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| 1 | Development of Cementitious Materials Utilizing Alkali-activated Yellow River Silt显示文摘The possibility of preparing cementitious materials by the alkali-activated method using Yellow River sediment(The second largest river in China)as raw material and the modification effect on different slag addition were investigated.Sodium silicate and calcium hydroxide were used as the activator,and the specimens were prepared by the press molding method.The hydration process,hydration products,pore characteristics,and mechanical properties were investigated using SEM/EDS,FTIR,TG/DTG,XRD,MIP,and uniaxial compressive strength experiments,respectively.The results showed that the compressive strength of the modified yellow river silt-based cementitious material was significantly increased when the water glass dosage was 12 wt%(Ms=1.8)and the slag dosage was 40%,and its 90-day maximum compressive strength could reach 53 MPa. | 王宝民 WANG Wanli 梁晓霞 刘慧 HAN Junnan ZHAO Lu YANG Xingxing YAN Jifei | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，3： | 5 |
| 2 | An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair显示文摘Acute myocardial infarction(AMI)remains a dominant origin of morbidity,mortality and disability worldwide.Increases in reactive oxygen species(ROS)are key contributor to excessive cardiac injury after AMI.Here we developed an immobilized enzyme with Superoxide Dismutase(SOD)activity cross-link with Zr-based metal-organic framework(ZrMOF)(SOD-ZrMOF)for mitigate ROS-caused injury.In vitro and in vivo evidence indicates that SOD-ZrMOF exhibits excellent biocompatibility.By efficiently scavenging ROS and suppressing oxidative stress,SOD-ZrMOF can protect the function of mitochondria,reduce cell death and alleviate inflammation.More excitingly,long-term study using an animal model of AMI demonstrated that SOD-ZrMOF can reduce the infarct area,protect cardiac function,promote angiogenesis and inhibit pathological myocardial remodeling.Therefore,SOD-ZrMOF holds great potential as an efficacious and safe nanomaterial treatment for AMI. | Jiacheng Guo Zhenzhen Yang Yongzheng Lu Chunyan Du Chang Cao Bo Wang Xiaoting Yue Zenglei Zhang Yanyan Xu Zhen Qin Tingting Huang Wei Wang Wei Jiang Jinying Zhang Junnan Tang | 2022 | Bioactive Materials2022，7，4： | 4 |
| 3 | NaV6O15:A promising cathode material for insertion/extraction of Mg^2+with excellent cycling performance显示文摘The rechargeable magnesium batteries(RMBs)are getting more and more attention because of their high-energy density,high-security and low-cost.Nevertheless,the high charge density of Mg^2+makes the diffusion of Mg2+in the conventional cathodes very slow,resulting in a lack of appropriate electrode materials for RMBs.In this work,we enlarge the layer spacing of V2Os by introducing Na^2+in the crystal structure to promote the diffusion kinetics of Mg^2+.The NaVeO15(NVO)synthesized by a facile method is studied as a cathode material for RMBs with the anhydrous pure Mg^2+electrolyte.As a result,the NVO not only exhibits high discharge capacity(119.2 mAh:g^-1 after 100 cycles at the current density of 20 mA:g^-1)and working voltage(above 1.6 V vs.Mg^2+/Mg),but also expresses good rate capability.Besides,the eX-situ characterizations results reveal that the Mg^2+storage mechanism in NVO is based on the intercalation and deintercalation.The density functional theory(DFT)calculation results further indicate that Mg^2+tends to occupy the semi-occupied sites of Na^+in the NVO.Moreover,the galvanostatic intermittent titration technique(GITT)demonstrates that NVO electrode has the fast diffusion kinetics of Mg^2+during discharge process ranging from 7.55×10^-13 to2.41×10^-11 cm^2·s^-1.Our work proves that the NVO is a potential cathode material for RMBs. | Dongzheng Wu Jing Zeng Haiming Hua Junnan Wu Yang Yang Jinbao Zhao | 2020 | Nano Research2020，13，2： | 2 |
| 4 | Rce1 expression in renal cell carcinoma and its regulatory effect on 786-O cell apoptosis through endoplasmic reticulum stress显示文摘(Rce1 ) 地岬和 a-factor-converting 酶 1 位于 endoplasmic 蜂窝胃(嗯) 并且被认为为绝大多数 CAAX 蛋白质处理的 endoproteolytic 负责。Endoplasmic 蜂窝胃应力(ERS ) 在肾的房间癌(RCC ) 起一个重要作用;然而,在 RCC 的 Rce1 的表示和角色广泛地没被学习。我们试图在 RCC 786-O 房间在嗯导致 apoptosis 在 RCC 纸巾和它的分子的机制调查 Rce1 的表示。我们首先使用了检测在肾的癌纸巾和 paracancerous 纸巾的 Rce1 表示的西方的弄污,量的反向的 transcriptase 聚合酶链反应,和 immunohistochemistry。Rce1 表示是在 RCC 的 upregulated,这被发现纸巾,和它的积极表示水平强烈与 clinicopathologic 特征被联系。下次,我们在人的胚胎的肾房间线 HEK293 和人的肾的癌房间线 786-O 检测了 Rce1 的表示, ACHN,和 A498。Rce1 的更高的表示在人的肾的癌房间线被发现,特别在 786-O 房间。在 786-O 房间的 Rce1 击倒增加的 apoptosis | Jianjun Li Delin Wang Junnan Liu Yunlang Qin Liangliang Huang Qiangfeng Zeng Maolin Xiao Jie Hu Qixin Yang Jiang He Li Mai Ying Li Wujiang Liu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，3： | 2 |
| 5 | Abnormal bone marrow microenvironment: the “harbor” of acute lymphoblastic leukemia cells显示文摘Bone marrow(BM)microenvironment regulates and supports the production of blood cells which are necessary to maintain homeostasis.In analogy to normal hematopoiesis,leukemogenesis is originated from leukemic stem cells(LSCs)which gives rise to more differentiated malignant cells.Leukemia cells occupy BM niches and reconstruct them to support leukemogenesis.The abnormal BM niches are the main sanctuary of LSCs where they can evade chemotherapy-induced death and acquire drug resistance.In this review,we focus on the protective effects of BM niche cells on acute lymphoblastic leukemia cells. | Zehui Chen Yaxin Zheng Yaling Yang Junnan Kang M.James You Chen Tian | 2021 | Blood Science2021，3，2： | 1 |
| 6 | Research on Adaptive Optics Image Restoration Algorithm Based on Improved Joint Maximum a Posteriori Method显示文摘在这篇论文,我们建议一个点传播功能(PSF ) 重建方法和联合最大值为适应光学图象恢复的一个 posteriori (JMAP ) 评价方法。把 JMAP 方法用作基本原则,我们建立多框架的联合日志可能性的函数基于图象 Gaussian,噪音建模的适应光学(AO ) 图象。首先,联合观察条件和 AO 系统特征,为波前阶段效果的一个预言的 PSF 模型被开发;然后,我们基于我们的建议算法建立 AO 图象的反复的答案公式,探讨多框架 AO 图象关节 deconvolution 方法的实现过程。我们进行一系列实验在上模仿并且评估我们的建议算法的真实降级的 AO 图象。与维纳相比反复的盲目 deconvolution (Wiener-IBD ) 算法和 Richardson 露西 IBD 算法,我们的算法比其它包括更高的山峰 signal-to-noise 比率(PSNR ) 和拉普拉斯算符和(LS ) 价值有更好的恢复效果。研究结果为实际 AO 图象恢复有某个应用程序值。 | Lijuan ZHANG Yang LI Junnan WANG Ying LIU | 2018 | Photonic Sensors2018，8，1： | 1 |
| 7 | CENP-A的Ser68位动态磷酸化调控它在着丝粒区域的细胞周期依赖性装配显示文摘细胞出版社《发育细胞》创刊于2001年,本刊致力于搭建细胞生物学与发育生物学两大学科之间的桥梁。受过专业博士训l练的科学编辑与作者、审稿人、编委会成员共同合作,及时发布横跨两个领域令人振奋的研究成果,强调两个领域之间共同面临的问题以及相互之间的关系。该杂志2015年公布的影响因子为9.708。 | Zhouliang Yu Xiang Zhou Wenjing Wang Wenqiang Deng Junnan Fang Hao Hu Zichen Wang Shangze Li Lei Cui Jing Shen Linhui Zhai Shengyi Peng Jiemin Wong Shuo Dong Zengqiang Yuan Guangshuo Ou Xiaodong Zhang Ping Xu Jizhong Lou Na Yang Ping Chen Rui-Ming Xu 李国红 | 2016 | 科学新闻2016，0，1： | 1 |
| 8 | Engineering multifunctional bioadhesive powders through dynamic metal-ligand coordination显示文摘Bioadhesive gels with robust adhesion on wet and irregular tissue surfaces are desirable for clinical applications.Assembly of bioadhesive powders is an effective strategy for obtaining gels that adhere to wet and irregular tissue surfaces by absorbing interfacial water.However,current bioadhesive powders lack positive biological functions and are prone to postoperative adhesion.Here,we present a powder strategy based on metal-ligand coordination to create a series of bioadhesive polyacrylic acid(PAA)gels.In the gel network,metal ions(M^(n+))are used to coordinate with the carboxy ligands of PAA to form dynamic noncovalent crosslinks.The powders can absorb interfacial water and assemble into gels on wet and irregular tissue surfaces within a few seconds,forming an initial adhesion layer by electrostatic interactions.Furthermore,the polymers can diffuse into the tissue matrix,and metal-ligand coordination is reconstructed to enhance the adhesion.Moreover,with a cationic shield layer,the bioadhesive powders can effectively avoid postoperative adhesion.Importantly,M^(n+) ions endow the gel with customized biological functions.We demonstrate that the hemostatic,antibacterial,peroxidase-like catalytic,and photodetachment abilities of the gels by incorporating different M^(n+) ions.These advantages make the bioadhesive powder a promising platform for diverse tissue repair applications. | Junchang Guo Yue Hou Liansong Ye Junnan Chen Hong Wang Li Yang Jinbo Jiang Qiangqiang Sun Chaoming Xie Bing Hu Jiaxi Cui Xu Deng | 2022 | Science China Chemistry2022，65，11： | 0 |
| 9 | Clinical Study on the Relationship between Fixation of Prosthesis and Health of Surrounding Tissues显示文摘[Objectives] To explore the effect of mouth outside bonding screw fixation and inside bonding fixation in implanting the prosthesis( crown or bridge) on the health of surrounding tissues,to provide a certain reference for the selection of fixation methods for clinically implanting the prosthesis. [Methods]160 cases of patients needing implanting the prosthesis due to dental arch deficiency were selected. They had excellent alveolar bone. They did not smoke,had no diabetes,and their bone tissue healing was at the early stage. They were randomly divided into A and B groups,80 cases in each group. Group A: the mouth inside and abutment of prosthesis was bonded to a single abutment crown or a single abutment bridge; the bonder on the surface of prosthesis was completely removed and then moved into the implant,and fixed with central retaining screw,this group was called ' mouth outside bonding group'. Group B: the abutment was located in the implant and fixed using central retaining screw,then the prosthesis( crown or bridge) was bonded to the abutment,the bonder on the surface of prosthesis was removed,and this group was called mouth ' mouth inside bonding group'. The health condition was compared between two fixing methods for the surrounding tissues of the implant in 24-36 months after restoration. [Results] Group A: the surrounding tissues of the implants for 126 teeth of 80 patients were healthy without occurrence of peripheral inflammation; Group B: in the implants of 112 teeth of 80 patients,7 teeth suffered the peripheral inflammation. Dental implant examination found that there was residue of bonder in the bonding of prosthesis and abutment,3 teeth exfoliated,and 4 teeth were restored after treatment. Through the X2 test,there was significant difference between Group A and Group B( P < 0. 05). [Conclusions] Implant-supported denture often adopts the mouth inside bonding. Since the bonder can not be removed completely,its residue will remain in gingival trough and stimulate the surrounding tissues of the implant and bring about the inflammatory reaction,and even lead to exfoliation of the implant; the mouth inside and abutment of prosthesis was bonded to a single abutment crown or a single abutment bridge,the bonder on the surface of prosthesis was completely removed and then moved into the implant,and fixed with central retaining screw. This method is an effective method for preventing the peripheral inflammation and increasing the success rate of dental implant. | Lei LI Yanzheng SUN Shengteng SUN Xinxin SUI Junnan XIA Yi LI Jianjun YANG | 2017 | Medicinal Plant2017，8，2： | 0 |
| 10 | Shunxin decoction(顺心组方) improves diastolic function in rats with heart failure with preserved ejection fraction induced by abdominal aorta constriction through cyclic guanosine monophosphate-dependent protein kinase Signaling Pathway显示文摘OBJECTIVE: To determine whether Shunxin decoction(顺心组方) improves diastolic function in rats with heart failure with preserved ejection fraction(HFp EF) by regulating the cyclic guanosine monophosphatedependent protein kinase(c GMP-PKG) signaling pathway. METHODS: Except for control group 8 and sham surgery group 8, the remaining 32 male Sprague-Dawlay rats were developed into HFp EF rat models using the abdominal aorta constriction method. These rats in the HFp EF model were randomly divided into the model group, the Shunxin high-dose group, the Shunxin lowdose group, and the Qiliqiangxin capsule group. The three groups received high-dose Shunxin decoction, lowdose Shunxin decoction, and Qiliqiangxin capsule by gavage, respectively, for 14 d. After the intervention, the diastolic function of each rat was evaluated by testing E/A, heart index, hematoxylin-eosin staining, Masson, myocardial ultrastructure, and N-terminal pro-brain natriuretic peptide(NT-pro BNP). The Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine(BATMAN-TCM) software was used to predict targets for which Shunxin decoction acts on the c GMP-PKG pathway. Natriuretic peptide receptor A(NPRA) and guanylate cyclase(GC) were detected by immunohistochemistry, and e NOS, phosphodiesterase 5A(PDE5A), and c GMP-dependent protein kinase 1(PKG I) were determined by Western blotting. RESULTS: Compared to the model group, the thickness of the interventricular septum at the end of diastole(IVSd) and the thickness of the posterior wall at the end of diastole(PWd) of the Shunxin decoction high-dose group, Shunxin decoction low-dose group, and Qiliqiangxin capsule group were all significantly reduced(P < 0.01). Furthermore, Shunxin decoction high-dose group E/A value was decreased(P < 0.01). Compared to the model group, the expression of NPRA and GC increased in the Shunxin decoction low-dose group and the Qiliqiangxin capsule group(P < 0.01). Compared to the model group, the expressions of e NOS and PKG I increased(P < 0.05) in the Shunxin decoction high-dose group. The expression of PDE5A expression decreased in the myocardium of the Shunxin decoction high-dose group, Shunxin decoction low-dose group, and Qiliqiangxin capsule group compared to the model group(P < 0.01). CONCLUSIONS: Shunxin decoction can improve diastolic function in rats with HFp EF. It increases the expression of NPRA, GC, and e NOS in the myocardial cell c GMP-PKG signaling pathway, upregulates c GMP expression, decreases PDE5A expression to reduce the c GMP degradation. Thus, the c GMP continually stimulates PKG I, reversing myocardial hypertrophy and improving myocardial compliance in HFp EF rats. | ZHANG Jiaying WEI Xiangxiang LI Xuefeng YUAN Yang DOU Yinghuan SHI Yanbin XIE Ping ZHOU Mengru ZHAO Junnan LI Miao ZHANG Shuwen ZHU Rui TIAN Ying TAN Hao TIAN Feifei | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 0 |
| 11 | Reconstructing cell lineage trees with genomic barcoding:approaches and applications显示文摘In multicellular organisms,developmental history of cell divisions and functional annotation of terminal cells can be organized into a cell lineage tree(CLT).The reconstruction of the CLT has long been a major goal in developmental biology and other related fields.Recent technological advancements,especially those in editable genomic barcodes and single-cell high-throughput sequencing,have sparked a new wave of experimental methods for reconstructing CLTs.Here we review the existing experimental approaches to the reconstruction of CLT,which are broadly categorized as either image-based or DNA barcode-based methods.In addition,we present a summary of the related literature based on the biological insight pro-vided by the obtained CLTs.Moreover,we discuss the challenges that will arise as more and better CLT data become available in the near future.Genomic barcoding-based CLT reconstructions and analyses,due to their wide applicability and high scalability,offer the potential for novel biological discoveries,especially those related to general and systemic properties of the developmental process. | Zizhang Li Wenjing Yang Peng Wu Yuyan Shan Xiaoyu Zhang Feng Chen Junnan Yang Jian-Rong Yang | 2024 | Journal of Genetics and Genomics2024，51，1： | 0 |
| 12 | Lack of evolutionary convergence in multiple primary lung cancer suggests insufficient specificity of personalized therapy显示文摘Multiple primary lung cancer(MPLC)is an increasingly prevalent subtype of lung cancer.According to recent genomic studies,the different lesions of a single MPLC patient exhibit functional similarities that may reflect evolutionary convergence.We perform whole-exome sequencing for a unique cohort of MPLC patients with multiple samples from each lesion found.Using our own and other relevant public data,evolutionary tree reconstruction reveals that cancer driver gene mutations occurred at the early trunk,indicating evolutionary contingency rather than adaptive convergence.Additionally,tumors from the same MPLC patient are as genetically diverse as those from different patients,while within-tumor genetic heterogeneity is significantly lower.Furthermore,the aberrant molecular functions enriched in mutated genes for a sample show a strong overlap with other samples from the same tumor,but not with samples from other tumors or other patients.Overall,there is no evidence of adaptive convergence during the evolution of MPLC.Most importantly,the similar between-tumor diversity and between-patient diversity suggest that personalized therapies may not adequately account for the genetic diversity among different tumors in an MPLC patient.To fully exploit the strategic value of precision medicine,targeted therapies should be designed and delivered on a per-lesion basis. | Hua Cheng Ziyan Guo Xiaoyu Zhang Xiao-Jin Wang Zizhang Li Wen-Wen Huo Hong-Cheng Zhong Xiao-Jian Li Xiang-Wen Wu Wen-Hao Li Zhuo-Wen Chen Tian-Chi Wu Xiang-Feng Gan Bei-Long Zhong Vassily ALyubetsky Leonid Yu Rusin Junnan Yang Qiyi Zhao Qing-Dong Cao Jian-Rong Yang | 2023 | Journal of Genetics and Genomics2023，50，5： | 0 |
| 13 | Modeling potential scenarios of the Tangjiashan Lake outburst and risk assessment in the downstream valley显示文摘 | Vera KIDYAEVA Sergey CHERNOMORETS Inna KRYLENKO Fangqiang WEI Dmitry PETRAKOV Pengcheng SU Hongjuan YANG Junnan XIONG | 2017 | Frontiers of Earth Science2017，11，3： | 0 |
| 14 | AICellCounter:A Machine Learning-Based Automated Cell Counting Tool Requiring Only One Image for Training显示文摘Dear Editor,To decipher brain functions,brain cells are generally prelabeled and then imaged using a high-resolution confocal system,and manual or automatic counting methods are widely used in the quantitative and semiquantitative analysis of these confocal images.Therefore,cell counting becomes a bottleneck in efficient analysis because manual counting is laborious and time-consuming.Therefore,an accurate and user-friendly automated cell counting tool is needed for biological researchers. | Junnan Xu Andong Wang Yunfeng Wang Jingting Li Ruxia Xu Hao Shi Xiaowen Li Yu Liang Jianming Yang Tian-Ming Gao | 2023 | Neuroscience Bulletin2023，39，1： | 0 |
| 15 | Hybrid working mechanism enables highly reversible Zn electrodes显示文摘Zn dendrite growth and water-related side reactions have been criticized to hinder actual applications of aqueous Zn-ion batteries.To address these issues,a series of Zn interfacial modifications of building solid/electrolyte interphase(SEI)and nucleation layers have been widely proposed,however,their effectiveness remains debatable.Here,we report a boron nitride(BN)/Nafion layer on the Zn surface to efficiently solve Zn problems through combining the hybrid working mechanisms of SEI and nucleation layers.In our protective layer,Nafion exhibits the SEI mechanism by blocking water from the Zn surface and providing abundant channels for rapid Zn^(2+)þtransmission,whilst BN nanosheets induce Zn deposition underneath with a preferred(002)orientation.Accordingly,dendrite-free and side-reaction-free Zn electrode with(002)deposition under the protective layer is realized for the first time,as reflected by its high reversibility with average Coulombic efficiency of 99.2%for>3000 h.The protected Zn electrode also shows excellent performance in full cells when coupling with polyaniline cathode under the strict condition of lean electrolyte addition.This work highlights insights for designing highly reversible metal electrodes towards practical applications. | Libei Yuan Junnan Hao Bernt Johannessen Chao Ye Fuhua Yang Chao Wu Shi-Xue Dou Hua-Kun Liu Shi-Zhang Qiao | 2023 | eScience2023，3，2： | 0 |
| 16 | OsNPF3.1,a nitrate,abscisic acid and gibberellin transporter gene,is essential for rice tillering and nitrogen utilization efficiency显示文摘Low-affinity nitrate transporter genes have been identified in subfamilies 4-8 of the rice nitrate transporter 1(NRT1)/peptide transporter family(NPF),but the OsNPF3 subfamily responsible for nitrate and phytohormone transport and rice growth and development remains unknown.In this study,we described OsNPF3.1 as an essential nitrate and phytohormone transporter gene for rice tillering and nitrogen utilization efficiency(NUtE).OsNPF3.1 possesses four major haplotypes of its promoter sequence in 517 cultivars,and its expression is positively associated with tiller number.Its expression was higher in the basal part,culm,and leaf blade than in other parts of the plant,and was strongly induced by nitrate,abscisic acid(ABA)and gibberellin 3(GA_3)in the root and shoot of rice.Electrophysiological experiments demonstrated that OsNPF3.1 is a pH-dependent low-affinity nitrate transporter,with rice protoplast uptake assays showing it to be an ABA and GA_3 transporter.OsNPF3.1 overexpression significantly promoted ABA accumulation in the roots and GA accumulation in the basal part of the plant which inhibited axillary bud outgrowth and rice tillering,especially at high nitrate concentrations.The NUtE of OsNPF3.1-overexpressing plants was enhanced under low and medium nitrate concentrations,whereas the NUtE of OsNPF3.1 clustered regularly interspaced short palindromic repeats(CRISPR)plants was increased under high nitrate concentrations.The results indicate that OsNPF3.1 transports nitrate and phytohormones in different rice tissues under different nitrate concentrations.The altered OsNPF3.1 expression improves NUtE in the OsNPF3.1-overexpressing and CRISPR lines at low and high nitrate concentrations,respectively. | Junnan Hang Bowen Wu Diyang Qiu Guo Yang Zhongming Fang Mingyong Zhang | 2024 | Journal of Integrative Agriculture2024，23，4： | 0 |
| 17 | 克隆整合影响严重光胁迫下第一分株世代的生长和沉积物特征但不影响后续分株世代的生长和沉积物特征显示文摘克隆整合通过缓冲环境压力和提高资源获取效率使克隆植物受益。然而,在一个克隆系统中,受益于克隆整合的连接分株世代的数量很少受到关注。我们进行了一个盆栽实验来评估沉水植物苦草(Vallisneria natans)克隆系统内的生理整合程度,该克隆系统由一个母株和3个依次连接的后代分株组成。母株生长在正常光照下,而后代分株被严重遮荫。母株与后代分株间的匍匐茎被切断或保持连接,但3个后代分株之间的连接仍然存在。与遮荫的后代分株连接时,苦草未遮荫的母株的光合能力显著增强,但其生物量积累大大减少。克隆整合显著增加了第一分株世代(相邻分株)的生物量积累和土壤的碳氮可用性、胞外酶活性和微生物生物量,但没有增加后续分株世代的这些特征。我们的结果表明,在严重光胁迫下,来自苦草母株的支持可能仅限于克隆系统中相邻的后代分株,这暗示着一个分株世代的效应。我们的结果有助于更好地理解克隆植物的层次结构和分段化。这些发现表明克隆整合程度在分株种群的生态相互作用中起着至关重要的作用。 | Xiaowen Ma Yang Li Weicheng Yu Junnan Wang Chunhua Liu | 2022 | Journal of Plant Ecology2022，15，5： | 0 |
| 18 | Studying bona fide SARS-CoV-2 biology in a BSL-2 biosafety environment using a split-virus-genome system显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARSCoV-2)was identified as the pathogen causing the coronavirus disease(COVID-19),which sometimes resulted in fatal pneumonia(Hu et al.,2021).SARS-CoV-2 is a biosafety level 3(BSL-3)pathogen,and the requirement for high containment conditions is a bottleneck for basic research on viral biology.To help general researchers who wish to study SARS-CoV-2 but do not have access to a BSL-3 facility,a system that(1)can mimic the real life cycle of the virus;(2)allows easy genetic manipulation;and(3)shows high biosafety in BSL-2 laboratory is required. | Yingxin Ma Guobin Mao Weishan Yang Guoqiang Wu Guoqiang Li Xiaoying Li Xin Lin Junnan Lu Shijun Zhao Wei Zhao Junbiao Dai Xian-En Zhang | 2022 | Science China(Life Sciences)2022，65，9： | 0 |
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