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| 1 | Visualization of perforin/gasdermin/complement-formed pores in real cell membranes using atomic force microscopy显示文摘Different types of pores ubiquitously form in cell membranes,leading to various types of cell death that profoundly influence the fate of inflammation and the disease status.However,these pores have never truly been visualized to date.Atomic force microscopy(AFM),which is emerging as a powerful tool to analyze the mechanical properties of biomolecules and cells,is actually an excellent imaging platform that allows biological samples to be visualized by probing surface roughness at the level of atomic resolution.Here,membrane pore structures were clearly visualized using AFM.This visualization not only describes the aperture and depth of the pore complexes but also highlights differences among the pores formed by perforin and gasdermins in tumor cell membranes and by complement in immune cell membranes.Additionally,this type of visualization also reveals the dynamic process of pore formation,fusion,and repair. | Yuying Liu Tianzhen Zhang Yabo Zhou Jiping Li Xiaoyu Liang Nannan Zhou Jiadi Lv Jing Xie Feiran Cheng Yiliang Fang Yunfeng Gao Ning Wang Bo Huang | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 2 | Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19显示文摘Silent hypoxia has emerged as a unique feature of coronavirus disease 2019(COVID-19).In this study,we show that mucins are accumulated in the bronchoalveolar lavage fluid(BALF)of COVID-19 patients and are upregulated in the lungs of severe respiratory syndrome coronavirus 2(SARS-CoV-2)-infected mice and macaques.We find that induction of either interferon(IFN)-P or IFN-y upon SARS-CoV-2 infection results in activation of aryl hydrocarbon receptor(AhR)signaling through an IDO-Kyn-dependent pathway,leading to transcriptional upregulation of the expression of mucins,both the secreted and membrane-bound,in alveolar epithelial cells.Consequently,accumulated alveolar mucus affects the blood-gas barrier,thus inducing hypoxia and diminishing lung capacity,which can be reversed by blocking AhR activity.These findings potentially explain the silent hypoxia formation in COVID-19 patients,and suggest a possible intervention strategy by targeting the AhR pathway. | Yuying Liu Jiadi Lv Jiangning Liu Man Li Jing Xie Qi Lv Wei Deng Nannan Zhou Yabo Zhou Jiangping Song Peng Wang Chuan Qin Wei-Min Tong Bo Huang | 2020 | Cell Research2020，30，12： | 5 |
| 3 | Conversion of Au(Ⅲ)-polluted waste eggshell into functional CaO/Au nanocatalyst for biodiesel production显示文摘Developing an environmental-friendly and highly active catalyst in transesterification for biodiesel production is of great importance for a more economic biodisel process.Herein,we reported that waste eggshells were used to adsorb Au(Ⅲ) in water and convert the Au(Ⅲ)-polluted eggshells into the functional nanocatalyst-Ca O/Au for the transesterification reaction between soybean oil and methanol to the preparation of biodiesel.By coupling of Ca O and Au nanoparticles,Ca O/Au nanoparticles showed superior catalytic activity for the transesterification reaction between soybean oil and methanol.An optimum performance was observed over Ca O/Au nanocomposites in a methanol-oil molar ratio at 12:1with catalyst content of 1.0 wt% at 70°C for 3 h.Besides,the catalytic activity of Ca O/Au nanocatalyst was almost unchanged after recycling for 5 times and the yield of biodiesel still kept at 88.9%.The proof-of concept study provided us a sustainable method for utilization of waste eggshells to remedy the metal ions-polluted wastewater and the synthesis of functional nanocomposite for biodiesel production,show great potential application of waste eggshell in adsorption and catalytic reactions. | Jiadi Liu Minghuan Liu Shaoyun Chen Bingqing Wang Jin Chen Da-Peng Yang Shangzhou Zhang Wenxiao Du | 2022 | Green Energy & Environment2022，7，2： | 2 |
| 4 | Escaping alveolar macrophage endosomal retention explains massive expansion of SARS-CoV-2 delta variant显示文摘Dear Editor,Genetic variant Delta(B.1.617.2)of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which possesses a remarkable ability to transmit and spread,is currently becoming predominant worldwide.Despite its great harm to human beings,how the Delta variant with T478K,P681R and L452R mutations achieves its ultrafast spread remains elusive.Entry of SARS-CoV-2 into host cells is mediated by a rapid enzymatic hydrolysis. | Zhenfeng Wang Yabo Zhou Linlin Bao Dan Li Jiadi Lv Dianheng Wang Shunshun Li Wei-Min Tong Jiangning Liu Chuan Qin Bo Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 1 |
| 5 | ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques显示文摘During the current outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),more than 115 million people have been infected,and 2.5 million have died.1,2 Despite such great harm to human health,the pathogenesis of COVID-19 remains unclear.As the first step in the pathogenetic process,viral entry is mediated by the binding of the SARS-CoV-2 surface spike(S)protein to angiotensin-converting enzyme 2(ACE2)on host cells,such as lung epithelial cells.As an alternative to S protein-blocking strategies,manipulating host cell ACE2 expression may exert an inhibitory effect on SARS-CoV-2 infection.However,the molecular mechanism regulating ACE2 expression remains unclear. | Jiadi Lv Pin Yu Zhenfeng Wang Wei Deng Linlin Bao Jiangning Liu Fengli Li Qiangqiang Zhu Nannan Zhou Qi Lv Guanpeng Wang Shunyi Wang Yabo Zhou Jiangping Song Wei-Min Tong Yuying Liu Chuan Qin Bo Huang | 2021 | Cellular & Molecular Immunology2021，18，5： | 1 |
| 6 | SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterolincreased endosomal pH of alveolar macrophages显示文摘Exploring the cross-talk between the immune system and advanced biomaterials to treat SARS-CoV-2 infection is a promising strategy.Here,we show that ACE2-overexpressing A549 cell-derived microparticles(AO-MPs)are a potential therapeutic agent against SARS-CoV-2 infection.Intranasally administered AO-MPs dexterously navigate the anatomical and biological features of the lungs to enter the alveoli and are taken up by alveolar macrophages(AMs).Then,AO-MPs increase the endosomal pH but decrease the lysosomal pH in AMs,thus escorting bound SARS-CoV-2 from phago-endosomes to lysosomes for degradation.This pH regulation is attributable to oxidized cholesterol,which is enriched in AO-MPs and translocated to endosomal membranes,thus interfering with proton pumps and impairing endosomal acidification.In addition to promoting viral degradation,AO-MPs also inhibit the proinflammatory phenotype of AMs,leading to increased treatment efficacy in a SARS-CoV-2-infected mouse model without side effects.These findings highlight the potential use of AO-MPs to treat SARS-CoV-2-infected patients and showcase the feasibility of MP therapies for combatting emerging respiratory viruses in the future. | Zhenfeng Wang Jiadi Lv Pin Yu Yajin Qu Yabo Zhou Li Zhou Qiangqiang Zhu Shunshun Li Jiangping Song Wei Deng Ran Gao Yuying Liu Jiangning Liu Wei-Min Tong Chuan Qin Bo Huang | 2022 | Cellular & Molecular Immunology2022，19，2： | 1 |
| 7 | Airway administration of bisphosphate and dexamethasone inhibits SARS-CoV-2 variant infection by targeting alveolar macrophages显示文摘Dear Editor,Alveolar macrophages(AMs)are among the first immune cells to encounter SARS-CoV-2 during an infection due to their abundant numbers and physical location in the lungs.Thus,the reaction of AMs to SARS-CoV-2 has a profound impact on the outcome of the infection.In most cases,AMs can release cytokines and prime adaptive T-and B-cell immune responses to resolve the infection. | Zhenfeng Wang Yabo Zhou Linlin Bao Dan Li Jiadi Lv Dianheng Wang Shunshun Li Jiangning Liu Chuan Qin Wei-Min Tong Bo Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 1 |
| 8 | Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1显示文摘Macrophages in tumors(tumor-associated macrophages,TAMs),a major population within most tumors,play key homeostatic functions by stimulating angiogenesis,enhancing tumor cell growth,and suppressing antitumor immunity.Resetting TAMs by simple,efficacious and safe approach(s)is highly desirable to enhance antitumor immunity and attenuate tumor cell malignancy.Previously,we used tumor cell-derived microparticles to package chemotherapeutic drugs(drug-MPs),which resulted in a significant treatment outcome in human malignant pleural effusions via neutrophil recruitments,implicating that drug-MPs might reset TAMs,considering the inhibitory effects of M2 macrophages on neutrophil recruitment and activation.Here,we show that drug-MPs can function as an antitumor immunomodulator by resetting TAMs with M1 phenotype and IFN-βrelease.Mechanistically,drug molecules in tumor MPs activate macrophage lysosomal P450 monooxygenases,resulting in superoxide anion formation,which further amplifies lysosomal ROS production and pH value by activating lysosomal NOX2.Consequently,lysosomal Ca^(2+)signaling is activated,thus polarizing macrophages towards M1.Meanwhile,the drug molecules are delivered from lysosomes into the nucleus where they activate DNA sensor hnRNPA2B1 for IFN-βproduction.This lysosomal-nuclear machinery fully arouses the antitumor activity of macrophages by targeting both lysosomal pH and the nuclear innate immunity.These findings highlight that drug-MPs can act as a new immunotherapeutic approach by revitalizing antitumor activity of macrophages.This mechanistic elucidation can be translated to treat malignant ascites by drug-MPs combined with PD-1 blockade. | Keke Wei Huafeng Zhang Shuaishuai Yang Yuxiao Cui Bingxia Zhang Jincheng Liu Liang Tang Yaoyao Tan Simin Liu Shiqi Chen Wu Yuan Xiao Luo Chen Chen Fei Li Junwei Liu Jie Chen Pingwei Xu Jiadi Lv Ke Tang Yi Zhang Jingwei Ma Bo Huang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 9 | MdAIL5 overexpression promotes apple adventitious shoot regeneration by regulating hormone signaling and activating the expression of shoot development-related genes显示文摘Adventitious shoot(AS)regeneration is a significant factor in the genetic transformation of horticultural plants.It is also a noteworthy approach to their vegetative propagation.AS regeneration remains highly dependent on the genotype or maturity of explants.We here found that the AS regeneration abilities of apple leaves were positively correlated with MdAIL5 expression.MdAIL5 overexpression dramatically increased AS regeneration efficiency.Notably,MdAIL5 overexpression could restore the AS formation ability of explants to a certain extent,which was lost with an increase in maturity.Endogenous hormone detection revealed that MdAIL5 overexpression changed the contents of auxin,cytokinin(CK),and other hormones in apple leaves.Transcriptome analysis revealed that many genes related to auxin,CK,and brassinolide signaling pathways were significantly and differentially expressed between MdAIL5-overexpressing transgenic apple and wild-type apple plants.Yeast one-hybrid assays,the electrophoretic mobility shift assay,and the dual-luciferase reporter assay revealed that MdAIL5 directly binds to MdARF9 and MdHB14 promoters and positively affects their expression.We here established a model of MdAIL5 regulating AS formation,which acts as a theoretical basis for facilitating genotype-or explant maturity-independent AS regeneration in the future. | Kai Liu An Yang Jiadi Yan Zhaolin Liang Gaopeng Yuan Peihua Cong Liyi Zhang Xiaolei Han Caixia Zhang | 2023 | Horticulture Research2023，10，11： | 0 |
| 10 | 肿瘤再生细胞通过犬尿氨酸转移以及芳香烃受体激活诱导CD8^+T细胞表达PD-1显示文摘文章简介肿瘤免疫治疗是当前肿瘤研究的热点领域之一,通过利用免疫细胞、免疫分子直接或间接杀伤肿瘤细胞,以控制或清除肿瘤,被认为是人类战胜癌症的希望所在。肿瘤免疫治疗主要依赖活化的T细胞杀伤肿瘤细胞. | 刘玉英 梁晓雨 董文茜 Yi Fang Jiadi Lv Tianzhen Zhang Roland Fiskesund Jing Xie Jinyan Liu Xiaonan Yin Xun Jin Degao Chen Ke Tang Jingwei Ma Huafeng Zhang Jing Yu Jun Yan Huaping Liang Siqi Mo Feiran Cheng Yabo Zhou Haizeng Zhang Jing Wang Jingnan Li Yang Chen Bing Cui Zhuo-Wei Hu Xuetao Cao F. Xiao-Feng Qin 黄波 | 2019 | 科学新闻2019，0，2： | 0 |
| 11 | Adsorption and Visible Light Photocatalytic Degradation of Electrospun PAN@W_(18)O_(49) Nanofibers显示文摘Low density and high porosity polyacrylonitrile(PAN)nanofibers prepared by electrospinning were used as brackets for photocatalyst W_(18)O_(49) to prepare a kind of light weight and easy recycling water purification material for the first time.The influence of tungsten source concentration on the formation of W_(18)O_(49) during a solvothermal process was systematically investigated.The prepared PAN@W_(18)O_(49) nanofibers(NFs)utilize the outstanding visible light photocatalytic performance and the adsorption performance of W_(18)O_(49),and at the same time give the advantages of low density and easy recyclability.The pollutant removal performance of the composite nanofibers was investigated by using five contaminants including rhodamine B(RhB),methylene blue(MB),malachite green(MG),methyl orange(MO)and chlortetracycline(CTC)as substrates.Among them,the degradation process of rhodamine B has been studied in detail.After five cycles,the degradation efficiency did not decrease significantly,showing excellent reusability of PAN@W_(18)O_(49) NFs.Besides,the adsorption performance of PAN@W_(18)O_(49) NFs during the photocatalytic process was also studied in detail.Compared with recently reported literature,the degradation efficiency of organic pollutants by PAN@W_(18)O_(49) NFs showed better performance,and PAN@W_(18)O_(49) NFs felt had a promising prospect in the field of degradation of contaminants. | MA Yuying HE Dayong LIU Jiadi WANG Yuannan YANG Mei WANG Hao QIU Ju LI Wenyan LI Yongxin WANG Ce | 2021 | Chemical Research in Chinese Universities2021，37，3： | 0 |
| 12 | A Novel Hollow Carbon@MnO_(2) Electrospun Nanofiber Adsorbent for Efficient Removal of Pb^(2+) in Wastewater显示文摘Lead ion(Pb^(2+))is one of the most hazardous heavy metal ions in aquatic environments.Carbon materials and manganese dioxide(MnO_(2))have been shown to be prospective adsorbents to cope with the lead pollution.In this study,a novel hollow carbon@MnO_(2) composite nanofiber adsorbent was prepared by the combination of electrospinning and carbonization.The PAN nanofiber membrane is subjected to a pre-oxidation and carbonization process,and then the obtained carbon nanofibers react with KMnO4 solution during the hydrothermal process to develop the hollow carbon@MnO_(2) nanofibers.The hollow carbon@MnO_(2) nanofibers displayed a higher adsorption capacity of Pb^(2+)than carbon and MnO_(2)/PDA/PAN nanofibers.The maximum adsorption capacity toward Pb^(2+)by hollow carbon@MnO_(2) nanofibers was 460.83 mg/g.After 5 adsorption-desorption cycles,the carbon@MnO_(2) nanofibers had a good recyclability and the removal efficiency remained 81.47%.Moreover,the removal efficiency of the hollow composite nanofibers for Pb^(2+)from real wastewater could reach 94.37%.This work shows a strategy for synthetics of the hollow carbon@MnO_(2) nanofibers,which exhibits a promising potential in actual wastewater treatment. | LI Wenyan LI Yanzi LIU Jiadi CHAO Shen YANG Tianyi LI Lijuan WANG Ce LI Xiang | 2021 | Chemical Research in Chinese Universities2021，37，3： | 0 |
| 13 | Drop impact dynamic and directional transport on dragonfly wing surface显示文摘The ability of dragonflies to fly in the rain without being wetted by raindrops has motivated researchers to investigate the impact behavior of a drop on the superhydrophobic wings of dragonflies.This superhydrophobic surface is used as a reference for the design of directional surfaces and has attracted extensive attention owing to its wide applicability in microfluidics,self-cleaning,and other fields.In this study,the static contact angle and rebound process of a drop impacting a dragonfly wing surface are investigated experimentally,whereas the wetting pressure,Gibbs free energy,and Stokes number vs.coefficient of restitution are theoretically calculated to examine the dynamic and unidirectional transport behaviors of the drop.Results show that the initial inclination angle of the dragonfly wing is similar to the sliding angles along with the drop sliding.The water drop bounces from the bottom of the dragonfly wing to the distal position,demonstrating directional migration.The drop impacts the dragonfly wing surface,and the drop exhibits compression,recovery,and separation phases;in these three phases,the drop morphology evolves.As the Gibbs free energy and cross-sectional area evolve,the coefficient of restitution decreases as the drop continues to bounce,and the Stokes number increases. | Jing XU Wenjun LIU Weixiao SHANG Jun CHEN Jiadi LIAN | 2023 | Friction2023，11，5： | 0 |
| 14 | Novel isostructural iron‐series‐MOF calcined derivatives as positive and negative electrodes: A new strategy to obtain matched electrodes in a supercapacitor device显示文摘The performance of asymmetric supercapacitors(ASCs)is strongly restricted by the capacity gap between the positive and negative electrodes.To address this issue,two new electrode materials deriving from Co‐and Fe‐based metal–organic frameworks(MOFs,Co‐TAMBA‐d,and Fe‐TAMBA‐d)through a single‐step sintering method have been developed by considering the superiorities of the derivatives of MOFs including large surface areas,sufficient metal‐atom‐doping content,and extreme surface wettability to the bath solution.The as‐prepared Co‐TAMBA‐d as a positive electrode delivers typical pseudocapacitive behavior with the improvement of capacity,which is better than those of pristine MOF materials,while Fe‐TAMBA‐d as negative electrodes displays better electrochemical behavior than those of activated carbon.ASCs based on these two electrodes exhibits excellent energy density and power density of 47Wh/kg and 1658 W/kg,respectively,where this device can maintain prominent cycling stability with capacity retention after 5000 cycles being about 75%.Furthermore,the capacity can feed a series of red light‐emitting diodes,which gives solid evidence of the potential utilization.These results can afford the feasibility of isostructural MOF derivatives as promising electrodes in novel ASCs. | Yawen Dong Jiadi Liu Hui Zhang Qingqing Li Feifei Mao Aimin Lu Hua Wu Kuaibing Wang Cheng Zhang Qichun Zhang | 2023 | SmartMat2023，4，3： | 0 |
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