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| 1 | Over-activation of TLR5 signaling by high-dose flagellin induces liver injury in mice显示文摘Flagellin 是涉及天生、适应的免疫的大量房间类型的有势力使活跃之物。因此,它是疫苗的一个好辅助候选人,并且它可能在癌症放射疗法和放射紧急情况的一个缓和者期间对主要尖锐放射症候群作为生物杀虫撒布剂工作。然而,积累证据含有在一些煽动性的疾病的出现的 flagellin 例如尖锐的肺发炎,心血管的倒塌和煽动性的肠疾病。这研究的目的是阐明 flagellin-TLR5 发信号激活是否仅仅或是否在肝的 pathophysiology 起一个作用某另外的 flagellin 活动也经由细菌的感染或在临床的应用期间贡献肝损害。Recombinant flagellin 蛋白质与或没有刺激 TLR5 活动被用来评估 flagellin-TLR5 在肝损害发信号在的角色野类型并且 TLR5 击倒老鼠。粗野损害和 hepatocellular 坏死的大区域在 100 或 200 µ 的 intraperitoneal 管理以后在肝织物 12 h 被观察;在一个剂量依赖者的 g flagellin (警察) 和在野类型的老鼠,然而并非在 TLR5 击倒老鼠的时间依赖者举止。flagellin 的 N 终端或 TLR5 绑定域的删除禁止了导致 flagellin 的煽动性的回答和随后的尖锐的肝函数反常和损坏。这些数据证实 flagellin 是肝损害的一个必要决定因素并且证明由高剂量的 flagellin 发信号的 TLR5 的在激活上在肝引起了尖锐煽动性的回答,嗜中性的累积和氧化应力,它贡献导致 flagellin 的肝损害的前进和严厉。 | Yang Xiao Fang Liu Jingyi Yang Maohua Zhong Ejuan Zhang Yaoming Li Dihan Zhou Yuan Cao Wei Li Jie Yu Yi Yang Huimin Yan | 2015 | Cellular & Molecular Immunology2015，12，6： | 9 |
| 2 | The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis显示文摘 | Fang Wang Wei Song Hongmei Zhao Yanni Ma Yuxia Li Di Zhai Jingnan Pi Yanmin Si Jiayue Xu Lei Dong Rui Su Mengmeng Zhang Yong Zhu Xiaoxia Ren Fei Miao Wenjie Liu Feng Li Junwu Zhang Aibin He Ge Shan Jingyi Hui Linfang Wang Jia Yu | 2017 | Cell Research2017，27，3： | 7 |
| 3 | Light field imaging: models-, calibrations, reconstructions, and applications显示文摘光场成像是计算摄像学领域一项新兴技术。基于对成像模型和光路的创新设计,光场相机不仅记录了三维物体的空间强度,而且捕获了物理世界中的角度信息。这为解决三维重建、显著区域检测、目标识别等计算机视觉问题提供了新途径。本文首先回顾了光场相机的三个关键问题,包括成像模型、标定理论以及重建方法。然后,系统介绍了光场成像技术在信息学、物理学、医学和生物学等领域的应用现状。最后,讨论了光场成像目前存在的问题,并展望了光场成像技术的应用前景。 | Hao ZHU Qing WANG Jingyi YU | 2017 | Frontiers of Information Technology & Electronic Engineering2017，18，9： | 6 |
| 4 | Life prediction and test period optimization research based on small sample reliability test of hydraulic pumps显示文摘Hydraulic pumps belong to reliable long-life hydraulic components. The reliability evaluation includes characters such as long test period,high cost,and high power loss and so on. Based on the principle of energy-saving and power recovery,a small sample hydraulic pump reliability test rig is built,and the service life of hydraulic pump is predicted,and then the sampling period of reliability test is optimized. On the basis of considering the performance degradation mechanism of hydraulic pump,the feature information of degradation distribution of hydraulic pump volumetric efficiency during the test is collected,so an optimal degradation path model of feature information is selected from the aspect of fitting accuracy,and pseudo life data are obtained. Then a small sample reliability test of period constrained optimization search strategy for hydraulic pump is constructed to solve the optimization problem of the test sampling period and tightening end threshold,and it is verified that the accuracy of the minimum sampling period by the non-parametric hypothes is tested. Simulation result shows it could possess instructional significance and referenced value for hydraulic pump reliability life evaluation and the test's research and design. | 郭锐 Ning Chao Zhao Jingyi Wang Ping Shi Yu Zhou Jinsheng Luo Jing | 2017 | High Technology Letters2017，23，1： | 5 |
| 5 | NLRC4 downregulates 的激活对 flagellin 的调停 TLR5 的抗体免疫者回答显示文摘细菌的 flagellin 是一个唯一的联系病原体的分子的模式(PAMP ) ,它能被表面认出局部性的像使用费的受体 5 (TLR5 ) 并且 cytosolic 像点头的受体(NLR ) 蛋白质 4 (NLRC4 ) 受体。由 flagellin 和产生有免疫力的回答戏表明小径的 TLR5 或 NLRC4 的激活在抗菌剂免疫的重要角色。然而,它仍然保持不清楚怎么 flagellin 的双活动激活 TLR5 或 NLRC4 发信号小径安排有免疫力的回答。在这研究,我们估计了缺乏能力对 flagellin 在适应有免疫力的回答上独自或在联合激活 TLR5 和 NLRC4 的 flagellin 和它的异种的效果。是不能的激活 NLRC4 的 Flagellin 比的导致了显著地更高的抗体回答野类型的 flagellin。当巨噬细胞在 vivo 被弄空时,增加的抗体反应能被消除。由 flagellin downregulated 的 NLRC4 的激活对 flagellin 的导致 flagellin 、调停 TLR5 的有免疫力的回答。 | Wei Li Jingyi Yang Ejuan Zhang Maohua Zhong Yang Xiao Jie Yu Dihan Zhou Yuan Cao Yi Yang Yaoming Li Huimin Yan | 2016 | Cellular & Molecular Immunology2016，13，4： | 5 |
| 6 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 7 | QKI-5 regulates the alternative splicing of cytoskeletal gene ADD3 in lung cancer显示文摘Accumulating evidence indicates that the alternative splicing program undergoes extensive changes during cancer develop-ment and progression.The RNA-binding protein QKI-5 is frequently downregulated and exhibits anti-tumor activity in lung cancer.Howeve-r,little is known about the functional targets and regulatory mechanism of QKI-5.Here,we report that upregulation of exon 14 inclusion of cytoskeletal gene Adducin 3(ADD3)significantly correlates with a poor prognosis in lung cancer.QKI-5 inhibits cell proliferation and migration in part through suppressing the splicing of ADD3 exon 14.Through genome-wide mapping of QKI-5 binding sites in vivo at nucleotide resolution by iCLIP-seq analysis,we found that QKI-5 regulates alternative splicing of its target mRNAs in a binding position-dependent manner.By binding to multiple sites in an upstream intron region,QKI-5 represses the splicing of ADD3 exon 14.We also identified several QKI mutations in tumors,which cause dysregulation of the splicing of QKI targets ADD3 and NUMB.Taken together,our results reveal that QKI-mediated alternative splicing of ADD3 is a key lung cancer-associated splicing event,which underlies in part the tumor suppressor function of QKI. | Jin-Zhu Wang Xing Fu Zhaoyuan Fang Hui Liu Feng-Yang Zong Hong Zhu Yan-Fei Yu Xiao-Ying Zhang Shen-Fei Wang Ying Huang jingyi Hui | 2021 | Journal of Molecular Cell Biology2021，13，5： | 4 |
| 8 | Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N^(6)-Methyladenosine-Modified Yap Expression显示文摘Circular RNAs take crucial roles in several pathophysiological processes.The regulatory role and its underlying mechanisms of circ-ZNF609 in the heart remains largely unknown.Here,we report that circ-ZNF609 is upregulated during myocardial ischemia/reperfusion(I/R)remodeling.Knockdown of circ-ZNF609 protects against acute I/R injury and attenuates left ventricle dysfunction after I/R remodeling in vivo.In vitro,circ-ZNF609 regulates cardiomyocyte survival and proliferation via modulating the crosstalk between Hippo-YAP and Akt signaling.Mechanically,N6-methyladenosine-modification is involved in the regulatory role of circ-ZNF609 on YAP.An in-depth study indicates that knockdown of circ-ZNF609 decreases the expression of YTHDF3 and further fine-tuned the accessibility of Yap mRNA to YTHDF1 and YTHDF2 to regulate YAP expression.circ-ZNF609 knockdown represents a promising therapeutic strategy to combat the pathological process of myocardial I/R injury. | Lijun Wang Pujiao Yu Jiaqi Wang Guie Xu Tianhui Wang Jingyi Feng Yihua Bei Jiahong Xu Hongbao Wang Saumya Das Junjie Xiao | 2022 | Research2022，，3： | 3 |
| 9 | Crucial control measures to contain China's first Delta variant outbreak显示文摘The SARS-C oV-2 B.1.617.2(Delta) variant flared up in late May in Guangzhou,China.Transmission characteristics of Delta variant were analysed for 153 confirmed cases and two complete transmission chains with seven generations were fully presented.A rapid transmission occurred in five generations within10 days.The basic reproduction number(R_0) was 3.60(95% confidence interval:2.50-5.30).After redefining the concept of close contact,the proportion of confirmed cases discovered from close contacts increased from 43% to 100%.With the usage of a yellow health code,the potential exposed individuals were self-motivated to take a nucleic acid test and regained public access with a negative testing result.Facing the massive requirement of screening,novel facilities like makeshift inflatable laboratories were promptly set up as a vital supplement and 17 cases were found,with 1 pre-symptomatic.The dynamic adjustment of these three interventions resulted in the decline of Rt from 5.00 to 1.00 within 9 days.By breaking the transmission chain and eliminating the transmission source through extending the scope of the close-contact tracing,health-code usage and mass testing,the Guangzhou D elta epidemic was effectively contained. | Lei Luo Zifeng Yang Jingyi Liang Yu Ma Hui Wang Chitin Hon Mei Jiang Zhengshi Lin Wenda Guan Zhitong Mai Yongming Li Kailin Mai Zhiqi Zeng Chuanmeizi Tu Jian Song Bin Liu Yong Liu Jianfeng He Huiyuan Li Bosheng Li Hang Dong Yutian Miao Shujun Fan Lirui Fan Xingyi Liang Ke Li Chun Chen Huihong Deng Zhicong Yang Nanshan Zhong | 2022 | National Science Review2022，9，4： | 2 |
| 10 | Controlling plasmon‐exciton interactions through photothermal reshaping显示文摘We investigated the plasmon-exciton interactions in an individual gold nanorod(GNR)with monolayer MoS2 at room temperature with the single-particle spectroscopy technique.To control the plasmon-exciton interaction,we tuned the local surface plasmon resonance of an individual GNR in-situ by employing the photothermal reshaping effect.The scattering spectra of the GNR-MoS2 hybrids exhibited two dips at the frequencies of the A and B excitons of monolayer MoS2,which were caused by the plasmon-induced resonance energy transfer effect.The resonance energy transfer rate increased when the surface plasmon resonance of the nanorod matched well with the exciton transition energy.Also,we demonstrated that the plasmon-enhanced fluorescence process dominated the photoluminescence of the GNR-MoS2 hybrid.These results provide a flexible way to control the plasmon-exciton interaction in an all-solid-state operating system at room temperature. | Aiqin Hu Shuai Liu Jingyi Zhao Te Wen Weidong Zhang Qihuang Gong Yongqiang Meng Yu Ye Guowei Lu | 2020 | Opto-Electronic Advances2020，3，1： | 2 |
| 11 | The Helicobacter pylori Protein CagM is Located in the Transmembrane Channel That is Required for CagA Translocation显示文摘 | Feng Ling Xiaochun Wang DongFang Dai Min Yu Cheng Chen Jingyi Qian Chang Liu Yuanyuan Zhang Jie Ding Xian Wei Guan Shihe Shao | 2013 | Current Microbiology2013，，5： | 2 |
| 12 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 13 | Vertically aligned two-dimensional materials-based thick electrodes for scalable energy storage systems显示文摘Together with the blooming of portable smart devices and electric vehicles in the last decade,electrochemical energy storage(EES)devices capable of high-energy and high-power storage are urgently needed.Two-dimensional(2D)materials,benefiting from the short solid-state diffusion distance,are well recognized to possess excellent electrochemical performance.However,liquid diffusion,the rate-determining process in thick electrodes,is notably slow in 2D materials-based electrodes stemming from their stacking during electrode processing,which considerably limits their applications for high energy storage.To fully exploit intrinsic advantages of 2D materials for scalable energy storage devices,this review summarizes several important strategies,ranging from assembly to template methods,to fabricate vertically aligned 2D materials-based electrodes.We further discuss the advantages and challenges of these methods in terms of key features of thick electrodes and illustrate the design principles for high-energy/power devices. | Zhengyu Ju Xiao Zhang Jingyi Wu Guihua Yu | 2021 | Nano Research2021，14，10： | 1 |
| 14 | Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissuespecific therapy显示文摘 | Yan Li Jingyi Yu | 2004 | Nature2004，429，： | 1 |
| 15 | Macrophage polarization is involved in liver fibrosis induced byβ_(1)-adrenoceptor autoantibody显示文摘Accumulating evidence suggests that liver injury can be induced by the over-expression ofβ_(1)-adrenergic receptors(β_(1)-ARs).High titers of autoantibodies specific toβ_(1)-adrenergic receptors(β_(1)-AA)are detected in the sera of heart failure patients,potentially playing agonist-like roles.However,the role ofβ_(1)-AA in liver function has not been characterized.In this study,we collect the sera of primary biliary cholangitis(PBC)patients,a condition which easily develops into liver fibrosis,and analyze the relationship between PBC andβ_(1)-AA.A passive immunization model is established to assess the effect ofβ_(1)-AA on the liver.Subsequently,the effect ofβ_(1)-AA on macrophages is investigated in vitro.Results show that PBC patients have a high titer and ratio ofβ_(1)-AA,compared to controls.Liver injury and fibrosis are induced byβ_(1)-AA.In vitro experiments with ROS probe demonstrate thatβ_(1)-AA induces macrophages to produce ROS and secrete TNFα.These effects can be partially reversed by metoprolol,a blocker forβ_(1)-AR.Results from the transwell and phagocytosis assays show thatβ_(1)-AA promotes macrophage migration and phagocytosis.FCM tests suggest thatβ_(1)-AA induces the alteration of M1 rather than M2 markers in macrophages.Finally,the Annexin V/PI assay indicates that macrophage culture supernatants stimulated byβ_(1)-AA cause hepatocyte apoptosis.Overall,these results suggest thatβ_(1)-AA is involved in PBC.Theβ_(1)-AA-induced activation,phagocytosis and phenotypic modification of macrophages may play an important role in the development of hepatic fibrosis and injury. | Ye Wu Xiongxiong Fan Haicun Yu Jingyi Liu Yanru Duan Suli Zhang Li Yan Yunhui Du Huirong Liu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，8： | 1 |
| 16 | Synthesis and surface properties of several nonionic–anionic surfactants with straight chain alkyl-benzyl hydrophobic group显示文摘 | Xianguang Wang Feng Yan Zhenquan Li Lu Zhang Sui Zhao Jingyi An Jiayong Yu | 2007 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2007，，1： | 1 |
| 17 | Feasibility of sentinel lymph node biopsy omission after integration of ^(18)F-FDG dedicated lymph node PET in early breast cancer: a prospective phase II trial显示文摘Objective:Sentinel lymph node biopsy(SLNB)is currently the standard of care in clinically node negative(cN0)breast cancer.The present study aimed to evaluate the negative predictive value(NPV)of 18F-FDG dedicated lymph node positron emission tomography(LymphPET)in cN0 patients.Methods:This was a prospective phase II trial divided into 2 stages(NCT04072653).In the first stage,cN0 patients underwent axillary LymphPET followed by SLNB.In the second stage,SLNB was omitted in patients with a negative preoperative axillary assessment after integration of LymphPET.Here,we report the results of the first stage.The primary outcome was the NPV of LymphPET to detect macrometastasis of lymph nodes(LN-macro).Results:A total of 189 patients with invasive breast cancer underwent LymphPET followed by surgery with definitive pathological reports.Forty patients had LN-macro,and 16 patients had only lymph node micrometastasis.Of the 131 patients with a negative LymphPET result,16 patients had LN-macro,and the NPV was 87.8%.After combined axillary imaging evaluation with ultrasound and LymphPET,100 patients were found to be both LymphPET and ultrasound negative,9 patients had LN-macro,and the NPV was 91%.Conclusions:LymphPET can be used to screen patients to potentially avoid SLNB,with an NPV>90%.The second stage of the SOAPET trial is ongoing to confirm the safety of omission of SLNB according to preoperational axillary evaluation integrating LymphPET. | Junjie Li Jingyi Cheng Guangyu Liu Yifeng Hou Genghong Di Benglong Yang Yizhou Jiang Liang Huang Feilin Qu Sheng Chen Yan Wang Keda Yu Zhimin Shao | 2022 | Cancer Biology & Medicine2022，19，7： | 1 |
| 18 | De-enhancing the dynamic contrast-enhanced breast MRI for robust registration显示文摘 | Zheng Yuanjie Yu Jingyi Kambhamettu Chandra | 2007 | Med Image Comput Comput Assist Interv2007，10，1： | 1 |
| 19 | Modeling complex unfoliaged trees from a sparse set of images 显示文摘 | LOPEZ L D DING Yuanyuan YU Jingyi | 2010 | Comput Graphics Forum2010，29，7： | 1 |
| 20 | Criterion Analysis on Nonpoisoning of the Target Surface 显示文摘 | Chen Wei Wang Yu Zhao Ning He Xiaoming | 1993 | J Appl Phys1993，73，5： | 1 |
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