维普期刊资源整合服务平台（V6.5）

50篇 您的检索式：作者名="JOERG M"

选中清除导出查看参考文献查看引证文献引用追踪共3页首页上一页第1页下一页末页 /3 跳转

	题名	作者	年代	出处	被引量
1	Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans.	Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier	2018	Bone Research2018，6，1：	5
2	Connecting Closed World Research Information Systems through the Linked Open Data Web 显示文摘	Joerg B Ruiz-Rube I Sicilia M A	2012	International Journal of Software Engineering and Knowledge Engineering2012，，3：	1
3	Treadmill training of paraplegic patients using a robotic orthosis显示文摘	Colombo G Joerg M Schreier R	2000	Journal of Rehabilitation Research and Development2000，37，6：	1
4	Microbial Biosynthesis of Polyglutamic Acid Biopolymer and Applications in the Biopharmaceuti- cal, Biomedical and Food Industries 显示文摘	Joerg M Buescher	2007	Critical Reviews in Biotechnol2007，27，1：	1
5	Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘	Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A	2014	Plant Biotechnol J2014，12，：	1
6	Treadmill training of paraplegic patients using a robotic orthosis显示文摘	Colombo G Joerg M Schreier R Dietz V	2000	Journal of Rehabilitation Research and Development2000，37，6：	1
7	Treadmill training of paraplegic patients using a robotic orthosis显示文摘	Colombo G Joerg M Schreier R	2000	Journal of Rehabilitation Research and Development2000，37，6：	1
8	Spontaneous Control of HCV Is Associated With Expression of HLA-B*57 and Preservation of Targeted Epitopes显示文摘	Arthur Y. Kim Thomas Kuntzen Joerg Timm Brian E. Nolan Melanie A. Baca Laura L. Reyor Andrew C. Berical Andrea J. Feller Kristin L. Johnson Julian Schulze Zur Wiesch Gregory K. Robbins Raymond T. Chung Bruce D. Walker Mary Carrington Todd M. Allen Georg M	2011	Gastroenterology2011，，2：	1
9	Determination of morphine and 6-acetylmorphine in blood with use of dried blood spots 显示文摘	Regine G B Joerg H Rainer M	2008	Therapeutic Drug Monitorin2008，30，6：	1
10	Fracture connectivity from fracture intersections in borehole image logs显示文摘	Sait I Joerg M	2003	Computers & Geosciences2003，29，2：	1
11	Oral osmotically driven systems: 30 years of development and clinical use 显示文摘	Vincent M Joerg O Nicoletta L	2009	Eur J Pharm Biopharm2009，73，3：	1
12	Treadmill training of paraplegic patients using a robotic outhouses显示文摘	COLOMBO G JOERG M SCHREIER R	2000	Journal of Rehabilitation Research2000，37，：	1
13	Spontaneous Control of HCV Is Associated With Expression of HLA-B*57 and Preservation of Targeted Epitopes显示文摘	Arthur Y. Kim Thomas Kuntzen Joerg Timm Brian E. Nolan Melanie A. Baca Laura L. Reyor Andrew C. Berical Andrea J. Feller Kristin L. Johnson Julian Schulze Zur Wiesch Gregory K. Robbins Raymond T. Chung Bruce D. Walker Mary Carrington Todd M. Allen Georg M	2011	Gastroenterology2011，，2：	1
14	Oral osmotically driven systems:30 years of development and clinical use显示文摘	Vincent M Joerg O Nicoletta L	2009	Eur J Pharm Biopharm2009，73，3：	1
15	Treadmill training of paraplegic patients using a robotic orthosis显示文摘	Colombo G Joerg M Schreier R	2000	J Rehabil Res Dev2000，37，：	1
16	Treadmill training of paraplegic patients using a robotic orthosis显示文摘	COLOMBO G JOERG M SCHREIER R	2000	Journal ofRehabilitation Research and Development2000，37，6：	1
17	Treadmill training of paraplegic patients using robotic orthrosis显示文摘	Joerg M Schreier R	2000	J Rehabil Res Dev2000，37，：	1
18	Microbial biosynthesis of polyglutamic acid biopolymer and applications in the biopharmaceutical, biomedical and food indnstriers显示文摘	Joerg M Buescher	2007	Critical Reviews in Bio- technol2007，27，：	1
19	Sinus floor augmentation with β-tricalciumphosphate(β-TCP) : dose platelet-rich plasma promotes its osseous integration and degradation? 显示文摘	Joerg W Kart Andreas S Stafan S M	2003	Clin Oral lmpl Res2003，14，：	1
20	The facile synthesis and energetic prop- erties of an energetic furoxan lacking traditional 'explosophore' moieties显示文摘	Klapotke Thomas M Piercey Davin G Stierstor- fer Joerg	2011	Propellants Explo- sives Pyrotechnics2011，36，：	1

返回顶部每页显示：

共3页首页上一页第1页下一页末页 /3 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示