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| 1 | The Calcineurin B-Like Calcium Sensors CBL1 and CBL9 Together with Their Interacting Protein Kinase ClPK26 Regulate the Arabidopsis NADPH Oxidase RBOHF显示文摘象反应的氧种类(ROS ) 和 Ca2+ 一样的第二个送信人的刺激特定的累积对许多在植物发信号和规定过程中央。然而,管理发信号的 Ca2+ 和 ROS 的相互的相互关系的机制开始仅仅正在出现。呼吸爆炸 oxidase 相当或相同的事物(RBOH ) 的 NADPH oxidases 家庭是当和他们的交往的 kinases (CIPK ) 的 Calcineurin 象 B 一样(CBL )Ca2+ 传感器蛋白质被显示了在表明过程的许多 Ca2+- 工作时,贡献 ROS 的产生的批评部件。在这研究,我们识别在两个都表明系统之间的直接功能的相互作用。我们报导交往 CBL 蛋白质 kinase CIPK26 明确地在酵母与 RBOHF 的 N 终端领域交往二混血儿的分析并且与在植物房间的全身的 RBOHF 蛋白质。另外,在有 CIPK26 的 CBL1 或 CBL9 的 vitro 和合作表示的 CIPK26 phosphorylates RBOHF 强烈在 HEK293T 房间由 RBOHF 提高 ROS 生产。一起,这些调查结果识别在调停 CBLCIPK 的 Ca2+ 在植物发信号并且 ROS 发信号之间的直接互联并且为 NADPH oxidase RBOHF 的 synergistic 激活提供证据由对它由 CBL1/9CIPK26 建筑群的 EF 传递和导致 Ca2+ 的 phosphorylation 直接 Ca2+ 有约束力。 | Maria Magdalena Drerup Kathrin Schlückinga Kenji Hashimoto Prabha Manishankar Leonie Steinhorst Kazuyuki Kuchitsu Jōrg Kudl | 2013 | Molecular Plant2013，6，2： | 35 |
| 2 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 3 | Is the schatzki ring a unique esophageal entity?显示文摘AIM:To study,whether the association of Schatzki rings with other esophageal disorders support one of the theories about its etiology.METHODS:From 1987 until 2007,all patients with newly diagnosed symptomatic Schatzki rings (SRs) were prospectively registered and followed.All of them underwent structured interviews with regards to clinical symptoms,as well as endoscopic and/or radiographic examinations.Endoscopic and radiographic studies determined the presence of an SR and additional morphological abnormalities.RESULTS:One hundred and sixty-seven patients (125 male,42 female) with a mean age of 57.1±14.6 years were studied.All patients complained of intermittent dysphagia for solid food and 113 (79.6%) patients had a history of food impaction.Patients experienced symptoms for a mean of 4.7±5.2 years before diagnosis.Only in 23.4% of the 64 patients who had endoscopic and/or radiological examinations before their first presentation to our clinic,was the SR previously diagnosed.At presentation,the mean ring diameter was 13.9±4.97 mm.One hundred and sixty-two (97%) patients showed a sliding hiatal hernia.Erosive reflux esophagitis was found in 47 (28.1%) patients.Twenty-six (15.6%) of 167 patients showed single or multiple esophageal webs;five (3.0%) patients exhibited eosinophilic esophagitis;and four (2.4%) had esophageal diverticula.Four (7%) of 57 patients undergoing esophageal manometry had nonspecific esophageal motility disorders.CONCLUSION:Schatzki rings are frequently associated with additional esophageal disorders,which support the assumption of a multifactorial etiology.Despite typical symptoms,SRs might be overlooked. | Michaela Müller Ines Gockel Philip Hedwig Alexander J Eckardt Kathrin Kuhr Jochem Knig Volker F Eckardt | 2011 | World Journal of Gastroenterology2011，17，23： | 2 |
| 4 | Mucosal Healing in Inflammatory Bowel Disease: Results From a Norwegian Population-Based Cohort显示文摘 | Kathrine Frey Fr?slie J?rgen Jahnsen Bj?rn A. Moum Morten H. Vatn | 2007 | Gastroenterology2007，，2： | 2 |
| 5 | Deletion of CD73 promotes dyslipidemia and intramyocellular lipid accumulation in muscle of mice显示文摘 | Sandra Burghoff Ulrich Fl?gel Sabine Bongardt Volker Burkart Henrike Sell Sara Tucci Kathrin Ikels Daniel Eberhard Matthias Kern Nora Kl?ting Jürgen Eckel Jürgen Schrader | 2013 | Archives Of Physiology And Biochemistry2013，，2： | 1 |
| 6 | Role of histone H3 lysine 27 methylation in X inactivation显示文摘 | Kathrin P Fang J Susanna K | 2003 | Science2003，300，： | 1 |
| 7 | Phenotypic characterization of skin lesions in urticaria pigmentosa and mastocytomas显示文摘 | Norbert Haas Kathrin Hamann Jürgen Grabbe Bernd Algermissen Beate M. Czarnetzki | 1995 | Archives of Dermatological Research (-)1995，，3： | 1 |
| 8 | SOCS-1 and SOCS-3 inhibit IFN-α-induced expression of the antiviral proteins 2,5-OAS and MxA显示文摘 | George Vlotides Astrid S S?rensen Florian Kopp Kathrin Zitzmann Neziha Cengic Stephan Brand Reinhart Zachoval Christoph J Auernhammer | 2004 | Biochemical and Biophysical Research Communications2004，，3： | 1 |
| 9 | The degradative pathway of the S2 triazinemelamine 显示文摘 | Kathrin J | 1982 | J Biochem1982，208，： | 1 |
| 10 | Exposure to estrogen and women’s risk for Parkinson’s disease: A prospective cohort study in Denmark显示文摘 | Kathrine Rugbjerg Jane Christensen Anne Tj?nneland J?rgen H. Olsen | 2013 | Parkinsonism and Related Disorders2013，，： | 1 |
| 11 | Mucosal Healing in Inflammatory Bowel Disease: Results From a Norwegian Population-Based Cohort显示文摘 | Kathrine Frey Fr?slie J?rgen Jahnsen Bj?rn A. Moum Morten H. Vatn | 2007 | Gastroenterology2007，，2： | 1 |
| 12 | A pharmacist-led information technology intervention for medication errors (PINCER): a multicentre, cluster randomised, controlled trial and cost-effectiveness analysis显示文摘 | Anthony J Avery Sarah Rodgers Judith A Cantrill Sarah Armstrong Kathrin Cresswell Martin Eden Rachel A Elliott Rachel Howard Denise Kendrick Caroline J Morris Robin J Prescott Glen Swanwick Matthew Franklin Koen Putman Matthew Boyd Aziz Sheikh | 2012 | The Lancet . 2012 (9823)2012，，： | 1 |
| 13 | The impact of transformational, transactional and non-leadership styles on employee job satisfaction in the German hospitality industry显示文摘 | Kathrin Rothfelder Michael C Ottenbacher Robert J Harrington | 2013 | Tourism and Hospitality Research2013，，： | 1 |
| 14 | Estradiol decreases IGF-1 and IGF-1 receptor expression in rat aortic smooth muscle cells 显示文摘 | Kathrin J Scheidegger Bruno Cenni | 2000 | Biol Chem2000，275，38： | 1 |
| 15 | Symptoms of detachment from the self or from the environment in patients with an acquired deficiency of the special senses显示文摘 | Kathrine Jáuregui-Renaud Verónica Ramos-Toledo Miriam Aguilar-Bola?os Bertha Monta?o-Velázquez Alejandro Pliego-Maldonado | 2008 | Journal of Vestibular Research2008，，2： | 1 |
| 16 | Stroke seasonality associations with subtype, etiology and laboratory results in the Ludwigshafen Stroke Study (LuSSt)显示文摘 | Frederick Palm Michael Dos Santos Christian Urbanek Matthias Greulich Kathrin Zimmer Anton Safer Armin Jürgen Grau Heiko Becher | 2013 | European Journal of Epidemiology2013，，5： | 1 |
| 17 | Parenteral nutrition with standard solutions in paediatric intensive care patients显示文摘 | Kathrin Krohn Jürgen Babl Karl Reiter Berthold Koletzko | 2004 | Clinical Nutrition2004，，2： | 1 |
| 18 | Mucosal Healing in Inflammatory Bowel Disease: Results From a Norwegian Population-Based Cohort显示文摘 | Kathrine Frey Fr?slie J?rgen Jahnsen Bj?rn A. Moum Morten H. Vatn | 2007 | Gastroenterology2007，，2： | 1 |
| 19 | The degradative pathway of the S-friazine melamine 显示文摘 | Kathrin J | 1982 | J Biochem1982，208，： | 1 |
| 20 | An expanded population of natural killer cells in mice with severe combined immunodeficieney (SCID) lack rearrange-ment and expression of T cell receptor genes 显示文摘 | Robert J Lauzou Kathrine A Simnovitch Gabrielie M Fulop | 1986 | Exp Med1986，164，11： | 1 |
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