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| 1 | Near-infrared light-driven Janus capsule motors: Fabrication, propulsion, and simulation显示文摘我们报导一没有燃料,在红外线附近(NIR ) 驾驶 Janus microcapsule 马达。Janus microcapsule 马达被帮助模板的聚合电解质 layer-by-layer 汇编制作,由在一个方面上金层喷洒列在后面。NIR 动力的 Janus 马达以 42 /DLHC 的最大的速度完成了高推进合成交付一个高特定的能力(930 mAed nanoparticles,有 81.8% 的轻发射度和 118.62ichia coli 的一个水接触角度(E。coli ) ,肠球菌(ENT ) 和全部的大肠菌(TC ) 被分析。除了 EC 和没有 3, ,结果揭示了低 concentrati 吗?? | Yingjie Wu Tieyan Si Jingxin Shao Zhiguang Wu Qiang He | 2016 | Nano Research2016，9，12： | 6 |
| 2 | Epithelial-mesenchymal transition status of circulating tumor cells in breast cancer and its clinical relevance显示文摘Objective:Circulating tumor cells(CTCs)play a critical role in cancer metastasis,but their prevalence and significance remain unclear.This study attempted to track the epithelial-mesenchymal transition(EMT)status of CTCs in breast cancer patients and investigate their clinical relevance.Methods:In this study,the established negFACS-IF:E/M platform was applied to isolate rare CTCs and characterize their EMT status in breast cancer.A total of 89 breast cancer patients were recruited,including stage 0–III(n=60)and late stage(n=29)cases.Results:Using the negFACS-IF:E/M platform,it was found that in human epidermal growth factor receptor 2(HER2)+patients,mesenchymal CTCs usually exhibited a high percentage of HER2+cells.Stage IV breast cancer patients had considerably more CTCs than stage 0–III patients.Among stage 0–III breast cancers,the HER2 subtype included a significantly higher percentage of mesenchymal and biphenotypic(epithelial and mesenchymal)CTCs than the luminal A or B subtypes.Among stage IV patients,CTCs were predominantly epithelial in cases with local recurrence and were more mesenchymal in cases with distant metastasis.By applying a support vector machine(SVM)algorithm,the EMT status of CTCs could distinguish between breast cancer cases with metastasis/local recurrence and those without recurrence.Conclusions:The negFACS-IF:E/M platform provides a flexible and generally acceptable method for the highly sensitive and specific detection of CTCs and their EMT traits in breast cancer.This study demonstrated that the EMT status of CTCs had high clinical relevance in breast cancer,especially in predicting the distant metastasis or local recurrence of breast cancer. | Jiaojiao Zhou Xuan Zhu Shijie Wu Jingxin Guo Kun Zhang Chunjing Xu Huihui Chen Yuxi Jin Yuting Sun Shu Zheng Yiding Chen | 2020 | Cancer Biology & Medicine2020，17，1： | 3 |
| 3 | Effect of peanut protein isolate on functional properties of chicken salt-soluble proteins from breast and thigh muscles during heat-induced gelation显示文摘 | Jingxin Sun Zhen Wu Xinglian Xu Peng Li | 2011 | Meat Science2011，，1： | 2 |
| 4 | Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2显示文摘Dear Editor To date,tens of millions of people have been infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),causing the outbreak of the respiratory disease named the coronavirus disease 2019(COVID-19).As a newly emerged member of the coronavirus family,SARS-CoV-2 is an enveloped positive-strand RNA virus,which has probably the largest genome(approximately 30 kb)among all RNA viruses.The nucleocapsid(N)protein of SARS-CoV-2 is mainly responsible for recognizing and wrapping viral RNA into helically symmetric structures(Malik,2020). | Dan Zhao Weifan Xu Xiaofan Zhang Xiaoting Wang Yiyue Ge Enming Yuan Yuanpeng Xiong Shenyang Wu Shuya Li Nian Wu Tingzhong Tian Xiaolong Feng Hantao Shu Peng Lang Jingxin Li Fengcai Zhu Xiaokun Shen Haitao Li Pilong Li Jianyang Zeng | 2021 | Protein & Cell2021，12，9： | 1 |
| 5 | Effect of peanutprotein isolate on functional properties of chicken salt - solubleproteins from breast and thigh muscles during heat - inducedgelation 显示文摘 | Jingxin Sun Zhen Wu Xinglian Xu | 2012 | Meat Science2012，91，： | 1 |
| 6 | Immunological surrogate endpoints of COVID-2019 vaccines:the evidence we have versus the evidence we need显示文摘lIn response to the severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)pandemic,over 200 vaccine candidates againstcoronavirus disease 2019(COVID-2019)are under development and currently moving forward at an unparalleled speed.Theavailability of surrogate endpoints would help to avoid large-scale filed efficacy trials and facilitate the approval of vaccine candidates,which is crucial to control COVID-19 pandemic.Several phase 3 efficacy trials of COVID-19 vaccine candidates are underway,which provide opportunities for the determination of COVID-19 correlates of protection.In this paper,we review currentknowledge for existence of COVD-19 correlates of protection,methods for assessment of immune correlates of protection andissues related to COVID-19 correlates of protection. | Pengfei Jin Jingxin Li Hongxing Pan Yanfei Wu Fengcai Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 1 |
| 7 | Effect of peanut protein isolate on functional properties of chicken salt-soluble proteins from breast and thigh muscles during heat-induced gelation显示文摘 | SUN Jingxin WU Zhen LI Ping | 2012 | Meat Science2012，91，1： | 1 |
| 8 | High-entropy(Sm_(0.2)Eu_(0.2)Gd_(0.2)Dy_(0.2)Er_(0.2))_(2)Hf_(2)O_(7) ceramic with superb resistance to radiation-induced amorphization显示文摘Nuclear engineering materials are required to possess outstanding extreme environmental tolerance and irradiation resistance.A promising novel pyrochlore-type of(Sm_(0.2)Eu_(0.2)Gd_(0.2)Dy_(0.2)Er_(0.2))2 Hf_(2)O_(7)high-entropy ceramic(HE-RE2 Hf_(2)O_(7))for control rod was prepared by solid-state reaction method.The ion irradiation of HE-RE_(2) Hf_(2)O_(7)with 400 keV Kr+at 400℃was investigated using a 400 kV ion implanter and compared with single-component pyrochlore Gd2 Hf_(2)O_(7)to evaluate the irradiation resistance.For HE-RE2 Hf_(2)O_(7),the phase transition from pyrochlore to defective fluorite is revealed after irradiation at 60 dpa.After irradiation at 120 dpa,it maintained crystalline,which is comparable to Gd2 Hf_(2)O_(7)but superior to the titanate pyrochlores previously studied.Moreover,the lattice expansion of HE-RE2 Hf_(2)O_(7)(_(0.2)2%)is much lower than that of Gd2 Hf_(2)O_(7)(0.62%),indicating excellent irradiation damage resistance.Nanoindentation tests displayed an irradiation-induced increase in hardness and a decrease in elastic modulus by about 2.6%.Irradiation-induced segregation of elements is observed on the surface of irradiated samples.In addition,HE-RE2 Hf_(2)O_(7)demonstrates a more sluggish grain growth rate than Gd2 Hf_(2)O_(7)at 1200℃,suggesting better high-temperature stability.The linear thermal expansion coefficient of HE-RE2 Hf_(2)O_(7)is 10.7×10-6 K-1 at 298–1273 K.In general,it provides a new strategy for the design of the next advanced nuclear engineering materials. | Jingxin Wu Meng Zhang Zhanqiang Li Minzhong Huang Huiming Xiang Liyan Xue Zhengming Jiang Zhigang Zhao Lianfeng Wei Yong Zheng Fan Yang Guang Ran Yanchun Zhou Heng Chen | 2023 | Journal of Materials Science & Technology2023，，24： | 1 |
| 9 | Distributed attitude consensus of spacecraft formation flying显示文摘The consensus problem of the distributed attitude synchronization in the spacecraft formation flying is considered.Firstly,the attitude dynamics of a rigid body spacecraft is described by modified Rodriguez parameters(MRPs).Then global stable distributed cooperative attitude control laws are proposed for different cases.In the first case,the control law guarantees the state consensus during the attitude synchronization.In the second case,the control law ensures both the attitudes synchronizing to a desired constant attitude and the angular velocities converging at zero.In the third case,an attitude consensus control law with bounded control input is proposed.Finally,the effectiveness and validity of the control laws are demonstrated by simulations of six rigid bodies formation flying. | Xinsheng Wang jingxin Wu Xiaoli Wang | 2013 | Journal of Systems Engineering and Electronics2013，24，2： | 1 |
| 10 | Effect of peanut protein isolate on functional properties of chicken salt-soluble proteins from breast and thigh muscles during heat-induced gelation显示文摘 | Jingxin Sun Zhen Wu Xinglian Xu | 2012 | Meat Science2012，91，： | 1 |
| 11 | Carbon Encapsulated Nickel Nanocomposites for the Cathode in Advanced Lithium Sulfur Batteries显示文摘Lithium sulfur(Li-S)batteries are poised to be the next generation of high-density energy storage devices.In recent years,the concept of“electrocatalysis”has been introduced into the field of Li-S batteries,and some transition metals have been proved to catalyze the electrochemical conversion reaction of sulfur species.In this study,carbon encapsulated nickel nanoparticles(Ni@C)with a specific surface area of 146 m^(2)/g are shown to play a definitive electrocatalytic role for the sulfur cathode.With Ni@C incorporated,the Ni@C/G-S electrode achieved a better electrochemical performance than the G-S electrode.Moreover,the reversible capacity and cycle stability were further improved through chemical modifications of the carbon shell.The influence of doping with different elements on the Li-S battery performance was also investigated in detail.Higher specific capacities of 1229 mA·h/g,927 mA·h/g,and 830 mA·h/g were achieved at 0.2 C,0.5 C,and 1.0 C for the N-Ni@C-G/S electrode.Besides,the B-Ni@C-G/S electrode possessed a best cycle stability. | Yang Yuxiang Xie Jingxin Wu Genghuang Zhu Na Li Huan Rong Junfeng | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，4： | 1 |
| 12 | SLC34A2 Gene mutation of pulmonary alveolar microlithiasis: Report of four cases and review of literatures显示文摘 | Xinzhen Yin Huiying Wang Dingwen Wu Guohua Zhao Jingxin Shao Yu Dai | 2012 | Respiratory Medicine2012，，： | 1 |
| 13 | An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19显示文摘The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed an integrative drug repositioning framework,which fully takes advantage of machine learning and statistical analysis approaches to systematically integrate and mine large-scale knowledge graph,literature and transcriptome data to discover the potential drug candidates against SARS-CoV-2.Our in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1(PARP1)inhibitor,CVL218,currently in Phase I clinical trial,may be repurposed to treat COVID-19.Our in vitro assays revealed that CVL218 can exhibit effective inhibitory activity against SARS-CoV-2 replication without obvious cytopathic effect.In addition,we showed that CVL218 can interact with the nucleocapsid(N)protein of SARS-CoV-2 and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathology induced by SARS-CoV-2 infection. | Yiyue Ge Tingzhong Tian Suling Huang Fangping Wan Jingxin Li Shuya Li Xiaoting Wang Hui Yang Lixiang Hong Nian Wu Enming Yuan Yunan Luo Lili Cheng Chengliang Hu Yipin Lei Hantao Shu Xiaolong Feng Ziyuan Jiang Yunfu Wu Ying Chi Xiling Guo Lunbiao Cui Liang Xiao Zeng Li Chunhao Yang Zehong Miao Ligong Chen Haitao Li Hainian Zeng Dan Zhao Fengcai Zhu Xiaokun Shen Jianyang Zeng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 14 | Flexible Dry Hydrogel with Lamella-Like Structure Engineered via Dehydration in Poor Solvent显示文摘Hydrogels are among the most promising biologic materials in recent technology with numerous desired applications,including serving as biosensors,drug delivery vehicles,and tissue-engineered products for cell matrices.However,they often dehydrate,and become stiff and brittle in air,causing loss of flexibility and functions.Several layered structures have been proven to increase the strength,toughness,and even flexibility of these materials,which might provide a new clue for the sustenance of the flexibility of drying gels.Herein,we report a novel solvent-dehydrated hydrogel engineering approach,aimed to change the inner structure and keep the flexibility of a dehydrated hydrogel in the air via solvent-induced dehydration,for example,acetonedehydrated polyacrylic acid hydrogel.This flexible dry gel could be folded,twisted,and stretched without any damage due to the assumed lamella-like structures,contrary to dry gels without these microstructures or those with porous structures,which retain brittle consistency.The flexible dry gel also exhibited excellent self-healing capability with the assistance of solvents.Fascinatingly,this flexible gel film displayed strain-visualizing paper writing/erasing performance properties,with water acting as invisible ink.Thus,this fabricated flexible hydrogel film might function as confidential information storage material.Our current approach is versatile,hence applicable to other hydrogels,and provides insight into the engineering of other functional gels for extended future applications. | Feilong Zhang Jiajia Zhou Zhen Gu Man Yang Siheng Li Yongyang Song Jun-Bing Fan Jingxin Meng Peiyi Wu Lei Jiang Shutao Wang | 2020 | CCS Chemistry2020，2，1： | 0 |
| 15 | Single-Exosome Profiling Identifies ITGB3+and ITGAM+Exosome Subpopulations as Promising Early Diagnostic Biomarkers and Therapeutic Targets for Colorectal Cancer显示文摘Tumor metastasis is a hallmark of colorectal cancer(CRC),in which exosome plays a crucial role with its function in intercellular communication.Plasma exosomes were collected from healthy control(HC)donors,localized primary CRC and liver-metastatic CRC patients.We performed proximity barcoding assay(PBA)for single-exosome analysis,which enabled us to identify the alteration in exosome subpopulations associated with CRC progression.By in vitro and in vivo experiments,the biological impact of these subpopulations on cancer proliferation,migration,invasion,and metastasis was investigated.The potential application of exosomes as diagnostic biomarkers was evaluated in 2 independent validation cohorts by PBA.Twelve distinct exosome subpopulations were determined.We found 2 distinctly abundant subpopulations:one ITGB3-positive and the other ITGAM-positive.The ITGB3-positive cluster is rich in liver-metastatic CRC,compared to both HC group and primary CRC group.On the contrary,ITGAM-positive exosomes show a large-scale increase in plasma of HC group,compared to both primary CRC and metastatic CRC groups.Notably,both discovery cohort and validation cohort verified ITGB3+exosomes as potential diagnostic biomarker.ITGB3+exosomes promote proliferation,migration,and invasion capability of CRC.In contrast,ITGAM+exosomes suppress CRC development.Moreover,we also provide evidence that one of the sources of ITGAM+exosomes is macrophage.ITGB3+exosomes and ITGAM+exosomes are proven 2 potential diagnostic,prognostic,and therapeutic biomarkers for management of CRC. | Wei Guo Yanling Cai Xianming Liu Yuge Ji Cuiyu Zhang Liyan Wang Wenting Liao Yuefei Liu Nan Cui Jinsheng Xiang Zesong Li Di Wu Jingxin Li | 2023 | Research2023，，3： | 0 |
| 16 | Observation of the Effect of Gait-induced Functional Electrical Stimulation on Stroke Patients with Foot Drop显示文摘Objective:To explore the effects of functional electrical stimulation and functional mid frequency electrical stimulation on lower limb function and balance function in stroke patients.Methods:20 cases of stroke patients with foot drop after admission were randomly divided into the observation group and the control group,10 cases in each group.On the basis of the two groups of patients,the observation group used the gait induced functional electrical stimulation to stimulate the peroneal nerve and the pretibial muscle in the observation group.The control group used the computer medium frequency functional electrical stimulation to stimulate the peroneal nerve and the anterior tibial muscle for 2 weeks.Before and after treatment,the lower extremity simple Fugl-Meyer scale(FMA),the Berg balance scale(BBS)and the improved Ashworth scale were evaluated respectively,and the comparative analysis was carried out in the group and between the groups.Results:After 2 weeks of treatment,the scores of FMA and BBS in the two groups were significantly higher than those before the treatment(P<0.05),and the scores of FMA and BBS in the observation group were higher than those in the control group(P<0.05),and the flexor muscle tension of the ankle plantar flexor muscle of the observed group was lower than that of the control group(P<0.05).Conclusions:Exercise therapy combined with gait induced functional electrical stimulation or computer intermediate frequency functional electrical stimulation can significantly improve lower limb function and balance function in patients with ptosis,and the therapeutic effect of functional electrical stimulation combined with gait is better. | Anqi Zhang Mengjiao Wu Luxi Mao Qianhuan Zhang Bingqian Zhou Jingxin Wang | 2022 | Journal of Advances in Medicine Science2022，5，1： | 0 |
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