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| 1 | Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients显示文摘胃的癌症是世界范围的第四很普通的癌症,与死亡的高率和低 5 年的幸存率。迄今为止,有为胃的癌症的有效治疗学的协议的缺乏。最近的研究建议癌症干细胞(CSC ) 为肿瘤开始,侵略,转移,和抵抗负责到 anticancer 治疗。因此,指向胃的 CSC 的治疗是吸引人的。然而,在人的胃的腺癌(GAC ) 的 CSC 没被描述。这里,我们从 GAC 病人在肿瘤纸巾和外部血识别 CSC。从肿瘤纸巾和病人的外部血被孤立的人的 GAC (GCSC ) 的 CSC 带了 CD44 和 CD54 表面标记,当注入了 immunodeficient 老鼠时,高度类似于原来的人的肿瘤的产生肿瘤,在 vitro 区分了进胃的上皮的房间,并且在 vivo 并且在 vitro 自我更新。我们的调查结果建议有效治疗学的协议必须指向 GCSC。从 GAC 病人的循环的 GCSC 的俘获也为为肿瘤转移潜在地负责的一张批评房间人口的鉴定显示出大潜力,并且为早诊断并且胃的癌症的纵的监视提供一个有效协议。 | Tie Chen Kun Yang Jianhua Yu Wentong Meng Dandan Yuan Feng Bi Fang Liu Jie Liu Bing Dai Xinzu Chen Fang Wang Fan Zeng Hong Xu Jiankun Hu Xianming Mo | 2012 | Cell Research2012，22，1： | 50 |
| 2 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 3 | 120 mm Single-crystalline perovskite and wafers: towards viable applications显示文摘As the large single-crystalline silicon wafers have revolutionized many industries including electronics and solar cells, it is envisioned that the availability of large single-crystalline perovskite crystals and wafers will revolutionize its broad applications in photovoltaics, optoelectronics, lasers, photodetectors, light emitting diodes(LEDs), etc. Here we report a method to grow large single-crystalline perovskites including single-halide crystals: CH3NH3PbX3(X=I, Br, Cl), and dual-halide ones:CH3NH3Pb(ClxBr1.x)3 and CH3NH3Pb(BrxI1.x)3, with the largest crystal being 120 mm in length. Meanwhile, we have advanced a process to slice the large perovskite crystals into thin wafers. It is found that the wafers exhibit remarkable features:(1)its trap-state density is a million times smaller than that in the microcrystalline perovskite thin films(MPTF);(2) its carrier mobility is 410 times higher than its most popular organic counterpart P3HT;(3) its optical absorption is expanded to as high as910 nm comparing to 797 nm for the MPTF;(4) while MPTF decomposes at 150 °C, the wafer is stable at high temperature up to270 °C;(5) when exposed to high humidity(75% RH), MPTF decomposes in 5 h while the wafer shows no change for overnight;(6) its photocurrent response is 250 times higher than its MPTF counterpart. A few electronic devices have been fabricated using the crystalline wafers. Among them, the Hall test gives low carrier concentration with high mobility. The trap-state density is measured much lower than common semiconductors. Moreover, the large SC-wafer is found particularly useful for mass production of integrated circuits. By adjusting the halide composition, both the optical absorption and the light emission can be fine-tuned across the entire visible spectrum from 400 nm to 800 nm. It is envisioned that a range of visible lasers and LEDs may be developed using the dual-halide perovskites. With fewer trap states, high mobility, broader absorption, and humidity resistance, it is expected that solar cells with high stable efficiency maybe attainable using the crystalline wafers. | Yucheng Liu Xiaodong Ren Jing Zhang Zhou Yang Dong Yang Fengyang Yu Jiankun Sun Changming Zhao Zhun Yao Bo Wang Qingbo Wei Fengwei Xiao Haibo Fan Hao Deng Liangping Deng Shengzhong (Frank) Liu | 2017 | Science China Chemistry2017，60，10： | 5 |
| 4 | Systematic Characterization of Long Non-Coding RNAs and Their Responses to Drought Stress in Dongxiang Wild Rice显示文摘Long non-coding RNAs(lncRNAs) play important roles in response to various biotic and abiotic stresses. So far, systematic identification and characterization of lncRNAs have been reported in a few model plant species and major crops, but their roles in abiotic stress response have not yet been reported in common wild rice(Oryza rufipogon). Dongxiang wild rice(DXWR) possesses a high degree of drought resistance and has been well recognized as a precious genetic resource for drought resistant rice breeding. We presented the reference catalog of 1 655 novel lncRNA transcripts in DXWR using strand-specific RNA sequencing and bioinformatics approaches. Meanwhile, a total of 1092 lncRNAs were determined as differentially expressed lncRNAs under drought stress. Quantitative real-time PCR results exhibited a high concordance with RNA sequencing data, which confirmed that the expression patterns of lncRNAs based on RNA sequencing were highly reliable. Furthermore, 8 711 transcripts were predicted as target genes of the differentially expressed lncRNAs. Functional annotation analysis based on Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases showed that the target genes were significantly enriched in cellular and metabolic processes, cell part, binding and plant hormone signal transduction, as well as many other terms related to abiotic stress resistance. These results expanded our understanding of lncRNA biology and provided candidate regulators for genetic improvement of drought resistance in rice cultivars. | QI Weidong CHEN Hongping YANG Zuozhen HU Biaolin LUO Xiangdong AI Bing LUO Yuan HUANG Yu XIE Jiankun ZHANG Fantao | 2020 | Rice science2020，27，1： | 3 |
| 5 | Reinforcement effects of ground treatment with dynamic compaction replacement in cold and saline soil regions显示文摘The mechanical property of saline soils varies with moisture and climate in the cold and salt lake region of Qinghai-Tibet Plateau, which influences project construction. In order to improve foundation reinforcement effect of the Qarhan-Golmud Highway, Qinghai Province, China, dynamic compaction replacement (DCR) composite foundation was applied in saline soils. A field experiment was conducted in this area, where strength and working mechanism of pier-soil and deformation modulus of the composite foundation was analyzed after reinforcement. This paper presents methods for determining the coefficient on the bearing capacity evaluation and deformation modulus of composite foundation with DCR. Reinforcement case of DCR is highly effective in saline soils of the salt lake regions, which helps the migration of water and salt in saline soils. | Yu Zhang JianKun Liu JianHong Fang AnHua Xu | 2013 | Research in Cold and Arid Regions2013，5，4： | 2 |
| 6 | Multiple origins of Tibetan Y chromosomes显示文摘 | Yaping Qian Binzhi Qian Bing Su Jiankun Yu Yuehai Ke Zhengtao Chu Lei Shi Daru Lu Jiayou Chu Li Jin | 2000 | Human Genetics2000，，4： | 1 |
| 7 | A Conserved Serine of Heterogeneous Nuclear Ribonucleoprotein L (hnRNP L) Mediates Depolarization-regulated Alternative Splicing of Potassium Channels显示文摘 | Guodong Liu Aleh Razanau Yan Hai Jiankun Yu Muhammad Sohail Vincent G. Lobo Jiayou Chu Sam K. P. Kung Jiuyong Xie | 2012 | Journal of Biological Chemistry2012，，27： | 1 |
| 8 | Eco-friendly biodegradable polyurethane based coating for antibacterial and antifouling performance显示文摘Biofouling, which comprises the absorption of proteins and the adhesion of bacteria to the surface of living entities, is a severe concern for the maritime sector since it ultimately leads to hydrodynamic drag,resulting in a higher increase in fuel consumption. As a result, polymer resins are crucial in the marine sector for anti-biofouling coatings. In this work, the poly(caprolactone-ethylene glycol-caprolactone)-p olyurethane(PECL-PU) are prepared through ε-caprolactone(CL), poly(ethylene glycol)(PEG), 4,4'-methylene bis(cyclohexyl isocyanate) and 1,4 butanediol. Our study demonstrate that the PECL-PU copolymer degraded in artificial seawater(5.21%), enzymatic solution(12.63%), and seawater(13.75%)due to the presence of PEG segments in the laboratory-based test under static condition. Because the addition of PEG segments are increased the polymer's amorphous area and decreased the crystallization of the polycaprolactone(PCL) in the copolymer, as demonstrated by differential scanning calorimetry, X-ray diffraction, and water contact angle studies. Therefore, the hydrolysis rates of PECL-PU were higher than the caprolactone-co-polyurethane(CL-PU). The antifouling test showed that PECL-PU3 copolymer had about 90.29% protein resistance, 85.2% Escherichia coli(E. coli) reduction and 94.61% marine diatom Navicula incerta reduction comparison to the control. We have developed an eco-friendly and inexpensive promising degradable polyurethane for reduction of bacterial biofilm, which can preserve the formation of biofouling on marine coating under practical sea conditions. | Abid Ali Bilal Ul Amin Wenwu Yu Taijiang Gui Weiwei Cong Kai Zhang Zheming Tong Jiankun Hu Xiaoli Zhan Qinghua Zhang | 2023 | Chinese Journal of Chemical Engineering2023，54，2： | 1 |
| 9 | Multiple origins of Tibetan Y chromosomes显示文摘 | Yaping Qian Binzhi Qian Bing Su Jiankun Yu Yuehai Ke Zhengtao Chu Lei Shi Daru Lu Jiayou Chu Li Jin | 2000 | Human Genetics2000，，4： | 1 |
| 10 | Experimental research on physical properties of saline soil subgrade filler in Chaerhan region显示文摘In order to improve the engineering stability of saline soil of high chloride content in the Chaerhan salt lake region,six typical characteristics saline soil samples were selected,and tests on their primary physical properties(total salt content,specific gravity of soil,liquid limit,plastic limit,maximum dry density,and optimal water content) were conducted.The relationships among them were analyzed,a series of variation laws between salt content and these basic physical parameters were determined,and regression equations were derived.This research can improve future engineering design and construction in saline soils and can also help prevent subgrade filler from undermining subgrade stability and producing disease. | Yu Zhang JianHong Fang JianKun Liu AnHua Xu | 2015 | Research in Cold and Arid Regions2015，7，3： | 1 |
| 11 | A two-grid search scheme for large-scale 3-D finite element analyses of slope stability显示文摘 | Xi Chen Yongkang Wu Yuzhen Yu Jiankun Liu Xi Frank Xu Jun Ren | 2014 | Computers and Geotechnics2014，，： | 1 |
| 12 | The effect of confining boundary on soil deformation in one dimensional frost heave tests and the theoretical volume correction显示文摘Frost heave is one of the major complications in highway construction in cold regions. Laboratory experiments are important in the study frost heave behavior of soils, and one-dimensional frost heave experiments are the easiest way to evaluate the soil frost heave potential. In a one dimensional frost heave test, the deformation in axial direction is non-uniform because of the confining effect of the cutting ring's sidewall. If the effect of confining boundary on soil deformation is ignored, the deformation will be over-estimated. In this paper, the effect of confining boundary on soil deformation is theoretically studied and a volume correction method is developed and applied to the frost heave test of a sulfite saline soil. Test results demonstrate that the sulfite saline soil will expand to a loose, low-density state after several freezing-thawing cycles under the condition of zero axial stress. | XueWen Zhao Xu Li JianKun Liu Yu Zhang | 2013 | Research in Cold and Arid Regions2013，5，5： | 1 |
| 13 | Synergistic-engineered van der Waals photodiodes with high efficiency显示文摘Van der Waals(vdW)heterostructures based on two-dimensional transitionmetal dichalcogenides have provided unprecedented opportunities for photovoltaic detectors owing to their strong light-matter interaction and ultrafast interfacial charge transfer.Despite continued advancement,insufficient control of photocarrier behaviors still limits the external quantum efficiency(EQE)and operation speed of such detectors.Here,we propose a synergistic strategy of contact-configuration design and thickness-modulation to construct high-performance vdW photodiodes based on the typical type II heterostructure(MoS2/WSe2).Through integrating three contact architectures into one device to exclude other factors,we solid the superiority of designed 1L-MoS2/WSe2/graphene heterostructures incorporating efficient photocarrier collection and gate modulation.Together with leveraging the layer-numberdependent properties of WSe2,we observe the critical thickness of WSe2(11 layers)for the highest EQE,which verifies the thickness-dependent competition between photocarrier generation,dissociation,and collection.Finally,we demonstrate the synergistic-engineered vdW heterostructure can trigger record-high EQE(61%)and manifest ultrafast photoresponse(4.1μs)at the atomically thin limit(8 nm).The proposed strategy enables architecture-design and thickness-engineering to unlock the potential to realize high-performance optoelectronic devices. | Baishan Liu Xiankun Zhang Junli Du Jiankun Xiao Huihui Yu Mengyu Hong Li Gao Yang Ou Zhuo Kang Qingliang Liao Zheng Zhang Yue Zhang | 2022 | InfoMat2022，4，3： | 1 |
| 14 | Nanoscale all-optical logic devices显示文摘Commercial computers based on electronic logic devices have brought great changes to the world. However, traditional electronic devices are suffering from numerous technical challenges in their attempts to continue to satisfy Moore's law. Alloptical logic devices, as promising successors to their electronic counterparts, have become a major focus of optics research. In this paper, we provide a review of current all-optical logic devices. The logic gates in these devices, which are described in the first part of the review, are divided into five categories based on the different principles used in their realization. Complex optical devices with various functions and reconfigurable devices are summarized in the next section. In the final part of this paper, we discuss some of the previous works on all-optical integrated chips with specific functions. This review will provide a complete technological roadmap for all-optical devices and aims to be helpful in possible future developments in this growing field. | Ye Chen YinKe Cheng RongBin Zhu FeiFan Wang HaoTian Cheng ZhenHuan Liu ChongXiao Fan YuXuan Xue ZhongCheng Yu JianKun Zhu XiaoYong Hu QiHuang Gong | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，4： | 1 |
| 15 | A simple and efficient hidden Markov model scheme for host-based anomaly intrusion detection 显示文摘 | HU Jiankun YU Xinghuo QIU Dong | 2009 | IEEE Network2009，23，1： | 1 |
| 16 | Oxidation characteristics of boron particles显示文摘硼粒子的氧化特征,硼 -- 有 2.545 的直径的 | YU Dan KONG ChengDong ZHUO JianKun LI ShuiQing YAO Qiang | 2015 | Science China(Technological Sciences)2015，58，12： | 1 |
| 17 | Intracellular distribution and internalization pathways of guanidinylated bioresponsive poly(amido amine)s in gene delivery显示文摘Guanidinylated bioresponsive poly(amido amine)s polymers, CAR-CBA and CHL-CBA, weresynthesized by Michael-type addition reaction between guanidine hydrochloride(CAR) orchlorhexidine(CHL) and N,N-cystaminebisacrylamide(CBA). Previous studies have shownthat both polymers had high transfection efficiencies as gene delivery carriers. In this study,we investigated the nucleolus localization abilities and cellular internalization pathways ofthese two polymers in gene delivery. Each polymer condensed plasmid DNA(p DNA) andformed nanoparticle complexes, and then their transfection studies were performed inMCF-7 cells. Both complexes were found enriched in nucleolus after cellular transfection,and their transfection efficiencies were significantly improved when transfection was per-formed on MCF-7 cells arrested at M phase. The transfection efficiency of CAR-CBA-pDNAwas inhibited by chlorpromazine, and cell endosomes were disrupted after being exposedto CAR-CBA-pDNA. In regards to CHL-CBA-pDNA, its transfection efficiency was not affected by three types of endocytosis inhibitors used in the study, and CHL-CBA-pDNA showed no effect on endosomes. Cellular lactate dehydrogenase release and membrane morphology were changed after cells were transfected by the two complexes. The results indicated that both CAR-CBA and CHL-CBA polymers demonstrated good nucleolus localization abilities. It was beneficial for transfection when cells were arrested at M phase. CAR-CBA-pDNA cellular internalization was involved with clathrin-mediated endocytosis pathway, and escaping from endosomal entrapment, while the cellular uptake of CHL-CBA-pDNA occurs via clathrin-and caveolae-independent mechanism. | Jinmina Zhang Chunxi Wang Mei Lu Haonan Xing Tianzhi Yang Cuifang Cai Xiaoyun Zhao Minjie Wei Jiankun Yu Pingtian Ding | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，4： | 1 |
| 18 | SOLS: A scheme for outsourced location based service显示文摘 | Chi Chen Xiaojie Zhu Peisong Shen Jing Yu Jiankun Hu | 2015 | Jour- nal of Network and Computer Applications (JNCA)2015，56，： | 1 |
| 19 | Spatio-temporal keyword query in semantic trajectories显示文摘1 Introduction With the development of the GPS positioning technology and the popularization of smart mobile devices,more and more trajectory data are collected continuously.Semantic trajectories can be obtained by adding semantic information such as landmarks and activities to raw trajectories.Keyword query in semantic trajectory database that returns the relevant places/routes has attracted increasing attention from researchers in recent years.[1]studies spatial keyword query which consists of a set of query locations and a set of query keywords representing user’s preference.[2]is the first work to study the activity query on semantic trajectories.The query is in the form of a sequence of query locations,each associated with a set of desired activities.[3]is an extended work of[2]to support approximate keyword search.However,these works only consider spatial and textual feature of keywords,which cannot answer the query with temporal requirements.Additionally,they match keywords only by string similarity without considering their semantic meanings. | Xia WU Jiankun YU Xiaoming ZHAO | 2022 | Frontiers of Computer Science2022，16，2： | 1 |
| 20 | Record-high saturation current in end-bond contacted monolayer MoS_(2) transistors显示文摘Monolayer two-dimensional(2D)semiconductors are emerging as top candidates for the channels of the future chip industry due to their atomically thin body and superior immunity to short channel effect.However,the low saturation current caused by the high contact resistance(R_(c))in monolayer MoS2 field-effect transistors(FETs)limits ultimate electrical performance at scaled contact lengths,which seriously hinders application of monolayer MoS_(2 )transistors.Here we present a scalable strategy with a clean end-bond contact scheme that leads to size-independent electrodes and ultralow contact resistance of 2.5 kΩ·μm to achieve record high performances of saturation current density of 730μA·μm^(-1)at 300 K and 960μA·μm^(-1)at 6 K.Our end-bond contact strategy in monolayer MoS2 FETs enables the great potential for atomically thin integrated circuitry. | Jiankun Xiao Zhuo Kang Baishan Liu Xiankun Zhang Junli Du Kuanglei Chen Huihui Yu Qingliang Liao Zheng Zhang Yue Zhang | 2022 | Nano Research2022，15，1： | 0 |
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