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| 1 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 2 | Size-Dependent Joule Heating of Gold Nanoparticles Using Capacitively Coupled Radiofrequency Fields显示文摘Capacitively coupled shortwave radiofrequency fields(13.56 MHz)resistively heat low concentrations(~1 ppm)of gold nanoparticles with a thermal power dissipation of~380 kW/g of gold.Smaller diameter gold nanoparticles(<50 nm)heat at nearly twice the rate of larger diameter gold nanoparticles(≥50 nm),which is attributed to the higher resistivity of smaller gold nanostructures.A Joule heating model has been developed to explain this phenomenon and provides critical insights into the rational design and engineering of nanoscale materials for noninvasive thermal therapy of cancer. | Christine H.Moran Sean M.Wainerdi Tonya K.Cherukuri Carter Kittrell Benjamin J.Wiley Nolan W.Nicholas Steven A.Curley John S.Kanzius Paul Cherukuri | 2009 | Nano Research2009，2，5： | 4 |
| 3 | A randomised control trial of a self-management program for people with a chronic illness from Vietnamese, Chinese, Italian and Greek backgrounds显示文摘 | Hal Swerissen John Belfrage Amanda Weeks Lucinda Jordan Christine Walker John Furler Brian McAvoy Meredith Carter Chris Peterson | 2006 | Patient Education and Counseling2006，，1： | 2 |
| 4 | The pre-clinical absorption, distribution, metabolism and excretion properties of IPI-926, an orally bioavailable antagonist of the hedgehog signal transduction pathway显示文摘 | Sherri Smith Jennifer Hoyt Nigel Whitebread Joseph Manna Marisa Peluso Kerrie Faia Veronica Campbell Martin Tremblay Somarajan Nair Michael Grogan Alfredo Castro Matthew Campbell Jeanne Ferguson Brendan Arsenault Jylle Nevejans Bennett Carter John Lee Joi | 2013 | Xenobiotica2013，，10： | 1 |
| 5 | Apparent Idiopathic Hyponatremia in an Ambulatory Geriatric Population显示文摘 | Myron Miller Melanie S. Hecker Deborah A. Friedlander John M. Carter | 1996 | Journal of the American Geriatrics Society1996，，4： | 1 |
| 6 | Effect of Interface Friction on Tunnel Liner Internal Forces Due to Seismic S: and P-Wave Propagation 显示文摘 | GEORGE P Kouretzisn SCOTT W Sloan JOHN P Carter | 2013 | Soil Dynamics and Earthquake Engineering2013，46，： | 1 |
| 7 | Atmospheric carbon isotope signatures in phytolith-occluded carbon显示文摘 | John A. Carter | 2007 | Quaternary International2007，，1： | 1 |
| 8 | Temporal and spatial expression patterns of TUB9, a β-tubulin gene of Arabidopsis thaliana显示文摘 | Zigang Cheng D. Peter Snustad John V. Carter | 2001 | Plant Molecular Biology2001，，3： | 1 |
| 9 | Two β-tubulin genes, TUB1 and TUB8, of Arabidopsis exhibit largely nonoverlapping patterns of expression显示文摘 | Boyang Chu Theresa J. Wilson Christine McCune-Zierath D. Peter Snustad John V. Carter | 1998 | Plant Molecular Biology1998，，5： | 1 |
| 10 | Carcinoma of the pancreatic head and periampullary region 显示文摘 | John TG Greig JD Carter DC | 1995 | Ann Surg1995，221，2： | 1 |
| 11 | The Swift Ultra-Violet/Optical Telescope显示文摘 | Peter W. A. Roming Thomas E. Kennedy Keith O. Mason John A. Nousek Lindy Ahr Richard E. Bingham Patrick S. Broos Mary J. Carter Barry K. Hancock Howard E. Huckle S D. Hunsberger Hajime Kawakami Ronnie Killough T Scott Koch Michael K. Mclelland Kelly Smith | 2005 | Space Science Reviews (-)2005，，3： | 1 |
| 12 | Pressure measurements on the impingement surface of sonic and sub-sonic jets impinging onto a flat plate at inclined angles 显示文摘 | Jim Crafton Campbell Carter John Sullivan | 2006 | Experiments in Fluids2006，44，5： | 1 |
| 13 | Superior staging of liver tumors with laparoscopy and laparoscopic ultrasonography显示文摘 | Greig JD Carter DC | 1995 | Ann Sury1995，221，2： | 1 |
| 14 | Recurrent intrapulmonary malignant small cell tumor of the thoracopulmonary region with metastasis to the oral cavity:review of literature and case report显示文摘 | Smith JD Bruce Carter A | 1995 | Ultra Path1995，19，： | 1 |
| 15 | Related Articles,Nucleotide,Protein Human keratinocytes express a new CD44 core protein(CD44E) as a heparan-sulfate Intrinsic membrane proteoglycan with additional exons显示文摘 | Brow TA Bouchard T St John T Wayner E Carter WG | 1991 | J Cell Biol1991，113，1： | 1 |
| 16 | Some computational aspects for solving deep penetration problems in geomechanics显示文摘 | SHENG DAI-CHAO NAZEM MAJIDREZA CARTER JOHN P | 2009 | Computational Mechanics2009，44，： | 1 |
| 17 | Effect of hydraulic hysteresis on seepage analysis for unsatu- rated soils显示文摘 | CHAO Yang DAI Chao-sheng John P Carter | 2012 | Computers and Geotechnics2012，41，4： | 1 |
| 18 | The efficacy of mitomycin and stenting in choanal atresia repair: A 20 year experience显示文摘 | John M. Carter Claire Lawlor J. Lindhe Guarisco | 2013 | International Journal of Pediatric Otorhinolaryngology2013，，： | 1 |
| 19 | Institutional Variation in the Surgical Treatment of Breast Cancer: A Study of the NCCN显示文摘 | Caprice C. Greenberg Stuart R. Lipsitz Melissa E. Hughes Stephen B. Edge Richard Theriault John L. Wilson W. Bradford Carter Douglas W. Blayney Joyce Niland Jane C. Weeks | 2011 | Annals of Surgery2011，，2： | 1 |
| 20 | Combined Lung and Liver Transplantation: The United States Experience显示文摘 | Neal R. Barshes Daniel J. DiBardino E Dean McKenzie Timothy C. Lee Stephen A. Stayer George B. Mallory Saul J. Karpen Ruben E. Quiros-Tejeira Beth A. Carter Charles D. Fraser John A. Goss | 2005 | Transplantation2005，，9： | 1 |
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