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| 1 | Inter-annual variations in vegetation and their response to climatic factors in the upper catchments of the Yellow River from 2000 to 2010显示文摘在黄河的上面的集水在有气候因素的植被和他们的关联理解变化,中国,从 2000 ~ 2010 的规范的差别植被索引(NDVI ) 时间系列数据基于 MOD13Q1 产品被收集。变化, Theil 参议员中部的趋势分析和 Mann-Kendall 测试的系数被联合调查轻快特征和植被的趋势特征。气候数据集合然后被用来在植被和气候变化分析在变化之间的关联。以时间的变化,在这个学习区域的植被从 2000 ~ 2010 稍微改善了,尽管轻快特征比在 20062010 在 20002005 是更大的。以空间变化,相对稳定并且有一个显著地增加的趋势的植被说明学习区域的最大的部分。它的空间分发高度与高度被相关,它在这个区域从大约 2000 ~ 3000 m 。显示出一个显著地减少的趋势的高度波动的植被和植被主要与水力发出的电力开发在水库附近并且在河的活动范围被散布。有一个相对稳定、显著地减少的趋势的植被和有高度波动和显著地增加的趋势的植被广泛地被驱散。关于到气候变化的植被的反应,大约 2030% 植被与气候的因素有重要关联,在大多数区域的关联是积极的:有降水的区域作为关键影响因素占超过 10% 区域;有温度的区域作为关键影响因素占不到 10% 区域;并且有降水和温度的区域作为一起影响因素的钥匙占大约 5% 全部的区域。超过 70% 植被与气候的因素有不足道的关联。 | CAO Ran JIANG Weiguo YUAN Lihua WANG Wenjie LV Zhongliang CHEN Zheng | 2014 | Journal of Geographical Sciences2014，24，6： | 19 |
| 2 | High-precision relocation of the aftershock sequence of the January 8,2022,M_(S)6.9 Menyuan earthquake显示文摘The 2022 Menyuan M_(S)6.9 earthquake,which occurred on January 8,is the most destructive earthquake to occur near the Lenglongling(LLL)fault since the 2016 Menyuan M_(S)6.4 earthquake.We relocated the mainshock and aftershocks with phase arrival time observations for three days after the mainshock from the Qinghai Seismic Network using the double-difference method.The total length and width of the aftershock sequence are approximately 32 km and 5 km,respectively,and the aftershocks are mainly concentrated at a depth of 7-12 km.The relocated sequence can be divided into 18 km west and 13 km east segments with a boundary approximately 5 km east of the mainshock,where aftershocks are sparse.The east and west fault structures revealed by aftershock locations differ significantly.The west fault strikes EW and inclines to the south at a 71°-90°angle,whereas the east fault strikes 133°and has a smaller dip angle.Elastic strain accumulates at conjunctions of faults with different slip rates where it is prone to large earthquakes.Based on surface traces of faults,the distribution of relocated earthquake sequence and surface ruptures,the mainshock was determined to have occurred at the conjunction of the Tuolaishan(TLS)fault and LLL fault,and the west and east segments of the aftershock sequence were on the TLS fault and LLL fault,respectively.Aftershocks migrate in the early and late stages of the earthquake sequence.In the first 1.5 h after the mainshock,aftershocks expand westward from the mainshock.In the late stage,seismicity on the northeast side of the east fault is higher than that in other regions.The migration rate of the west segment of the aftershock sequence is approximately 4.5 km/decade and the afterslip may exist in the source region. | Liping Fan Boren Li Shirong Liao Ce Jiang Lihua Fang | 2022 | Earthquake Science2022，35，2： | 14 |
| 3 | Yolk-shell structured Co-C/Void/Co9S8 composites with a tunable cavity for ultrabroadband and efficient low- frequency microwave absorption显示文摘 | Xiaofang Liu Chengcheng Hao Lihua He Cheng Yang Yubin Chen Chengbao Jiang Ronghai Yu | 2018 | Nano Research2018，11，8： | 10 |
| 4 | Vertical root distribution and root cohesion of typical tree species on the Loess Plateau, China显示文摘Black locust(Robinia pseudoacacia L.) and Chinese pine(Pinus tabulaeformis Carr.) are two woody plants that are widely planted on the Loess Plateau for controlling soil erosion and land desertification. In this study, we conducted an excavation experiment in 2008 to investigate the overall vertical root distribution characteristics of black locust and Chinese pine. We also performed triaxial compression tests to evaluate the root cohesion(additional soil cohesion increased by roots) of black locust. Two types of root distribution, namely, vertical root(VR) and horizontal root(HR), were used as samples and tested under four soil water content(SWC) conditions(12.7%, 15.0%, 18.0% and 20.0%, respectively). Results showed that the root lengths of the two species were mainly concentrated in the root diameter of 5–20 mm. A comparison of root distribution between the two species indicated that the root length of black locust was significantly greater than that of Chinese pine in nearly all root diameters, although the black locust used in the comparison was 10 years younger than the Chinese pine. Root biomass was also significantly greater in black locust than in Chinese pine, particularly in the root diameters of 3–5 and 5–10 mm. These two species were both found to be deep-rooted. The triaxial compression tests showed that root cohesion was greater in the VR samples than in the HR samples. SWC was negatively related to both soil shear strength and root cohesion. These results could provide useful information on the architectural characteristics of woody root system and expand the knowledge on shallow slope stabilization and soil erosion control by plant roots on the Loess Plateau. | ChaoBo ZHANG LiHua CHEN Jing JIANG | 2014 | Journal of Arid Land2014，6，5： | 9 |
| 5 | Expression of IL-1α, IL-6, TGF-β, FasL and ZNF265 During Sertoli Cell Infection by Ureaplasma Urealyticum显示文摘 | Rongping Li Yebin Xi Xiuzhi Liu Guangjie Chen Baoguo Wang Lihua Jiang Weiyi Li | 2009 | Cellular & Molecular Immunology2009，6，3： | 8 |
| 6 | Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis显示文摘 | Xu Xiaojie Fan Zhongyi Kang Lei Han Juqiang Jiang Chengying Zheng Xiaofei Zhu Ziman Jiao Huabo Lin Jing Jiang Kai Ding Lihua Zhang Hao Cheng Long Fu Hanjiang Song Yi Jiang Ying Liu Jiahong Wang Rongfu Du Nan Ye Qinong | 2013 | Journal of Clinical Investigation2013，，2： | 7 |
| 7 | Study on electromechanical coupling nonlinear vibration of flywheel energy storage system显示文摘The electromechanical coupling dynamics of the flywheel energy storage system (FESS) with a hybrid permanent magnetic-dynamic spiral groove bearing has been studied. The functions of the kinetic energy, the potential energys, the magnetic field energy in air gap of the flywheel motor and the energy dissipation of the whole system were obtained, and the differential equations set with electromagnetic parameters of FESS was established by applying the extended Lagrange-Maxwell equation. The four-order implicit Runge-Kutta formula to the equations was derived, and the nonlinear algebraic equations were solved by using the Gauss-Newton method. The analytical solution of an example shows that the upper damping coefficient, the lower damping coefficient and the residual magnetic induction of the rare earth permanent magnet play an important role in electromechanical resonance of the flywheel rotor system. There is a small change for the electromechanical coupling resonance frequency with the upper damping coefficient in-creasing, but the resonance amplitude decreases with the upper damping coefficient in-creasing. With the lower damping coefficient increasing, the resonance frequency in-creases, and the resonance amplitude decreases. With the residual magnetic induction of the permanent magnet increasing, the resonance frequency decreases, and the reso-nance amplitude increases. | JIANG Shuyun JU Lihua | 2006 | Science China(Technological Sciences)2006，49，1： | 6 |
| 8 | Nanoparticle monolayer-based flexible strain gauge with ultrafast dynamic response for acoustic vibration detection显示文摘The relatively poor dynamic response of current flexible strain gauges has prevented their wide adoption in portable electronics. In this work, we present a greatly improved flexible strain gauge, where one strip of Au nanoparticle (NP) monolayer assembled on a polyethylene terephthalate film is utilized as the active unit. The proposed flexible gauge is capable of responding to applied stimuli without detectable hysteresis via electron tunneling between adjacent nanoparticles within the Au NP monolayer. Based on experimental quantification of the time and frequency domain dependence of the electrical resistance of the proposed strain gauge, acoustic vibrations in the frequency range of 1 to 20,000 Hz could be reliably detected. In addition to being used to measure musical tone, audible speech, and creature vocalization, as demonstrated in this study, the ultrafast dynamic response of this flexible strain gauge can be used in a wide range of applications, including miniaturized vibratory sensors, safe entrance guard management systems, and ultrasensitive pressure sensors. | Lizhi Yi Weihong Jiao Ke Wu Lihua Qian Xunxing Yu Qi Xia Kuanmin Mao Songliu Yuan Shuai Wang Yingtao Jiang | 2015 | Nano Research2015，8，9： | 6 |
| 9 | Large numbersLarge numbers of new bacterial taxa found by Yunnan Institute of Microbiology显示文摘Extreme environments, primeval forest, sea sediments and plants in China yielded members of a new suborder, Jiangellineae, a new family Sinobacteraceae, and 23 new genera of actinomycetes and other bacteria. Three suggestions were made for further discoveries of new actinomycetes. First, natural habitats such as old growth forests, and extreme environments, should be given sampling priority; second, culturing procedures need to be constantly improved to mimic natural habitats; third, less than 98.5% similarity of 16S rRNA sequence to that of a known species could be used as an indicator of a new species. | JIANG Yi CAO YanRu ZHAO LiXing TANG ShuKun WANG Yun LI WenJun XU Ping LOU Kai MAO PeiHong XU LiHua | 2011 | Chinese Science Bulletin2011，56，8： | 5 |
| 10 | Bimodular effects of D614G mutation on the spike glycoprotein of SARS-CoV-2 enhance protein processing,membrane fusion,and viral infectivity显示文摘Dear Editor,By the end of June 2020,the pandemic of coronavirus diseases 2019(COVID-19)had resulted in more than 10 million individuals,all over the world,being infected with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).1 The high contagiousness of SARS-CoV-2 virus was largely attributed to the relatively unique sequence composition in its spike(S)glycoprotein,which is in charge of the host entry by interacting with its cellular receptor angiotensin-converting enzyme 2(ACE2).2,3 The S glycoprotein can be processed into an N terminal S1 fragment that is responsible for receptor binding,and a C terminal S2 fragment that functions to promote membrane fusion.4 SARS-CoV-2 is a type of single-stranded positive-sense ribonucleic acid(RNA)virus,and an increasing number of mutations were identified across the SARS-CoV-2 genome,including the region encoding S glycoprotein.Nevertheless,the functional implications of these mutations remain largely unknown,we here reported the mutation analysis of S gene and a functional exploration of the dominant D614G mutation. | Xiaoyi Jiang Zhengrong Zhang Chenxi Wang Hongguang Ren Lihua Gao Haoran Peng Zubiao Niu He Ren Hongyan Huang Qiang Sun | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 11 | Mitochondrial Genome of Episesarma lafondii(Brachyura:Sesarmidae)and Comparison with Other Sesarmid Crabs显示文摘Complete mitochondrial genomes(mitogenomes)can provide useful information for phylogenetic relationships,gene rearrangement,and molecular evolution.Here,the complete mitogenome of Episesarma lafondii(Brachyura:Grapsoidea:Sesarmidae)was sequenced through next-generation sequencing technique for the first time.The 15640 bp mitogenome contains the entire set of 37 genes and an AT-rich region.The rearrangements of two tRNA genes(tRNA-His and tRNA-Gln)are compared with that in the pancrustacean ground pattern,and the tandem duplication/random loss model was selected to explain the observed gene rearrangements.The phylogenetic results showed that all sesarmid crabs belong to the same group,wherein the genus Episesarma showed the closest relationship with Clistocoeloma.Furthermore,the monophyly of each family was well supported except for Xanthidae,Gecarcinidae,and Homolidae.The correlation between the phylogeny of Sesarmidae species and the gaps in the QIM region was analyzed.Evidently,the gaps between Q and I(Gap3 and between I and M(Gap4)degenerated with the evolution process.In general,the results will contribute to the in-depth understanding of gene rearrangements in Sesarmidae mitogenomes and provide new insights into the phylogeny of Brachyura. | ZHANG Ying GAO Yan GONG Li LU Xinting JIANG Lihua LIU Bingjian LIU Liqin LU Zhenming LI Pengfei | 2021 | Journal of Ocean University of China2021，20，6： | 4 |
| 12 | Summer sea-surface temperatures and climate events on the North Icelandic shelf through the last 3000 years显示文摘Diatom data from core MD992271 on the North Icelandic shelf record a cooling trend through the last 3000 years. This is indicated by a general decrease in warm water species and an increase in cold water taxa. The relative abundance of these two diatom groups changed periodically, suggesting that the climate also fluctuated within this time period. The results of diatom-based transfer function calculation show that the summer sea-surface temperatures (SSTs) before 1400 cal. a BP were generally higher than the mean value for the last 3000 years and the summer SSTs fluctuated around the mean between 1400 and 700 cal. a BP, and dropped to the values below the mean after 700 cal. a BP. Four cooling events were distinguished, centered at around 2600, 1900, 1300 and 600 cal. a BP respectively. The results are not only consistent with the data from neighbouring cores HM107-03 and MD992275, but also comparable with those from the GISP2 ice core and from other marine sediment records in the North Atlantic. This suggests that changes in the summer SSTs reflect regional climate variations in the North Atlantic. On the North Icelandic shelf, the summer SST variation is a result of changes in the in-teraction between the cold and the warm currents in the area. | JIANG Hui REN Jian Karen Luise KNUDSEN Jon EIRiKSSON RAN LiHua | 2007 | Chinese Science Bulletin2007，52，6： | 4 |
| 13 | Comparison of the earthquake detection abilities of PhaseNet and EQTransformer with the Yangbi and Maduo earthquakes显示文摘PhaseNet and EQTransformer are two state-of-the-art earthquake detection methods that have been increasingly applied worldwide.To evaluate the generaliz-ation ability of the two models and provide insights for the development of new models,this study took the sequences of the Yunnan Yangbi M6.4 earthquake and Qinghai Maduo M7.4 earthquake as examples to compare the earthquake detection effects of the two abovementioned models as well as their abilities to process dense seismic sequences.It has been demonstrated from the corresponding research that due to the differences in seismic waveforms found in different geographical regions,the picking performance is reduced when the two models are applied directly to the detection of the Yangbi and Maduo earthquakes.PhaseNet has a higher recall than EQTransformer,but the recall of both models is reduced by 13%-56%when compared with the results rep-orted in the original papers.The analysis results indicate that neural networks with deeper layers and complex structures may not necessarily enhance earthquake detection perfor-mance.In designing earthquake detection models,attention should be paid to not only the balance of depth,width,and architecture but also to the quality and quantity of the training datasets.In addition,noise datasets should be incorporated during training.According to the continuous waveforms detected 21 days before the Yangbi and Maduo earthquakes,the Yangbi earthquake exhibited foreshock,while the Maduo earthquake showed no foreshock activity,indicating that the two earthquakes’nucleation processes were different. | Ce Jiang Lihua Fang Liping Fan Boren Li | 2021 | Earthquake Science2021，34，5： | 4 |
| 14 | Effects of intermedinl-53 on myocardial fibrosis显示文摘Intermedin (IMD ) 是 calcitonin/calcitonin 的一个成员基因相关的肽(CGRP ) 家庭并且类似或更多的有势力心血管的行动比 adrenomedullin (ADM ) 和任何另外的 CGRP。现在的工作的目的是在 vivo 并且在 vitro 在心脏的成纤维细胞纤维变性上学习 IMD1-53 的效果。心肌的梗塞模型被绑扎准备老鼠左前面的下降冠的动脉。在左室的间充质的骨胶原内容被天狼星红污点存取。心功能被血液动力学的变化探索。表示我和 III 打骨胶原, IMD1-53,受体修改活动的蛋白质(斜面) 1/2/3,和 calcitonin 在左室的像受体的受体(CRLR ) 被西方的污点分析检测。心脏的成纤维细胞(CFbs ) 纤维变性被与醛固酮(ALD ) 对待房间导致。在上层清液的 CFbs 增长和 hydroxyproline 内容被 3- 决定[4,5-dimehyl-2-thiazolyl ]-2,5-diphenyl-2H-tetrazolium 溴化物试金和连接酶的 immunosorbent 试金。心功能在心肌的梗塞模型老鼠被减少。类型的表示我和在在心肌的老鼠的 infarcted 地区的类型 III 骨胶原是比在假冒操作组的那些高级的。在左室的 IMD1-53,斜面,和 CRLR 也是起来调整的。在 vitro,实验证明 ALD 是 CFbs 激活的一个强大的激发器。IMD1-53 减少了以一种剂量依赖者方式的导致 ALD 的 CFbs 增长。而且, CGRP8-37 和 ADM22-52 显著地在导致 ALD 的心肌的房间纤维变性上堵住了 IMD1-53 的效果。IMD 能涉及心脏的纤维变性的发作。象 ADM 一样, IMD1-53 在 CFbs 上施加 antifibrotic 效果,它可能被 CRLR/RAMP 建筑群和 ADM 受体调停。 | Xiaoling Yang Huiping Zhang Yuexia Jia Lan Ni Guizhong Li Lihua Xue Yideng Jiang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，2： | 4 |
| 15 | LiPO_(2)F_(2) electrolyte additive for high-performance Li-rich cathode material显示文摘Li-rich layered oxide cathodes have received considerable attention because of the high operating potential and specific capacity. However, the structural instability and parasitic reactions at high potential cause severe degradation of the electrochemical performance. In our studies, the cycling stability of Li_(1.14)Ni_(0.133)Co_(0.133)Mn_(0.544)O_(2) cathode is improved with LiPO_(2)F_(2) electrolyte additive. After 500 cycles, the capacity retention is increased from 53.6% to 85% at 3 C by LiPO_(2)F_(2) modification. This performance is mainly attributed to the enhanced interfacial stability of the Li-rich cathode. Based on systematic characterization, LiPO_(2)F_(2) additive was found to promote a stable interface film on the cathode surface during the cycling and mitigates the interfacial side reactions. This study provides new insights for improving high-potential Li-rich layered oxide batteries. | Bing Jiang Jingru Li Bi Luo Qizhang Yan Hao Li Lehao Liu Lihua Chu Yingfeng Li Qiaobao Zhang Meicheng Li | 2021 | Journal of Energy Chemistry2021，30，9： | 3 |
| 16 | Up-regulation of glycolipid transfer protein by bicyclol causes spontaneous restriction of hepatitis C virus replication显示文摘Bicyclol is a synthetic drug for hepatoprotection in clinic since 2004. Preliminary clinical observations suggest that bicyclol might be active against hepatitis C virus(HCV) with unknown mechanism. Here, we showed that bicyclol significantly inhibited HCV replication in vitro and in hepatitis C patients. Using bicyclol as a probe, we identified glycolipid transfer protein(GLTP) to be a novel restrictive factor for HCV replication. The GLTP preferentially bound host vesicle-associated membrane protein-associated protein-A(VAP-A) in competition with the HCV NS5 A, causing an interruption of the complex formation between VAP-A and HCV NS5 A. As the formation of VAP-A/NS5 A complex is essential for viral RNA replication, up-regulation of GLTP by bicyclol reduced the level of VAP-A/NS5 A complex and thus inhibited HCV replication. Bicyclol also exhibited an inhibition on HCV variants resistant to direct-acting antiviral agents(DAAs) with an efficacy identical to that on wild type HCV. In combination with bicyclol, DAAs inhibited HCV replication in a synergistic fashion. GLTP appears to be a newly discovered host restrictive factor for HCV replication, Up-regulation of GLTP causes spontaneous restriction of HCV replication. | Meng-Hao Huang Hu Li Rong Xue Jianrui Li Lihua Wang Junjun Cheng Zhouyi Wu Wenjing Li Jinhua Chen Xiaoqin Lv Qiang Li Pei Lan Limin Zhao Yongfeng Yang Zonggen Peng Jiandong Jiang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 3 |
| 17 | Superresolution imaging of telomeres with continuous wave stimulated emission depletion (STED) microscope显示文摘The significant role of telomeres in cells has attracted much attention since they were discovered.Fluorescence imaging is an effective method to study subcellular structures like telomeres.However,the diffraction limit of traditional optical microscope hampers further investigation on them.Recent progress on superresolution fluorescence microscopy has broken this limit.In this work,we used stimulated emission depletion(STED) microscope to observe fluorescence-labeled telomeres in interphase cell nuclei.The results showed that the size of fluorescent puncta representing telomeres under the STED microscope was much smaller than that under the confocal microscope.Two adjacent telomeres were clearly separated via STED imaging,which could hardly be discriminated by confocal microscopy due to the diffraction limit.We conclude that STED microscope is a more powerful tool that enable us to obtain detailed information about telomeres. | Shaopeng Wang Suhui Deng Xiaoqing Cai Shangguo Hou Jiajun Li Zhaoshuai Gao Jiang Li Lihua Wang Chunhai Fan | 2016 | Science China Chemistry2016，59，11： | 3 |
| 18 | Characterization and validation of somatic mutation spectrum to reveal heterogeneity in gastric cancer by single cell sequencing显示文摘Gastric cancer(GC) is a highly heterogeneous disease with multiple cellular types and poor prognosis.However, the cellular evolution and molecular basis of GC at the individual intra-tumor level has not been well demonstrated. We performed single-cell whole exome sequencing to detect somatic singlenucleotide variants(SNVs) and significantly mutated genes(SMGs) among 34 tumor cells and 9 normal cells from a patient with GC. The Complete Prediction for Protein Conformation(CPPC) approach directly predicting the folding conformation of the protein 3D structure with Protein Folding Shape Code, combined with functional experiments were used to confirm the characterization of mutated SMGs in GC cells. We identified 201 somatic SNVs, including 117 non-synonymous mutations in GC cells. Further analysis identified 24 significant mutated genes(SMGs) in single cells, for which a single amino acid change might affect protein conformation. Among them, two genes(CDC27 and FLG) that were mutated only in single cells but not in the corresponding tumor tissue, were recurrently present in another GC tissue cohort, and may play a potential role to promote carcinogenesis, as confirmed by functional characterization. Our findings showed a mutational landscape of GC at intra-tumor level for the first time and provided opportunities for understanding the heterogeneity and individualized target therapy for this disease. | Lihua Peng Rui Xing Dongbing Liu Li Bao Wenxiang Cheng Hongyi Wang Yuan Yu Xiaofeng Liu Lu Jiang Yan Wu Zhongxue An Qiaoyi Liang Ryong Nam Kim Young Kee Shin Huanming Yang Jian Wang Jun Yu Xiuqing Zhang Xun Xu Jiaan Yang Kui Wu Shida Zhu Youyong Lu | 2019 | Science Bulletin2019，64，4： | 3 |
| 19 | Clinical and microbiological characterization of Clostridium difficile infection in a tertiary care hospital in Shanghai, China显示文摘 | Dong Danfeng Peng Yibing Zhang Lihua Jiang Cen Wang Xuefeng Mao Enqiang | 2014 | Chinese Medical Journal2014，，9： | 3 |
| 20 | Genetically encoded X-ray cellular imaging for nanoscale protein localization显示文摘Spatial resolution defines the physical limit of microscopes for probing biomolecular localization and interactions in cells.Whereas synchrotron-based X-ray microscopy(XRM)represents a unique approach for imaging a whole cell with nanoscale resolution due to its intrinsic nanoscale resolution and great penetration ability,existing approaches to label biomolecules rely on the use of exogenous tags that are multi-step and error-prone.Here,we repurpose engineered peroxidases as genetically encoded X-ray-sensitive tags(GXET)for site-specific labeling of protein-of-interest in mammalian cells.We find that 3,3-diaminobenzidine(DAB)polymers that are in-situ catalytically formed by fusion-expressed peroxidases are visible under XRM.Using this new tag,we imaged the protein location associated with the alteration of a DNA-methylation pathway with an ultra-high resolution of 30 nanometers.Importantly,the excellent energy resolution of XRM enables multicolor imaging using different peroxidase tags.The development of GXET enlightens the way to nanoscopic imaging for biological studies. | Huating Kong Jichao Zhang Jiang Li Jian Wang Hyun-Joon Shin Renzhong Tai Qinglong Yan Kai Xia Jun Hu Lihua Wang Ying Zhu Chunhai Fan | 2020 | National Science Review2020，7，7： | 3 |
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