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| 1 | Distribution and Accumulation Characteristics of Heavy Metals in Sediments in Southern Sea Area of Huludao City, China显示文摘The southern sea area of the Huludao City, Liaoning Province might be polluted by heavy metals because it is close to the Jinzhou Bay, one of the heaviest sea area polluted by heavy metals in China. The undisturbed modern sediment core can be used to analyze the accumulation and source of the pollutants using 137 Cs and 210 Pb ex . Thirty-five samples of surface sediment and two core sediments were collected from the southern sea area of Huludao City. The concentrations of copper (Cu), lead (Pb), chrome (Cr), zinc (Zn), arsenic (As) and mercury (Hg) in the surface sediments as well as Cu, Pb, Zn, Cr, 137 Cs and 210 Pb ex in the core sediments were determined to research the spatial distribution and accumulation characteristics, and to analyze the sources and the potential risks of heavy metals. The results show that the pollution levels of Zn and Hg are serious, and 26 stations are at moderate or heavy ecological risks. The concentrations of the heavy metals increase from east to west, as well as from open sea to offshore marine area. The concentrations of heavy metals are not high in the sediments adjacent to the Jinzhou Bay, and the influence caused by the seawater exchange with the Jinzhou Bay is little. The concentrations of the heavy metals in the core sediments show low-high-low characteristic, and it coincides with the pollution history of Huludao City. The atmospheric deposition of heavy metals from the Huludao Zinc Plant is likely to be the main source of pollution without direct discharge of wastewater. The high concentrations of heavy metals appear on the upper sediment of 20 cm. The shallow sediment with high heavy metal contents might be exposed to surface when it was disturbed by the ocean engineering and big storm surge, then cause risk to the safety of aquaculture and human healthy. | WANG Yan LIU Ruhai FAN Dejiang YU Ping WANG Jinyu TANG Aikun | 2013 | Chinese Geographical Science2013，23，2： | 12 |
| 2 | Research on hybrid multi-terminal high-voltage DC technology for offshore wind farm integration显示文摘Multi-terminal high-voltage DC(MTDC)technology is a promising way to transmit large amounts of offshore wind power to the main grids.This paper proposes a hybrid MTDC scheme to integrate several offshore wind farms into the onshore power grids at different locations.A hybrid four-terminal HVDC system comprising two onshore line commutated converters(LCCs)and two voltage source converters(VSCs)connecting an offshore wind farm is constructed in PSCAD/EMTDC.A coordination control scheme based on the VSCs’AC voltage control and the LCCs’DC voltage droop control is designed to ensure smooth system operation and proper power sharing between onshore AC grids.The operational characteristics of the system are analyzed.In addition,a black start-up method without any auxiliary power supply for the VSCs is proposed.The transmission scheme is tested through simulations under various conditions,including start-up,wind speed variation,and the disconnection of one VSC or of one LCC. | Peng ZHAN Chenghao LI Jinyu WEN Yu HUA Meiqi YAO Naihu LI | 2013 | Journal of Modern Power Systems and Clean Energy2013，1，1： | 9 |
| 3 | Injectable ECM hydrogel for delivery of BMSCs enabled full-thickness meniscus repair in an orthotopic rat model显示文摘Meniscal injuries have poor intrinsic healing capability and are associated with the development of osteoarthritis.Decellularized meniscus extracellular matrix(mECM)has been suggested to be efficacious for the repair of meniscus defect.However,main efforts to date have been focused on the concentration,crosslinking density and anatomical region dependence of the mECM hydrogels on regulation of proliferation and differentiation of adult mesenchymal stem cells(MSCs)in vitro 2D or 3D culture.A systematic investigation and understanding of the effect of mECM on encapsulated MSCs response and integrative meniscus repair by in vivo rat subcutaneous implantation and orthotopic meniscus injury model will be highly valuable to explore its potential for clinical translation.In this study,we investigated the in situ delivery of rat BMSCs in an injectable mECM hydrogel to a meniscal defect in a SD rat model.Decellularized mECM retained essential proteoglycans and collagens,and significantly upregulated expression of fibrochondrogenic markers by BMSCs versus collagen hydrogel alone in vitro 3D cell culture.When applied to an orthotopic model of meniscal injury in SD rat,mECM is superior than collagen I scaffold in reduction of osteophyte formation and prevention of joint space narrowing and osteoarthritis development as evidenced by histology and micro-CT analysis.Taken together,these results indicate mECM hydrogel is a highly promising carrier to deliver MSCs for long-term repair of meniscus tissue,while preventing the development of osteoarthritis. | Gang Zhong Jun Yao Xing Huang Yixuan Luo Meng Wang Jinyu Han Fei Chen Yin Yu | 2020 | Bioactive Materials2020，5，4： | 9 |
| 4 | Research on fast solid state DC breaker based on a natural current zero-crossing point显示文摘The DC fault characteristics of voltage source converter based high voltage direct current(VSC-HVDC)systems are analyzed in this paper.The phenomenon whereby the capacitor on DC side discharges quickly during a DC fault contributes to a large short-circuit fault current.Neither traditional DC breakers nor DC switches can cut off the fault current under this condition.A fast solid state DC breaker design method is proposed in this paper.This method is based on the fault current characteristics of the inverter in multi-terminal HVDC systems(MTDC),where a fault current appears at the natural zerocrossing point near the inverter.At this point,by coordinating the AC breakers near the rectifier,the DC breaker could reliably cut off the DC fault current and protect the system.A detailed model for this fast solid state DC breaker and its operation sequence are studied,based on this design method.Simulations modeling a five-terminal meshed DC grid and a fast DC breaker were carried out with PSCAD/EMTDC using this design method.The results from the simulations confirmed the validity of the design method. | Wang XIANG Yu HUA Jinyu WEN Meiqi YAO Naihu LI | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，1： | 9 |
| 5 | Recent Progresses in Deep Learning Based Acoustic Models显示文摘In this paper,we summarize recent progresses made in deep learning based acoustic models and the motivation and insights behind the surveyed techniques.We first discuss models such as recurrent neural networks(RNNs) and convolutional neural networks(CNNs) that can effectively exploit variablelength contextual information,and their various combination with other models.We then describe models that are optimized end-to-end and emphasize on feature representations learned jointly with the rest of the system,the connectionist temporal classification(CTC) criterion,and the attention-based sequenceto-sequence translation model.We further illustrate robustness issues in speech recognition systems,and discuss acoustic model adaptation,speech enhancement and separation,and robust training strategies.We also cover modeling techniques that lead to more efficient decoding and discuss possible future directions in acoustic model research. | Dong Yu Jinyu Li | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，3： | 7 |
| 6 | Pigment analysis of a color-leaf mutant in Wandering Jew (Tradescantia fluminensis) irradiated by carbon ions显示文摘Many mutants of plant induced by heavy ion beam irradiation have been reported in recent years,but leaf anthocyan mutants induced by ion irradiation in evergreen were rarely found.In this study,a color-leaf mutant with purple leaves,stems and petals was isolated from clones of Wandering Jew irradiated by 95.8 MeV/u carbon ion beam.The concentration and histological distribution of leaf pigment were surveyed in wild type and mutant.In mutant,contents of total chlorophylls (Chl),chlorophyll a (Chl a),chlorophyll b (Chl b) and carotenoids (Car) decreased significantly,while concentration of the anthocyanins was 6.2-fold higher than that of wild type.Further composition analysis of anthocyanins by electrospray ionization mass spectrometry (ESI-MS) indicated that the purple pigmentation of leaves in mutant was caused by accumulation of petunidin anthocyanin.Microscopic examination showed that most petunidin anthocyanin accumulated in the lower epidermis,and little in vascular parenchyma of mutant,while there was no pigment in wild type.Meanwhile,in spongy parenchyma of mutant we observed little Chl,which the wild type abounds in.In conclusion,the color-leaf mutant of Wandering Jew induced by irradiation of carbon ions was improved in ornamental value,and it could be contribute to variation in level,component and distribution of foliar pigment.The possible mutation mechanisms were discussed. | HE Jinyu LU Dong YU Lixia LI Wenjian | 2011 | Nuclear Science and Techniques2011，22，2： | 4 |
| 7 | Genomic landscapes of Chinese sporadic autism spectrum disordersrevealed by whole-genome sequencing显示文摘Autism spectrum disorder (ASD) is a neurodevelopmental disorder with considerable clinical and genetic heterogeneity.In this study,we identified all classes of genomic variants from whole-genome sequencing (WGS) dataset of 32 Chinese trios with ASD,including de novo mutations,inherited variants,copy number variants (CNVs) and genomic structural variants.A higher mutation rate (Poisson test,P<2.2×10^(-16)) in exonic (1.37×10^(-8)) and 3'-UTR regions (1.42×10^(-8)) was revealed in comparison with that of whole genome (1.05×10^(-8)).Using an integrated model,we identified 87 potentially risk genes (P<0.01) from 4832 genes harboring various rare deleterious variants,including CHD8 and NRXN2,implying that the disorders may be in favor to multiple-hit.In particular,frequent rare inherited mutations of several microcephaly-associated genes (ASPM,WDR62,and ZNF335)were found in ASD.In chromosomal structure analyses,we found four de novo CNVs and one de novo chromosomal rearrangement event,including a de novo duplication of UBE3A-containing region at 15q11.2-q13.1,which causes Angelman syndrome and microcephaly,and a disrupted TNR due to de novo chromosomal translocation t (1;5) (q25.1;q33.2).Taken together,our results suggest that abnormalities of centrosomal function and chromatin remodeling of the microcephaly-associated genes may be implicated in pathogenesis of ASD.Adoption of WGS as a new yet efficient technique to illustrate the full genetic spectrum in complex disorders,such as ASD,could provide novel insights into pathogenesis,diagnosis and treatment. | Jinyu Wu Ping Yu Xin Jin Xiu Xu Jinchen Li Zhongshan Li Mingbang Wang Tao Wang Xueli Wu Yi Jiang Wanshi Cai Junpu Mei Qingjie Min Qiong Xu Bingrui Zhou Hui Guo Ping Wang Wenhao Zhou Zhengmao Hu Yingrui Li Tao Cai Yi Wang Kun Xia Yong-Hui Jiang Zhong Sheng Sun | 2018 | Journal of Genetics and Genomics2018，45，10： | 3 |
| 8 | A hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier ocular drug delivery platform显示文摘The objective of this study was to develop a novel hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier(NLC) drug delivery platform. An ophthalmic antiinflammatory drug, baicalin(BN) was chosen as the model drug. BN –NLC was prepared using melt-emulsification combined with ultra-sonication technique. Additionally, a dual pH-and thermo-sensitive hydrogel composed of carboxymethyl chitosan(CMCS) and poloxamer 407(F127) was fabricated by a cross-linking reaction with a nontoxic crosslinker genipin(GP). GP-CMCS/F127 hydrogel was characterized by FTIR, NMR, XRD and SEM. The swelling studies showed GP-CMCS/F127 hydrogel was both pH-and thermo-sensitive. The results of in vitro release suggested BN –NLC gel can prolong the release of baicalin comparing with BN eye drops and BN –NLC. Ex vivo cornea permeation study was evaluated using Franz diffusion cells. The apparent permeability coefficient(Papp) of BN –NLC gel was much higher(4.46-fold) than that of BN eye drops. Through the determination of corneal hydration levels, BN –NLC gel was confirmed that had no significant irritation to cornea. Ex vivo precorneal retention experiments were carried out by a flow-through approach. The results indicated that the NLC-based hydrogel can prolong precorneal residence time. In conclusion, the hybrid NLCbased hydrogel has a promising potential for application in ocular drug delivery. | Yibin Yu Ruoxi Feng Jinyu Li Yuanyuan Wang Yiming Song Guoxin Tan Dandan Liu Wei Liu Xinggang Yang Hao Pan Sanming Li | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，4： | 3 |
| 9 | Identification of the Quaternary low gas-saturation reservoirs in the Sanhu area of the Qaidam Basin,China显示文摘低煤气浸透的水库是煤气的忍受其煤气的浸透是不到 47% 的间隔。他们是普通的在在 Qaidam 盆的 Sanhu 区域第四级。由于复杂开始机制和特殊地质的特征,低煤气浸透的水库的记载的曲线被歧义和差异描绘,也就是没有重要木头反应特征。因此,在学习区域识别低煤气浸透的水库是特别地困难的。另外,传统的方法象在岩性学,电的性质,忍受性质的物理性质和气体之中使用关系那样,以及他们的阀值价值,不能有效地识别低 gassaturation 水库。解决这个问题,我们采用决定树,支持向量机器和建立低煤气浸透的水库的一个预兆的模型的不平的集合方法,它能够分类多维、模糊的数据的一个团。根据学习过程和学习结果的可理解性的透明性,预兆的模型被吸收实际水库特征也修订。实际应用显示预兆的模型在在学习区域识别低煤气浸透的水库是有效的。 | Li Xiongyan Li Hongqi Zhou Jinyu He Xu Chen Yihan Yu Hongyan | 2011 | Petroleum Science2011，8，1： | 2 |
| 10 | Precise robust motion control of cell puncture mechanism driven by piezoelectric actuators with fractional-order nonsingular terminal slidingmode control显示文摘A novel robust controller is proposed in this study to realize the precise motion control of a cell puncture mechanism(CPM)driven by piezoelectric ceramics(PEAs).The entire dynamic model of CPM is constructed based on the Bouc–Wen model,and the nonlinear part of the dynamic model is optimized locally to facilitate the construction of a robust controller.A model-based,nonlinear robust controller is constructed using time-delay estimation(TDE)and fractional-order nonsingular terminal sliding mode(FONTSM).The proposed controller does not require prior knowledge of unknown disturbances due to its real-time online estimation and compensation of unknown terms by using the TDE technology.The controller also has finite-time convergence and high-precision trajectory tracking capabilities due to FONTSM manifold and fast terminal sliding mode-type reaching law.The stability of the closed-loop system is proved by Lyapunov stability theory.Computer simulation and hardware-in-loop simulation experiments of CPM verify that the proposed controller outperforms traditional terminal sliding mode controllers,such as the integer-order or model-free controller.The proposed controller can also continuously output without chattering and has high control accuracy.Zebrafish embryo is used as a verification target to complete the cell puncture experiment.From the engineering application perspective,the proposed control strategy can be effectively applied in a PEA-driven CPM. | Shengdong Yu Hongtao Wu Mingyang Xie Haiping Lin Jinyu Ma | 2020 | Bio-Design and Manufacturing2020，3，4： | 2 |
| 11 | Wetting of polypropylene hollow fiber membrane contactors显示文摘 | Yuexia Lv Xinhai Yu Shan-Tung Tu Jinyue Yan Erik Dahlquist | 2010 | Journal of Membrane Science2010，，1： | 2 |
| 12 | Calibration of Confi- dence Measures in Speech Recognition 显示文摘 | Dong Yu Jinyu Li Li Deng | 2011 | IEEE Transactions on Audio Speech and Language Pro- cessing2011，19，8： | 1 |
| 13 | TZ-Container:protecting container from untrusted OS with ARM TrustZone显示文摘Containers are widely deployed on cloud platforms because of their low resource footprint, fast start-up time, and high performance, especially compared with their counterpart virtual machines. However,the Achilles’ heel of container technology is its weak isolation. For an attacker, jailbreaking into a host OS from a container is easier than attacking a hypervisor from a virtual machine, because of its notably larger attack surface and larger trusted computing base(TCB). Researchers have proposed various solutions to protect applications from untrusted OS;yet, few of them focus on protecting containers, especially those hosting multiple applications and shared by multiple users. In this paper, we first identify several new attacks that cannot be prevented using the existing solutions. Furthermore, we systematically analyze the security properties that should be maintained to defend against these attacks and protect a full-fledged container from a malicious host OS. We then present the TZ-Container, a TrustZone-based secure container mechanism that can keep all these security properties. The TZ-Container specifically leverages TrustZone to construct multiple isolated execution environments(IEEs). Each IEE has a memory space isolated from the underlying OS and any other processes. By interposing switching between the user and the kernel modes,IEEs enforce security checks on each system call according to its semantics. We have implemented TZContainer on the Hikey development board ensuring that it can support running unmodified Docker images downloaded from existing repositories such as http://gffzzb700e51cfd45483bs09v0xbk9pouf6vcf.ffgz.tsg.suse.edu.cn/. The evaluation results demonstrate that the TZ-Container has a performance overhead of approximately 5%. | Zhichao HUA Yang YU Jinyu GU Yubin XIA Haibo CHEN Binyu ZANG | 2021 | Science China(Information Sciences)2021，64，9： | 1 |
| 14 | Fabrication and characterization of superhydrophobic polypropylene hollow fiber membranes for carbon dioxide absorption显示文摘 | Yuexia Lv Xinhai Yu Jingjing Jia Shan-Tung Tu Jinyue Yan Erik Dahlquist | 2010 | Applied Energy2010，，1： | 1 |
| 15 | Effects of SO2 on CO2 capture using a hollow fiber membrane contactor显示文摘 | Yang Jie Yu Xinhai Yan Jinyue | 2013 | Applied Energy2013，112，： | 1 |
| 16 | Synergistic and opposing regulation of the stress-responsive gene IEX-1 by p53, c- Myc, and multiple NF-kB/rel complexes 显示文摘 | Huang Y H Wu Jinyu Zhang Yu | 2002 | Oncogene2002，21，44： | 1 |
| 17 | A unified framework of HMM adaptation with joint compensation of additive and convolutive distortions显示文摘 | Li Jinyu Deng Li Yu Dong | 2009 | Computer Speech & Language2009，23，3： | 1 |
| 18 | Biodieselproduction from waste cooking oilcatalyzed by TiO2–MgO mixed oxides显示文摘 | Zhenzhong Wen Xinhai Yu Shan-TungTu Jinyue Yan Erik Dahlquist | 2010 | Bioresource Technology2010，101，2010： | 1 |
| 19 | Adenovirus-mediated tissue factor pathway inhibitor gene transfer induces apoptosis by blocking the phosphorylation of JAK-2/STAT-3 pathway in vascular smooth muscle cells显示文摘 | Yu Fu Yong Zhao Yue Liu Yejing Zhu Jinyu Chi Jing Hu Xiaohui Zhang Xinhua Yin | 2012 | Cellular Signalling2012，，10： | 1 |
| 20 | Mutations of ANK3 identified by exome sequencing are associated with Autism susceptibility显示文摘 | Cheng Bi Jinyu Wu Tao Jiang Qi Liu Wanshi Cai Ping Yu Tao Cai Mei Zhao Yong‐hui Jiang Zhong Sheng Sun | 2012 | Hum Mutat2012，，12： | 1 |
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