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| 1 | Dispersion stability of thermal nanofluids显示文摘Thermal nanofluids, the engineered fluids with dispersed functional nanoparticles, have exhibited extraordinary thermophysical properties and added functionalities, and thus have enabled a broad range of important applications. The poor dispersion stability of thermal nanofluids, however, has been considered as a longexisting issue that limits their further development and practical application. This review overviews the recent efforts and progresses in improving the dispersion stability of thermal nanofluids such as mechanistic understanding of dispersion behavior of nanofluids, examples of both water-based and oil-based nanofluids,strategies to stabilize nanofluids, and characterization techniques for dispersion behavior of nanofluids. Finally,on-going research needs, and possible solutions to research challenges and future research directions in exploring stably dispersed thermal nanofluids are discussed. | Fan Yu Yingying Chen Xingbo Liang Jiale Xu Chiahsun Lee Qi Liang Peng Tao Tao Deng | 2017 | Progress in Natural Science:Materials International2017，27，5： | 5 |
| 2 | The Research on 220GHz Multicarrier High-Speed Communication System显示文摘This paper presents our investigation into a 220 GHz multicarrier highspeed communication system based on solid state transceivers.The proposed system has eased the demand of high sampling rate analog-to-digital converter(ADC)by providing several signal carriers in microwave band and converting them to 220 GHz channel.The system consists of a set of 220 GHz solid-state transceiver with 2 signal carriers,two basebands for 4 GSPS ADCs.It has achieved 12.8 Gbps rate real-time signal transmission using 16QAM modulation over a distance of 20 m without any other auxiliary equipment or test instruments.The baseband algorithm overcomes the problem of frequency difference generates by non-coherent structure,which guarantees the feasibility of long-distance transmission application.Most importantly,the proposed system has already carried out multi-channel 8K video parallel transmission through switch equipment,which shows the multicarrier high-speed communication system in submillimeter wave has great application prospects.To the best of the authors’knowledge,this is the first all-solid-state electronics multicarrier communication system in submillimeter and terahertz band. | Zhongqian Niu Bo Zhang Jiale Wang Ke Liu Zhi Chen Ke Yang Zhen Zhou Yong Fan Yaohui Zhang Dongfeng Ji Yinian Feng Yang Liu | 2020 | China Communications2020，17，3： | 5 |
| 3 | Unified optimal power flow model for AC/DC grids integrated with natural gas systems considering gas-supply uncertainties显示文摘A unified optimal power flow(OPF) model for AC/DC grids integrated with natural gas systems is proposed for the real-time scheduling of power systems.Herein, the primary physical couplings underlying this coordinated system are modeled and investigated. In addition, the uncertainties of gas loads are considered when studying the role of gas supply for gas-fired units in power system operations. The nonlinear gas system constraints are converted to the second-order cone forms that allow for the use of the Benders decomposition techniques and the interior-point method to obtain the optimal solution. The numerical results of the modified IEEE 118-bus test system that integrates the Belgium 20-node natural gas system demonstrate the effectiveness of the proposed model. The effects of gas demand uncertainties on the optimal schedule of thermal generators are investigated as well. | Jiale FAN Xiaoyang TONG Junbo ZHAO | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，6： | 3 |
| 4 | Photocrosslinking silver nanoparticles–aloe vera–silk fibroin composite hydrogel for treatment of full-thickness cutaneous wounds显示文摘Damage to the skin causes physiological and functional issues.The most effective treatment approach is the use of wound dressings.Silk fibroin(SF)is a promising candidate biomaterial for regulating wound healing;however,its antibacterial properties and biological activity must be further improved.In this study,a photocrosslinking hydrogel was developed to treat full-thickness cutaneous wounds.The composite hydrogel(Ag-AV-SF hydrogel)was prepared by introducing the silver nanoparticles(AgNPs)and aloe vera(AV)as the modifiers.In vitro study exhibited great antibacterial ability,biocompatibility and cell-proliferation and-migration-promoting capacities.It also showed the pH-response releasing properties which release more AgNPs in a simulated chronic infection environment.The healing effect evaluation in vivo showed the healing-promoting ability of the Ag-AV-SF hydrogel was stronger than the single-modifiers groups,and the healing rate of it reached 97.02%on Day 21,higher than the commercial wound dressing,silver sulfadiazine(SS)cream on sale.Additionally,the histological and protein expression results showed that the Ag-AV-SF hydrogel has a greater effect on the pro-healing regenerative phenotype with M2 macrophages at the early stage,reconstructing the blood vessels networks and inhibiting the formation of scars.In summary,the Ag-AV-SF hydrogel developed in this study had good physical properties,overwhelming antibacterial properties,satisfactory biocompatibility and significantly promoting effect on cell proliferation,migration and wound healing.Overall,our results suggest that the Ag-AV-SF hydrogel we developed has great potential for improving the wound healing in clinical treatment. | Yangkun Liu JinChuan Fan MingQi Lv Kepeng She Jiale Sun Qingqing Lu Changhao Han SongTao Ding Shuang Zhao GuiXue Wang YuChan Zhang GuangChao Zang | 2021 | Regenerative Biomaterials2021，8，6： | 2 |
| 5 | 2D-layered Sn/Ge anodes for lithium-ion batteries with high capacity and ultra-fast Li ion diffusivity显示文摘As a new type of green energy, lithium-ion battery(LIB) has been widely used in various electric portable devices because of its high-voltage, large specific capacity, long cycle life and environmental friendliness [1,2]. However, today’s anode materials of commercial LIBs cannot meet the further development requirements of smart devices and electric car due to the limitations of the electrode capacity(e.g. 372 mAh g-1 for graphite). | Xiyu Cao Yanchen Fan Jiale Qu Tianshuai Wang Dominik Legut Qianfan Zhang | 2020 | Journal of Energy Chemistry2020，29，8： | 2 |
| 6 | Identification of quantitative trait loci associated with resistance to Xanthomonas oryzae pv. oryzae pathotypes prevalent in South China显示文摘Bacterial blight(BB), which is caused by Xanthomonas oryzae pv. oryzae(Xoo), is an important rice disease responsible for significant yield losses. In the rice-growing regions of South China where BB outbreaks are common, the resistance of cultivars with BB resistance genes Xa4 and Xa21 has been lost because of rapid changes in the Xoo population structure and virulence. In this study, 421 diverse rice accessions were evaluated regarding their resistance to two Xoo strains, namely GD1358(C5) and IV, which are prevalent pathotypes in South China and overcame the resistance of Xa4 and Xa21, respectively. Using the 4.8 mio filtered SNP dataset, we conducted a genome-wide association study, which identified 13 loci associated with BB resistance, including eight new quantitative trait loci(QTL) and five QTL harboring known BB resistance genes: Xa3/Xa26, xa5, Xa35(t), Xa36(t), Xa40, Xa43(t), and xa44(t). Intriguingly, a steep peak was detected on chromosomes 5 and 11. Six QTL including three new ones, were distributed on chromosome 11, whereas a new QTL q BB5.1 and a known QTL were detected on chromosome 5. Haplotype analyses indicated that the LOC;s05 g01610(Os PRAF2) gene within the q BB5.1 region, which encodes a PRAF protein, is associated with BB resistance. Furthermore, Os PRAF2 knockout lines generated using the CRISPR-Cpf1 system were significantly more resistant to Xoo strains than the wild-type plants. Our results provide researchers and breeders with useful information regarding QTL and gene resources,which may be relevant for developing new BB-resistant rice cultivars. | Jialing Lu Quanlin Li Chunchao Wang Mingming Wang Dan Zeng Fan Zhang Wenxue Zhai Yongli Zhou | 2022 | The Crop Journal2022，10，2： | 1 |
| 7 | Double adaptive selection strategy for MOEA/D显示文摘Since most parameter control methods are based on prior knowledge, it is difficult for them to solve various problems.In this paper, an adaptive selection method used for operators and parameters is proposed and named double adaptive selection(DAS) strategy. Firstly, some experiments about the operator search ability are given and the performance of operators with different donate vectors is analyzed. Then, DAS is presented by inducing the upper confidence bound strategy, which chooses suitable combination of operators and donates sets to optimize solutions without prior knowledge. Finally, the DAS is used under the framework of the multi-objective evolutionary algorithm based on decomposition, and the multi-objective evolutionary algorithm based on DAS(MOEA/D-DAS) is compared to state-of-the-art MOEAs. Simulation results validate that the MOEA/D-DAS could select the suitable combination of operators and donate sets to optimize problems and the proposed algorithm has better convergence and distribution. | GAO Jiale XING Qinghua FAN Chengli LIANG Zhibing | 2019 | Journal of Systems Engineering and Electronics2019，30，1： | 1 |
| 8 | Design and experiment of a subsoiling variable rate fertilization machine显示文摘In order to improve soil fertility and fertilizer utilization,a subsoiling variable rate fertilization machine based on conservation tillage and precision agriculture was designed and tested.The relationship between suspension parameters and penetrating distance was analyzed,and a matching model between fertilizing quantity and penetrating distance was established.The variable rate fertilization control machine was developed based on an Advantech PCM-9363 industrial control mainboard.The machine operates under two patterns:DGPS-based positioning and straight-line path positioning based on a planar coordinate system.This machine can perform on-demand fertilization according to the spatial differences in soil nutrients and the prescription maps pre-set before the operation.Field experiments showed the machine has a subsoiling stability of 92.5%,a soil breaking rate of 61.1%,a maximum positioning relative error of 2.68%and a maximum variable rate fertilization error of 3.89%.The subsoiling performance and variable rate fertilization indices of this machine satisfy the requirements of GB/T24675.2-2009.The tested indices meet the national and industrial standards and satisfy the design requirements.The findings of the research can be used as the structural design of the subsoiling variable rate fertilization machine. | Jiangtao Qi Xinliang Tian Yang Li Xuhui Fan Hongfang Yuan Jiale Zhao Honglei Jia | 2020 | International Journal of Agricultural and Biological Engineering2020，13，4： | 1 |
| 9 | Ursolic Acid Inhibits Proliferation and Induces Apoptosis of Cancer Cells In Vitro and In Vivo显示文摘 | Xuemei Wang Fan Zhang Ling Yang Ying Mei Hai Long Xiaowen Zhang Jialing Zhang Qimuge-Suyila Xiulan Su David J. Yang | 2011 | Journal of Biomedicine and Biotechnology2011，，： | 1 |
| 10 | Ga-In liquid metal nanoparticles prepared by physical vapor deposition显示文摘Controlled synthesis and appropriate characterization of nanoscale particles of gallium-based liquid metals are critical to fulfilling their broad range of applications in the field of flexible, stretchable, and printable micro-/nanoelectronics. Herein, we report a new way to synthesize surfactant-free gallium-indium nanoparticles with controlled particle size on a variety of substrates through a facile physical vapor deposition method. It was found that with prolonged deposition time the liquid metal nanoparticles gradually grew from near-monodispersed small particles with a diameter of ~25 nm to bimodal distributed particles. A nucleation, growth, ripening and merging process was proposed to explain the observed evolution of particle size. Atomic force microscopy measurement indicates that the fabricated liquid metal nanoparticles demonstrate elastic deformation with a certain range of loads and the scanned particle size is dependent on the applied loads. We further investigated the gradual breaking process of the core-shell structured liquid metal nanoparticles, which was evidenced by multiple kinks on the force-separation curve. This work presents a new bottom-up approach to prepare nanoscale liquid metal particles and demonstrates that atomic force microscopy is a suitable technique to characterize the synthesized liquid metal nanoparticles. | Fan Yu Jiale Xu Huiqin Li Zizhao Wang Limin Sun Tao Deng Peng Tao Qi Liang | 2018 | Progress in Natural Science:Materials International2018，28，1： | 1 |
| 11 | Sprayable nanodrug-loaded hydrogels with enzyme-catalyzed semiinter penetrating polymer network(Semi-IPN)for solar dermatitis显示文摘Solar dermatitis is an acute or chronic high incidence of skin injury caused by ultraviolet(UV)radiation based on strong sunlight,which seriously endangers people's health.In this study,we designed and demonstrated enzyme-catalyzed semi-inter penetrating polymer network(Semi-IPN)sprayable nanodrug-loaded hydrogels based on gelatin,3-(4-hydroxyphenyl)propionic acid(HPA),polyvinyl alcohol(PVA),glycerol,and dexamethasone sodium phosphate(DEXP)for solar dermatitis.The hydrogels had high water content,excellent biocompatibility,effective encapsulation and sustained release of nanodrugs,antiinflammatory,and strong anti-ultraviolet B(anti-UVB)radiation properties based on glycerol and phenol functional groups,but also controllable spray gelation mode to make them adhere well on the dynamic skin surfaces and achieve continuous transdermal drugs delivery for solar dermatitis.The sprayable nanodrug-loaded hydrogel systems could be used as a highly effective therapeutic method for solar dermatitis,and also provide a good strategy for designing novel nanodrug-loaded hydrogel delivery systems. | Jialing Yao Junfeng Hui Jing Yang Jiaxin Yao Chaoquan Hu Daidi Fan | 2022 | Nano Research2022，15，7： | 0 |
| 12 | A Method for Identifying Channeling Paths in Low-Permeability Fractured Reservoirs显示文摘Often oilfield fractured horizontal wells produce water flowing in multiple directions.In this study,a method to identify such channeling paths is developed.The dual-medium model is based on the principle of inter-well connectivity and considers the flow characteristics and related channeling terms.The Lorentz curve is drawn to qualitatively discern the geological type of the low-permeability fractured reservoir and determine the channeling direction and size.The practical application of such an approach to a sample oilfield shows that it can accurately identify the channeling paths of the considered low-permeability fractured reservoir and predict production performances according to the inter-well connectivity model.As a result,early detection of water channeling becomes possible,paving the way to real-time production system optimization in low-permeability fractured reservoirs. | Zhenfeng Zhao Bin Li Zubo Su Lijing Chang Hongzheng Zhu Ming Liu Jialing Ma Fan Wang Qianwan Li | 2022 | Fluid Dynamics & Materials Processing2022，18，6： | 0 |
| 13 | Stress-Activated Protein Kinase OsSAPK7 Regulates Salt- Stress Tolerance by Modulating Diverse Stress-Defensive Responses in Rice显示文摘Soil salinity is an environmental threat limiting rice productivity.Identification of salinity tolerance genes and exploitation of their mechanisms in plants are vital for crop breeding.In this study,the function of stress-activated protein kinase 7(OsSAPK7),a SnRK2 family member,was characterized in response to salt stress in rice.Compared with variety 9804,OsSAPK7-overexpression plants had a greater survival rate,increased chlorophyll and proline contents,and superoxide dismutase and catalase activities at the seedling stage under salt-stress conditio ns,as well as decreased sodium potassium ratio(Na+/K+)and malondialdehyde contents.After salt stress,the OsSAPK7 knockout plants had lower survival rates,in creased Na^K*ratios and malomdiadehyde contents,and decreased physiological parameters compared with 9804.These changes in transgenic lines suggested that OsSAPK7 increased the salt tolerance of rice by modulating ion homeostasis,redox reactions and photosynthesis.The results of RNA-Seq indicated that genes involved in redox-dependent signaling pathway,photosynthesis and zeatin synthesis pathways were significantly down-regulated in the OsSAPK7 knockout line compared with 9804 un der salt-stress conditio n,which con firmed that OsSAPK7 positively regulated salt tolera nee by modulating diverse stress-defe nsive resp on ses in rice.These findings provided novel in sights for the genetic improvement of rice and for understanding the regulatory mechanisms of salt-stress toleranee. | ZENG Dan WANG Chunchao XIE Junpin ZHANG Fan LU Jialing SHI Xiaorong SHI Yingyao ZHOU Yongli | 2021 | Rice science2021，28，6： | 0 |
| 14 | National Proficiency Testing of Molecular Diagnostics forTuberculosis and Drug Resistance Detection-China,2014-2019显示文摘Summary What is already known about this topic?Proficiency testing(PT)is a key component of qualityassurance and is essential in ensuring accuratelaboratory diagnosis of tuberculosis(TB)and drug-resistant TB.The National Tuberculosis ReferenceLaboratory(NTRL)developed a novel PT panel to testlaboratories’proficiency for molecular TB diagnosticassays throughout the TB laboratory network.A totalof 6 PT rounds for molecular diagnostics wereconducted by NTRL from 2014 to 2019. | Xichao Ou Hui Xia Shengfen Wang Bing Zhao Jiale Fan Yuanyuan Song Yang Zhou Yang Zheng Yanlin Zhao | 2021 | China CDC weekly2021，3，12： | 0 |
| 15 | Ultraviolet‑Irradiated All‑Organic Nanocomposites with Polymer Dots for High‑Temperature Capacitive Energy Storage显示文摘Polymer dielectrics capable of operating efficiently at high electric fields and elevated temperatures are urgently demanded by next-generation electronics and electrical power systems.While inorganic fillers have been extensively utilized to improved high-temperature capacitive performance of dielectric polymers,the presence of thermodynamically incompatible organic and inorganic components may lead to concern about the long-term stability and also complicate film processing.Herein,zero-dimensional polymer dots with high electron affinity are introduced into photoactive allyl-containing poly(aryl ether sulfone)to form the all-organic polymer composites for hightemperature capacitive energy storage.Upon ultraviolet irradiation,the crosslinked polymer composites with polymer dots are efficient in suppressing electrical conduction at high electric fields and elevated temperatures,which significantly reduces the high-field energy loss of the composites at 200℃.Accordingly,the ultraviolet-irradiated composite film exhibits a discharged energy density of 4.2 J cm^(−3)at 200℃.Along with outstanding cyclic stability of capacitive performance at 200℃,this work provides a promising class of dielectric materials for robust high-performance all-organic dielectric nanocomposites. | Jiale Ding Yao Zhou Wenhan Xu Fan Yang Danying Zhao Yunhe Zhang Zhenhua Jiang Qing Wang | 2024 | Nano-Micro Letters2024，16，3： | 0 |
| 16 | Core-shell-structured Composite ZSM-5@MCM-41 Catalysts:Fabrication,Characterization,and Enhanced Performance in Hexane Catalytic Cracking显示文摘A series of core-shell zeolites with a ZSM-5 zeolite core and a MCM-41 shell with varying shell thicknesses were successfully fabricated via a cetyltrimethylammonium bromide(CTAB)-directed sol-gel coating method in an ultradilute solution. Extensive characterization techniques, including XRD, TEM, N_(2) adsorption-desorption, NH_(3)-TPD, and IR measurements, confirmed the successful coating of a microporous ZSM-5 core with a mesoporous MCM-41 shell layer and were further employed to explore the textural properties and acidic properties of the samples. The hexane cracking results revealed a significant enhancement in olefin yields after introducing the MCM-41 shell to ZSM-5. Interestingly, a volcanic trend in olefin yields was observed with the increase in the shell thickness. In particular, the highest olefin yield of 51.5%, exceeding that of the core catalyst by 17.1%, was achieved when the shell thickness was controlled at 40 nm.Moreover, the catalyst lifetime investigation revealed that the core-shell composite catalyst exhibited a minimal reduction in hexane conversion of merely 3.8% over a 120 h reaction period, significantly outperforming the 11.3% reduction exhibited by the core catalyst. This remarkable catalytic performance was attributed to the passivation of external acid sites and the introduction of more developed pore channels by the shell, which effectively mitigated unwanted side reactions. The successful synthesis of these core-shell structured catalysts presents a novel strategy for improving catalytic performance in hexane cracking, in addition to serving as a solid foundation for the design of industrial catalysts for light naphtha cracking. | Zhu Jiale Zhu Xuedong Yang Fan | 2023 | China Petroleum Processing & Petrochemical Technology2023，25，4： | 0 |
| 17 | Measurements of the concentration of organic solutions by femtosecond time-resolved ERE-CARS显示文摘A variant of all-resonant CARS named electronic-resonant enhancement CARS(ERE-CARS) is applied to measure the methanol-water solution concentration at room temperature.The measurements are performed using the ERE-CARS signal of the Raman vibrations near the C-H stretching modes(at 2835 and 2942 cm 1) in methanol.By changing the timing(t>0) of the laser pulses of this non-degenerate four wave mixing technique,the concentration information based on the vibrational dynamics of the C-H bonds can be successfully detected as the frequency-spread dephasing rate during the first few hundred fs in the ERE-CARS signal with high sensitivity and accuracy.Femtosecond time-resolved ERE-CARS technique is applied to the concentration analysis of a mixture of the organic solution.This investigation indicates that femtosecond time-resolved ERE-CARS technique might be a powerful tool for real-time detection for solution concentration of different liquids. | HE Ping WANG Ming WANG HuiLi FAN RongWei CHEN DeYing YU Xin WANG JiaLing JIANG YuGang | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，10： | 0 |
| 18 | Terahertz beats of vibrational modes in methanol and ethanol selectively excited by tr-CARS technique显示文摘A recently developed time-resolved coherent anti-Stokes Raman scattering(tr-CARS) technique allows the measurement of vibrational coherences with high frequency differences with the ambient environment.The method is based on the short spatial extension of femtosecond pulses with a broadband tunable nonlinear optical parametric amplifier(NOPA) and an internal time delay between the probe and pump/Stokes pulse pair in the CARS process.The different beat frequencies between Raman modes can be selectively detected as oscillations in the tr-CARS transient signal with the broadband tunable NOPA.In this work,we aim at the Raman C-H stretching vibrations from 2800 cm 1 to 3000 cm 1,within which the different vibrational modes in both ethanol and methanol are selectively excited and simultaneously detected.The high time resolution of the experimental set-up allows one to monitor the vibrational coherence dynamics and to observe the quantum beat phenomena on a terahertz scale.This investigation indicates that the femtosecond tr-CARS technique is a powerful tool for the real-time monitoring and detection of molecular and biological agents,including airborne contaminants such as bacterial spores,viruses and their toxins. | HE Ping WANG HuiLi FAN RongWei CHEN DeYing XIA YuanQin YU Xin WANG JiaLing JIANG YuGang | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 0 |
| 19 | Comparative microRNA profiling reveals microRNAs involved in rice resistant response to bacterial blight显示文摘Bacterial blight(BB), which is caused by Xanthomonas oryzae pv. oryzae(Xoo), is one of the most destructive bacterial diseases of rice(Oryza sativa L.). During plant defense responses, micro RNAs(mi RNAs) play important roles in regulating disease resistance. However, the functions of mi RNAs in the interaction between rice and Xoo remain relatively uncharacterized. In this study, we compared the mi RNA profiles of the BB resistant rice introgression line F329 and its susceptible recurrent parent Huang-Hua-Zhan(HHZ) at multiple time points after inoculation with Xoo. A total of 538 known and 312 novel mi RNAs were identified, among which only 17 and 26 were responsive to Xoo infection in F329 and HHZ, respectively. Compared with the expression levels in HHZ, 37 up-regulated and 53 down-regulated mi RNAs were detected in F329. The predicted target genes for the mi RNAs differentially expressed between F329 and HHZ were revealed to be associated with flavonoid synthesis, the reactive oxygen species regulatory pathway, plant hormone signal transduction, defense responses, and growth and development.Additionally, the patterns of interactions between osa-mi R390-3 p, novel_mi R_104, novel_mi R_238,osa-mi R166 k-5 p, osa-mi R529 b, and osa-mi R167 h-3 p and their target genes were further validated by quantitative real-time PCR. Furthermore, we overexpressed osa-mi R167 h-3 p in transgenic plants and proved that this mi RNA positively regulates the resistance of rice to BB. These results provide novel information regarding the mi RNA-based molecular mechanisms underlying the disease resistance of rice. The data presented herein may be useful for engineering rice BB resistance via mi RNAs. | Jialing Lu Chunchao Wang Fan Zhang Dan Zeng Yongli Zhou | 2021 | The Crop Journal2021，9，4： | 0 |
| 20 | Metformin:A promising clinical therapeutical approach for BPH treatment via inhibiting dysregulated steroid hormones-induced prostatic epithelial cells proliferation显示文摘The occurrence of benign prostate hyperplasia(BPH)was related to disrupted sex steroid hormones,and metformin(Met)had a clinical response to sex steroid hormone-related gynaecological disease.However,whether Met exerts an antiproliferative effect on BPH via sex steroid hormones remains unclear.Here,our clinical study showed that along with prostatic epithelial cell(PEC)proliferation,sex steroid hormones were dysregulated in the serum and prostate of BPH patients.As the major contributor to dysregulated sex steroid hormones,elevated dihydrotestosterone(DHT)had a significant positive relationship with the clinical characteristics of BPH patients.Activation of adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK)by Met restored dysregulated sex steroid hormone homeostasis and exerted antiproliferative effects against DHT-induced proliferation by inhibiting the formation of androgen receptor(AR)-mediated Yes-associated protein(YAP1)-TEA domain transcription factor(TEAD4)heterodimers.Met’s anti-proliferative effects were blocked by AMPK inhibitor or YAP1 overexpression in DHT-cultured BPH-1 cells.Our findings indicated that Met would be a promising clinical therapeutic approach for BPH by inhibiting dysregulated steroid hormone-induced PEC proliferation. | Tingting Yanga Jiayu Yuana Yuting Penga Jiale Pang Zhen Qiu Shangxiu Chen Yuhan Huang Zhenzhou Jiang Yilin Fan Junjie Liu Tao Wang Xueyan Zhou Sitong Qian Jinfang Song Yi Xu Qian Lu Xiaoxing Yin | 2024 | Journal of Pharmaceutical Analysis2024，14，1： | 0 |
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