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| 1 | Ascorbic acid accelerates Wallerian degeneration after peripheral nerve injury显示文摘Wallerian degeneration occurs after peripheral nerve injury and provides a beneficial microenvironment for nerve regeneration.Our previous study demonstrated that ascorbic acid promotes peripheral nerve regeneration,possibly through promoting Schwann cell proliferation and phagocytosis and enhancing macrophage proliferation,migration,and phagocytosis.Because Schwann cells and macrophages are the main cells involved in Wallerian degeneration,we speculated that ascorbic acid may accelerate this degenerative process.To test this hypothesis,400 mg/kg ascorbic acid was administered intragastrically immediately after sciatic nerve transection,and 200 mg/kg ascorbic acid was then administered intragastrically every day.In addition,rat sciatic nerve explants were treated with 200μM ascorbic acid.Ascorbic acid significantly accelerated the degradation of myelin basic protein-positive myelin and neurofilament 200-positive axons in both the transected nerves and nerve explants.Furthermore,ascorbic acid inhibited myelin-associated glycoprotein expression,increased c-Jun expression in Schwann cells,and increased both the number of macrophages and the amount of myelin fragments in the macrophages.These findings suggest that ascorbic acid accelerates Wallerian degeneration by accelerating the degeneration of axons and myelin in the injured nerve,promoting the dedifferentiation of Schwann cells,and enhancing macrophage recruitment and phagocytosis.The study was approved by the Southern Medical University Animal Care and Use Committee(approval No.SMU-L2015081)on October 15,2015. | Lixia Li Yizhou Xu Xianghai Wang Jingmin Liu Xiaofang Hu Dandan Tan Zhenlin Li Jiasong Guo | 2021 | Neural Regeneration Research2021，16，6： | 6 |
| 2 | Geospatial Service Web:towards integrated cyberinfrastructure for GIScience显示文摘A geospatial cyberinfrastructure is needed to support advanced GIScience research and education activities.However,the heterogeneous and distributed nature of geospatial resources creates enormous obstacles for building a unified and interoperable geospatial cyberinfrastructure.In this paper,we propose the Geospatial Service Web(GSW)to underpin the development of a future geospatial cyberinfrastructure.The GSW excels over the traditional spatial data infrastructure by providing a highly intelligent geospatial middleware to integrate various geospatial resources through the Internet based on interoperable Web service technologies.The development of the GSW focuses on the establishment of a platform where data,information,and knowledge can be shared and exchanged in an interoperable manner.Theoretically,we describe the conceptual framework and research challenges for GSW,and then introduce our recent research toward building a GSW.A research agenda for building a GSW is also presented in the paper. | GONG Jianya WU Huayi ZHANG Tong GUI Zhipeng LI Zhenlong YOU Lan SHEN Shengyu ZHENG Jie GENG Jing QI Kunlun YANG Wenjing LI Zhenqiang YU Jingmin | 2012 | Geo-Spatial Information Science2012，15，2： | 5 |
| 3 | Biodegradation behavior of magnesium and ZK60 alloy in artificial urine and rat models显示文摘In this work, the biodegradable and histocompatibility properties of pure Mg and ZK60 alloy wereinvestigated as new temporary implants for urinary applications. The corrosion mechanism in artificialurine was proposed using electrochemical impedance spectroscopy and potentiodynamic polarizationtests. The corrosion potential of pure magnesium and ZK60 alloy were -1820 and -1561 mV, respectively,and the corrosion current densities were 59.66 ± 6.41 and 41.94 ± 0.53 μA cm^-2, respectively. Thein vitro degradation rates for pure Mg and ZK60 alloy in artificial urine were 0.382 and 1.023 mm/y,respectively, determined from immersion tests. The ZK60 alloy degraded faster than the pure Mg in bothartificial urine and in rat bladders (the implants of both samples are ø 3 mm × 5 mm). Histocompatibilityevaluations showed good histocompatibility for the pure Mg and ZK60 alloy during the 3 weeks postimplantationin rat bladders, and no harm was observed in the bladder, liver and kidney tissues. Theresults provide key information on the degradation properties and corrosion mechanism of pure Mg andZK60 alloy in the urinary system. | Shiying Zhang Yanze Bi Jianye Li Zhenguo Wang Jingmin Yan Jiawang Song Haibo Sheng Heqing Guo Yan Li | 2017 | Bioactive Materials2017，2，2： | 4 |
| 4 | THEORETICAL AND EXPERIMENTAL STUDY ON THE PRESSURE AND VACUUM CONTINUOUS CONTROL SYSTEM BASED ON HYBRID PUMP显示文摘一个新奇压力和真空连续控制系统,作为压力和真空来源采用混合的泵,被介绍。系统的数学模型被开发。系统上的理论模拟和分析被实现以便在特征,参数和系统的工作的点之中学习关系。系统特征上的试验性的调查随一个 fuzzy-PID 控制器的采纳被介绍。模拟和试验性的结果显示连续控制系统基于混合的泵有的压力和真空好动态、静态的性能,强壮的坚韧性和令人满意的适应性到各种各样的系统参数。根据结果,系统能成功地获得高精确性和快反应信号。另外,系统的数学模型被试验性的结果也证明。 | LI Jinyun DU Jingmin FU Xiaoyun LI Baoren | 2007 | Chinese Journal of Mechanical Engineering2007，20，6： | 3 |
| 5 | Effect of Yizhitongxuan decoction on learning and memory ability,Gαq/11 expression and Na^+-K^+-ATP enzyme activity in rat models of Alzheimer's Disease显示文摘OBJECTIVE: To study the effects of Yizhitongxuan decoction on learning and memory abilities, Gαq/11expression and Na+-K+-ATPenzymeactivityin rat models of Alzheimer's disease(AD) caused by injecting Aβ25-35 into the hippocampus.METHODS: Ninety male Wistar rats(age ≥10 months)were selected and injected with Aβ25-35 into their hippocampi to establish model animals,which were randomly divided into six groups including a sham-operated group(blank group), a model group, a donepezil HCL group(Western Medicinegroup),and ahigh/general/dilute concentrations of Yizhitongxuan decoction groups(TCMⅠⅡⅢgroup).The Morris watermaze was used to examine the learning and memory abilities of rats in each group by place navigation and spatial probe tests.Then, the rats were sacrificed to collect the hippocampi for biochemical tests, using western blotting to detect the expression of Gαq/11 and an ultramicro Na+-K+-ATP enzyme kit to measure Na+-K+-ATP enzyme activity.RESULTS:Yizhitongxuan decoction improved model rats' learning and memory abilities, and increased the expression of Gαq/11 in the hippocampus and the level of Na+-K+-ATP enzyme activity in braintissue.CONCLUSION: Yizhitongxuan decoction could improve model rats' learning and memory abilities,and had a regulating effect on the expression of Gαq/11and Na+-K+-ATP enzyme activity. | Jing Teng Zhexue Xu Jing Zhang Jingmin Li | 2014 | Journal of Traditional Chinese Medicine2014，34，4： | 3 |
| 6 | Quantitation of HBV covalently closed circular DNA in micro formalin fixed paraffin-embedded liver tissue using rolling circle amplification in combination with real-time PCR显示文摘 | Yanwei Zhong Jiaqi Han Zhengsheng Zou Shuhong Liu Bo Tang Xiaoqiang Ren Xiaodong Li Yulai Zhao Yan Liu Dongqing Zhou Weijie Li Jingmin Zhao Dongping Xu | 2011 | Clinica Chimica Acta2011，，21： | 2 |
| 7 | Preparation and evaluation of tamsulosin hydrochloride sustained-release pellets modified by two-layered membrane techniques显示文摘The aim of the present study was to develop tamsulosin hydrochloride sustained-release pellets using two-layered membrane techniques.Centrifugal granulator and fluidizedbed coater were employed to prepare drug-loaded pellets and to employ two-layered membrane coating respectively.The prepared pellets were evaluated for physicochemical characterization,subjected to differential scanning calorimetry(DSC)and in vitro release of different pH.Different release models and scanning electron microscopy(SEM)were utilized to analyze the release mechanism of Harnual■ and home-made pellets.By comparing the dissolution profiles,the ratio and coating weight gain of Eudragit■ NE30D and Eudragit■ L30D55 which constitute the inside membrane were identified as 18:1 and 10%-11%.The coating amount of outside membrane containing Eudragit■ L30D55 was determined to be 0.8%.The similarity factors(f_(2))of home-made capsule and commercially available product(Harnual■)were above 50 in different dissolution media.DSC studies confirmed that drug and excipients had good compatibility and SEM photographs showed the similarities and differences of coating surface between Harnual■ and self-made pellets before and after dissolution.According to Ritger-Peppas model,the two dosage form had different release mechanism. | Jingmin Wang Yinghua Sun Bo Li Rui Fan Bing Li Tengrui Yin Ling Rong Jin Sun | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，1： | 2 |
| 8 | Atomic-scale structural and chemical evolution of Li3V2(PO4)3 cathode cycled at high voltage window显示文摘Here,by using atomically resolved scanning transmission electron microscopy and electron energy loss spectroscopy,we investigate the structural and chemical evolution of Li3V2(PO4)3 (LVP) upon the high-voltage window (3.0-4.8 V).We find that the valence of vanadium gradually increases towards the core corresponding to the formation of electrochemically inactive Li3-xV2(PO4)3 (L3-xVP) phases.These Li-deficient phases exhibit structure distortion with superstructure stripes,likely caused by the migration of the vanadium,which can slow down the lithium ion diffusion or even block the diffusion channels.Such kinetic limitations lead to the formation of Li-deficient phase along with capacity loss.Thus,the LVP continuously losses of electrochemical activity and Li-deficient phases gradually grow from the particle core towards the surface during cycling.After 500 cycles,the thickness of active LVP layer decreases to be - 5-20 nm.Moreover,the micromorphology and chemical composition of solid electrolyte interphase (SEI) have been investigated,indicating the thick SEI film also contributes to the capacity loss.The present work reveals the structural and chemical evolution in the cycled electrode materials at an atomic scale,which is essential to understand the voltage fading and capacity decaying of LVP cathode. | Shulin Chen Jian Zou Yuehui Li Ning Li Mei Wu Jinghuang Lin Jingmin Zhang Jian Cao Jicai Feng Xiaobin Niu Jianming Bai Junlei Qi Peng Gao Liping Wang Hong Li | 2019 | Nano Research2019，12，7： | 1 |
| 9 | New Enhancement of Infrared Image Based on Human Visual System 显示文摘 | Yu Tianhe Li Qiuming Dai Jingmin | 2009 | China Optical Letters2009，7，1： | 1 |
| 10 | Role of microtubule dynamics in Wallerian degeneration and nerve regeneration after peripheral nerve injury显示文摘Wallerian degeneration,the progressive disintegration of distal axons and myelin that occurs after peripheral nerve injury,is essential for creating a permissive microenvironment for nerve regeneration,and involves cytoskeletal reconstruction.However,it is unclear whether microtubule dynamics play a role in this process.To address this,we treated cultured sciatic nerve explants,an in vitro model of Wallerian degeneration,with the microtubule-targeting agents paclitaxel and nocodazole.We found that paclitaxel-induced microtubule stabilization promoted axon and myelin degeneration and Schwann cell dedifferentiation,whereas nocodazole-induced microtubule destabilization inhibited these processes.Evaluation of an in vivo model of peripheral nerve injury showed that treatment with paclitaxel or nocodazole accelerated or attenuated axonal regeneration,as well as functional recovery of nerve conduction and target muscle and motor behavior,respectively.These results suggest that microtubule dynamics participate in peripheral nerve regeneration after injury by affecting Wallerian degeneration.This study was approved by the Animal Care and Use Committee of Southern Medical University,China(approval No.SMUL2015081) on October 15,2015. | Jingmin Liu Lixia Li Ying Zou Lanya Fu Xinrui Ma Haowen Zhang Yizhou Xu Jiawei Xu Jiaqi Zhang Mi Li Xiaofang Hu Zhenlin Li Xianghai Wang Hao Sun Hui Zheng Lixin Zhu Jiasong Guo | 2022 | Neural Regeneration Research2022，17，3： | 1 |
| 11 | Improving interfacial reaction nonhomogeneity during laser welding–brazing aluminum to titanium显示文摘 | Shuhai Chen Liqun Li Yanbin Chen Jingmin Dai Jihua Huang | 2011 | Materials and Design2011，，8： | 1 |
| 12 | Induction of an effective anti-tumor immune response and tumor regression by combined administration of IL-18 and Apoptin显示文摘 | Hai Lian Ningyi Jin Xiao Li Zhiqiang Mi Jingmin Zhang Lili Sun Xuemei Li Hongling Zheng Ping Li | 2007 | Cancer Immunology Immunotherapy2007，，2： | 1 |
| 13 | MicroRNA-101 suppresses SOX9-dependent tumorigenicity and promotes favorable prognosis of human hepatocellular carcinoma显示文摘 | Yanqiong Zhang<.--Q1: Please confirm that given names and surnames have been identified correctly.--> Xiaodong Guo Lu Xiong Xiangying Kong Ying Xu Chunfang Liu Lin Zou Zhiwei Li Jingmin Zhao Na Lin | 2012 | FEBS Letters2012，，： | 1 |
| 14 | Recent research progress in burning rate catalysts显示文摘 | Gao Jingmin Wang Li Yu Haojie | 2011 | Propellants Explosives and Pyrotechnics2011，36，： | 1 |
| 15 | Element and mineral characterization of dust emission from the saline land at Songnen Plain, Northeastern China显示文摘Recent observations of Asian dust storms show an eastern expansion of the source area to degraded lands, where dust emissions have been little studied. The dust concentrations over the saline land of the western Songnen Plain (SSL), Northeastern China, are circumstantially higher than those from the northwestern Chinese deserts. These concentrations are sensitive to the surface soil conditions and wind velocity on the ground. The dust samples collected during dust storm events on the SSL contain abundant Na, Mg, Al, K, Ca, Fe and Ti, as well as toxic elements such as Cu, V, Zn and Ba. Individual particle analysis reveals that fine saline particles (< 10 μm in diameter) on the saline land, consisting largely of carbonate, halite and sulfate together with lithogenic minerals such as SiO2 and aluminosilicate, are eventually uplifted during the interval from spring to autumn. The predominantly fine saline particles uplifted from the SSL are likely transported eastward by the winter monsoon circulation and westerlies. Recent degradation of saline lands in Northeastern China would not only increase the frequency of dust storm events in the downwind area, but also might change the chemical composition of the Asian dust emissions. | CHEN Bing KITAGAWA Hiroyuki HU Ke JIE Dongmei YANG Junpeng LI Jingmin | 2009 | Journal of Environmental Sciences2009，21，10： | 1 |
| 16 | Effect of dose-reduced scan protocols on cardiac coronary image quality with 64-row MDCT: A cardiac phantom study显示文摘 | Xiaolu Fei Xiangying Du Pengyu Li Jingmin Liao Yun Shen Kuncheng Li | 2007 | European Journal of Radiology2007，，： | 1 |
| 17 | Synthesis of Fe3O4@poly (methylmethacrylate-co-divinylbenzene) magnetic porous microspheres and their application in the separation of phenol from aqueous solutions显示文摘 | Tai Yulei Wang Li Gao Jingmin | 2011 | Journal of Colloid and Interface Science2011，360，： | 1 |
| 18 | Fabrication of a thermoplastic muhilayer microfluidic chip 显示文摘 | LI Jingmin LIU Chong KE Xue | 2012 | Journal of Materials Processing Technology2012，212，11： | 1 |
| 19 | Six novel single-nucleotide polymorphisms in SPAG11 gene and their association with sperm quality traits in Chinese Holstein bulls显示文摘 | Xinyan Liu Zhihua Ju Lingling Wang Yan Zhang Jingmin Huang Qiuling Li Jianbin Li Jifeng Zhong Liguo An Changfa Wang | 2011 | Animal Reproduction Science2011，，1： | 1 |
| 20 | MicroRNA-101 suppresses SOX9-dependent tumorigenicity and promotes favorable prognosis of human hepatocellular carcinoma显示文摘 | Yanqiong Zhang< !--Q1: Please confirm that given names and surnames have been identified correctly.--> Xiaodong Guo Lu Xiong Xiangying Kong Ying Xu Chunfang Liu Lin Zou Zhiwei Li Jingmin Zhao Na Lin | 2012 | FEBS Letters2012，，24： | 1 |
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