|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Blockade of Tim-3 Pathway Ameliorates Interferon-γ Production from Hepatic CD8^+ T Cells in a Mouse Model of Hepatitis B Virus Infection显示文摘T cell immunoglobulin-and mucin-domain-containing molecule-3(Tim-3) has been reported to participate in the pathogenesis of inflammatory diseases. However,whether Tim-3 is involved in hepatitis B virus(HBV) infection remains unknown. Here,we studied the expression and function of Tim-3 in a hydrodynamics-based mouse model of HBV infection. A significant increase of Tim-3 expression on hepatic T lymphocytes,especially on CD8+ T cells,was demonstrated in HBV model mice from day 7 to day 18. After Tim-3 knockdown by specific shRNAs,significantly increased IFN-γ production from hepatic CD8+ T cells in HBV model mice was observed. Very interestingly,we found Tim-3 expression on CD8+ T cells was higher in HBV model mice with higher serum anti-HBs production. Moreover,Tim-3 knockdown influenced anti-HBs production in vivo. Collectively,our data suggested that Tim-3 might act as a potent regulator of antiviral T-cell responses in HBV infection. | Ying Ju Nan Hou Xiaoning Zhang Di Zhao Ying Liu Jinjin Wang Fang Luan Wei Shi Faliang Zhu Wensheng Sun Lining Zhang Chengjiang Gao Lifen Gao Xiaohong Liang Chunhong Ma | 2009 | Cellular & Molecular Immunology2009，6，1： | 19 |
| 2 | Urban expansion in China and its effect on cultivated land before and after initiating'Reform and Open Policy'显示文摘Urbanization in China has expanded at an unprecedented speed since the declaration of 'Reform and Open Policy'and presented many challenges. Unbalanced regional development, appearance of super megacities and concomitant problems,and conflicts between urbanization and cultivated land protection are three critical problems that Chinese urbanization has to face. To develop new plans for foreseeable future urbanization in China, it is critical to understand the evolving history of cities across China. This study maps urban expansion of 60 typical Chinese cities based on large amount of remote sensing data and the labor-intensive image interpretation method, in order to understand the history of urban expansion from the 1970 s to 2013.Results showed that area of cities expanded 5.23 times compared to their area in the 1970 s. Urban expansion in China accelerated three times(1988–1996, 1999–2006, and 2009–2011) and decelerated three times(1997–1998, 2007–2008, and 2012–2013) over the 40 years. The urban area of South China expanded most significantly 9.42 times, while the urban area in Northeast China expanded only 2.37 times. The disparity among different administrative ranks of cities was even greater than(3.81 times) the differences among different regions. Super megacities have been continuously expanding at a fast rate(8.60-fold), and have not shown obvious signs of slowing down. The proportion of cultivated land among the land sources for urban expansion decreased to a small extent in the 1990 s, but cultivated land continues to be the major land source for urban expansion. Effective future urbanization needs controlling the expansion scale of large cities and reasonably developing medium and small cities, as well as balancing regional development. | ZHANG ZengXiang WEN QingKe LIU Fang ZHAO XiaoLi LIU Bin XU JinYong YI Ling HU ShunGuang WANG Xiao ZUO LiJun LI Na LI MinMin SHI LiFeng ZENG Tian JU HongRun | 2016 | Science China Earth Sciences2016，59，10： | 12 |
| 3 | Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals显示文摘线粒体为精力新陈代谢和反应的氧种类(ROS ) 的生产是必要的。在未经触动的房间,呼吸线粒体展览自发的 “ superoxide flashes”,对短暂 mitochondrial 渗透转变(tMPT ) 结果的 quantal 生产 ROS 事件。这里,我们在表示 superoxide 生物传感器 mt-cpYFP 的生活老鼠在 mitochondrial superoxide 闪光和 tMPT 活动的 vivo 成像执行第一,并且表明他们联合到整个身体的葡萄糖新陈代谢。柔韧的 tMPT/superoxide 闪光活动发生在骨胳的肌肉和 anesthetized 的臀部的神经转基因的老鼠。在骨胳的肌肉,成像 tMPT/superoxide 闪光揭示了线粒体的迷宫的三维的网络同时地操作。tMPT/superoxide 闪光活动响应全身的葡萄糖挑战或胰岛素刺激澎湃,以一种显然调制频率的方式并且也在 tMPT 的 gating 模式包含移动。因此,在 tMPT 依赖的 mitochondrial ROS 的 vivo 成像,信号和 metabolism-tMPT-superoxide 的发现闪光联合标记为 mitochondrial 功能并且 ROS 处于健康和疾病发信号的学习的重要工艺、概念的进展。 | Huaqiang Fang Min Chen Yi Ding Wei Shang Jiejia Xu Xing Zhang Wanrui Zhang Kaitao Li Yao Xiao Feng Gao Shujiang Shang Jing-Chao Li Xiao-Li Tian Shi-Qiang Wang Jingsong Zhou Noah Weisleder Jianjie Ma Kunfu Ouyang Ju Chen Xianhua Wang Ming Zheng Wang Wang Xiuqin Zhang Heping Cheng | 2011 | Cell Research2011，21，9： | 11 |
| 4 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 5 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 6 | Simulation of Paleotectonic Stress Fields and Distribution Prediction of Tectonic Fractures at the Hudi Coal Mine, Qinshui Basin显示文摘Study on tectonic fractures based on the inversion of tectonic stress fields is an effective method. In this study, a geological model was set up based on geological data from the Hudi Coal Mine, Qinshui Basin, a mechanical model was established under the condition of rock mechanics and geostress, and the finite element method was used to simulate the paleotectonic stress field. Based on the Griffith and Mohr-Coulomb criterion, the distribution of tectonic fractures in the Shanxi Formation during the Indosinian, Yanshanian, and Himalayan period can be predicted with the index of comprehensive rupture rate. The results show that the acting force of the Pacific Plate and the India Plate to the North China Plate formed the direction of principal stress is N-S, NW-SE, and NE-SW, respectively, in different periods in the study area. Changes in the direction and strength of the acting force led to the regional gradients of tectonic stress magnitude, which resulted in an asymmetrical distribution state of the stress conditions in different periods. It is suggested that the low-stress areas are mainly located in the fault zones and extend along the direction of the fault zones. Furthermore, the high-stress areas are located in the junction of fold belts and the binding site of multiple folds. The development of tectonic fractures was affected by the distribution of stress intensity and the tectonic position of folds and faults, which resulted in some developed areas with level Ⅰ and Ⅱ. There are obvious differences in the development of tectonic fractures in the fold and fault zones and the anticline and syncline structure at the same fold zones. The tectonic fractures of the Shanxi Formation during the Himalayan period are more developed than those during the Indosinian and Yanshanian period due to the superposition of the late tectonic movement to the early tectonic movement and the differences in the magnitude and direction of stress intensity. | FANG Huihuang SANG Shuxun WANG Jilin LIU Shiqi JU Wei | 2017 | Acta Geologica Sinica(English Edition)2017，91，6： | 8 |
| 7 | Effect of Calcium Oxide Additive on the Performance of Iron Oxide Sorbent for High-Temperature Coal Gas Desulfurization显示文摘The effect of calcium oxide additive in iron oxide sorbent for hot gas desulfurization was investigated by XRD and TPR techniques.XRD characterization showed that CaO was highly dispersed after the calcination of sorbents.Calcium sulfate formed in the desulfurization was decomposed and regenerated to CaO by reacting with CO before the next sulfidation process.Calcium participated in every sulfidation/regeneration cycle and contributed to the enhancement of sulfur capacity.The TPR results showed that the reduction temperature of the sorbent increased with the increase of the content of calcium.Calcium played a role of retarding reduction.Therefore,the addition of calcium oxide additive will benefit the utilization of iron oxide sorbent in strongly reducing atmospheres. | Huiling Fan Kechang Xie Ju Shangguan Fang Shen Chunhu Li | 2007 | Journal of Natural Gas Chemistry2007，16，4： | 7 |
| 8 | A Multicenter Study of Viral Aetiology of Community-Acquired Pneumonia in Hospitalized Children in Chinese Mainland显示文摘Community-acquired pneumonia(CAP) is one of the leading causes of morbidity and mortality in children worldwide.In this study,we aimed to describe the aetiology of viral infection of pediatric CAP in Chinese mainland.During November2014 to June 2016,the prospective study was conducted in 13 hospitals.The hospitalized children under 18 years old who met the criteria for CAP were enrolled.The throat swabs or nasopharyngeal aspirates(NPAs) were collected which were then screened 18 respiratory viruses using multiplex PCR assay.Viral pathogens were present in 56.6%(1539/2721) of the enrolled cases,with the detection rate of single virus in 39.8% of the cases and multiple viruses in 16.8% of the cases.The most frequently detected virus was respiratory syncytial virus(RSV)(15.2%,414/2721).The highest detection rate of virus was in <6-month-age group(70.7%,292/413).RSV,human metapneumovirus(HMPV),human parainfluenza viruses(HPIVs) and influenza B virus(Flu B) showed the similar prevalence patterns both in north and south China,but HPIVs,Flu A,human bocavirus(HBoV),human adenovirus(HAdV) and human coronaviruses(HCoVs) showed the distinct circulating patterns in north and south China.Human enterovirus/human rhinovirus(HEV/HRV)(27.6%,27/98),HBoV(18.4%,18/98),RSV(16.3%,16/98) and HMPV(14.3%,14/98) were the most commonly detected viruses in severe pneumonia cases with single virus infection.In conclusion,viral pathogens are frequently detected in pediatric CAP cases and may therefore play a vital role in the aetiology of CAP.RSV was the most important virus in hospitalized children with CAP in Chinese mainland. | Yun Zhu Baoping Xu Changchong Li Zhimin Chen Ling Cao Zhou Fu Yunxiao Shang Aihuan Chen Li Deng Yixiao Bao Yun Sun Limin Ning Shuilian Yu Fang Gu Chunyan Liu Ju Yin Adong Shen Zhengde Xie Kunling Shen | 2021 | Virologica Sinica2021，36，6： | 7 |
| 9 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 10 | China Nutrition and Health Surveys(1982−2017)显示文摘The status of nutrition and health among residents is one of the important indicators reflecting the developing level in a country or a region.China’s government initiated the first China National Nutrition Survey in 1959.The Second National Nutrition Survey and the Third National Nutrition Survey were then conducted in 1982 and 1992,respectively(1-2).The China National Nutrition and Health Survey(2002)combined the nutrition and chronic diseases survey and became the fourth survey(3). | Dongmei Yu Liyun Zhao Jian Zhang Zhenyu Yang Lichen Yang Jian Huang Hongyun Fang Qiya Guo Xiaoli Xu Lahong Ju Gangqiang Ding | 2021 | China CDC weekly2021，3，9： | 6 |
| 11 | An evaluation of moving shadow detection techniques显示文摘Shadows of moving objects may cause serious problems in many computer vision applications,including object tracking and object recognition. In common object detection systems, due to having similar characteristics, shadows can be easily misclassified as either part of moving objects or independent moving objects. To deal with the problem of misclassifying shadows as foreground, various methods have been introduced. This paper addresses the main problematic situations associated with shadows and provides a comprehensive performance comparison on up-todate methods that have been proposed to tackle these problems. The evaluation is carried out using benchmark datasets that have been selected and modified to suit the purpose. This survey suggests the ways of selecting shadow detection methods under different scenarios. | Mosin Russell Ju Jia Zou Gu Fang | 2016 | Computational Visual Media2016，2，3： | 6 |
| 12 | Anthocyanin profi les and color properties of red wines made from Vitis davidii and Vitis vinifera grapes显示文摘Spine grape(Vitis davidii Foex.)is an important wild grape species native to China.Fifteen red spine grape clones and three red Vitis vinifera grape varieties were used to evaluate the differences in the anthocyanin profiles and color properties of wines made from V.davidii and V.vinifera grapes.Among spine wines,‘Junzi#2’wine had the highest total phenolic and total anthocyanin,‘Xiangzhenzhu’wine had the highest total flavonoids,and‘Junzi#1’wine had the highest total tannin.The anthocyanin compositions of all of the spine wines were dominated by Mv-3,5-diglucoside.The total individual anthocyanin contents in spine wines,except‘Gaoshan#5’,‘Junzi#5055’,‘Junzi#5061’,and‘Junzi#5044’,were signifi cantly higher than in V.vinifera wines.Most of the spine wines had a stronger red intensity and a brighter chroma with a bluer hue than V.vinifera wines.Correlation analysis revealed that the color properties were closely related to the anthocyanin composition.These results suggest that wines made from spine grapes may be useful for the wine industry for their color properties and high individual anthocyanin contents. | Yanlun Ju La Yang Xiaofeng Yue Yunkui Li Rui He Shenglin Deng Xin Yang Yulin Fang | 2021 | Food Science and Human Wellness2021，10，3： | 5 |
| 13 | Bone Loss Induced by Simulated Microgravity,Ionizing Radiation and/or Ultradian Rhythms in the Hindlimbs of Rats显示文摘Objective To better understand the pathological causes of bone loss in a space environment, including microgravity, ionizing radiation, and ultradian rhythms. Methods Sprague Dawley(SD) rats were randomly divided into a baseline group, a control group, a hindlimb suspension group, a radiation group, a ultradian rhythms group and a combined-three-factor group. After four weeks of hindlimb suspension followed by X-ray exposure and/or ultradian rhythms, biomechanical properties, bone mineral density, histological analysis, microstructure parameters, and bone turnover markers were detected to evaluate bone loss in hindlimbs of rats. Results Simulated microgravity or combined-three factors treatment led to a significant decrease in the biomechanical properties of bones, reduction in bone mineral density, and deterioration of trabecular parameters. Ionizing radiation exposure also showed adverse impact while ultradian rhythms had no significant effect on these outcomes. Decrease in the concentration of the turnover markers bone alkaline phosphatase(b ALP), osteocalcin(OCN), and tartrate-resistant acid phosphatase-5 b(TRAP-5 b) in serum was in line with the changes in trabecular parameters. Conclusion Simulated microgravity is the main contributor of bone loss. Radiation also results in deleterious effects but ultradian rhythms has no significant effect. Combined-three factors treatment do not exacerbate bone loss when compared to simulated microgravity treatment alone. | ZHANG Ya Nan SHI Wen Gui LI He HUA Jun Rui FENG Xiu WEI Wen Jun WANG Ju Fang HE Jin Peng LEI Su Wen | 2018 | Biomedical and Environmental Sciences2018，31，2： | 4 |
| 14 | Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation显示文摘Myocardial infarction(MI)leads to the loss of cardiomyocytes,left ventricle dilation and cardiac dysfunction,eventually developing into heart failure.Mzb1(Marginal zone B and B1 cell specific protein 1)is a B-cell-specific and endoplasmic reticulum-localized protein.Mzb1 is an inflammation-associated factor that participates a series of inflammatory processes,including chronic periodontitis and several cancers.In this study we investigated the role of Mzb1 in experimental models of MI.MI was induced in mice by ligation of the left descending anterior coronary artery,and in neonatal mouse ventricular cardiomyocytes(NMVCs)by H2O_(2)treatment in vitro.We showed that Mzb1 expression was markedly reduced in the border zone of the infarct myocardium of MI mice and in H2O_(2)-treated NMVCs.In H2O_(2)-treated cardiomyocytes,knockdown of Mzb1 decreased mitochondrial membrane potential,impaired mitochondrial function and promoted apoptosis.On contrary,overexpression of Mzb1 improved mitochondrial membrane potential,ATP levels and mitochondrial oxygen consumption rate(OCR),and inhibited apoptosis.Direct injection of lentiviral vector carrying Len-Mzb1 into the myocardial tissue significantly improved cardiac function and alleviated apoptosis in MI mice.We showed that Mzb1 overexpression significantly decreased the levels of Bax/Bcl-2 and cytochrome c and improved mitochondrial function in MI mice via activating the AMPK-PGC1αpathway.In addition,we demonstrated that Mzb1 recruited the macrophages and alleviated inflammation in MI mice.We conclude that Mzb1 is a crucial regulator of cardiomyocytes after MI by improving mitochondrial function and reducing inflammatory signaling pathways,implying a promising therapeutic target in ischemic cardiomyopathy. | Lu Zhang Yi-ning Wang Jia-ming Ju Azaliia Shabanova Yue Li Ruo-nan Fang Jia-bin Sun Ying-ying Guo Tong-zhu Jin Yan-yan Liu Tian-yu Li Hong-li Shan Hai-hai Liang Bao-feng Yang | 2021 | Acta Pharmacologica Sinica2021，42，5： | 3 |
| 15 | Intake of Vitamin A,Thiamine,Riboflavin,Vitamin C,and Niacin Among Children Aged 6−11 Years Old—China,2016−2017显示文摘Summary What is already known on this topic?Insufficient intake of vitamins is one of the major nutritional problems in children aged 6-11 years old in China,and the problem is particularly severe for rural populations.What is added by this report?Among children aged 6-11 years old in 2016-2017,the average intakes of vitamin A,thiamine. | Wei Piao Lahong Ju Hongyun Fang Qiya Guo Shuya Cai Xiaoli Xu Shujuan Li Xue Cheng Liyun Zhao Dongmei Yu | 2021 | China CDC weekly2021，3，11： | 3 |
| 16 | A new C_(21)-steroidal glycoside from Cynanchum stauntonii显示文摘A new C21-steroidal glycoside with two known compounds were isolated from the root of Cynanchum Stauntonii.Based on thespectral analysis,including MS,1H NMR,13C NMR,DEPT,1H-1H COSY,13C-1H COSY,HMQC and HMBC,their chemicalstructures were determinated as glaucogenin-C 3-O-a-L-cymaropyranosyl-(1→4)-b-D-digitoxopyranosyl-(1→4)-β-D-canaropyranoside(1),stigmasterol(2)and ursolic acid(3). | Mei Hong Fu Zhu Ju Wang Hong Jun Yang Mayila Maimai Jing Fang Li Ying Tang Lan Yang | 2007 | Chinese Chemical Letters2007，18，4： | 3 |
| 17 | Cooking Oil and Salt Intakes Among Children Aged 6−17 Years——China,2016−2017显示文摘Summary What is already known on this topic?High-level intakes of both cooking oil and salt are issues of concern in China as they can lead to an increased risk of chronic diseases later in life.Reducing intakes of cooking oil and salt should be prioritized in children.What is added by this report?Among children aged 6-17 years in China in 2016-2017,the median intake of cooking oil and salt were 27.7 and 6.1 g/d,respectively.The percentages of children with intake of cooking oil and salt that exceeded the recommended guidelines were 50.4%and 67.8%,respectively. | Lahong Ju Dongmei Yu Wei Piao Hongyun Fang Qiya Guo Xiaoli Xu Shujuan Li Xue Cheng Shuya Cai Liyun Zhao | 2021 | China CDC weekly2021，3，31： | 3 |
| 18 | Effects of a Multivitamin/multimineral Supplement on Young Males with Physical Overtraining: A Placebo-controlled, Randomized, Double-blinded Cross-over Trial显示文摘Objective To investigate the effects of vitamin-mineral supplement on young males with physical overtraining. Methods Two hundred and forty male Chinese field artillery personnel who undertook large scale and endurance military training and were on ordinary Chinese diet were randomized to receive a multivitamin/multimineral supplement or a placebo for 1 week. After a 1-week wash-out period, a cross-over with 1 week course of a placebo or multivitamin/multimineral supplement was conducted. Blood and urine samples were analyzed for adrenal, gonadal and thyroid hormones. In addition, cellular immune parameters (CD3+, CD3+CD4+, CD3+CD8+, CD4/CD8, CD3-CD56+, CD3-CD19+) were examined and psychological tests were performed before and after the training program and nutrition intervention. Results After a large scale and endurance military training, the participants showed significantly increased thyroid function, decreased adrenal cortex, testosterone and immunological function, and significantly increased somatization, anger and tension. Compared to placebo, multivitamin/ multimineral intervention showed significant effects on functional recovery of the pituitary-adrenal axis, pituitary-gonadal axis, pituitary-thyroid axis and immune system as well as psychological parameters. Conclusion High-intensity military operations have significant impacts on the psychology, physical ability and neuroendocrine-immune system in young males. Appropriate supplementation of multivitamin/multimineral can facilitate the recovery of the psychology, physical ability and neuroendocrine-immune system in young males who take ordinary Chinese diet. | LI Xin HUANG Wen Xu LU Ju Ming YANG Guang MA Fang Ling LAN Ya Ting MENG Jun Hua DOU Jing Tao | 2013 | Biomedical and Environmental Sciences2013，26，7： | 2 |
| 19 | A Case-control Study of Environmental Risk Factors for Nonsyndromic Cleft of the Lip and/or Palate in Xuzhou,China显示文摘In this study,we sought to determine the association between environmental factors and nonsyndromic cleft of the lip and/or palate(NSCLP)to understand the etiology of the disease.A total of200 NSCLP cases and 327 controls were recruited at the Maternal and Child Health Hospital of Xuzhou City.We conducted face-to-face interviews with | XU Li Fang ZHOU Xiao Long WANG Qi ZHOU Ji Long LIU Ya Peng JU Qiang WANG Hui ZHANG Jin Peng WU Qing Rong LI Yi Qun XIA Yu Juan PENG Xiu ZHANG Mei Rong YU Hong Min XU Li Chun | 2015 | Biomedical and Environmental Sciences2015，28，7： | 2 |
| 20 | OsSRK1,an Atypical S-Receptor-Like Kinase Positively Regulates Leaf Width and Salt Tolerance in Rice显示文摘Receptor-like kinases(RLKs)are important for plant growth,development and defense responses.The S-receptor protein kinases(SRKs),which represent an RLK subfamily,control the selfincompatibility among Brassica species.However,little information is available regarding SRK functions in rice.We identified a gene OsSRK1 encoding an atypical SRK.The transcript of OsSRK1 was induced by abscisic acid(ABA),salt and polyethylene glycol.OsSRK1 localized to the plasma membrane and cytoplasm.Leaf width was increased in OsSRK1-overexpression(OsSRK1-OX)transgenic rice plants,likely because of an increase in cell number per leaf.Furthermore,the expression levels of OsCYCA3-1 and OsCYCD2-1,which encode positive regulators of cell division,were up-regulated in leaf primordium of OsSRK1-OX rice plants relative to those in wild type.Meanwhile,the expression level of OsKRP1,which encodes cell cycle inhibitor,was down-regulated in the OsSRK1-OX plants.Therefore,it is deduced that OsSRK1 regulates leaf width by promoting cell division in the leaf primordium.Additionally,OsSRK1-OX plants exhibited enhanced ABA sensitivity and salt tolerance compared with wild type.These results suggest that OsSRK1 plays important roles in leaf development and salt responses in rice. | ZHOU Jinjun JU Peina ZHANG Fang ZHENG Chongke BAI Bo LI Yaping WANG Haifeng CHEN Fan XIE Xianzhi | 2020 | Rice science2020，27，2： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员