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| 1 | ADAMTS-7 promotes vascular smooth muscle cells proliferation in vitro and in vivo显示文摘Vascular smooth muscle cell(VSMC) proliferation and migration are pivotal for the pathogenesis of atherosclerosis and post-angioplasty restenosis. We have recently reported that a disintegrin and metalloproteinase with thrombospondin motifs-7(ADAMTS-7), a novel metalloproteinase, contributes directly to neointima formation by mediating VSMC migration. However, whether ADAMTS-7 affects VSMC proliferation remains unclear. In this study, we found that luminal adenoviral delivery of ADAMTS-7 aggravated intimal hyperplasia 7 d after injury, paralleled by an increased percentage of PCNA-positive cells in both intima and media. In contrast, perivascular administration of ADAMTS-7 si RNA, but not scrambled si RNA to injured arteries attenuated intimal thickening at day 7, paralleled with reduced intimal VSMC replication, without alteration of VSMC proliferation in the media. In accordance, [3H]-thymidine incorporation assay in primary cultured rat VSMCs revealed an enhanced replication rate(by 61%) upon ADAMTS-7 overexpression and retarded proliferation(by 23%) upon ADAMTS-7 si RNA administration. Our data demonstrates that ADAMTS-7 promotes VSMC proliferation both in vitro and in vivo. ADAMTS-7 may therefore serve as a novel therapeutic target for atherosclerosis and post-angioplasty restenosis. | ZHANG Lu YU Fang WANG Li ZHENG JinGang DU YaoYao HUANG YaQian LIU Bo WANG Xian KONG Wei | 2015 | Science China(Life Sciences)2015，58，7： | 4 |
| 2 | Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury显示文摘Compelling evidence has revealed that biased activation of G protein-coupled receptor(GPCR)signaling,including angiotensin II(AngII)receptor type 1(AT1)signaling,plays pivotal roles in vascular homeostasis and injury,but whether a clinically relevant endogenous biased antagonism of AT1 signaling exists under physiological and pathophysiological conditions has not been clearly elucidated.Here,we show that an extracellular matrix protein,cartilage oligomeric matrix protein(COMP),acts as an endogenous allosteric biased modulator of the AT1 receptor and its deficiency is clinically associated with abdominal aortic aneurysm(AAA)development.COMP directly interacts with the extracellular N-terminus of the AT1 via its EGF domain and inhibits AT1-β-arrestin-2 signaling,but not Gq or Gi signaling,in a selective manner through allosteric regulation of AT1 intracellular conformational states.COMP deficiency results in activation of AT1a-β-arrestin-2 signaling and subsequent exclusive AAA formation in response to AngII infusion.AAAs in COMP–/–or ApoE–/–mice are rescued by AT1a orβ-arrestin-2 deficiency,or the application of a peptidomimetic mimicking the AT1-binding motif of COMP.Explorations of the endogenous biased antagonism of AT1 receptor or other GPCRs may reveal novel therapeutic strategies for cardiovascular diseases. | Yi Fu Yaqian Huang Zhao Yang Yufei Chen Jingang Zheng Chenfeng Mao Zhiqing Li Zhixin Liu Bing Yu Tuoyi Li Meili Wang Chanjuan Xu Yiwei Zhou Guizhen Zhao Yiting Jia Wei Guo Xin Jia Tao Zhang Li Li Ziyi Liu Shengchao Guo Mingliang Ma Heng Zhang Bo Liu Junbao Du Wengong Wang Chaoshu Tang Pei Gao Qingbo Xu Xian Wang Jianfeng Liu Jinpeng Sun Wei Kong | 2021 | Cell Research2021，31，7： | 2 |
| 3 | Synthesis and characterization of BaMgAl_(10)O_(17):Eu~(2+)phosphor prepared by homogeneous precipitation显示文摘A homogeneous precipitation process based on urea hydrolysis reaction was exploited to synthesize BaMgAl10O17:Eu2+phosphor.The process parameters,such as the dosage of urea,the calcination temperatures and the concentration of Eu2+,were refined in light of the characterization of the products.The experimental results revealed that pure and well-crystallized BaMgAl10O17:Eu2+phosphor could be obtained at 1250℃,a much lower temperature than that for traditional solid-state reaction.The as-prepared phosphor particles were small in grain size,regular in morphology,and uniform in size distribution.Because of the high homogeneity of the process,the as-prepared phosphor exhibited stronger emission intensity and higher thermal stability than the sample prepared by solid-state reaction at 1600℃. | ZhanhuiZhang Jingang Feng Zhiliang Huang | 2010 | Particuology2010，8，5： | 1 |
| 4 | 显示文摘 | Yu Jingang Huang Kelong Liu Suqin | 2008 | Physica E2008，40，： | 1 |
| 5 | Sepa- ration of Cobalt and Nickel from Wastewater by P204 Microemulsion Saponified 显示文摘 | Dushu Huang Jingang Yu Zhongzhou Yi | 2012 | Advanced Materials Re- search2012，49，6： | 1 |
| 6 | Comparative study of the stoichiometric characteristics of karst and non-karst forests in Guizhou, China显示文摘Carbon (C), nitrogen (N), and phosphorous (P) levels and their stoichiometry in plant components (leaves, branch trunks, roots) of trees in a karst forest and non-karst forest are compared. The results show that the C contents, C:N and C:P ratios of dominant species in the karst forest were lower than those in the non-karst forest, but the N and P and the N:P ratio were higher;C:N:P ratios in plant organs of trees in the karst forest were in the order of trunks>roots>branches>leaves. However, C:N:P ratio in the non-karst forest trees were trunks>branches>roots>leaves. Moreover, ratio of C:N:P in trunks was highest and lowest in leaves in both forests. In non-karst forest trees, N:P was in the order of leaves> roots>branches>trunks. There were no significant differences in the ratio of N:P in different plant components of trees in the karst forest. However, in karst and non-karst forest trees, the ratio of N:P in leaves was highest;positive correlations between N and P contents, and N and N:P ratios were observed in both karst and non-karst forests (p<0.001). Negative correlations between P and N:P ratios (p<0.05) were observed in karst forest trees, while positive correlations were observed in non-karst forest trees. | Yabing Zhang Chuanyan Zhou Wenqiang Lv Lihua Dai Jingang Tang Shaoqi Zhou Lihua Huang Anding Li Jianli Zhang | 2019 | Journal of Forestry Research2019，30，3： | 1 |
| 7 | Rapid Micro- wave Synthesis of Chitosan Modified Carbon Nanotube Composites 显示文摘 | Yu Jingang Huang Kelong Tang Jinchun | 2009 | International Journal of Biological Macromolecules2009，44，： | 1 |
| 8 | Effects of IL- l 13 and TNF-aon degradation of extracellular matrix of articular chondroeytes and related mechanism显示文摘 | Huang Jingang Tong Haijun Liu Hongqiang | 2010 | Journal of Shanghai Jiaotong Universlty(Medical Science)2010，30，9： | 1 |
| 9 | Machine learning enabled prediction and process optimization of VFA production from riboflavin-mediated sludge fermentation显示文摘Riboflavin is a redox mediator that promotes volatile fatty acids(VFAs)production from waste activated sludge(WAS)and is a promising method for WAS reuse.However,time-and labor-consuming experiments challenge obtaining optimal operating conditions for maximal VFA production.In this study,three machine learning(ML)models were developed to predict the VFAs production from riboflavin-mediated WAS fermentation systems.Among the three tested ML algorithms,eXtreme Gradient Boosting(XGBoost)presented the best prediction performance and excellent generalization ability,with the highest testing coefficient of determination(R^(2)of 0.93)and lowest root mean square error(RMSE of 0.070).Feature importance analysis and their interactions using the Shepley Additive Explanations(SHAP)method indicated that pH and soluble protein were the top two input features for the modeling.The intrinsic correlations between input features and microbial communities corroborated this deduction.On the optimized ML model,genetic algorithm(GA)and particle swarm optimization(PSO)solved the optimal solution of VFA output,predicting the maximum VFA output as 650 mg COD/g VSS.This study provided a data-driven approach to predict and optimize VFA production from riboflavin-mediated WAS fermentation. | Weishuai Li Jingang Huang Zhuoer Shi Wei Han Ting Lü Yuanyuan Lin Jianfang Meng Xiaobing Xu Pingzhi Hou | 2023 | Frontiers of Environmental Science & Engineering2023，17，11： | 0 |
| 10 | Message from Editors显示文摘SPECIAL motor systems are high-efficiency and high-quality electromechanical energy conversion devices suitable for complex operating conditions.As key components,special motor systems are widely used in the fields of aerospace,energy,power,transportation,high-end manufacturing,etc.Innovations of fundamental theories and application technologies in special motor systems can promote the progress of related disciplines and fields,which has drawn great attentions from countries all over the world. | Ping Zheng Fengge Zhang Shoudao Huang Deliang Liang Bo Zhou Xiuhe Wang Wei Hua Wenxiang Zhao Xiaoyong Zhu Chengde Tong Jingang Bai Yi Sui Mingqiao Wang | 2022 | CES Transactions on Electrical Machines and Systems2022，6，1： | 0 |
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