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| 1 | Treating COVID-19 with Chloroquine显示文摘A novel coronavirus disease 2019(COVID-19)emerged around December 2019 in Wuhan,China and has spread rapidly worldwide(Lu et al.,2020).Until March 27,2020,the Chinese health authorities had reported 82082 confirmed COVID-19 cases in China with 3298 deaths and 381443 confirmed cases with 20787 deaths outside China.The World Health Organization(WHO)named the virus SARS-CoV-2,which belongs to a distinct clade from the human severe acute respiratory syndrome CoV(SARS-CoV)and Middle East respiratory syndrome CoV(MERSCoV)(Zhu et al.,2020). | Mingxing Huang Tiantian Tang Pengfei Pang Man Li Ruolan Ma Jiahui Lu Jingxian Shu Yingying You Binghui Chen Jiabi Liang Zhongsi Hong Huili Chen Ling Kong Dajiang Qin Duanqing Pei Jinyu Xia Shanping jiang Hong Shan | 2020 | Journal of Molecular Cell Biology2020，12，4： | 1 |
| 2 | Caspofungin versus liposomal amphotericin B for treatment of invasive fungal infections or febrile neutropenia显示文摘 | Zhang Jinyu Gong Yizhen Wang Ke Kong Jinliang Chen Yiqiang | 2014 | Chinese Medical Journal2014，，4： | 1 |
| 3 | Defect spinel oxides for electrocatalytic reduction reactions显示文摘Electrocatalytic reduction reactions play a crucial role in electrochemical energy conversion and storage technology,which are emerging technologies to ameliorate environmental problems.Spinel oxides are widely explored in electrocatalytic oxidation reactions but have a poor intrinsic ability to reduction reactions,making their electrocatalytic ability less effective.To improve this,defect engineering is a valuable method for regulating the electronic structure and coordination environment.Herein,this manuscript discusses the use of defect spinel oxides in electrocatalytic reduction reactions,including the different types of defects,construction methods,and characterization techniques.It also outlines the various applications of defect spinel oxides in different electrocatalytic reduction reactions.Finally,it goes over the challenges and future outlooks for defect spinels.This review aims to thoroughly explain how defect spinels work in electrocatalytic reduction reactions and serve as a helpful guide for creating effective electrocatalysts. | Zhijuan Liu Jinyu Guo Lu-yu Liu Fen Wang Zhijie Kong Yanyong Wang | 2024 | Nano Research2024，17，5： | 0 |
| 4 | New progress in esophageal cancer research of China显示文摘China has the highest incidence of esophageal squamous cell carcinoma(ESCC).Unlike esophageal adenocarcinoma in western countries,90%of esophageal cancer in China is squamous cell carcinoma,and there are distinct regional differences.Cancer stem cells,microecology,and epigenetics are closely related to esophageal cancer occurrence and development.The application of endoscopic ultrasonography,PET-CT,and MRI are conducive to the accurate staging of esophageal cancer.Advanced technologies such as neoadjuvant/definitive concurrent chemoradiotherapy,minimally invasive surgery,and photodynamic therapy have improved the overall survival and quality.The application of immunotherapy in advanced esophageal cancer has achieved remarkable results. | JIA Ruinuo SHENG Manxi KONG Jinyu GAO Shegan | 2021 | 中国研究型医院2021，8，1： | 0 |
| 5 | Dietary coated essential oil and organic acid mixture supplementation improves health of broilers infected with avian pathogenic Escherichia coli显示文摘Colibacillosis caused by avian pathogenic Escherichia coli(APEC)is a very prevalent disease in poultry farms in China.The exploration of effective non-antibiotic substances is of great significance for the control of APEC infections.This experiment evaluated the efficacy of coated essential oil and organic acid(EOA)supplementation to prevent E.coli O78 infection in broiler chickens.A total of 288 one-day-old male broiler chicks were randomly distributed into 4 groups with 6 replicates per group.Chickens were fed a diet either supplemented with EOA(500 mg/kg feed)or not,and either uninfected or infected with E.coli O78 intratracheally.Results showed that E.coli O78 infection reduced body weight gain,increased mortality and the ratio of feed to gain along with cecal and liver E.coli load,damaged gut mucosa,induced local and systemic inflammation,and altered cecal microbial composition,diversity and function(P<0.05).Supplemental EOA improved feed conversion efficiency,lowered gross lesion scores and cecal E.coli population,enhanced intestinal goblet cells and serum IgG concentration,and tended to decrease serum IL-12 production(P<0.05).Essential oil and organic acid addition downregulated IFN-γmRNA,tended to decrease mucin-2 mRNA levels while upregulating IL-10 mRNA,and tended to increase ZO-1 gene expression in the jejuna of infected birds at 7 d after E.coli O78 challenge(P<0.05).The 16S rRNA gene sequencing indicated that both EOA addition and E.coli O78 challenge altered the diversity and composition of the cecal microbiota community.Furthermore,infected birds fed EOA showed decreased Bacteroidetes and genus Lactobacillus abundance compared with the infected control.LEfSe analysis showed that Firmicutes,Ruminococcaceae,Clostridiales,Clostridia,Lactobacillus,Lactobacilaceae,and cc-115 were enriched in the non-infected but EOA-treated group(P<0.05).Collectively,dietary EOA supplementation could mildly alleviate E.coli-induced gut injury and inflammation. | Van Hieu Pham Waseem Abbas Jinyu Huang Fangshen Guo Kaichen Zhang Linhua Kong Wenrui Zhen Yuming Guo Zhong Wang | 2023 | Animal Nutrition2023，，1： | 0 |
| 6 | Normal-Weight Abdominal Obesity: A Risk Factor for Hypertension and Cardiometabolic Dysregulation显示文摘Objective:This study aimed to examine the associations of waist circumference with hypertension and cardiometabolic dysregulation among normal-weight adults.Methods:This cross-sectional study included 8795 normal-weight participants aged 20 to 79 years from the 2009–2018 US National Health and Nutrition Examination Survey.The demographic characteristics and cardiometabolic risk factors across waist circumference quartiles were summarized.We used adjusted multivariate logistic regression models,subgroup analysis,and restricted cubic spline to analyze the association between waist circumference and the prevalence of hypertension.Thereafter,we used the random forest supervised machine learning method,together with least absolute shrinkage and selection operator regression,to select hypertension-related features and created a predictive model based on regression analysis to identify hypertension in normal-weight individuals.Results:Waist circumference was positively correlated with hypertension in the non-adjusted,minimally adjusted,and fully adjusted models,with odds ratios(95%confidence interval)of 2.28(2.14–2.44),1.27(1.12–1.44),and 1.27(1.12–1.44),respectively.In the fully adjusted model,participants in the highest waist circumference quartile had a higher risk of hypertension relative to those in the lowest quartile,with an odds ratio(95%confidence interval)of 3.87(1.59–10.34).Sensitivity analysis demonstrated the robustness of the association.In the testing set,the predictive model exhibited good performance,with an area under the curve of 0.803,sensitivity of 0.72,specificity of 0.76,and negative predictive value of 0.84.Conclusions:Measuring waist circumference may improve the evaluation of the risk of hypertension and help to manage cardiometabolic risk in normal-weight individuals. | Jinyu Sun Qiang Qu Yue Yuan Guozhen Sun Xiangqing Kong Wei Sun | 2022 | Cardiology Discovery2022，2，1： | 0 |
| 7 | Epigenetic regulation of SARS-Cov-2 spike protein modulates cellular viability and nascent RNA transcription in neuronal cells显示文摘SARS-CoV-2 has been demonstrated to be highly susceptible to neuron-and glial-like cells,1 but there is no consensus regarding how the virus affects neurons following neuroinvasion.It is therefore unknown if and how SARS-CoV-2 maintains the homeostasis of neuronal cells.Herein,we revealed that the receptor-binding domain(RBD)of the SARS-CoV-2 spike protein acted as an extracellular remodeling component to undermine epigenetic regulation,perturbnascentRNA(nsRNA)transcription,promote mitochondrial biogenesis,and increase cellular viability in SH-SY5Y cells. | Xi Kong Peng Lu Jinyue Zhang Zheng Bao Chenghao Kuang Bingqing Xie Jianhua Peng Ning Ma Yong Jiang Shigang Yin | 2024 | Genes & Diseases2024，11，2： | 0 |
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