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| 1 | The hierarchy quorum sensing networ in Pseudomonas aeruginosa显示文摘 | Jasmine Lee Lianhui Zhang | 2015 | Protein & Cell2015，6，1： | 76 |
| 2 | The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells显示文摘 | Lee Tuddenham Guy Wheeler Sofia Ntounia-Fousara Jasmine Waters Mohammad K. Hajihosseini Ian Clark Tamas Dalmay | 2006 | FEBS Letters2006，，17： | 3 |
| 3 | 轴突生长抑制因子DNA疫苗对大鼠中枢神经系统的影响(英文)显示文摘目的探讨轴突生长抑制因子DNA疫苗(pcDNA-NGIs)免疫是否会对中枢神经系统造成损害。方法以pcDNA-NGIs免疫成年Sprague-Dawley大鼠,免疫期间进行实验性自动免疫性脑髓鞘炎评分,同时观察实验动物的感觉运动功能和认知行为。结果以pcDNA-NGIs免疫的大鼠未出现实验性自动免疫性脑髓鞘炎症状。复合神经病学评分、粘附纸条清除试验和开放场地试验表明,pcDNA-NGIs免疫不会损害实验动物的感觉运动功能。另外,被动回避试验和主动回避试验证明,pcDNA-NGIs免疫不会引起学习和记忆障碍。结论pcDNA-NGIs免疫不会损害实验大鼠中枢神经系统。 | 朱兴宝 Jasmine Lee Jill Wong Wan Loo Tan 冯忠堂 肖志成 Ivan Ng | 2007 | 中华神经外科疾病研究杂志2007，6，3： | 3 |
| 4 | Poststroke DNA immunization against neurite growth inhibitors is beneficial to the recovery from local cerebral ischemia in rats显示文摘BACKGROUND: Inhibitory signals, i.e. neurite growth inhibitors (NGIs), presenting on central nervous system (CNS) myelin have been shown to play a crucial role in inhibiting lesioned axonal sprouting and leading to less functional recovery. Vaccines targeting NGIs may provide multifactorial protection against brain insults by overcoming the inhibitory effects of these NGIs and boosting the body's immune repair mechanisms. OBJECTIVE: To evaluate the effect of poststroke DNA immunization against NGIs on the rehabilitation for sensorimotor function of rat models of local cerebral ischemia. DESIGN: Completely randomized grouping design, and controlled experiment. SETTING: Brain Injury Research Laboratory, Department of Neurosurgery, National Neuroscience Institute, Singapore. MATERIALS: Sixty adult male Sprague-Dawley rats ranging in age from 45 to 120 days and in weight from 180 to 250 grams were provided by Animal Center of Department of Anatomy, Faculty of Medicine, National University of Singapore. pcDNA3.1(+)-neurite growth inhibitors (pcDNA-NGIs) a gift was provided by Dr. Xiao from Department of Clinical Research, Singapore General Hospital, Singapore. METHODS: The experiment was carried out at Brain Injury Research Laboratory, Department of Neurosurgery, National Neuroscience Institute, Singapore from August 2003 to April 2005. ①The involved rats were randomized into 3 groups: pcDNA-NGIs group (group A), pcDNA3.1 (+) group (group B) and model group (group C), with 20 rats in each group. Left focal cerebral ischemia (FCI) was permanently induced through middle cerebral artery occlusion (MCAO) with the assistance of an operating microscope. Successful MCAO was determined by a 20% decrease to baseline in the ipsilateral cerebral blood flow. 100 μg of pcDNA-NGIs eluted in phosphate-buffered saline (PBS) was intramuscularly injected into the tibial muscle once a week after MCAO for 6 weeks in group A. As control, pcDNA3.1 (+) was also administrated in the same way in group B and nothing was administrated in group C. ② The modified neurological severity score (mNSS), a composite of motor, sensory, reflex and balance tests, was used to test the sensorimotor deficit. The mNSS was graded on a scale of 0–18, i.e. normal score was 0, maximal deficit score was 18, and 1 point was warded for the inability to perform the tasks or the lack of a tested reflex. ③ The newly generated axons of corticorubral projection were traced by stereotaxic guided injection of 100 g/L biotinylated dextran amine. Rats were sacrificed two weeks after tracing, and cryostat coronal sections of midbrains (30 μm) were reacted to BDA according to the manufacturer's instruction by the free-floating method. Images were captured on a DM RXA2 LEICA Microscope with a Spot Digital Camera system (Germany), and the numbers of labeled axons on the denervated side in four standard coronal sections including the red nucleus were manually quantified. MAIN OUTCOME MEASURES: ① The number of newly generated axons of corticorubral projection. ②The improvement in sensorimotor deficit. RESULTS: All the involved 60 rats entered the stage of final analysis. ① The number of newly generated axons of corticorubral projection of rats: Only ipsilateral axons of CRP were noted with little evidence of fibers crossing to the contralateral red nucleus in rats of groups B and C. More BDA-positive fibers crossing the midline and terminating in the contralateral red nucleus in appropriate target areas mirroring thenon-differentiated red nucleus were found in rats of group A. Quantitative analysis showed that BDA-labeled axons in the denervated side of rats in group A were more than those in group B (P < 0.05). ② Improvement in sensorimotor deficit of rats: At 2 weeks after immunization, significant improvement in sensorimotor deficit was found in rats of group A. There were significant differences of improvement in sensorimotor deficit of rats between group A and group B or group C at 12 and 14 weeks after immunization (P < 0.05). CONCLUSION: ① Poststroke DNA immunization against NGIs leads to increased sensorimotor recovery following FCI and compensatory newly growth of axons from corticorubral projection. | Xingbao Zhu Jasmine Lee Jill Wong Wan Loo Tan Zhongtang Feng Tinghua Wang Zhicheng Xiao Ivan Ng | 2007 | Neural Regeneration Research2007，2，2： | 3 |
| 5 | Non-conventional modeling of extreme significant wave height through random sets显示文摘The analysis and design of offshore structures necessitates the consideration of wave loads. Realistic modeling of wave loads is particularly important to ensure reliable performance of these structures. Among the available methods for the modeling of the extreme significant wave height on a statistical basis, the peak over threshold method has attracted most attention. This method employs Poisson process to characterize time-varying properties in the parameters of an extreme value distribution. In this paper, the peak over threshold method is reviewed and extended to account for subjectivity in the modeling. The freedom in selecting the threshold and the time span to separate extremes from the original time series data is incorporated as imprecision in the model. This leads to an extension from random variables to random sets in the probabilistic model for the extreme significant wave height. The extended model is also applied to different periods of the sampled data to evaluate the significance of the climatic conditions on the uncertainties of the parameters. | ZHANG Yi LAM Jasmine Siu Lee | 2014 | Acta Oceanologica Sinica2014，33，7： | 2 |
| 6 | 轴突生长抑制因子DNA疫苗免疫促进脑缺血后神经功能恢复显示文摘目的为进一步证实突生长抑制因子DNA疫苗免疫对局部脑缺血后神经功能恢复的促进作用.方法采用永久性阻断SD大鼠大脑中动脉的方法制备左侧局部脑缺血模型;在中风前或中风后经腓肠肌注射轴突生长抑制因子DNA疫苗免疫动物,每周1次,共6周;分别采用改良神经病严重程度记分、被动逃避试验和悬臂迷宫试验评价中风后运动功能、认知行为和焦虑样情感的恢复.结果中风前或中风后进行轴突生长抑制因子DNA疫苗免疫,局部脑缺血后都出现明显的运动恢复.认知行为和焦虑样情感障碍则没有明显改善.结论中风前或中风后给予轴突生长抑制因子DNA疫苗免疫可促进脑缺血后的运动功能恢复. | 朱兴宝 Jasmine LEE Jill WONG 肖志成 范泉水 Ivan NG | 2008 | 昆明医学院学报2008，29，1： | 1 |
| 7 | Managing reverse logistics to enhance sustainability of industrial marketing显示文摘 | Le C K M Lam Jasmine Siu Lee | 2012 | Industrial Marketing Management2012，，4： | 1 |
| 8 | The Effect of institutional factors on public-private partnership success in ports显示文摘 | PHOTIS M PANAYIDES FRANCESCO PAROLA JASMINE SIU LEE LAM | 2015 | Transportation Research Part A:Policy and Practice2015，71，： | 1 |
| 9 | Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover显示文摘 | Yinyue Deng Nadine Schmid Chao Wang Jianhe Wang Gabriella Pessi Donghui Wu Jasmine Lee Claudio Aguilar Christian H. Ahrens Changqing Chang Haiwei Song Leo Eberl Lian-Hui Zhang | 2012 | Proceedings of the National Academy of Sciences2012，，38： | 1 |
| 10 | Dynamics of liner shipping network and port connectivity in supply chain systems: analysis on East Asia显示文摘 | Jasmine Siu Lee Lam Wei Yim Yap | 2011 | Journal of Transport Geography2011，，6： | 1 |
| 11 | Complications and perioperative factors associated with learning the technique of minimally invasive transforaminal lumbar interbody fusion (TLIF)显示文摘 | Darryl Lau Jasmine G. Lee Seunggu J. Han Daniel C. Lu Dean Chou | 2010 | Journal of Clinical Neuroscience2010，，5： | 1 |
| 12 | 中风前抗轴突生长抑制因子DNA免疫促进脑缺血后神经再生(英文)显示文摘目的为了澄清中风前抗轴突生长抑制因子DNA免疫对局部脑缺血神经再生的促进作用。方法经腓肠肌注射抗轴突生长抑制因子DNA疫苗免疫动物,每周一次,共6w;血清中检测出相关抗体后,采用永久性阻断大脑中动脉的方法制备左侧局部脑缺血模型,通过立体定向脑内注射生物素化葡聚糖胺(BDA)追踪皮质红核束的新生轴索。结果中风前接受抗轴突生长抑制因子DNA免疫,局部脑缺血后皮质红核束的代偿性新生轴索明显增多。结论中风前抗轴突生长抑制因子DNA免疫可提高永久性局部脑缺血后的神经再生。 | 朱兴宝 Jasmine Lee Jill Wong Wan Loo Tan 王廷华 冯忠堂 Xiao Zhicheng Ivan Ng | 2008 | 中华神经外科疾病研究杂志2008，7，1： | 1 |
| 13 | Inflammatory tumour microenvironment is associated with superior survival in hepatocellular carcinoma patients显示文摘 | Valerie Chew Charlene Tow Marissa Teo Hing Lok Wong Jasmine Chan Adam Gehring Marie Loh Alexandre Bolze Richard Quek Victor K.M. Lee Kang Hoe Lee Jean-Pierre Abastado Han Chong Toh Alessandra Nardin | 2009 | Journal of Hepatology2009，，3： | 1 |
| 14 | The “July Effect” in the intensive care units revisited:A bi-institutional 6-year experience of 57,160 patients显示文摘July coincides with the beginning of the academic year in teaching hospitals across the United States of America (USA).The increased responsibility assumed by trainees transitioning to a higher role in the healthcare team is hypothesized to lead to poorer patient outcomes,termed the“July Effect”.The consequence of a“July Effect”might be more severe in critical care settings,where the complexity of patients requires a higher level of experience and training.The only studies evaluating the“July Effect”in the ICU were published in the early 2000’s.;Since that time,several resident work-hour regulations have been implemented by the Accreditation Council for Graduate Medical Education (ACGME).;These regulations have resulted in more frequent sign-outs,reduced continuity of care,and less clinical time for trainees,which in theory could increase the risk of errors among young trainees at the time they are most vulnerable. | Leon Naar Ander D.Gallastegi Raghu R.Seethala B.Christian Renne Michael E.Billington Jasmine Kannikal Haytham M.A.Kaafarani Jarone Lee | 2022 | World Journal of Emergency Medicine2022，13，3： | 0 |
| 15 | 中风后抗轴突生长抑制因子DNA免疫促进脑缺血功能恢复显示文摘目的探讨中风后抗轴突生长抑制因子DNA免疫对脑缺血神经功能康复的促进作用。方法通过永久性阻断大脑中动脉诱导左侧局部脑缺血后,经腓肠肌注射抗轴突生长抑制因子DNA疫苗免疫动物,每周一次、共6周;分别采用改良的神经病严重程度记分、被动逃避试验和悬臂迷宫试验来评价运动功能、认知行为和焦虑样情感的恢复。结果中风后接受抗轴突生长抑制因子DNA免疫,局部脑缺血后出现明显的运动功能恢复,但是认知行为和焦虑样情感障碍则没有明显改善。结论中风后抗轴突生长抑制因子DNA免疫可促进脑缺血后的运动功能恢复。 | 朱兴宝 Jasmine Lee Jill Wong Wan Loo Tan 王廷华 冯忠堂 Xiao Zhicheng Ivan Ng | 2007 | 西南军医2007，9，4： | 0 |
| 16 | 亚洲廉航公司抢滩香港显示文摘廉价航空公司已订购1500架飞机,国泰航空正想方设法封锁香港市场随着廉航进驻,“国泰航空终于坐不住了” | Jasmine Wang Simon Lee 一毫(译) | 2014 | 商业周刊(中文版)2014，，4： | 0 |
| 17 | 纯电动车仍非最佳选择显示文摘纯电动车或许符合国家发展方向,但无论从使用成本还是从养护方面,目前纯电动车均不是消费者的首选。国家正在加大对新能源汽车的推广力度。在对新能源汽车进行补贴之后,又于今年7月9日决定免征三类新能源汽车购置税。虽然国家对纯电动汽车给出了各种各样的补助,但它依旧不是消费者的最佳选择。纯电动车迎来春天? | Jasmine Lee | 2014 | 消费者报道2014，0，8： | 0 |
| 18 | Pre-stroke DNA immunization against neurite growth inhibitors is beneficial to the recovery from focal cerebral ischemia in rats显示文摘BACKGROUND: Inhibitory signals, i.e. neurite growth inhibitors (NGIs), presenting on central nervous system (CNS) myelin have been shown to play a crucial role in inhibiting lesioned axonal sprouting and leading to less functional recovery. Vaccines targeting NGIs may provide multifactorial protection against brain insults by overcoming the inhibitory effects of these NGIs and boosting the immune repair mechanisms of body. OBJECTIVE: To evaluate the effect of pre-stroke DNA immunization against NGIs on the rehabilitation for sensorimotor function of rat models of focal cerebral ischemia. DESIGN: A completely randomized design, and controlled experiment. SETTING: Brain Injury Research Laboratory, Department of Neurosurgery, National Neuroscience Institute, Singapore. MATERIALS: Sixty adult male Sprague-Dawley rats ranging in age from 45 to 120 days and in body mass from 180 to 250 g were provided by the Animal Center of Department of Anatomy, Faculty of Medicine, National University of Singapore. pcDNA3.1(+)-neurite growth inhibitors (pcDNA-NGIs) a gift was provided by Dr. Xiao from the Department of Clinical Research, Singapore General Hospital, Singapore. METHODS: The experiment was carried out at Brain Injury Research Laboratory, Department of Neurosurgery, National Neuroscience Institute, Singapore from August 2003 to April 2005. ① The involved rats were randomized into 3 groups: model group (group A), pcDNA3.1(+) group (group B) and pcDNA-NGIs group (group C), with 20 rats in each group. Left focal cerebral ischemia was permanently induced through middle cerebral artery occlusion with the assistance of an operating microscope. Successful middle cerebral artery occlusion was determined by a 20% decrease to baseline in the ipsilateral cerebral blood flow. 100 μg of pcDNA-NGIs eluted in phosphate-buffered saline (PBS) was intramuscularly injected into the tibial muscle once a week before middle cerebral artery occlusion for 6 weeks in group C. As control, pcDNA3.1 (+) was also administrated in the same way in group B and nothing was administrated in group A. ② The modified neurological severity score (mNSS), a composite of motor, sensory, reflex and balance tests, was used to test the sensorimotor deficit. The mNSS was graded on 0-18, i.e. normal score was 0, maximal deficit score was 18, and 1 point was warded for the inability to perform the tasks or the lack of a tested reflex. ③ The newly generated axons of corticorubral projection were traced by stereotaxic guided injection of 100 g/L biotinylated dextran amine (BDA). Rats were sacrificed two weeks after tracing, and cryostat coronal sections of midbrains (30 μm) were reacted to BDA according to the manufacturer's instruction by the free-floating method. Images were captured on a DM RXA2 LEICA Microscope with a Spot Digital Camera system (Germany), and the numbers of labeled axons on the denervated side in four standard coronal sections including the red nucleus were manually quantified. MAIN OUTCOME MEASURES: ① The number of newly generated axons of corticorubral projection; ② The improvement of the sensorimotor deficit. RESULTS: All the involved 60 rats entered the final analysis. ① The number of newly generated axons of corticorubral projection of rats: Only ipsilateral axons of corticorubral projiction were noted with little evidence of fibers crossing to the contralateral red nucleus in rats of groups A and B. More BDA-positive fibers crossing the midline and terminating in the contralateral red nucleus in appropriate target areas mirroring the non-differentiated red nucleus were found in rats of group C. Quantitative analysis showed that BDA-labelled axons in the denervated side of rats in group C were more than those in group B (P < 0.05). ② The improvement of the sensorimotor deficit: At two weeks after middle cerebral artery occlusion, significant improvement in sensorimotor deficit was found in rats of group C. There was significant difference of improvement in sensorimotor deficit of rats between group C and group B or group A at eight and 10 weeks after middle cerebral artery occlusion (P < 0.05). CONCLUSION: Pre-stroke DNA immunization against NGIs led to increased sensorimotor recovery following focal cerebral ischemia and compensatory newly growth of axons from corticorubral projection. | Xingbao Zhu Jasmine Lee Jill Wong Wan Loo Tan Zhongtang Feng Tinghua Wang Zhicheng Xiao Ivan Ng | 2007 | Neural Regeneration Research2007，2，9： | 0 |
| 19 | Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic显示文摘Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were reported.The study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines.Methods We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke centres.Patients with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,codes.The 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May 2020.The prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal variation.Findings There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative drop.Subgroup analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this tertile.Interpretation There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 pandemic.These findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction. | Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sugimura Masaaki Uno Yohei Takenobu Yuji Matsumaru Satoshi Yamada Ryuhei Kono Takuya Kanamaru Masafumi Morimoto Junichi Iida Vasu Saini Dileep Yavagal Saif Bushnaq Wenguo Huang Italo Linfante Jawad Kirmani David S Liebeskind Viktor Szeder Ruchir Shah Thomas G Devlin Lee Birnbaum Jun Luo Anchalee Churojana Hesham E Masoud Carlos Ynigo Lopez Brendan Steinfort Alice Ma Ameer E Hassan Amal Al Hashmi Mollie McDermott Maxim Mokin Alex Chebl Odysseas Kargiotis Georgios Tsivgoulis Jane G Morris Clifford J Eskey Jesse Thon Leticia Rebello Dorothea Altschul Oriana Cornett Varsha Singh Jeyaraj Pandian Anirudh Kulkarni Pablo M Lavados Veronica V Olavarria Kenichi Todo Yuki Yamamoto Gisele Sampaio Silva Serdar Geyik Jasmine Johann Sumeet Multani Artem Kaliaev Kazutaka Sonoda Hiroyuki Hashimoto Adel Alhazzani David Y Chung Stephan A Mayer Johanna T Fifi Michael D Hill Hao Zhang Zhengzhou Yuan Xianjin Shang Alicia C Castonguay Rishi Gupta Tudor G Jovin Jean Raymond Osama O Zaidat Raul G Nogueira SVIN COVID-19 Registry,the Middle East North Africa Stroke and Interventional Neurotherapies Organization(MENA-SINO),Japanese Society of Vascular and Interventional Neurology Society(JVIN) | 2021 | Stroke & Vascular Neurology2021，6，4： | 0 |
| 20 | Saline and Heparinised Flush in Maintaining Patency ofArterial Catheters in Adult PatientsmA SystematicReview显示文摘This paper compares the effectiveness of normal saline and heparinised saline as a flushing solution in maintaining patencyof arterial catheters. Use of heparin as a flushing solution in maintaining patency of intra- arterial catheters has been a recognizedpractice. Due to its anticoagulation properties, heparin can cause side effects like heparin-induced thromhocytopenia in hypersensitivepatients. The alternative, normal saline solution increases the accuracy of patients' coagulation status and enhances safer clinicalpractice. A systematic search was conducted at Cochrane Library, Medline, CINAHL, OVID and Joanna Briggs Institute. Reviewperiod covered from 1990 to 2011. Methodological validity of included studies was evaluated using SIGN grading checklists fromScottish Intercollegiate Guidelines Network. There is inconsistent evidence and sample sizes were too small to allow statisticalsignificance to be achieved. Meta-analysis was performed for 2 studies; results revealed that heparinised saline offers no addedadvantage over normal saline. There is insufficient evidence to support the use of heparinised saline for flushing arterial catheters. Arigorous research design is needed to determine variables known to influence patency of arterial catheters. Sound clinical judgementmust be exercised in situations that require the need of heparinised saline. | Jasmine Lee Phillip Della | 2014 | Journal of Health Science2014，2，12： | 0 |
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