Jing CHANG Shouzhi | 2015 | Chinese Geographical Science2015，25，5： | 1 |
| 9 | Microbiological quality of roof tank water in an urban village in southeastern China显示文摘Urban villages are unique residential neighborhoods in urban areas in China. Roof tanks are their main form of water supply, and water quality deterioration might occur in this system because of poor hygienic conditions and maintenance. In this study, water samples were seasonally collected from an urban village to investigate the influence of roof tanks as an additional water storage device on the variation in the microbial community structure and pathogenic gene markers. Water stagnation in the roof tank induced significant decreases in chlorine(p < 0.05), residual chlorine was as low as 0.02 mg/L in spring. Propidium monoazide(PMA)-qPCR revealed a one-magnitude higher level of total viable bacterial concentration in roof tank water samples(2.14 ± 1.81 × 105gene copies/mL) than that in input water samples(3.57 ± 2.90 × 104gene copies/mL, p < 0.05), especially in spring and summer. In addition,pathogenic fungi, Mycobacterium spp., and Legionella spp. were frequently detected in the roof tanks. Terminal users might be exposed to higher microbial risk induced by high abundance of Legionella gene marker. Spearman’s rank correlation and redundancy analysis showed that residual chlorine was the driving force that promoted bacterial colonization and shaped the microbial community. It is worth noted that the sediment in the pipe will be agitated when the water supply is restored after the water outages, which can trigger an increase in turbidity and bacterial biomass. Overall, the findings provide practical suggestions for controlling microbiological health risks in roof tanks in urban villages. | Dong Hu Jie Zeng Jing Chen Wenfang Lin Xinyan Xiao Mingbao Feng Xin Yu | 2023 | Journal of Environmental Sciences2023，，3： | 0 |
| 10 | High-Dimensional Volatility Matrix Estimation with Cross-Sectional Dependent and Heavy-Tailed Microstructural Noise显示文摘The estimates of the high-dimensional volatility matrix based on high-frequency data play a pivotal role in many financial applications.However,most existing studies have been built on the sub-Gaussian and cross-sectional independence assumptions of microstructure noise,which are typically violated in the financial markets.In this paper,the authors proposed a new robust volatility matrix estimator,with very mild assumptions on the cross-sectional dependence and tail behaviors of the noises,and demonstrated that it can achieve the optimal convergence rate n-1/4.Furthermore,the proposed model offered better explanatory and predictive powers by decomposing the estimator into low-rank and sparse components,using an appropriate regularization procedure.Simulation studies demonstrated that the proposed estimator outperforms its competitors under various dependence structures of microstructure noise.Additionally,an extensive analysis of the high-frequency data for stocks in the Shenzhen Stock Exchange of China demonstrated the practical effectiveness of the estimator. | LIANG Wanwan WU Ben FAN Xinyan JING Bingyi ZHANG Bo | 2023 | Journal of Systems Science & Complexity2023，36，5： | 0 |
| 11 | Structural basis of Sphingosine-1-phosphate transport via human SPNS2显示文摘Dear Editor,Sphingosine 1-phosphate(S1P)plays crucial roles in various physiological processes,including immune response,vascular development,and neural system homeostasis1 through activating S1P receptors(S1PRs).Notably,a desirable concentration gradient of S1P which is achieved by S1P transporters,including spinster homolog 2 protein(SPNS2)and MFSD2B that transport S1P from the intracellular side to the extracellular side of cells,2,3 is essential for proper S1P signaling.SPNS2 and MFSD2B belong to the major facilitator superfamily(MFS),and specifically. | Yaning Duan Nancy C.P.Leong Jing Zhao Yu Zhang Dat T.Nguyen Hoa T.T.Ha Na Wang Ruixue Xia Zhenmei Xu Zhengxiong Ma Yu Qian Han Yin Xinyan Zhu Anqi Zhang Changyou Guo Yu Xia Long N.Nguyen Yuanzheng He | 2024 | Cell Research2024，34，2： | 0 |
| 12 | Analysis of the Energetic Particles Around the Chili Earthquake of M8.8显示文摘Based on the IDP data from the French DEMETER satellite,global distribution is shown,which corresponds to three precipitation zones:the aural precipitation zone,the mid-high latitude precipitation zone and the South Atlantic precipitation zone.Then the Chili earthquake with M8.8 which occurred on February 27,2010 is taken as an example.The IDP fluxes from repeat orbits are compared and the results show that there is a clear enhancement on February 26,2010,just one day ahead of the Chili earthquake.In the south zone with L=2.1~2.7,the flux on February 26 is higher than that on previous days.However in the north zone with L=2.1~2.7,there is no clear change during the day but great enhancement during the night,which is close to the time of the earthquake.At the same time,the flux on February 26 near the equator is far lower than that on previous days. | Huang Jianping Liu Jing Ouyang Xinyan Li Wenjing | 2011 | Earthquake Research in China2011，25，2： | 0 |
| 13 | Stabilizing zinc anode using zeolite imidazole framework functionalized separator for durable aqueous zinc-ion batteries显示文摘Aqueous zinc-ion batteries(AZIBs) hold great promise as a viable alternative to lithium-ion batteries owing to their high energy density and environmental friendliness.However,AZIBs are consistently plagued by the formation of zinc dendrites and concurrent side reactions,which significantly diminish their overall service life,In this study,the glass fiber separator(GF) is modified using zeolite imidazole salt framework-8(ZIF-8),enabling the development of efficient AZIBs.ZIF-8,which is abundant in nitrogen content,efficiently regulates the desolvation of [Zn(H_(2)O)_(6)]^(2+) to inhibit hydrogen production.Moreover,it possesses abundant nanochannels that facilitate the uniform deposition of Zn~(2+) via a localized action,thereby hindering the formation of dendrites.The insulating properties of ZIF-8 help prevent Zn^(2+) and water from trapping electron reduction at the layer surface,which reduces corrosion of the zinc anode.Consequently,ZIF-8-GF achieves the even transport of Zn^(2+) and regulates the homogeneous deposition along the Zn(002) crystal surface,thus significantly enhancing the electrochemical performance of the AZIBs,In particular,the Zn|Zn symmetric cell with the ZIF-8-GF separator delivers a stable cycle life at0.5 mA cm^(-2) of 2300 h.The Zn|ZIF-8-GF|MnO_(2) cell exhibits reduced voltage polarization while maintaining a capacity retention rate(93.4%) after 1200 cycles at 1.2 A g^(-1) The unique design of the modified diaphragm provides a new approach to realizing high-performance AZIBs. | Weisong Zhang Xinyan Zhu Ling Kang Ziyu Peng Jing Zhu Liang Pan Lei Dai Shude Liu Ling Wang Yongguang Liu Zhangxing He | 2024 | Journal of Energy Chemistry2024，90，3： | 0 |
| 14 | Prediction and interpretation of photocatalytic NO removal on g-C_(3)N_(4)-based catalysts using machine learning显示文摘Predictive modeling of photocatalytic NO removal is highly desirable for efficient air pollution abatement.However,great challenges remain in precisely predicting photocatalytic performance and understanding interactions of diverse features in the catalytic systems.Herein,a dataset of g-C_(3) N_(4)-based catalysts with 255 data points was collected from peer-reviewed publications and machine learning(ML)model was proposed to predict the NO removal rate.The result shows that the Gradient Boosting Decision Tree(GBDT)demonstrated the greatest prediction accuracy with R 2 of 0.999 and 0.907 on the training and test data,respectively.The SHAP value and feature importance analysis revealed that the empirical categories for NO removal rate,in the order of importance,were catalyst characteristics>reaction process>preparation conditions.Moreover,the partial dependence plots broke the ML black box to further quantify the marginal contributions of the input features(e.g.,doping ratio,flow rate,and pore volume)to the model output outcomes.This ML approach presents a pure data-driven,interpretable framework,which provides new insights into the influence of catalyst characteristics,reaction process,and preparation conditions on NO removal. | Jing Li Xinyan Liu Hong Wang Yanjuan Sun Fan Dong | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 15 | Pepper variome reveals the history and key loci associated with fruit domestication and diversification显示文摘Pepper(Capsicum spp.)is an important vegetable crop that provides a unique pungent sensation when eaten.Through construction of a pepper variome map,we examined the main groups that emerged during domestication and breeding of C.annuum,their relationships and temporal succession,and the molecular events underlying the main transitions.The results showed that the initial differentiation in fruit shape and pungency,increase in fruit weight,and transition from erect to pendent fruits,as well as the recent appearance of large,blocky,sweet fruits(bell peppers),were accompanied by strong selection/fixation of key alleles and introgressions in two large genomic regions.Furthermore,we identified Up,which encodes a BIG GRAIN protein involved in auxin transport,as a key domestication gene that controls erect vs pendent fruit orientation.The up mutation gained increased expression especially in the fruit pedicel through a 579-bp sequence deletion in its 5′upstream region,resulting in the phenotype of pendent fruit.The function of Up was confirmed by virus-induced gene silencing.Taken together,these findings constitute a cornerstone for understanding the domestication and differentiation of a key horticultural crop. | Yacong Cao Kang Zhang Hailong Yu Shumin Chen Donghui Xu Hong Zhao Zhenghai Zhang Yinqing Yang Xiaozhen Gu Xinyan Liu Haiping Wang Yaxin Jing Yajie Mei Xiang Wang Véronique Lefebvre Weili Zhang Yuan Jin Dongliang An Risheng Wang Paul Bosland Xixiang Li IIan Paran Baoxi Zhang Giovanni Giuliano Lihao Wang Feng Cheng | 2022 | Molecular Plant2022，15，11： | 0 |
| 16 | Role of cyclooxygenase-2 in lipid metabolism in hepatic stellate cells显示文摘Hepatic stellate cells(HSCs) are a kind of adipocytes. In HSCs lipids mainly exist in the form of lipid droplets. They are abundantly found in the cytoplasm and their main constituents are triglycerides. Lipid metabolism in HSCs is closely related to its biological activity, however the mechanism of lipid droplets disappearance after HSC activation is not clearly established yet. Recent research shows that, cyclooxygenase-2 plays an important regulatory role in the lipid metabolism of HSCs. This paper seeks to review the subject based on studies that have been conducted so far to understand the role of cyclooxygenase-2 in the metabolism of lipids in HSCs. | JING Xinyan YANG Xuefeng OU Yangyan QING Kai | 2013 | Journal of Medical Colleges of PLA(China)2013，28，6： | 0 |
| 17 | Exploring the psychological impact of the 2022 SARS-CoV-2 Omicron variant outbreak in China显示文摘To the editor:The impact of the coronavirus disease 2019(COVID-19)pandemic in 2020 on mental health was substantialin Chinai2and various other countries.34 Beyond the direct consequences of COVID-19,the pandemic created an environment in which many determinants of mental health were affected.Issues associated with the pandemic,such as loss of livelihood,limited access to medical services,reduced social interactions,and economic downturn,could potentially have adverse effects on the population's mental well-being.5 In November 2021,the World Health Organization(WHO)designated the new variant of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),variant B.1.1.529,as a variant of concern and named it Omicron;its rapid mutation and spread raised a new global health concern. | Gangbin Han Guirong Cheng Feifei Hu Chunli Li Dan Liu Juan Zhou Jing Liu Linya Huang Xiaochang Liu Qianqian Nie Dan Song Deyang Zeng Lang Xu Jinquan Li Yushan Chen Zhen Wei Qiong Wu Xiaoming He Qingming Wu Wei Tan Yufei Mei Xingxing Chen Yangming Ou Jingjing ZhangYafu Yu Mengliu Yang Pengfei Lian Fukai Zhou Renjia Fan Hong Wan Chenlu Hu Yidi Fu Shiyue Li Junyi Wang Cheng Cai Mengdie Pei Yuyang Cui Wanying Cai Yiqing Li Shiyao Pan Chang Chen Yan He Zhaoxia Wu Liu Hu Liang Tao Hongyan Xiao Xinyan Xie Yan Zeng | 2023 | General Psychiatry2023，36，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员