|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Propofol differentially induces unconsciousness and respiratory depression through distinct interactions between GABAa receptor and GABAergic neuron in corresponding nuclei显示文摘Propofol is the most commonly used intravenous anesthetic worldwide.It can induce loss of consciousness prior to the occurrence of severe respiratory suppression,which is also a pharmacodynamic feature of all general anesthetics.However,the neural mechanisms underlying this natural phenomenon are controversial and highly related to patient safety.In the present study,we demonstrated that the pharmacodynamic effects of propofol(50 and 100 μM)on suppression of consciousness-related excitatory postsynaptic currents in the medial prefrontal cortex(mPFC)and centromedian nucleus of the thalamus(CMT)were lower than those in the kernel respiratory rhythmogenesis nucleus pre-Botzinger complex(PrBo).Furthermore,we unexpectedly found that the GABAa receptor β3 subunit is the key target for propofol's action and that it is mutually and exclusively expressed in GABAergic neurons.It is also more abundant in the mPFC and CMT,but mainly co-localized with GABAergic neurons in the PrBo.As a result,the differentiated expression pattern should mediate more neuron suppression through the activation of GABAergic neurons in the mPFC and CMT at low doses of propofol(50 μM).However,PrBo GABAergic neurons were only activated by propofol at a high dose(100 μM).These results highlight the detailed pharmacodynamic effects of propofol on consciousness-related and respiration-related nuclei and provide the distinct interaction mechanism between the β3 subunit and GABAergic neurons in mediating the suppression of consciousness compared to the inhibition of respiration. | Junli Jiang Yingfu Jiao Po Gao Wen Yin Wei Zhou Yunchun Zhang Yanjun Liu Daxiang Wen Yuan Wang Liang Zhou Tian Yu Weifeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 11 |
| 2 | Generation of 33 fs pulses directly from a Kerr-lens mode-locked Yb:CaYAlO4 laser显示文摘We experimentally demonstrated a diode-pumped Kerr-lens mode-locked femtosecond laser with a Yb:CaYAlO4 crystal as the gain medium. Pulse duration as short as 33 fs was obtained directly from the oscillator at a repetition rate of 115 MHz. The central wavelength was at 1059 nm with a spectral bandwidth of 49 nm. These are, to the bestof our knowledge, the shortest pulses generated from a Yb:CaYAlO4 oscillator. | Ziye Gao Jiangfeng Zhu Junli Wang Zhiyi Wei Xiaodong Xu Lihe Zheng Liangbi Su Jun Xu | 2015 | Photonics Research2015，3，6： | 8 |
| 3 | Competitive virus and host RNAs: the interplay of a hidden virus and host interaction显示文摘在病毒感染期间,病毒的 RNA 和 mRNAs 在天生的免疫作为联系病原体的分子的模式(PAMP ) 为病毒的蛋白质合成并且可能作为蓝图工作。这里,在 microRNAs (miRNAs ) 和竞争内长的 RNA (ceRNAs ) 考虑最近的研究进步,我们作为海绵推测那病毒的 RNA 行为并且能扣押在内的内长的 miRNAs 感染了细胞,这样跨 regulating 稳定性和有分享的 miRNA 反应元素的宿主 mRNAs 的翻译效率。在病毒的 RNA 和主人 mRNAs 之间的这串音和这些相互的相互作用被称为竞争病毒并且主人 RNA (cvhRNAs ) 。我们进一步在肝炎 B 为 cvhRNAs 网络的存在提供最近的试验性的证据病毒(HBV ) ,以及 Herpesvirus saimiri (HVS ) , lysin 的鼠科的 cytomegalovirus (MCMV ) 和人的 cytomegalovirus (HCMV ) 感染。另外, cvhRNA 假设也预言可能在主人和另外的病毒之间跨规定例如丙肝病毒(HCV ) , HIV,流行性感冒病毒,人的乳头状瘤病毒(HPV ) 。因为在 miRNAs 和病毒的 RNA 之间的相互作用不可避免地也导致病毒的 RNA 功能的压抑,我们推测那个病毒可以演变采用 cvhRNA 网络或避免在主机以内为最佳的健康指向的 miRNA。CvhRNA 网络可以因此在病毒的复制,感染建立,和病毒的致病的规定起一个基本作用。 | Changfei Li Jun Hu Junli Hao Bao Zhao Bo Wu Lu Sun Shanxin Peng George F. Gao Songdong Meng | 2014 | Protein & Cell2014，5，5： | 6 |
| 4 | Liposomes for systematic delivery of vancomycin hydrochloride to decrease nephrotoxicity:Characterization and evaluation显示文摘Vancomycin hydrochloride(VANH),the first glycopeptide antibiotic,is a water-soluble drug for the treatment of acute osteomyelitis.Liposomal formulations of VANH have already been manipulated and characterized,which was a mean of increasing their therapeutic index,reducing their toxicity and altering drug biodistribution.One of the challenges for preparing VANH-Lips is their low encapsulation efficiency(EE).In the present study,we aim to improve the liposomal formulation of VANH for higher EE,longer systemic circulation,reduced nephrotoxicity and enhanced antimicrobial activities.Vancomycin hydrochloride-loaded liposomes(VANH-Lips)were formulated by the method of modified reverse phase evaporation.Based on the optimization of formulation with orthogonal experimental design,the average drug encapsulation efficiency and the mean particle size of VANH-Lips were found to be 40.78±2.56%and 188.4±2.77 nm.In vitro drug release of VANH-Lips possessed a sustained release characteristic and their release behavior was in accordance with the Weibull equation.After intravenous injection to mice,the mean residence time(MRT)of VANH-Lips group was significantly prolonged in vivo and the AUC value was improved as well compared with the vancomycin hydrochloride solution(VANH-Sol)group.Furthermore,the biodistribution results in mice showed that VANH-Lips decreased the accumulation of VANH in kidney after intravenous injection.In conclusion,VANH-Lips may be a potential delivery system for VANH to decrease nephrotoxicity in the treatment of osteomyelitis. | Junli Liu Zhonglan Wang Fubing Li Jinhua Gao Longmei Wang Guihua Huang | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，3： | 4 |
| 5 | Activation of anterior thalamic reticular nucleus GABAergic neurons promotes arousal from propofol anesthesia in mice显示文摘Propofol is widely used for the induction and maintenance of anesthesia,which causes a rapid loss of consciousness.However,the mechanisms underlying the hypnosis effect of propofol are still not fully understood.The thalamic reticular nucleus(TRN)is crucial for regulating wakefulness,sleep rhythm generation,and sleep stability,while the role of TRN in the process of propofol-induced anesthesia is still unknown.Here,we investigated the function of the anterior TRN in propofol general anesthesia.Our results demonstrated that the neural activity of anterior TRN is suppressed during propofol anesthesia,whereas it is robustly activated from anesthesia by recording the calcium signals using fiber photometry technology.The results showed that the activation of anterior TRN neurons by chemogenetic and optogenetic methods shortens the emergency time without changing the induction time.Conversely,chemogenetic or optogenetic inhibition of the TRN neurons leads to a delay in the recovery time.Our study showed that anterior TRN is crucial for behavioral arousal without affecting the induction time of propofol anesthesia. | Yanjun Liu Bing Chen Yirong Cai Yuan Han Ying Xia Nanqi Li Bingqian Fan Tianjie Yuan Junli Jiang Po Gao Weifeng Yu Yingfu Jiao Wenxian Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 3 |
| 6 | Correlation between radiologic features on contrastenhanced CT and pathological tumor grades in pancreatic neuroendocrine neoplasms显示文摘Contrast-enhanced computed tomography(CT)contributes to the increasing detection of pancreatic neuroendocrine neoplasms(PNENs).Nevertheless,its value for differentiating pathological tumor grades is not well recognized.In this report,we have conducted a retrospective study on the relationship between the 2017 World Health Organization(WHO)classification and CT imaging features in 94 patients.Most of the investigated features eventually provided statistically significant indicators for discerning PNENs G3 from PNENs G1/G2,including tumor size,shape,margin,heterogeneity,intratumoral blood vessels,vascular invasion,enhancement pattern in both contrast phases,enhancement degree in both phases,tumor-to-pancreas contrast ratio in both phases,common bile duct dilatation,lymph node metastases,and liver metastases.Ill-defined tumor margin was an independent predictor for PNENs G3 with the highest area under the curve(AUC)of 0.906 in the multivariable logistic regression and receiver operating characteristic curve analysis.The portal enhancement ratio(PER)was shown the highest AUC of 0.855 in terms of quantitative features.Our data suggest that the traditional contrastenhanced CT still plays a vital role in differentiation of tumor grades and heterogeneity analysis prior to treatment. | Wenbin Xu Han Yan Lulu Xu Mingna Li Wentao Gao Kuirong Jiang Junli Wu Yi Miao | 2021 | The Journal of Biomedical Research2021，35，3： | 2 |
| 7 | Nutrient value of wild fodder species and the implications for improving the diet of mithun (Bos frontalis) in Dulongjiang area, Yunnan Province, China显示文摘Wild fodder plants are valuable because they provide an important livestock feed resource globally,especially for smallholder farmers,and have important roles in natural resource management.In-depth knowledge of wild forage plants can motivate local people for feed resource and habitat conservation of threatened herbivores such as Mithun(Bos frontalis).Mithun occur in small patches in the mountains of Dulongjiang,nearby villagers domesticated this animal but left animal to freely graze in the mountains.Many fodder plants occur in these mountains,however,little is known about their nutritional value.We conducted an ethnobotanical survey to document important wild fodder plants consumed by mithun in the Dulongjiang Township.The nutritional content of 21 highly mentioned wild fodder plants in an ethnobotanical survey was examined.Laboratory analysis showed that Fagopyrum dibotrys were the fodder species with the highest crude protein(CP)content(26.89%),followed by Polygonum molle(21.88%)and Hydrangea longipes(21.12%).Synthesis of relative feed value index and grey relational grade,P.molle,H.longipes and Tetrastigma obtectum were ranked the top three nutritional fodders.There was a significant difference between 21 species on their in vitro digestibility and the most highly digestible fodder species was Elatostema hookerianum.Linear model analysis on relationship between frequency of citation of 21 wild forage plants by local farmers and their nutrient composition showed that the frequency was significantly positively correlated with the nutritional value of the feed(R2?0.28,P<0.05).We concluded that these species have high nutritional values to improve mithun production in integrated crop-livestock systems.Fodder species or mixtures of species with useful nutritional characters could be cultivated to improve livestock productivity,habitat conservation including that of mithun and wild forage resource management. | Yanfei Geng Sailesh Ranjitkar Qiaoshun Yan Zhijun He Baqi Su Shengtao Gao Junli Niu Dengpan Bu Jianchu Xu | 2020 | Plant Diversity2020，42，6： | 2 |
| 8 | Copper-nickel superalloys as inert alloy anodes for aluminum electrolysis 显示文摘 | Zhongning Shi Junli Xu Zhuxiaa Qiu Zhaowen Wang Bingliang Gao | 2003 | JOM2003，55，11： | 1 |
| 9 | Key immunity characteristics of diverse stages of brucellosis in rural population from Inner Mongolia, China显示文摘Background: Brucellosis poses a serious threat to human and animal health,particularly in developing countries such as China.The Inner Mongolia Autonomous Region is one of the most severely brucellosis-endemic provinces in China.Currently,the host immune responses functioning to control Brucella infection and development remain poorly understood.The aim of this study is to further clarify the key immunity characteristics of diverse stages of brucellosis in Inner Mongolia.Methods: We collected a total of 733 blood samples from acute(n=137),chronic(n=316),inapparent(n=35),recovery(n=99),and healthy(n=146)groups from the rural community of Inner Mongolia between 2014 and 2015.The proportions of CD4^(+),CD8^(+),Th1,Th2,and Th17 T cells in peripheral blood and the expression of TLR2 and TLR4 in lymphocytes,monocytes and granulocytes were examined using flow cytometry analysis.The differences among the five groups were compared using one-way ANOVA and the Kruskal–Wallis method,respectively.Results: Our results revealed that the proportions of CD4^(+) and CD8^(+) T cells were significantly different among the acute,chronic,recovery,and healthy control groups(P<0.05),with lower proportions of CD4^(+) T cells and a higher proportion of CD8^(+) T cells in the acute,chronic,and recovery groups.The proportion of Th1 cells in the acute,chronic,and inapparent groups was higher than that in the healthy and recovery groups;however,there was no significant difference between patients and healthy individuals(P>0.05).The proportion of Th2 lymphocytes was significantly higher in the acute and healthy groups than in the inapparent group(P<0.05).The proportion of Th17 cells in the acute group was significantly higher than that in the healthy control,chronic,and inapparent groups(P<0.05).Finally,the highest expression of TLR4 in lymphocytes,monocytes and granulocytes was observed in the recovery group,and this was followed by the acute,chronic,healthy control,and inapparent groups.There was a significant difference between the recovery group and the other groups,except for the acute group(P<0.05).Moreover,a correlation in TLR4 expression was observed in lymphocytes,monocytes and granulocytes among the five groups(r>0.5),except for the inapparent group between lymphocytes and granulocytes(r=0.34).Conclusions: Two key factors(CD8^(+)T cells and TLR4)in human immune profiles may closely correlate with the progression of brucellosis.The detailed function of TLR4 in the context of a greater number of cell types or tissues in human or animal brucellosis and in larger samples should be further explored in the future. | Yongzhang Zhu Li Shi Yige Zeng Dongri Piao Yingbo Xie Juan Du Meng Gao Wei Gao Junli Tian Jun Yue Min Li XiaoKui Guo Yufeng Yao YaoXia Kang | 2022 | Infectious Diseases of Poverty2022，11，3： | 1 |
| 10 | CEACAM6 induces epithelial-mesenchymal transition and mediates invasionand metastasis in pancreatic cancer显示文摘 | Jianmin Chen Qiang Li Yong An Nan Lv Xiaofeng Xue Jishu Wei Kuirong Jiang Junli Wu Wentao Gao Zhuyin Qian Cuncai Dai Zekuan Xu Yi Miao | 2013 | International Journal of Oncology2013，，3： | 1 |
| 11 | Synergistic-engineered van der Waals photodiodes with high efficiency显示文摘Van der Waals(vdW)heterostructures based on two-dimensional transitionmetal dichalcogenides have provided unprecedented opportunities for photovoltaic detectors owing to their strong light-matter interaction and ultrafast interfacial charge transfer.Despite continued advancement,insufficient control of photocarrier behaviors still limits the external quantum efficiency(EQE)and operation speed of such detectors.Here,we propose a synergistic strategy of contact-configuration design and thickness-modulation to construct high-performance vdW photodiodes based on the typical type II heterostructure(MoS2/WSe2).Through integrating three contact architectures into one device to exclude other factors,we solid the superiority of designed 1L-MoS2/WSe2/graphene heterostructures incorporating efficient photocarrier collection and gate modulation.Together with leveraging the layer-numberdependent properties of WSe2,we observe the critical thickness of WSe2(11 layers)for the highest EQE,which verifies the thickness-dependent competition between photocarrier generation,dissociation,and collection.Finally,we demonstrate the synergistic-engineered vdW heterostructure can trigger record-high EQE(61%)and manifest ultrafast photoresponse(4.1μs)at the atomically thin limit(8 nm).The proposed strategy enables architecture-design and thickness-engineering to unlock the potential to realize high-performance optoelectronic devices. | Baishan Liu Xiankun Zhang Junli Du Jiankun Xiao Huihui Yu Mengyu Hong Li Gao Yang Ou Zhuo Kang Qingliang Liao Zheng Zhang Yue Zhang | 2022 | InfoMat2022，4，3： | 1 |
| 12 | Preparation and magnetic properties of NdsFe95_xB, nanowire arrays显示文摘 | Gao Daqiang Fu Junli Xu Yan | 2008 | Materials Letters2008，107，： | 1 |
| 13 | Robust Sampled-Data H∞ Control with Stochastic Sampling显示文摘 | Gao Huijin Wu Junli Shi Peng | 2009 | Automatica2009，45，7： | 1 |
| 14 | Highly selective electrocatalytic Cl− oxidation reaction by oxygen-modified cobalt nanoparticles immobilized carbon nanofibers for coupling with brine water remediation and H2 production显示文摘Combining the H2 production with brine remediation is regarded as a sustainable approach to achieving clean H2 energy. However, designing stable Cl− oxidation reaction (COR) electrocatalyst is the key to realize this route. Herein, a type of oxygen-modified Co nanoparticles anchored graphitic carbon nanofibers catalyst (Co/GCFs) was synthesized through a two-step strategy of adsorption and pyrolysis. The Co/GCFs-2.4 exhibits high selectivity and stability for COR at neutral electrolyte. It is worth noting that unlike the water oxidation, the chemical valence of cobalt has not changed during the COR. Further results demonstrated that the oxygen-modified Co nanoparticles provide active sites for selective COR, meanwhile, the graphitic carbon gives rise to strong catalytic stability. Thanks to the superior COR and H2 production activity of Co/GCFs-2.4, a two-electrode brine electrocatalysis system employing Co/GCFs-2.4 as both cathode and anode for H2 production exhibited robust stability, efficient and high Faraday efficiency (98%-100%). We propose that this work provides a novel strategy for designing efficient and stable catalysts with electrocatalytic COR and HER activities at neutral brine water for practically coupling with H2 production by water electrolysis and brine water remediation. | Qizhong Xiong Xian Zhang Qipeng Cheng Guoqiang Liu Gang Xu Junli Li Xinxin Ye Hongjian Gao | 2021 | Nano Research2021，14，5： | 1 |
| 15 | The effect of high-voltage electrostatic field (HVEF) on aged rice ( Oryza sativa L.) seeds vigor and lipid peroxidation of seedlings显示文摘 | Guixue Wang Junli Huang Weina Gao Jiang Lu Jian Li Ruijin Liao Cheruth Abdul Jaleel | 2009 | Journal of Electrostatics2009，，5： | 1 |
| 16 | Preparation and magnetic properties of Nd 5 Fe 95? x B x nanowire arrays显示文摘 | Daqiang Gao Junli Fu Yan Xu Desheng Xue | 2008 | Materials Letters2008，，17： | 1 |
| 17 | Preparation and magnetic properties of Nd5Fe95-xBx nanowire arrays 显示文摘 | Daqiang Gao Junli Fu Yan Xu | 2008 | Materials Letters2008，62，： | 1 |
| 18 | Maternal control of seed oil content in Brassica napus: the role of silique wall photosynthesis显示文摘 | WeiHua Rong‐JunLi Gao‐MiaoZhan JingLiu JunLi Xin‐FaWang Gui‐HuaLiu Han‐ZhongWang | 2012 | The Plant Journal2012，，3： | 1 |
| 19 | From'step-up'to'step-jump':a leap-forward intervention for infected necrotizing pancreatitis显示文摘Acute pancreatitis(AP)can vary widely in its severity,from being clinically self-limiting to a rapidly fatal course.[1]Necrotizing pancreatitis(NP)is the most serious form and is associated with a poor prognosis;the mortality rate is approximately 15%,or up to 30%for cases of infected necrotizing pancreatitis(INP),which often progresses to sepsis and multiple organ failure,the major cause of death and severe complications.[2]The approach to the management of INP has significantly changed during the last 20 years and continues to evolve with the accumulation of experience,new techniques,and research data.Major surgical intervention and debridement were once the mainstay of therapy for patients with symptomatic necrotic foci,but a minimally invasive approach that focuses on percutaneous and/or endoscopic drainage or debridement is now favored.[2]The'step-up'approach,which involves minimally invasive techniques,represents a new paradigm for the treatment of patients with INP,and open pancreatic debridement is now considered to be the final step in the treatment of NP.[2] | Dongya Huang Qiang Li Zipeng Lu Kuirong Jiang Junli Wu Wentao Gao Bin Xiao Yi Miao | 2022 | Chinese Medical Journal2022，，3： | 0 |
| 20 | Enhanced piezoelectric properties and temperature stability in KNN-based textured ceramics显示文摘Considering the advantages of high Curie temperature and environment-friendly nature of KNN piezoelectric ceramics,the limitation of weak piezoelectric response and their temperature sensitivity to applications is worth exploring.Herein,the<001>textured(1-x)(K_(0.5)Na_(0.5))(Nb0.96Sb0.04)O3-x(Bi_(0.5)Na_(0.5))HfO_(3)(x=0.01-0.045)lead-free ceramics were synthesized by templated grain-growth method.The high piezoelectric performance(d33 of 474 pC/N and strain of 0.21%)and excellent temperature stability(unipolar strain maintained within 4.3%change between 30℃and 165℃)were simultaneously achieved in the textured KNNS-0.03BNH ceramics.The high piezoelectric performance can be attributed to the summation of the crystallographic anisotropy and phase structure contributions in<001>textured ceramics.The superior temperature stability of piezoelectric properties can be interpreted by the contribution of crystal anisotropy to piezoelectric properties reduces the effect of phase transition on piezoelectric properties deterioration.This study provides an effective strategy for simultaneously achieving high piezoelectric properties and superior temperature stability in KNN-based textured ceramics. | Yan Lin Ru Wang Jiawei Qu Shuo Gao Yi Zhang Junli Yan Jigong Hao Peng Li Wei Li | 2022 | Journal of Advanced Dielectrics2022，12，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员