|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 2 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum显示文摘典型药用的植物的主要成分,蓼 multiflorum (用汉语的 Heshouwu ) ,那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害,而独唱治疗不能导致看得见的损害。在现在的工作,用成分大美人和敲门在里面策略,我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase, aspartate aminotransferase,和肝 histologic 的重要举起变化,而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且,孤立的 cis- ,并且不它的 trans 异构体,显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外,血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停,我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。 | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2017 | Frontiers of Medicine2017，11，2： | 41 |
| 3 | Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injury Issued by China Food and Drug Administration显示文摘1. Introduction Drug-induced liver injury (DILI), defined as liver injury caused by a drug and/or its metabolites, is a common clinical adverse drug reaction1–4. This type of injury can cause acute liver failure and even death in severe cases5. | Xiaohe Xiao Jianyuan Tang Yimin Mao Xiuhui Li Jiabo Wang Chenghai Liu Kewei Sun Yong’an Ye Zhengsheng Zou Cheng Peng Ling Yang Yuming Guo Zhaofang Bai Tingting He Jing Jing Fengyi Li Na An | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 22 |
| 4 | Motion simulation and test on threshed grains in tapered threshing and transmission device for plot wheat breeding based on CFD-DEM显示文摘Mechanization of field experiments is the only way to improve crop breeding and seed propagation effects.In order to further clarify and improve the working performance of tapered threshing device for plot breeding,and reduce the remaining seeds in the device,the numerical simulation was carried out on the motion process of materials in the longitudinal-axial tapered cylinder threshing and transmission device of the plot wheat breeding combine harvester based on CFD-DEM method.Simulation results showed that,threshing and transmission of particles and short stalks at axial direction could be realized under the influence of air flow.Meanwhile,the material transference and distribution rule and stream field distribution rule of air flow in the threshing and transmission device were obtained,the variations of velocity and displacement of particles and short stalks with time were obtained;the motion trajectories and forms of particles in different types of retention were also studied.At rotating speed of 1300-1600 r/min for the tapered threshing cylinder in the verification test,the particle retention rate in the enclosure was 0-0.13%,while in the simulation the particle retention rate in the enclosure was 0-0.11%,only a 0.02%difference between them.The results proved a favorable feasibility to simulate the working performance of the tapered threshing and transmission device for plot breeding through gas-solid coupling method. | Fei Dai Xuefeng Song Wuyun Zhao Zhengsheng Han Fengwei Zhang Shilin Zhang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，1： | 16 |
| 5 | Underwater Explosion Treatment of Marine Soft Foundation显示文摘The consolidation of soft foundation is a problem that commonly appears in harbor construction engineering on muddy coast. Introduced in this paper is the experimental study on underwater explosion treatment of soft foundation, including the regulations of explosion hollow development and medium movement, the law of similarity of densification and settlement of filled stone mass by shock wave pressure and explosion energy and their construction technologies, etc. A number of projects have been completed by applying this new technique, and the technique itself has been proved practicable. | Zheng, Zhemin Yang, Zhengsheng Jin, Liu | 1991 | China Ocean Engineering1991，6，2： | 16 |
| 6 | Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients显示文摘B 房间对再感染在肝炎 B 病毒(HBV ) 和保护的清理起一个重要作用。然而,与长期的 HBV 感染的结果被联系的这些房间的功能的特征仍然保持未知。我们包括地在不同阶段从 CHB 病人调查了外部 B 房间子集的频率,显型,和功能:有免疫力的忍耐(信息技术) ,有免疫力的激活(IA ) ,有免疫力的清理(IC ) ,有 HBsAg seroconversion 的应答者(解决的病人, RP ) ,并且健康控制(HC ) 。IA 病人与另外的组相比显示了外部血记忆 B 房间的更低的百分比。B 房间的全面 polyclonal 激活,由激活标记和 IgG 和 IgM 的分泌物的高水平显示了,在 IA 病人被观察。这 B 房间 hyperactivation 能被增加的 IFN-α 导致;并且在 IA 病人的可溶的 CD40 ligands。尤其是,合作激发器分子 CD80 和浆液 HBsAb 的表示和 HBsAg 特定的 B 房间的频率显著地与 HC 题目相比在信息技术, IA,和 IC 病人被减少。更重要地, B 房间 hyperactivation, co-stimulatory 分子 downregulation 和 HBsAg 特定的 B 房间缺陷在 RP 病人被颠倒。B 房间 hyperactivation 和功能的缺陷的颠倒在长期的肝炎 B 病人与 HBsAg seroconversion 被联系。 | Xiangsheng Xu Qinghua Shang Xinyue Chen Weimin Nie Zhengsheng Zou Ang Huang Ming Meng Lei Jin Ruonan Xu Ji-Yuan Zhang Junliang Fu Lifeng Wang Zirong Tang Yunbo Xie Xiaoming Yang Zheng Zhang Fu-Sheng Wang | 2015 | Cellular & Molecular Immunology2015，12，3： | 15 |
| 7 | Constructing a high-density linkage map for Gossypium hirsutum × Gossypium barbadense and identifying QTLs for lint percentage显示文摘To introgress the good fiber quality and yield from Gossypium barbadense into a commercial Upland cotton variety, a high-density simple sequence repeat(SSR) genetic linkage map was developed from a BC1F1 population of Gossypium hirsutum×Gossypium barbadense. The map comprised 2,292 loci and covered 5115.16 centi Morgan(c M) of the cotton AD genome, with an average marker interval of 2.23 c M. Of the marker order for 1,577 common loci on this new map, 90.36% agrees well with the marker order on the D genome sequence genetic map. Compared with five published high-density SSR genetic maps, 53.14% of marker loci were newly discovered in this map. Twenty-six quantitative trait loci(QTLs) for lint percentage(LP) were identified on nine chromosomes. Nine stable or common QTLs could be used for marker-assisted selection. Fifty percent of the QTLs were from G. barbadense and increased LP by 1.07%–2.41%. These results indicated that the map could be used for screening chromosome substitution segments from G. barbadense in the Upland cotton background, identifying QTLs or genes from G. barbadense, and further developing the gene pyramiding effect for improving fiber yield and quality. | Yuzhen Shi Wentan Li Aiguo Li Ruihua Ge Baocai Zhang Junzhi Li Guangping Liu Junwen Li Aiying Liu Haihong Shang Juwu Gong Wankui Gong Zemao Yang Feiyü Tang Zhi Liu Weiping Zhu Jianxiong Jiang Xiaonan Yu Tao Wang Wei Wang Tingting Chen Kunbo Wang Zhengsheng Zhang Youlu Yuan | 2015 | Journal of Integrative Plant Biology2015，57，5： | 7 |
| 8 | THE NEIGHBORHOOD INTERSECTIONS OF ESSENTIAL SETS AND HAMILTONICITY OFGRAPHS显示文摘Let G be a graph. An independent set Y in G is called an essential independent set (or essential set for simplicity) if there is {yi , y2} Y such that dist(y1 , y2) - 2. For integer t > 0, let It(G) = {Y| Y is an independent set of G, |Y| = t}, It(G) = {Y|Y is an essential set of G, |Y| = t}. For ∈E It(G), let si(y) = |{v|v ∈V(G), |N(v) n Y| = i}|(i = 0, 1,…, t). Let X, Y g V(G). Define dist(X, Y) = dist(u, v), n(Y) = |{v|v ∈V(G), dist({v}, Y) ≤ 2}|. A non-negative rational sequence (a1,a2,…, ak+1) (k ≥2) is called an LTW-sequence, if it satisfies 1) a1 ≤ 1; 2) for arbitrary i1, i2,…,ih. ∈{2,3,……, k + 1}, The main new results of this paper are as follows: Let (a1, a2,… ak+1) be all LTW-sequence, and k ≥ 2. If G is a k-connected graph, and then G has a Hamilton cycle; if G is a (k + 1)-connected graph and for each then G is Hamilton-connected. The existing results are generalized by these since Ik+1(G) is replaced by I(G). We introduce a new technique of T-insertion in this paper, by using the T-vertex inserting lemmas we give a unified proof for a graph to be hamiltonian or Hamilton-connected. | WU Zhengsheng(Department of Mathematics, Naming Normal University, Naming 210097, China)XU Xinping(Department of Mathematics, Jiangsu Education College, Naming 210013, China)ZHOU Xinghe(Department of Mathematics, Naming Normal University, Nabbing 210097, | 1998 | Systems Science and Mathematical Sciences1998，11，3： | 4 |
| 9 | CCAR1 5' UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance显示文摘 | Gaopeng Li Xiaoli Wu Wenchang Qian Huayong Cai Xinbao Sun Weijie Zhang Sheng Tan Zhengsheng Wu Pengxu Qian Keshuo Ding Xuefei Lu Xiao Zhang Hong Yan Haifeng Song Shouhong Guang Qingfa Wu Peter E Lobie Ge Shan Tao Zhu | 2016 | Cell Research2016，26，6： | 3 |
| 10 | Histological and cytological investigations of the infection and colonization of apple bark by Valsa mali var. mali显示文摘 | Xiwang Ke Lili Huang Qingmei Han Xiaoning Gao Zhengsheng Kang | 2013 | Australasian Plant Pathology2013，，1： | 3 |
| 11 | Integration of data-intensive,machine learning and robotic experimental approaches for accelerated discovery of catalysts in renewable energy-related reactions显示文摘Technological advancements in recent decades have greatly transformed the field of material chemistry.Juxtaposing the accentuating energy demand with the pollution associated,urgent measures are required to ensure energy maximization,while reducing the extended experimental time cycle involved in energy production.In lieu of this,the prominence of catalysts in chemical reactions,particularly energy related reactions cannot be undermined,and thus it is critical to discover and design catalyst,towards the optimization of chemical processes and generation of sustainable energy.Most recently,artificial intelligence(AI)has been incorporated into several fields,particularly in advancing catalytic processes.The integration of intensive data set,machine learning models and robotics,provides a very powerful tool in modifying material synthesis and optimization by generating multifarious dataset amenable with machine learning techniques.The employment of robots automates the process of dataset and machine learning models integration in screening intermetallic surfaces of catalyst,with extreme accuracy and swiftness comparable to a number of human researchers.Although,the utilization of robots in catalyst discovery is still in its infancy,in this review we summarize current sway of artificial intelligence in catalyst discovery,briefly describe the application of databases,machine learning models and robots in this field,with emphasis on the consolidation of these monomeric units into a tripartite flow process.We point out current trends of machine learning and hybrid models of first principle calculations(DFT)for generating dataset,which is integrable into autonomous flow process of catalyst discovery.Also,we discuss catalyst discovery for renewable energy related reactions using this tripartite flow process with predetermined descriptors. | Oyawale Adetunji Moses Wei Chen Mukhtar Lawan Adam Zhuo Wang Kaili Liu Junming Shao Zhengsheng Li Wentao Li Chensu Wang Haitao Zhao Cheng Heng Pang Zongyou Yin Xuefeng Yu | 2021 | Materials Reports(Energy)2021，1，3： | 3 |
| 12 | Quantitation of HBV covalently closed circular DNA in micro formalin fixed paraffin-embedded liver tissue using rolling circle amplification in combination with real-time PCR显示文摘 | Yanwei Zhong Jiaqi Han Zhengsheng Zou Shuhong Liu Bo Tang Xiaoqiang Ren Xiaodong Li Yulai Zhao Yan Liu Dongqing Zhou Weijie Li Jingmin Zhao Dongping Xu | 2011 | Clinica Chimica Acta2011，，21： | 2 |
| 13 | Instability characteristics of the cracked roof rock beam under shallow mining conditions显示文摘To establish the movement relationship for the roof breaking under shallow mining conditions, the mechanical model of the roof rock beam was built, then the structure instability process of the roof rock beam was analyzed. The changing criterion of the vertical displacement was established and the relationship between the deflection and the rotary motion of roof block was determined. Regarding a mining face in Shangwan Mine, the responsing laws of the deflection and horizontal thrust of the roof rock beam were obtained through FLAC3D numerical analysis. The results show that the structure instability of the cracked roof rock beam depends on the interaction between the vertical load and the horizontal thrust.For the roof rock beam, when the vertical load keeps constant, the horizontal thrust fluctuating rises with increasing deflection. The horizontal thrust increases constantly with the deeper buried depth and the smaller span. | Zhao Yanhai Wang Shuren Zou Zhengsheng Ge Linlin Cui Fang | 2018 | International Journal of Mining Science and Technology2018，28，3： | 2 |
| 14 | Large extracellular vesicles secreted by human iPSC-derived MSCs ameliorate tendinopathy via regulating macrophage heterogeneity显示文摘Tendinopathy is a common musculoskeletal disorder which results in chronic pain and reduced performance.The therapeutic effect of stem cell derived-small extracellular vesicles(sEVs)for tendinopathy has been validated in recent years.However,whether large extracellular vesicles(lEVs),another subset of extracellular vesicles,possesses the ability for the improvement of tendinopathy remains unknown.Here,we showed that lEVs secreted from iPSC-derived MSCs(iMSC-lEVs)significantly mitigated pain derived from tendinopathy in rats.Immuno-histochemical analysis showed that iMSC-lEVs regulated the heterogeneity of infiltrated macrophages and several inflammatory cytokines in rat tendon tissue.Meanwhile,in vitro experiments revealed that the M1 pro-inflammatory macrophages were repolarized towards M2 anti-inflammatory macrophages by iMSC-lEVs,and this effect was mediated by regulating p38 MAPK pathway.Moreover,liquid chromatography-tandem mass spectrometry analysis identified 2208 proteins encapsulated in iMSC-lEVs,including 134 new-found proteins beyond current Vesiclepedia database.By bioinformatics and Western blot analyses,we showed that DUSP2 and DUSP3,the negative regulator of p38 phosphorylation,were enriched in iMSC-lEVs and could be transported to macrophages.Further,the immunomodulatory effect of iMSC-lEVs on macrophages was validated in explant tendon tissue from tendinopathy patients.Taken together,our results demonstrate that iMSC-lEVs could reduce inflammation in tendinopathy by regulating macrophage heterogeneity,which is mediated via the p38 MAPK pathway by delivery of DUSP2 and DUSP3,and might be a promising candidate for tendinopathy therapy. | Teng Ye Zhengsheng Chen Jieyuan Zhang Lei Luo Renzhi Gao Liangzhi Gong Yuhang Du Zongping Xie Bizeng Zhao Qing Li Yang Wang | 2023 | Bioactive Materials2023，，3： | 2 |
| 15 | Single-event burnout hardening of planar power MOSFET with partially widened trench source显示文摘We present a single-event burnout(SEB) hardened planar power MOSFET with partially widened trench sources by three-dimensional(3 D) numerical simulation. The advantage of the proposed structure is that the work of the parasitic bipolar transistor inherited in the power MOSFET is suppressed effectively due to the elimination of the most sensitive region(P-well region below the N+ source). The simulation result shows that the proposed structure can enhance the SEB survivability significantly. The critical value of linear energy transfer(LET),which indicates the maximum deposited energy on the device without SEB behavior, increases from 0.06 to0.7 p C/μm. The SEB threshold voltage increases to 120 V, which is 80% of the rated breakdown voltage. Meanwhile, the main parameter characteristics of the proposed structure remain similar with those of the conventional planar structure. Therefore, this structure offers a potential optimization path to planar power MOSFET with high SEB survivability for space and atmospheric applications. | Jiang Lu Hainan Liu Xiaowu Cai Jiajun Luo Bo Li Binhong Li Lixin Wang Zhengsheng Han | 2018 | Journal of Semiconductors2018，39，3： | 1 |
| 16 | Cotton flavonoid structural genes related to the pigmentation in brown fibers显示文摘 | Xiao Yuehua Zhang Zhengsheng Yin Menghui | | 0，，1： | 1 |
| 17 | Mierostrueture and glass-transition temperature of novel star N-SIBR显示文摘 | Zhengsheng Wang Yurong Wang Yang Li | 2006 | Journal of Applied Polymer seienee2006，102，6： | 1 |
| 18 | T1 locus in cotton is the candidate gene affecting lint percentage, fiber quality and spiny bollworm (Earias spp.) resistance显示文摘 | Qun Wan Zhengsheng Zhang Meichun Hu Li Chen Dajun Liu Xiao Chen Wei Wang Jing Zheng | 2007 | Euphytica (-)2007，，1： | 1 |
| 19 | The existence of almost periodic solutions of linear system显示文摘 | Lin Zhengsheng | 1979 | Acta Mathematics Sinica1979，22，5： | 1 |
| 20 | SecurityMechanismforDistributedGISSDatialDataBasedonobject2basedstorage显示文摘 | YuZhanwu LiZhongmin ZhengSheng et a1 | 2007 | ActaGeodaeticetcart0-graphicaSinica2007，36，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员