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| 1 | Current medical management of endocrine-related male infertility显示文摘男因素贡献全面不孕的 50%-60% ,但是是完全负责的在仅仅 20% 夫妇。尽管很男的因素不孕从反常精液分析被查明,如果样品归还正常,另外的男因素能特别是贡献的。男不孕能由于可能可逆或不可逆的可看作是相同的神经质或解剖的病原学。这张手稿将包括多种维生素,雌激素受体调节的人(clomiphene ) ,雌激素变换 blockers (anastrozole ) ,和荷尔蒙代替为男不孕和实验治疗为荷尔蒙评估加亮存在指南和我们的建议。 | Joshua D Ring Aye A Lwin Tobias S Kohler | 2016 | Asian Journal of Andrology2016，18，3： | 12 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies显示文摘 | Lehmann Brian D Bauer Joshua A Chen Xi Sanders Melinda E Chakravarthy A Bapsi Shyr Yu Pietenpol Jennifer A | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 4 | Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Christopher J L Murray Theo Vos Rafael Lozano Mohsen Naghavi Abraham D Flaxman Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Mohammad A | 2012 | The Lancet . 2012 (9859)2012，，9859： | 2 |
| 5 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Theo Vos Abraham D Flaxman Mohsen Naghavi Rafael Lozano Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Mohammad A AlMazroa Miriam Alvara | 2012 | The Lancet . 2012 (9859)2012，，9859： | 2 |
| 6 | Acid Suppressants Reduce Risk of Gastrointestinal Bleeding in Patients on Antithrombotic or Anti-Inflammatory Therapy显示文摘 | Kueiyu Joshua Lin Sonia Hernández–Díaz Luis A. García Rodríguez | 2011 | Gastroenterology2011，，1： | 1 |
| 7 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Theo Vos Abraham D Flaxman Mohsen Naghavi Rafael Lozano Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Mohammad A AlMazroa Miriam Alvara | 2012 | The Lancet2012，，9859： | 1 |
| 8 | Rationale for the use of optical mice chips for economic and accurate vehicle tracking 显示文摘 | JOSHUA D J DALE W C JON M A | 2007 | Automation Science Engineering2007，，9： | 1 |
| 9 | Consequences of Employment Protection? The Case of the Americans with Disabilities Act 显示文摘 | DARON A JOSHUA D A | 2001 | The Journal of Political Economy2001，109，5： | 1 |
| 10 | Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches显示文摘 | Robert Machold Shigemi Hayashi Michael Rutlin Mandar D Muzumdar Susana Nery Joshua G Corbin Amel Gritli-Linde Tammy Dellovade Jeffery A Porter Lee L Rubin Henryk Dudek Andrew P McMahon Gord Fishell | 2003 | Neuron2003，，1： | 1 |
| 11 | Silicene and transition metal based materials: prediction of a two-dimensionalpiezomagnet显示文摘 | Nelson Y Dzade Kingsley O Obodo Sampson K Adjokatse Akosa C Ashu Emmanuel Amankwah Clement D Atiso Abdulhakeem A Bello Emmanuel Igumbor Stany B Nzabarinda Joshua T Obodo Anthony O Ogbuu Olu Emmanuel Femi Josephine O Udeigwe Umesh V Waghmare | 2010 | Journal of Physics: Condensed Matter2010，，： | 1 |
| 12 | 显示文摘 | Zoran D P Stephen J A Joshua L G | 1998 | Phys Chem B1998，102，： | 1 |
| 13 | Identification of human triple-negative breast cancer subtypes end Targets of Triple-negative Breast Cancer 显示文摘 | Brian D Lehmann Joshua A Bauer Xi Chen | 2011 | Journal of Clinical Investigation2011，121，7： | 1 |
| 14 | Characterization of gut microbiome and metabolome in Helicobacter pylori patients in an underprivileged community in the United States显示文摘BACKGROUND Helicobacter pylori(H.pylori),a bacterium that infects approximately half of the world’s population,is associated with various gastrointestinal diseases,including peptic ulcers,non-ulcer dyspepsia,gastric adenocarcinoma,and gastric lymphoma.As the burden of antibiotic resistance increases,the need for new adjunct therapies designed to facilitate H.pylori eradication and reduce negative distal outcomes associated with infection has become more pressing.Characterization of the interactions between H.pylori,the fecal microbiome,and fecal fatty acid metabolism,as well as the mechanisms underlying these interactions,may offer new therapeutic approaches.AIM To characterize the gut microbiome and metabolome in H.pylori patients in a socioeconomically challenged and underprivileged inner-city community.METHODS Stool samples from 19 H.pylori patients and 16 control subjects were analyzed.16S rRNA gene sequencing was performed on normalized pooled amplicons using the Illumina MiSeq System using a MiSeq reagent kit v2.Alpha and beta diversity analyses were performed in QIIME 2.Non-targeted fatty acid analysis of the samples was carried out using gas chromatography-mass spectrometry,which measures the total content of 30 fatty acids in stool after conversion into their corresponding fatty acid methyl esters.Multi-dimensional scaling(MDS)was performed on Bray-Curtis distance matrices created from both the metabolomics and microbiome datasets and a Procrustes test was performed on the metabolomics and microbiome MDS coordinates.RESULTS Fecal microbiome analysis showed that alpha diversity was lowest in H.pylori patients over 40 years of age compared to control subjects of similar age group.Beta diversity analysis of the samples revealed significant differences in microbial community structure between H.pylori patients and control subjects across all ages.Thirty-eight and six taxa had lower and higher relative abundance in H.pylori patients,respectively.Taxa that were enriched in H.pylori patients included Atopobium,Gemellaceae,Micrococcaceae,Gemellales and Rothia(R.mucilaginosa).Notably,relative abundance of the phylum Verrucomicrobia was decreased in H.pylori patients compared to control subjects.Procrustes analysis showed a significant relationship between the microbiome and metabolome datasets.Stool samples from H.pylori patients showed increases in several fatty acids including the polyunsaturated fatty acids(PUFAs)22:4n6,22:5n3,20:3n6 and 22:2n6,while decreases were noted in other fatty acids including the PUFA 18:3n6.The pattern of changes in fatty acid concentration correlated to the Bacteroidetes:Firmicutes ratio determined by 16S rRNA gene analysis.CONCLUSION This exploratory study demonstrates H.pylori-associated changes to the fecal microbiome and fecal fatty acid metabolism.Such changes may have implications for improving eradication rates and minimizing associated negative distal outcomes. | Brian White John D Sterrett Zoya Grigoryan Lauren Lally Jared D Heinze Hyder Alikhan Christopher A Lowry Lark J Perez Joshua DeSipio Sangita Phadtare | 2021 | World Journal of Gastroenterology2021，27，33： | 1 |
| 15 | Laboratory, epidemiological, and human intervention studies show that tea (Camellia sinensis) may be useful in the prevention of obesity显示文摘 | KIMBERLY A G JOSHUA D L | 2010 | J Null''2010，140，： | 1 |
| 16 | Real-world cure rates for hepatitis C virus treatments that include simeprevir and/or sofosbuvir are comparable to clinical trial results显示文摘AIM To assess the real-world effectiveness and cost of simeprevir(SMV), and/or sofosbuvir(SOF)-based therapy for chronic hepatitis C virus(HCV) infection.METHODS The real-world performance of patients treated with SMV/SOF ± ribavirin(RBV), SOF/RBV, and SOF/RBV with pegylated-interferon(PEG) were analyzed in a consecutive series of 508 patients with chronic HCV infection treated at a single academic medical center. Patients with genotypes 1 through 4 were included. Rates of sustained virological response-the absence of a detectable serum HCV RNA 12 wk after the end of treatment [sustained virological response(SVR) 12]-were calculated on an intention-to-treat basis. Costs were calculated from the payer's perspective using Medicare/Medicaid fees and Redbook Wholesale Acquisition Costs. Patient-related factors associated with SVR12 were identified using multivariable logistic regression.RESULTS SVR 12 rates were as follows: 86%(95%CI: 80%-91%)among 178 patients on SMV/SOF ± RBV; 62%(95%CI: 55%-68%) among 234 patients on SOF/RBV; and 78%(95%CI: 68%-86%) among 96 patients on SOF/PEG/RBV. Mean costs-per-SVR 12 were $174442(standard deviation: ± $18588) for SMV/SOF ± RBV; $223003(± $77946) for SOF/RBV; and $126496(± $31052) for SOF/PEG/RBV. Among patients on SMV/SOF ± RBV, SVR12 was less likely in patients previously treated with a protease inhibitor [odds ratio(OR): 0.20, 95%CI: 0.06-0.56]. Higher bilirubin(OR: 0.47, 95%CI: 0.30-0.69) reduced the likelihood of SVR12 among patients on SOF/RBV, while FIB-4 score ≥ 3.25 reduced the likelihood of SVR 12(OR: 0.18, 95%CI: 0.05-0.59) among those on SOF/PEG/RBV. CONCLUSION SVR 12 rates for SMV and/or SOF-based regimens in a diverse real-world population are comparable to those in clinical trials. Treatment failure accounts for 27% of costs. | Kian Bichoupan Neeta Tandon James F Crismale Joshua Hartman David Del Bello Neal Patel Sweta Chekuri Alyson Harty Michel Ng Keith M Sigel Meena B Bansal Priya Grewal Charissa Y Chang Jennifer Leong Gene Y Im Lawrence U Liu Joseph A Odin Nancy Bach Scott L Friedman Thomas D Schiano Ponni V Perumalswami Douglas T Dieterich Andrea D Branch | 2017 | World Journal of Virology2017，6，4： | 1 |
| 17 | Healthy life expectancy for 187 countries, 1990–2010: a systematic analysis for the Global Burden Disease Study 2010显示文摘 | Joshua A Salomon Haidong Wang Michael K Freeman Theo Vos Abraham D Flaxman Alan D Lopez Christopher JL Murray | 2012 | The Lancet . 2012 (9859)2012，，9859： | 1 |
| 18 | Patients with mutations in Csαhave reduced activation of adownstream target in epithelial tissues due to haploinsufficiency显示文摘 | Stephanie C H Joshua D G Christian A M | 2007 | The Journal of Clinical Endocrinology and Metabolism2007，92，10： | 1 |
| 19 | Prestorage heat treatment delays development of superficial scald on ‘Granny Smith' apples显示文摘 | Lurie S Joshua D K Ruth B A | 1991 | Hortscience1991，26，2： | 1 |
| 20 | A review of mem- brane sampling from biological tissues with applications in phar- macokinetics, metabolism and pharmacodynamics 显示文摘 | Garrisona K E Stephanie A P Joshua D | 2002 | Eur J Pharm Sci2002，17，12： | 1 |
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