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| 1 | OsIDD2, a zinc finger and INDETERMINATE DOMAIN protein, regulates secondary cell wall formation显示文摘Previously, we found 123 transcription factors(TFs) as candidate regulators of secondary cell wall(SCW)formation in rice by using phylogenetic and co-expression network analyses. Among them, we examined in this work the role of OsIDD_2, a zinc finger and indeterminate domain(IDD) family TF. Its overexpressors showed dwarfism, fragile leaves, and decreased lignin content, which are typical phenotypes of plants defective in SCW formation, whereas its knockout plants showed slightly increased lignin content.The RNA-seq and quantitative reverse transcription polymerase chain reaction analyses confirmed that some lignin biosynthetic genes were downregulated in the OsIDD_2-overexpressing plants, and revealed the same case for other genes involved in cellulose synthesis and sucrose metabolism. The transient expression assay using rice protoplasts revealed that OsIDD_2 negatively regulates the transcription of genes involved in lignin biosynthesis, cinnamyl alcohol dehydrogenase 2 and 3(CAD_2 and 3), and sucrose metabolism, sucrose synthase 5(SUS_5), whereas an Alpha Screen assay, which can detect the interaction between TFs and their target DNA sequences, directly confirmed the interaction between OsIDD_2 and the target sequences located in the promoter regions of CAD_2 and CAD_3. Based on these observations, we conclude that OsIDD_2 is negatively involved in SCW formation and other biological events by downregulating its target genes. | Peng Huang Hideki Yoshida Kenji Yano Shunsuke Kinoshita Kyosuke Kawai Eriko Koketsu Masako Hattori Sayaka Takehara Ji Huang Ko Hirano Reynante Lacsamana Ordonio Makoto Matsuoka Miyako Ueguchi-Tanaka | 2018 | Journal of Integrative Plant Biology2018，60，2： | 3 |
| 2 | Hemorrhagic shock due to submucosal esophageal hematoma along with mallory-weiss syndrome:A case report显示文摘BACKGROUND Esophageal submucosal hematoma is a rare condition.Although the exact etiology remains uncertain,vessel fragility with external factors is believed to have led to submucosal bleeding and hematoma formation;the vessel was ruptured by a sudden increase in pressure due to nausea,and the hematoma was enlarged by antiplatelet or anticoagulant therapy.Serious conditions are rare,with a better prognosis.We present the first known case of submucosal esophageal hematoma-subsequent hemorrhagic shock due to Mallory-Weiss syndrome.CASE SUMMARY A 73-year-old female underwent endovascular treatment for an unruptured cerebral aneurysm.The patient received aspirin and clopidogrel before surgery and heparin during surgery,and was well during the surgery.Several hours after returning to the ICU,she complained of chest discomfort,vomited 500 m L of fresh blood,and entered hemorrhagic shock.Esophageal submucosal hematoma with Mallory-Weiss syndrome was diagnosed through an endoscopic examination and computed tomography.In addition to a massive fluid and erythrocyte transfusion,we performed a temporary compression for hemostasis with a Sengstaken-Blakemore(S-B)tube.Afterwards,she became hemodynamically stable.On postoperative day 1,we performed an upper gastrointestinal endoscopy and confirmed no expansion of the hematoma nor any recurring bleeding;therefore,we removed the S-B tube and clipped the gastric mucosal laceration at the esophagogastric junction.We started oral intake on postoperative day 10.The patient made steady progress,and was discharged on postoperative day 33.CONCLUSION We present the first known case of submucosal esophageal hematoma subsequent hemorrhagic shock due to Mallory-Weiss syndrome. | Jiro Oba Daisuke Usuda Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Hayabusa Takano Shintaro Shimozawa Yuta Hotchi Kenki Usami Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita | 2022 | World Journal of Clinical Cases2022，10，27： | 3 |
| 3 | 显示出与肝炎 B 病毒感染联系的微分表示的细胞的基因的鉴定显示文摘 AIM: To investigate the impact of hepatitis B virus (HBV) infection on cellular gene expression, by conducting both in vitro and in vivo studies. METHODS: Knockdown of HBV was targeted by stable expression of short hairpin RNA (shRNA) in huH-1 cells. Cellular gene expression was compared using a human 30K cDNA microarray in the cells and quantified by real-time reverse transcription-polymerase chain reaction (RT-PCR) (qRT-PCR) in the cells, hepatocellular carcinoma (HCC) and surrounding non-cancerous liver tissues (SL). RESULTS: The expressions of HBsAg and HBx protein were markedly suppressed in the cells and in HBx transgenic mouse liver, respectively, after introduction of shRNA. Of the 30K genes studied, 135 and 103 genes were identified as being down- and up-regulated, respectively, by at least twofold in the knockdown cells. Functional annotation revealed that 85 and 62 genes were classified into four up-regulated and five down-regulated functional categories, respectively. When gene expression levels were compared between HCC and SL, eight candidate genes that were confirmed to be up- or down-regulated in the knockdown cells by both microarray and qRT-PCR analyses were not expressed as expected from HBV reduction in HCC, but had similar expression patterns in HBV- and hepatitis C virus-associated cases. In contrast, among the eight genes, only APM2 was constantly repressed in HBV non-associated tissues irrespective of HCC or SL. | Yasuo Fukuhara Takeshi Suda Makoto Kobayashi Yasushi Tamura Masato Igarashi Nobuo Waguri Hirokazu Kawai Yutaka Aoyagi | 2012 | World Journal of Hepatology2012，4，4： | 2 |
| 4 | Markers of insulin resistance in day and shift workers aged 30–59 years显示文摘 | Teruo Nagaya Hideyo Yoshida Hidekatsu Takahashi Makoto Kawai | 2002 | International Archives of Occupational and Environmental Health2002，，8： | 1 |
| 5 | Gram-positive cocci are associated with the formation of completely pure cholesterol stones显示文摘 | Manabu Kawai Makoto Iwahashi Kazuhisa Uchiyama Minoru Ochiai Hiroshi Tanimura Hiroki Yamaue | 2002 | The American Journal of Gastroenterology2002，，1： | 1 |
| 6 | Prospective and randomized clinical trial for the treatment of hepatocellular carcinoma—a comparison between L-TAE with Farmorubicin and L-TAE with Adriamycin: preliminary results (second cooperative study)显示文摘 | Saburo Kawai Masayoshi Tani Jun Okamura Makoto Ogawa Yasuo Ohashi Morito Monden Shigeki Hayashi Jushiro Inoue Yoshifumi Kawarada Mitsuo Kusano Yasuhiko Kubo Chikazumi Kuroda Yu Sakata Yoshiyuki Shimamura Kenji Jinno Akira Takahashi Kenichi Takayasu Kazuo | 1994 | Cancer Chemotherapy and Pharmacology1994，，1： | 1 |
| 7 | Overexpression of the miR-34 family suppresses invasive growth of malignantmelanoma with the wild-type p53 gene显示文摘 | Hitoshi Yamazaki Tsuyoshi Chijiwa Yoshimasa Inoue Yoshiyuki Abe Hiroshi Suemizu Kenji Kawai Masatoshi Wakui Daisuke Furukawa Masaya Mukai Sadahito Kuwao Makoto Saegusa Masato Nakamura | 2012 | Experimental and Therapeutic Medicine2012，，5： | 1 |
| 8 | Clinical pathway to discharge 3 days after colorectal endoscopic submucosal dissection显示文摘 | Yuichi Tomiki Masaya Kawai Kazuhiro Takehara Yoshihiko Tashiro Shinya Munakata Kazumasa Kure Shun Ishiyama Kiichi Sugimoto Hirohiko Kamiyama Makoto Takahashi Kazuhiro Sakamoto | 2015 | Digestive Endoscopy2015，，6： | 1 |
| 9 | Intelligent vehicle and advanced safety technology 显示文摘 | KAWAI Makoto TAKAYUKI Shinnosuke | 2004 | Review of Automotive Engineering2004，25，2： | 1 |
| 10 | A novel endoscopic submucosal dissection technique with robust and adjustable tissue traction显示文摘 | Masashi Hirota Motohiko Kato Makoto Yamasaki Naoki Kawai Yasuhiro Miyazaki Takuya Yamada Tsuyoshi Takahashi Tetsuo Takehara Masaki Mori Yuichiro Doki Kiyokazu Nakajima | 2014 | Endoscopy2014，，： | 1 |
| 11 | Quantitative Evaluation of Tear Meniscus Height From Fluorescein Photographs显示文摘 | Masataka Kawai Masakazu Yamada Motoko Kawashima Makoto Inoue Eiki Goto Yukihiko Mashima Kazuo Tsubota | 2007 | Cornea2007，，4： | 1 |
| 12 | Improvement of the oral bioavailability of coenzyme Ql0 by e- mulsification with fats and emulsifiers used in the food industry 显示文摘 | Pariya Thanatuksorn Kiyoshi Kawai Makoto Hayakawa | 2009 | LWT - Food Science and Technology2009，42，1： | 1 |
| 13 | N-alkylation of aniline derivatives by use of potassium cation-exchanged Y-type zeolite显示文摘 | Makoto O Akihiro U Motomitsu Kawai | | 0，，： | 1 |
| 14 | Effects of Mutation in Hepatitis C Virus Nonstructural Protein 5A on Interferon Resistance Mediated by Inhibition of PKR Kinase Activity in Mammalian Cells显示文摘 | Tohru Noguchi Shinya Satoh Takeshi Noshi Eriko Hatada Ryuji Fukuda Akihiko Kawai Satoru Ikeda Makoto Hijikata Kunitada Shimotohno | 2001 | Microbiology and Immunology2001，，12： | 1 |
| 15 | Simultaneous Induction of Galectin-3 Phosphorylated on Tyrosine Residue, p21 WAF1/Cip1/Sdi1 , and the Proliferating Cell Nuclear Antigen at a Distinctive Period of Repair of Hepatocytes Injured by CCl4显示文摘 | Kazumaro Yamazaki Akiko Kawai Makoto Kawaguchi Yasuhide Hibino Fang Li Masakiyo Sasahara Kazuhiro Tsukada Koichi Hiraga | 2001 | Biochemical and Biophysical Research Communications2001，，4： | 1 |
| 16 | Prospective and randomized clinical trial for the treatment of hepatocellular carcinoma — a comparison of lipiodol-transcatheter arterial embolization with and without Adriamycin (first cooperative study)显示文摘 | Saburo Kawai Jun Okamura Makoto Ogawa Yasuo Ohashi Masayoshi Tani Jushiro Inoue Yoshifumi Kawarada Mitsuo Kusano Yasuhiko Kubo Chikazumi Kuroda Yu Sakata Yoshiyuki Shimamura Kenji Jinno Akira Takahashi Kenichi Takayasu Kazuo Tamura Naofumi Nagasue Yoshimi | 1992 | Cancer Chemotherapy and Pharmacology1992，，1： | 1 |
| 17 | Difference in risk factors between acute coronary syndrome and stable angina pectoris in the Japanese: Smoking as a crucial risk factor of acute coronary syndrome显示文摘 | Hidenori Yagi Kimiaki Komukai Koichi Hashimoto Makoto Kawai Takayuki Ogawa Ryuko Anzawa Kosuke Minai Tomohisa Nagoshi Kazuo Ogawa Ikuo Taniguchi Michihiro Yoshimura | 2010 | Journal of Cardiology2010，，3： | 1 |
| 18 | Isolation of a new potent cytotoxic pigment along with indigotin from the pathogenic basidiomycetous fungus Schizophyllum commune显示文摘 | Tomoo Hosoe Koohei Nozawa Nobuo Kawahara Kazutaka Fukushima Kazuko Nishimura Makoto Miyaji Ken-ichi Kawai | 1999 | Mycopathologia1999，，1： | 1 |
| 19 | Discovery of novel and orally active NR2B- selective N- methyl- D- aspartate (NMDA) antagonists, pyridinol derivatives with reduced HERG binding affinity 显示文摘 | Makoto Kawai Hiroshi Nakamura Isao Sakurada | 2007 | Bioorganic & Medicinal Chemistry Letters2007，17，： | 1 |
| 20 | Intelligent Vehicle and advanced Safety Technology显示文摘 | Kawai Makoto Shinnosuke Takayuki | 2004 | Review of automotive Engineering2004，25，2： | 1 |
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