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| 1 | In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids显示文摘Unlike most organs that mature during the fetal period,the male reproductive system reaches maturity only at puberty with the commencement of spermatogenesis.Robust modelling of human testicular organogenesis in vitro would facilitate research into mechanisms of and factors affecting human spermatogenic failure and male fertility preservation in prepubertal tumor patients.Here,we report successful recapitulation of human testicular organogenesis in vitro from fetal gonadal ridge.Our model displayed the formation of mature seminiferous epithelium and self-renewing spermatogonia.Remarkably,in vitro-derived haploid spermatids have undergone meiotic recombination,and showed increased genetic diversity as indicated by genetic analysis.Moreover,these spermatids were able to fertilize oocytes and support subsequent blastocyst formation.The in vitro testicular organogenesis system described here will play an important role in elucidating the regulation of human testis development and maintaining male fertility in prepubertal cancer patients. | Yan Yuan Laihua Li Qing Cheng Feiyang Diao Qiao Zeng Xiaoyu Yang Yibo Wu Hao Zhang Mingqian Huang Junqing Chen Quan Zhou Yunfei Zhu Rong Hua Jianyu Tian Xin Wang Zuomin Zhou Jie Hao Jinjin Yu Dong Hua Jiayin Liu Xuejiang Guo Qi Zhou Jiahao Sha | 2020 | Cell Research2020，30，3： | 6 |
| 2 | Thermally rearranged covalent organic framework with flame-retardancy as a high safety Li-ion solid electrolyte显示文摘Solid polymer electrolytes have demonstrated high promise to solve the safety problems caused by conventional liquid electrolytes in lithium ion batteries.However,the inherent flammability of most polymer electrolyte materials remains unresolved,hence hindering their further industrial application.Addressing this challenge,we designed and constructed a thermal-responsive imide-linked covalent organic framework(COF)bearing ortho-positioned hydroxy groups as precursors,which can conduct a thermal rearrangement to transform into a highly crystalline and robust benzoxazole-linked COF upon heating.Benefiting from the release of carbon dioxide through thermal rearrangement reaction,this COF platform exhibited excellent flame retardant properties.By contrast,classic COFs(e.g.,boronate ester,imine,olefin,imide linked)were all flammable.Moreover,incorpo-rating polyethylene glycol and Li salt into the COF channels can produce solid polymer electrolytes with outstanding flame retardancy,high ionic conductivity(6.42×10^(-4) S cm^(-1))and a high lithium-ion transference number of 0.95.This thermal rearrangement strategy not only opens a new route for the fabrication of ultrastable COFs,but also provides promising perspectives to designing flame-retardant materials for energy-related applications. | Zhifang Wang Yushu Zhang Penghui Zhang Dong Yan Jinjin Liu Yao Chen Qi Liu Peng Cheng Michael JZaworotko Zhenjie Zhang | 2022 | eScience2022，2，3： | 2 |
| 3 | Enzyme digestion to isolate and culture human scalp dermal papilla cells: a more efficient method显示文摘 | Jinjin J. Wu Rongqing Q. Liu Yuangang G. Lu Tangyou Y. Zhu Bo Cheng Xue Men | 2005 | Archives of Dermatological Research2005，，2： | 1 |
| 4 | Infer HIV transmission dynamics from gene sequences among young men who have sex with men in China显示文摘To investigate the transmission dynamics and temporal and spatial migration characteristics of HIV spread among men who have sex with men(MSM)in China,a total of 1012 HIV-1 partial pol sequences,including five subtypes,were studied.Bayesian analysis were applied for each subtype to infer its dynamic characters including the effective reproductive number(R_(e))and migration process.The mean curve of each R_(e) was almost always greater than 1(even the 95%highest posterior density(HPD)lower value)along with time,which supports the necessity for a comprehensive study about risk behaviors among young MSM group in China.We also should reappraise the free treatment strategy,especially the therapeutic effect during the free treatment policy. | Xin Jin Jinjin Cheng Jie Lou | 2021 | Infectious Disease Modelling2021，6，1： | 1 |
| 5 | Multiblock poly(ether-b-amide)copolymers comprised of PA1212 and PPO-PEO-PPO with specific moisture-responsive and antistatic properties显示文摘Functional multiblock poly(ether-b-amide)(PEBA)copolymers,comprised of PA1212(polyamide 1212)as hard segments and Jeffamine ED-2003 as soft segments,were successfully prepared via two-step melt polycondensation without any amidation catalyst.Here,using diamino-terminated poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide)(PPO-PEO-PPO),Jeffamine ED-2003,enhances the compatibility between polyamide oligomer and polyether,which is better than the traditional route using hydroxyl-terminated polyether.The chemical structure of multiblock PEBAs,as well as the microphase separated structure with crystalline phase of polyamide and polyether,were confirmed by heteronuclear multiple-bond correlation spectrum,heteronuclear multiple quantum correlation spectrum,Fourier transform infrared spectroscopy(FT-IR),differential scanning calorimetry and dynamic mechanical analysis.The hydrophilic PEBA copolymers showed water adsorption ranging from 87.3%to 17.1%depending on the polyether content,and specially showed moisture responsive behavior within seconds when exposed to moisture.The corresponding mechanism was studied using time-resolved attenuated total reflectance FT-IR spectroscopy in the molecular level and the water diffusion coefficient was estimated to be 1.07×10^(–8)cm^(2)∙s^(-1).Two-dimensional correlation FT-IR spectra analysis was performed to confirm that the interaction between water and polyether phase was in preference to that between water and polyamide matrix,and water molecule only forms hydrogen bond with the polyether segment.Due to the incorporation of PEO segments,the PEBAs have the surface resistivity varying from 5.6×10^(9)to 6.5×10^(10)Ω,which makes PEBA potential candidate as permanent antistatic agent. | Jie Jiang Wei Cheng Qiuyu Tang Xun Pan Jinjin Li Ling Zhao Zhenhao Xi Weikang Yuan | 2023 | Chinese Journal of Chemical Engineering2023，53，1： | 1 |
| 6 | Melt polymerization synthesis of a class of robust self-shaped olefin-linked COF foams as high-efficiency separators显示文摘The practical applications of crystalline porous materials toward industrial separations require shaping them into robust monoliths(e.g., foams). The current methods are often complicated, environmentally unfriendly, and unscalable, significantly hampering their practical application. Herein, we report a scalable, facile “one-step thermomolding” method to fabricate a class of hierarchically olefin-linked covalent organic framework(COF) foams via melt polymerization. The obtained pure COF foams possess higher crystallinity and porosity than literature, good moldability, and processability, greatly benefiting their practical applications(e.g., efficient oil-water separation with 99% removal efficiency and >100 cycle reusability). Moreover, a COF exhibiting the smallest(0.58 nm) eclipsed stacking pore among all 2-dimensional COFs with neutral skeletons is first fabricated via this protocol, demonstrating good C2 H2 purification performance and recyclability, surpassing the current benchmark materials. We believe that this facile fabrication strategy can promote access to a broad diversity of new COF foams and enlighten further avenues for green routes to large-scale synthesis and usage of COFs. | Penghui Zhang Zhifang Wang Yi Yang Sa Wang Ting Wang Jinjin Liu Peng Cheng Yao Chen Zhenjie Zhang | 2022 | Science China Chemistry2022，65，6： | 1 |
| 7 | Effect of C/SiC Volume Ratios on Mechanical and Oxidation Behaviors of C_(f)/C-SiC Composites Fabricated by Chemical Vapor Infiltration Technique显示文摘C/SiC volume ratios in carbon fiber-reinforced carbon-silicon carbide(C_(f)/C-SiC)composites may influence greatly mechanical and oxidation properties of the composites,but have not been well investigated yet.Herein,C_(f)/C-SiC composites with different C/SiC volume ratios were fabricated by chemical vapor infiltration(CVI)technique through alternating the thickness of a pyrocarbon(PyC)interlayer.The composites with C/SiC volume ratios of 0.37 and 0.84 exhibited the better comprehensive mechanical properties.The CS0.37 showed the highest flexural strength of 340.6 MPa,and CS0.84 had the maximum tensile strength of 139.1 MPa.The excellent mechanical properties were closely related to the relatively low C/SiC volume ratios and porosities,optimum interfacial bonding and reduced matrix micro-cracks.The composite with a low C/SiC volume ratio of 0.10 showed the best anti-oxidation performance due to its high SiC content.The oxidation mechanisms at 1100℃and 1400℃were discussed by considering the effect of the C/SiC volume ratios,pores and matrix micro-cracks,oxidation of carbon phase and SiC. | Jinjin Yao Shengyang Pang Yuanhong Wang Chenglong Hu Rida Zhao Jian Li Sufang Tang Hui-Ming Cheng | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，5： | 1 |
| 8 | Delineating the Source of Lead in the Urban Atmospheric Dust Based on Stable Isotopic Ratio: A Case Study from Panzhihua City of Southwest China显示文摘Atmospheric lead pollution is a global problem.Mining,coal mining,iron and steel smelting,and chemical and coal-fired power plants are major industries in Panzhihua City of southwest China.Many toxic and harmful heavy metals,including Pb,are emitted in production activities.Pb seriously affects human health and natural ecosystems.Thus,Pb source tracing is important for Pb pollution control(Souto-Oliveira et al.,2018;Zhao et al.,2015). | WANG Jinjin HUANG Yi LIU Rui CHENG Xin LONG Zhijie | 2019 | Acta Geologica Sinica(English Edition)2019，93，3： | 1 |
| 9 | Field-portable ratiometric fluorescence imaging of dual-color label-free carbon dots for uranyl ions detection with cellphone-based optical platform显示文摘Under the public spotlight,uranyl(UO22+)ions has attracted considerable attention for the extreme radioactive and chemical toxicity to ourselves and our environment.Herein,we present a simple and effective ratiometric fluorescence imaging method for the visualizing and quantitative detection UO22+ions by cellphone-based optical platform.The sensing solution was prepared by mixing label-free red carbon dots(r-CDs)and blue carbon dots(b-CDs)together with a fixed photoluminescence intensity ratio of 4:1.When UO22+ions were added,the fluorescence of r-CDs can be selectively quenched,while the fluorescence of b-CDs remains stable without spectral cha nges.With the gradually increase the amounts of UO22+ions,the different response of dual-color CDs resulted in a signification color evolution from deep red to dark purple under the ultraviolet(UV)light illumination.Then,a cellphone-based optical platform was constructed for directly imaging the color change of the samples,and the built-in Colorpicker APP quickly output the red,green and blue(RGB)channel values of these images within one second.Interesting,there was a linear relationship between the ratio of red and blue(R/B)channel values and UO22+ions concentration from 0μmol/L to 30.0μmol/L(R^2=0.92804)with the detection limit of^8.15μmol/L(signal-to-noise ratio of 3).In addition,the optical platform has also been applied to the quantification of UO22+ions in tap water and river water sample.With the advantage of low-cost,portable,easy to operation,we anticipate that this method would greatly improve the accessibility of UO22+ions detection even in resource-limited areas. | Jingjing Qian Nana Cao Jian Zhang Jinjin Hou Qian Chen Cheng Zhang Yudie Sun Shengjun Liu Lifang He Kui Zhang Haibo Zhou | 2020 | Chinese Chemical Letters2020，31，11： | 0 |
| 10 | Comparison of different strategies for controlling HIV/AIDS spreading in MSM显示文摘As proposed in the UNAIDSs 2014 report,to end global AIDS epidemic by 2030,90%of people living with HIV need to be diagnosed,90%of the diagnosed need to receive antiretroviral therapy(ART),and 90%of those on treatment need to achieve viral suppression(90-90-90 strategy).The strategies focus on the reservoir.It controls HIV spreading by reducing infectiousness of HIV infected individuals via diagnosis and treatment.In this manuscript,we compared the effects of HIV/AIDS interventions that focus on different individuals in MSM population through a dynamics model.Our results showed that,the success or not of the”90-90-90”strategies depends on a very important factor:the infectious strength among individuals taking ART.Without highly effective HIV treatment,the”90-90-90”strategies are likely to fail.Therefore,we call for the combination of both primary prevention among the susceptible with the 90-90-90 strategy among the infected to curb the HIV epidemic in Chinese MSM. | Jie Lou Jinjin Cheng Yan Li Chen Zhang Hui Xing Yuhua Ruan Yiming Shao | 2018 | Infectious Disease Modelling2018，3，1： | 0 |
| 11 | Decoding m^(6)A mRNA methylation by reader proteins in liver diseases显示文摘N6-methyladenosine(m^(6)A)is a dynamic and reversible epigenetic regulation.As the most prevalent internal post-transcriptional modification in eukaryotic RNA,it participates in the regulation of gene expression through various mechanisms,such as mRNA splicing,nuclear export,localization,translation efficiency,mRNA stability,and structural transformation.The involvement of m^(6)A in the regulation of gene expression depends on the specific recognition of m^(6)A-modified RNA by reader proteins.In the pathogenesis and treatment of liver disease,studies have found that the expression levels of key genes that promote or inhibit the development of liver disease are regulated by m^(6)A modification,in which abnormal expression of reader proteins determines the fate of these gene transcripts.In this review,we introduce m^(6)A readers,summarize the recognition and regulatory mechanisms of m^(6)A readers on mRNA,and focus on the biological functions and mechanisms of m^(6)A readers in liver cancer,viral hepatitis,non-alcoholic fatty liver disease(NAFLD),hepatic fibrosis(HF),acute liver injury(ALI),and other liver diseases.This information is expected to be of high value to researchers deciphering the links between m^(6)A readers and human liver diseases. | Lijiao Sun Xin Chen Sai Zhu Jianan Wang Shaoxi Diao Jinyu Liu Jinjin Xu Xiaofeng Li Yingyin Sun Cheng Huang Xiaoming Meng Xiongwen Lv Jun Li | 2024 | Genes & Diseases2024，11，2： | 0 |
| 12 | Pressure-Induced Intermetallic Charge Transfer and Semiconductor- Metal Transition in Two-Dimensional AgRuO_(3)显示文摘The intricate correlation between charge degrees of freedom and physical properties is a fascinating area of research in solid state chemistry and condensed matter physics.Herein,we report on the pressureinduced successive charge transfer and accompanied resistive evolution in honeycomb layered ruthenate AgRuO_(3).Structural revisiting and spectroscopic analyses affirm the ilmenite type R-3 structure with mixed valence cations as Ag^(+1/+2)Ru^(+4/+5)O_(3) at ambient pressure.In-situ pressure-and temperature-dependent resistance variation reveals a successive insulatormetal-insulator transition upon pressing,accompanied by unprecedented charge transfer between Ag and Ru under applied pressure,and a further structural phase transition in the insulator region at higher pressure.These phenomena are also corroborated by in-situ pressure-dependent Raman spectra,synchrotron X-ray diffraction,bond valence sums,and electronic structure calculations,emphasizing the dominated rare Ag2+,and near zero thermal expansion in the ab-plane in the metallic zone mostly due to the Jahn-Teller effect of d9-Ag2+.The multiple electronic instabilities in AgRuO_(3) may offer new possibilities toward novel and unconventionally physical and chemical behaviors in strongly correlated honeycomb lattices. | Chuanhui Zhu Jinjin Yang Pengfei Shan Mei-Huan Zhao Shuang Zhao Cuiying Pei Bowen Zhang Zheng Deng Mark Croft Yanpeng Qi Lihong Yang Yonggang Wang Xiaojun Kuang Long Jiang Dao-Xin Yao Jin-Guang Cheng Man-Rong Li | 2023 | CCS Chemistry2023，5，4： | 0 |
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