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| 1 | Discovery of the marine Eocene in the northern South China Sea显示文摘The nature of the Eocene stratigraphy of the South China Sea(SCS)has been a mystery for decades.In the southern SCS,the Eocene system with marine deposits is often considered as representing part of the‘Proto-South China Sea’[1].In the northern SCS,however,the Eocene is dominated by non-marine sequences of South China origin[2],probably also related to the Proto-SCS[3]. | Zhimin Jian Haiyan Jin Michael A Kaminski Fabricio Ferreira Baohua Li Pai-Sen Yu | 2019 | National Science Review2019，6，5： | 20 |
| 2 | Small RNA Profiling Reveals Phosphorus Deficiency as a Contributing Factor in Symptom Expression for Citrus Huanglongbing Disease显示文摘Huanglongbing (HLB ) 是与类 Candidatus Liberibacter 的细菌被联系的破坏柠檬疾病(Ca。L.) 。强大的诊断工具和管理策略被需要控制 HLB。小 RNA (sRNA ) 玩的主人在调整主人回答到病原体感染的一个重要角色并且为许多人的疾病被用作早诊断的标记,包括癌症。决定是否柠檬 sRNAs 调整主人回答到 HLB, sRNAs 从柠檬 sinensis 被介绍有 Ca 的 10 和 14 星期柱子 grafting。L。asiaticus (Las ) 积极或健康的织物。十新 microRNAs (miRNAs ) , 76 保存 miRNAs,和许多小介入 RNA (siRNAs ) 被发现。几 miRNAs 和 siRNAs 被 Las 感染高度导致,并且能潜在地被开发进 HLB 的早诊断标记。miR399,被磷饥饿在另外的植物种类导致,被与类似于 HLB 的症状引起柠檬 stubborna 疾病的 Las 然而并非 Spiroplasma citri 的感染明确地导致。我们与健康的树相比在 Las 积极的柠檬树上发现了磷的 35% 减小。HLB 积极的香甜的橘子树的适用的磷 oxyanion 答案减少了 HLB 症状严厉并且显著地在西南佛罗里达在 3 年的地试用期间改进了水果生产。我们的分子,生理,并且地数据建议那磷缺乏被连接到 HLB 疾病 symptomology。 | Hongwei Zhao Ruobai Sun Ute Albrecht Chellappan Padmanabhan Airong Wanga Michael D. Coffey Thomas Girke Zonghua Wang Timothy J. Close Mikeal Roose Raymond K. Yokomi Svetlana Folimonova Georgios Vidalakis Robert Rouse Kim D. Bowman Hailing Jin | 2013 | Molecular Plant2013，6，2： | 12 |
| 3 | Super-resolution dipole orientation mapping via polarization demodulation显示文摘Fluorescence polarization microscopy(FPM)aims to detect the dipole orientation of fluorophores and to resolve structural information for labeled organelles via wide-field or confocal microscopy.Conventional FPM often suffers from the presence of a large number of molecules within the diffraction-limited volume,with averaged fluorescence polarization collected from a group of dipoles with different orientations.Here,we apply sparse deconvolution and least-squares estimation to fluorescence polarization modulation data and demonstrate a super-resolution dipole orientation mapping(SDOM)method that resolves the effective dipole orientation from a much smaller number of fluorescent molecules within a sub-diffraction focal area.We further apply this method to resolve structural details in both fixed and live cells.For the first time,we show that different borders of a dendritic spine neck exhibit a heterogeneous distribution of dipole orientation.Furthermore,we illustrate that the dipole is always perpendicular to the direction of actin filaments in mammalian kidney cells and radially distributed in the hourglass structure of the septin protein under specific labelling.The accuracy of the dipole orientation can be further mapped using the orientation uniform factor,which shows the superiority of SDOM compared with its wide-field counterpart as the number of molecules is decreased within the smaller focal area.Using the inherent feature of the orientation dipole,the SDOM technique,with its fast imaging speed(at sub-second scale),can be applied to a broad range of fluorescently labeled biological systems to simultaneously resolve the valuable dipole orientation information with super-resolution imaging. | Karl Zhanghao Long Chen Xu-San Yang Miao-Yan Wang Zhen-Li Jing Hong-Bin Han Michael Q Zhang Dayong Jin Jun-Tao Gao Peng Xi | 2016 | Light(Science & Applications)2016，5，1： | 11 |
| 4 | Ventral medial prefrontal functional connectivity and emotion regulation in chronic schizophrenia: A pilot study显示文摘People with schizophrenia exhibit impaired social cognitive functions, particularly emotion regulation. Abnormal activations of the ventral medial prefrontal cortex (vMPFC) during emotional tasks have been demonstrated in schizophrenia, suggesting its important role in emotion processing in patients. We used the resting-state functional connectivity approach, setting a functionally relevant region, the vMPFC, as a seed region to examine the intrinsic functional interactions and communication between the vMPFC and other brain regions in schizophrenic patients. We found hypo-connectivity between the vMPFC and the medial frontal cortex, right middle temporal lobe (MTL), right hippocampus, parahippocampal cortex (PHC) and amygdala. Further, there was a decreased strength of the negative connectivity (or anticorrelation) between the vMPFC and the bilateral dorsal lateral prefrontal cortex (DLPFC) and pre-supplementary motor areas. Among these connectivity alterations, reduced vMPFC-DLPFC connectivity was positively correlated with positive symptoms on the Positive and Negative Syndrome Scale, while vMPFC-right MTL/PHC/amygdala functional connectivity was positively correlated with the performance of emotional regulation in patients. These findings imply that communication and coordination throughout the brain networks are disrupted in schizophrenia. The emotional correlates of vMPFC connectivity suggest a role of the hypo-connectivity between these regions in the neuropathology of abnormal social cognition in chronic schizophrenia. | Feng-Mei Fan Shu-Ping Tan Fu-De Yang Yun-Long Tan Yan-Li Zhao Nan Chen Bin-Bin Li Chong-Sheng Song Yun-Hui Wang Zhen Jin Dong-Feng Zhou Michael P. Milham Yi-Zhuang Zou Xi-Nian Zuo | 2013 | Neuroscience Bulletin2013，29，1： | 9 |
| 5 | Nature:通过控制血管生长来开发治疗癌症等多种疾病的新型疗法显示文摘最近,一项刊登在国际杂志Nature上的研究报告中,来自耶鲁大学的研究人员通过研究揭示了如何通过控制血管发育来帮助开发治疗心血管疾病以及癌症的新型疗法。 | Yu, Pengchun Wilhelm, Kerstin Dubrac, Alexandre Tung, Joe K. Alves, Tiago C. Fang, Jennifer S. Xie, Yi Zhu, Jie Chen, Zehua De Smet, Frederik Zhang, Jiasheng Jin, Suk-Won Sun, Lele Sun, Hongye Kibbey, Richard G. Hirschi, Karen K. Hay, Nissim Carmeliet, Peter Chittenden, Thomas W. Eichmann, Anne Potente, Michael Simons, Michael | 2017 | 现代生物医学进展2017，17，22： | 9 |
| 6 | Electrochemical measurements used for assessment of corrosion and protection of metallic materials in the field:A critical review显示文摘Corrosion degradation is detrimental to metal structures as it shortens their lifetime and leads to huge economic losses and unexpected disasters.Therefore,the detection and monitoring of corrosion degradation is of great importance.Herein,we briefly review the state-of-the-art electrochemical methods,instrumentation(based on virtual instrumentation),and advanced sensor/probes that are used in the field for the assessment of corrosion damage.Typical corrosion monitoring results,some of which have been obtained at Tianjin University in the past 30 years,for metallic materials and organic coating/metal systems in atmospheric,marine,and soil conditions in the field are presented.Detection methods,data analysis,and theoretical and mathematical models regarding each corrosion system are discussed,and the challenges,problems and possible solutions for each case are suggested.Lastly,future developments,such as wireless,intelligent,and automatic electrochemical measurement,that will augment the present electrochemical methods of evaluating corrosion degradation are summarized. | Da-Hai Xia Cheng-Man Deng Digby Macdonald Sina Jamali Douglas Mills Jing-Li Luo Michael G.Strebl Mehdi Amiri Weixian Jin Shizhe Song Wenbin Hu | 2022 | Journal of Materials Science & Technology2022，，17： | 8 |
| 7 | Bubble-like Fe-encapsulated N,S-codoped carbon nanofibers as efficient bifunctional oxygen electrocatalysts for robust Zn-air batteries显示文摘Nano Research volume 13,pages2175–2182(2020)Cite this article 208 Accesses 1 Altmetric Metrics details Abstract Efficient,robust and cost-effective bifunctional oxygen electrocatalysts for oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)are of vital importance to the widespread utilization of Zn-air batteries.Here we report the fabrication of a bubble-like N,S-codoped porous carbon nanofibers with encapsulated fine Fe/Fe5C2 nanocrystals(∼10 nm)(FeNSCs)by a facile one-pot pyrolysis strategy.The novel FeNSC nanostructures with high Fe content(37.3 wt.%),and synergetic N and S doping demonstrate remarkable ORR and OER catalytic activities in alkaline condition.Particularly for ORR,the optimal FeNSC catalyst exhibits superior performance in terms of current density and durability in both alkaline and acidic media.Moreover,as catalysts on the air electrodes of Zn-air batteries,the optimal FeNSCs show a high peak power density of 59.6 mW/cm^2 and extraordinary discharge-charge cycling performance for 200 h with negligible voltage gap change of only 8%at current density of 20 mA/cm,surpassing its noble metal counterpart(i.e.Pt).The impressive battery stability can be attributed to favorable electron transfer resulting from appropriate graphitization of the bubble-like carbon nanofibers and thorough protection of Fe/Fe5C2 nanoparticles by carbon wrapping to prevent oxidation,agglomeration and dissolution of Fe nanoparticles during battery cycling.The present FeNSC catalyst,which is highly active,robust yet affordable,shows promising prospects in large-scale applications,such as metal-air batteries and fuel cells. | Yiyi She Jin Liu Hongkang Wang Li Li Jinsong Zhou Michael K.H.Leung | 2020 | Nano Research2020，13，8： | 7 |
| 8 | New frontiers for the materials genome initiative显示文摘The Materials Genome Initiative(MGI)advanced a new paradigm for materials discovery and design,namely that the pace of new materials deployment could be accelerated through complementary efforts in theory,computation,and experiment.Along with numerous successes,new challenges are inviting researchers to refocus the efforts and approaches that were originally inspired by the MGI.In May 2017,the National Science Foundation sponsored the workshop“Advancing and Accelerating Materials Innovation Through the Synergistic Interaction among Computation,Experiment,and Theory:Opening New Frontiers”to review accomplishments that emerged from investments in science and infrastructure under the MGI,identify scientific opportunities in this new environment,examine how to effectively utilize new materials innovation infrastructure,and discuss challenges in achieving accelerated materials research through the seamless integration of experiment,computation,and theory.This article summarizes key findings from the workshop and provides perspectives that aim to guide the direction of future materials research and its translation into societal impacts. | Juan J.de Pablo Nicholas E.Jackson Michael A.Webb Long-Qing Chen Joel E.Moore Dane Morgan Ryan Jacobs Tresa Pollock Darrell G.Schlom Eric S.Toberer James Analytis Ismaila Dabo Dean M.DeLongchamp Gregory A.Fiete Gregory M.Grason Geoffroy Hautier Yifei Mo Krishna Rajan Evan J.Reed Efrain Rodriguez Vladan Stevanovic Jin Suntivich Katsuyo Thornton Ji-Cheng Zhao | 2019 | npj Computational Materials2019，，1： | 7 |
| 9 | 与耐多药肺结核相关的放射学征象的文献分析显示文摘背景尽管肺药物敏感结核(DS-TB)和耐多药结核(MDR-TB)的诊断需要微生物检查证实,但胸部影像学早期识别可疑MDR-TB可以对诊断过程提供指引。本文对文献资料中与MDR-TB相关的放射学征象进行分析。方法于2018年1月29日搜索PubMed数据库,搜索关键字组合为'((extensive drug resistant tuberculosis)OR(multidrug-resistant tuberculosis))AND(CT or radiograph or imaging or X-ray or computed tomography)',并分析了报道DS-TB和MDR-TB放射学征象的英文文献。结果我们发现和分析了与分析目的有充分相关性的17篇文章。我们将报告的肺MDR-TB病例分为四个类别:(1)之前治疗过(继发或获得性)的HIV阴性成人MDRTB;(2)新发(或原发)HIV阴性成人MDR-TB;(3)HIV阳性成人MDR-TB;(4)儿童MDR-TB。肺MDR-TB的常见放射学表现包括:小叶中央小结节、分枝状线征和结节影(树芽征)、斑块或叶实变、空洞和支气管扩张。虽然总体上MDR-TB病例倾向病变更广泛、更容易双侧发病、胸膜受累、支气管扩张,及肺体积缩小;但仅依据这些征象难以作出MDR-TB的鉴别诊断。迄今的文献提示,肺MDR-TB特异性较高的放射学征象是厚壁多发空洞病变(特别是空洞≥3个时),虽然可能其敏感性不高。对于成人HIV阴性患者,与继发MDR-TB一致,新发MDR-TB也往往有较高的空洞病变发生率,估计在70%左右。结论厚壁多发空洞病变是提示MDR-TB诊断最有意义的放射学征象。未来的研究应该细致地量化空洞病变形态特征。 | 王毅翔 Myung Jin Chung Aliaksandr Skrahin Alex Rosenthal Andrei Gabrielian Michael Tartakovsky 于英杰 陆普选 | 2018 | 新发传染病电子杂志2018，3，4： | 7 |
| 10 | Optical observations of LIGO source GW 170817 by the Antarctic Survey Telescopes at Dome A,Antarctica显示文摘The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical next step to explore in detail the physics involved. The Antarctic Survey Telescopes(AST3),located at Dome A, Antarctica, is uniquely situated for rapid response time-domain astronomy with its continuous night-time coverage during the austral winter. We report optical observations of the GW source(GW 170817) in the nearby galaxy NGC 4993 using AST3. The data show a rapidly fading transient at around 1 day after the GW trigger, with the i-band magnitude declining from 17:23 ± 0:13 magnitude to 17:72 ± 0:09 magnitude in ~1:8 h. The brightness and time evolution of the optical transient associated with GW 170817 are broadly consistent with the predictions of models involving merging binary neutron stars. We infer from our data that the merging process ejected about ~10^(-2) solar mass of radioactive material at a speed of up to 30% the speed of light. | lei hu xuefeng wu igor andreoni michael c.b.ashley jeff cooke xiangqun cui fujia du zigao dai bozhong gu yi hu haiping lu xiaoyan li zhengyang li ensi liang liangduan liu bin ma zhaohui shang tianrui sun n.b.suntzeff charling tao syed a.uddin lifan wang xiaofeng wang haikun wen di xiao jin xu ji yang shihai yang xiangyan yuan hongyan zhou hui zhang jilin zhou zonghong zhu | 2017 | Science Bulletin2017，62，21： | 6 |
| 11 | IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer显示文摘 | Florian R. Greten Lars Eckmann Tim F. Greten Jin Mo Park Zhi-Wei Li Laurence J. Egan Martin F. Kagnoff Michael Karin | 2004 | Cell2004，，3： | 4 |
| 12 | Impact of social isolation on behavioral health in elderly: Systematic review显示文摘AIM: To examine and compare the effects of subjective and objective social isolation on behavioral health in elderly adults.METHODS: A systematic search of Pub Med was performed for original research articles from peerreviewed journals examining one of the following topics: 'Social isolation and sleep disturbance', 'social isolation and depression', or 'social isolation and fatigue in older adults'. Studies were selected following the criteria established based on the aim of this review. Data were extracted from the articles by two independent reviewers. Due to the heterogeneity in study designs and outcome measures of the included studies, qualitative and narrative analyses were conducted.RESULTS: The set criteria were used to select a total of 16 studies for the review. Of the 16, 13 were crosssectional studies. The characteristics of study populations were identified as follows. A total of 12 studies randomly selected subjects irrespective of pre-existing health conditions. Consequently, an unspecified number of the study subjects had chronic diseases in the studies compared. In addition, cultural and ethnic backgrounds of studies in this review were diverse, and included subjects living in North America, South America, Asia, Europe, and Oceania. Both subjective and objective types of social isolation increased behavioral symptoms, such as sleep disturbance, depressive symptoms, and fatigue in older adults. Furthermore, a few recent studies reported stronger effects of subjective social isolation than objective social isolation on sleep disturbance and depressive symptoms.CONCLUSION: Social isolation affects behavioral health in older adults. Compared to the objective social isolation, subjective social isolation contributes more significantly to sleep disturbance and depression. | Hanbyul Choi Michael R Irwin Hyong Jin Cho | 2015 | World Journal of Psychiatry2015，5，4： | 4 |
| 13 | Bioactive hydrogel microcapsules for guiding stem cell fate decisions by release and reloading of growth factors显示文摘Human pluripotent stem cells(hPSC)hold considerable promise as a source of adult cells for treatment of diseases ranging from diabetes to liver failure.Some of the challenges that limit the clinical/translational impact of hPSCs are high cost and difficulty in scaling-up of existing differentiation protocols.In this paper,we sought to address these challenges through the development of bioactive microcapsules.A co-axial flow focusing microfluidic device was used to encapsulate hPSCs in microcapsules comprised of an aqueous core and a hydrogel shell.Importantly,the shell contained heparin moieties for growth factor(GF)binding and release.The aqueous core enabled rapid aggregation of hPSCs into 3D spheroids while the bioactive hydrogel shell was used to load inductive cues driving pluripotency maintenance and endodermal differentiation.Specifically,we demonstrated that one-time,1 h long loading of pluripotency signals,fibroblast growth factor(FGF)-2 and transforming growth factor(TGF)-β1,into bioactive microcapsules was sufficient to induce and maintain pluripotency of hPSCs over the course of 5 days at levels similar to or better than a standard protocol with soluble GFs.Furthermore,stem cell-carrying microcapsules that previously contained pluripotency signals could be reloaded with an endodermal cue,Nodal,resulting in higher levels of endodermal markers compared to stem cells differentiated in a standard protocol.Overall,bioactive heparin-containing core-shell microcapsules decreased GF usage five-fold while improving stem cell phenotype and are well suited for 3D cultivation of hPSCs. | Kihak Gwon Hye Jin Hong Alan M.Gonzalez-Suarez Michael Q.Slama Daheui Choi Jinkee Hong Harihara Baskaran Gulnaz Stybayeva Quinn P.Peterson Alexander Revzin | 2022 | Bioactive Materials2022，7，9： | 3 |
| 14 | 新浪潮:网络革命2.0显示文摘在Web 2.0的浪潮下,互联网的声音将体现得越来越真实,越来越个性化,这将改变互联网世界的传统面貌 Web 1.0的模式是读,Web 2.0则是写和贡献;Web 1.0是静态的,Web 2.0是动态的;Web 1.0的内容创建者是网页编写者,Web 2. | Michael Jin | 2005 | 中国信息界2005，，16： | 3 |
| 15 | Objective assessment of bradykinesia in Parkinson’s disease using evolutionary algorithms:clinical validation显示文摘Background:There is an urgent need for developing objective,effective and convenient measurements to help clinicians accurately identify bradykinesia.The purpose of this study is to evaluate the accuracy of an objective approach assessing bradykinesia in finger tapping(FT)that uses evolutionary algorithms(EAs)and explore whether it can be used to identify early stage Parkinson’s disease(PD).Methods:One hundred and seven PD,41 essential tremor(ET)patients and 49 normal controls(NC)were recruited.Participants performed a standard FT task with two electromagnetic tracking sensors attached to the thumb and index finger.Readings from the sensors were transmitted to a tablet computer and subsequently analyzed by using EAs.The output from the device(referred to as'PD-Monitor')scaled from−1 to+1(where higher scores indicate greater severity of bradykinesia).Meanwhile,the bradykinesia was rated clinically using the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale(MDS-UPDRS)FT item.Results:With an increasing MDS-UPDRS FT score,the PD-Monitor score from the same hand side increased correspondingly.PD-Monitor score correlated well with MDS-UPDRS FT score(right side:r=0.819,P=0.000;left side:r=0.783,P=0.000).Moreover,PD-Monitor scores in 97 PD patients with MDS-UPDRS FT bradykinesia and each PD subgroup(FT bradykinesia scored from 1 to 3)were all higher than that in NC.Receiver operating characteristic(ROC)curves revealed that PD-Monitor FT scores could detect different severity of bradykinesia with high accuracy(≥89.7%)in the right dominant hand.Furthermore,PD-Monitor scores could discriminate early stage PD from NC,with area under the ROC curve greater than or equal to 0.899.Additionally,ET without bradykinesia could be differentiated from PD by PD-Monitor scores.A positive correlation of PD-Monitor scores with modified Hoehn and Yahr stage was found in the left hand sides.Conclusions:Our study demonstrated that a simple to use device employing classifiers derived from EAs could not only be used to accurately measure different severity of bradykinesia in PD,but also had the potential to differentiate early stage PD from normality. | Chao Gao Stephen Smith Michael Lones Stuart Jamieson Jane Alty Jeremy Cosgrove Pingchen Zhang Jin Liu Yimeng Chen Juanjuan Du Shishuang Cui Haiyan Zhou Shengdi Chen | 2018 | Translational Neurodegeneration2018，7，1： | 3 |
| 16 | Cell:癌基因“遗传平衡”或会影响患者对癌症疗法的反应显示文摘进行癌症疗法的选择越来越需要确定肿瘤细胞中是否含有一些特殊突变的癌基因会驱动癌细胞异常生长。并且确定是否癌细胞会对特殊药物耐受或敏感.近日来自加州大学旧金山分校的研究人员就通过研究发现。以常见的癌基因KRAs突变为例。患者对疗法的反应往往会随着肿瘤的不断进化而发生改变。相关研究刊登于国际杂志Cell上。 | Michael R. Burgess Eugene Hwang Rana Mroue Craig M. Bielski Anica M. Wandler Benjamin J. Huang Ari J. Firestone Amy Young Jennifer A. Lacap Lisa Crocker Saurabh Asthana Elizabeth M. Davis Jin Xu Keiko Akagi Michelle M. Le Beau Qing Li Benjamin Haley David Stokoe Deepak Sampath Barry S. Taylor Marie Evangelista Kevin Shannon | 2017 | 现代生物医学进展2017，17，18： | 2 |
| 17 | HMGB1 in health and disease显示文摘 | Rui Kang Ruochan Chen Qiuhong Zhang Wen Hou Sha Wu Lizhi Cao Jin Huang Yan Yu Xue-gong Fan Zhengwen Yan Xiaofang Sun Haichao Wang Qingde Wang Allan Tsung Timothy R. Billiar Herbert J. Zeh Michael T. Lotze Daolin Tang | 2014 | Molecular Aspects of Medicine2014，，： | 2 |
| 18 | International study group on rectal cancer regression grading: interobserver variability with commonly used regression grading systems显示文摘 | Runjan Chetty Pelvender Gill Dhirendra Govender Adrian Bateman Hee Jin Chang Vikram Deshpande David Driman Marisa Gomez Godman Greywoode Eleanor Jaynes C. Soon Lee Michael Locketz Corwyn Rowsell Anne Rullier Stefano Serra Neil Shepherd Eva Szentgyorgyi Ra | 2012 | Human Pathology2012，，11： | 2 |
| 19 | Weakly-Supervised Single-view Dense 3D Point Cloud Reconstruction via Differentiable Renderer显示文摘In recent years,addressing ill-posed problems by leveraging prior knowledge contained in databases on learning techniques has gained much attention.In this paper,we focus on complete three-dimensional(3D)point cloud reconstruction based on a single red-green-blue(RGB)image,a task that cannot be approached using classical reconstruction techniques.For this purpose,we used an encoder-decoder framework to encode the RGB information in latent space,and to predict the 3D structure of the considered object from different viewpoints.The individual predictions are combined to yield a common representation that is used in a module combining camera pose estimation and rendering,thereby achieving differentiability with respect to imaging process and the camera pose,and optimization of the two-dimensional prediction error of novel viewpoints.Thus,our method allows end-to-end training and does not require supervision based on additional ground-truth(GT)mask annotations or ground-truth camera pose annotations.Our evaluation of synthetic and real-world data demonstrates the robustness of our approach to appearance changes and self-occlusions,through outperformance of current state-of-the-art methods in terms of accuracy,density,and model completeness. | Peng Jin Shaoli Liu Jianhua Liu Hao Huang Linlin Yang Michael Weinmann Reinhard Klein | 2021 | Chinese Journal of Mechanical Engineering2021，34，5： | 2 |
| 20 | Elastohydrodynamic lubrication and wear modelling of the knee joint replacements with surface topography显示文摘This numerical study predicted wear of lubricated total knee replacements with the existing of textured surfaceand the possibility of surface designs to reduce wear.In the first part,a wear model of metal-on-polyethylene total kneereplacement was developed.The medial and lateral knee compartments was accounted for separately,with the contactforce and motion during walking cycles applied.An adapted Archard wear formula was employed where the wearfactor was an exponential function of the'Lambda ratio'(film thickness to the average roughness).Wear of the softbearing surface(polyethylene insert)was simulated with regularly geometry update until a steady-state wear observed.ln the second part,the effect of surface topography of the knee replacements was investigated.The surface texturingtechniques have shown promising benefit to machine components in many areas of engineering practice.The textureparameters were designed using the Taguchi method for the geometry,size,and distribution of the micro dimples.twas observed that the lateral compartment may benefit from surface texturing if dimples were properly designed,while the texturing showed hardly advantageous effect on the medial surface in terms of lubrication enhancement andwear reduction.Some results were presented in the 6th World Tribology Conference. | Leiming Gao Zikai Hua Robert Hewson Michael Skipper Andersen Zhongmin Jin | 2018 | Biosurface and Biotribology2018，4，1： | 2 |
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