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| 1 | Proposed criteria to differentiate heterogeneous eosinophilic gastrointestinal disorders of the esophagus, including eosinophilic esophageal myositis显示文摘AIM To define clinical criteria to differentiate eosinophilic gastrointestinal disorder(Eo GD) in the esophagus. METHODS Our criteria were defined based on the analyses of the clinical presentation of eosinophilic esophagitis(Eo E), subepithelial eosinophilic esophagitis(s Eo E) and eosinophilic esophageal myositis(Eo EM), identified by endoscopy, manometry and serum immunoglobulin E levels(s-Ig E), in combination with histological and polymerase chain reaction analyses on esophageal tissue samples.RESULTS In five patients with Eo E, endoscopy revealed longitudinal furrows and white plaques in all, and fixed rings in two. In one patient with s Eo E and four with Eo EM, endoscopy showed luminal compression only. Using manometry, failed peristalsis was observed in patients with Eo E and s Eo E with some variation, while Eo EM was associated with hypercontractile or hypertensive peristalsis, with elevated s-Ig E. Histology revealed the following eosinophils per high-power field values. Eo E = 41.4 ± 7.9 in the epithelium and 2.3 ± 1.5 in the subepithelium; s Eo E = 3 in the epithelium and 35 in the subepithelium(conventional biopsy); Eo EM = none in the epithelium, 10.7 ± 11.7 in the subepithelium(conventional biopsy or endoscopic mucosal resection) and 46.8 ± 16.5 in the muscularis propria(peroral esophageal muscle biopsy). Presence of dilated epithelial intercellular space and downward papillae elongation were specific to Eo E. Eotaxin-3, IL-5 and IL-13 were overexpressed in Eo E.CONCLUSION Based on clinical and histological data, we identified criteria, which differentiated between Eo E, s Eo E and Eo EM, and reflected a different pathogenesis between these esophageal Eo GDs. | Hiroki Sato Nao Nakajima Kazuya Takahashi Go Hasegawa Ken-ichi Mizuno Satoru Hashimoto Satoshi Ikarashi Kazunao Hayashi Yutaka Honda Junji Yokoyama Yuichi Sato Shuji Terai | 2017 | World Journal of Gastroenterology2017，23，13： | 2 |
| 2 | Synthesis and structure activity relationships of no- vel fungal chitin synthase inhibitors 显示文摘 | Kazunao Masubuchi Mikio Taniguchi Isao Umeda et a/ | 2000 | Bioorg Med Chem Lett2000，10，： | 1 |
| 3 | Endoscopic ultrasound-guided fine-needle aspiration for diagnosing a rare extraluminal duodenal gastrointestinal tumor显示文摘Duodenal gastrointestinal stromal tumors(GISTs) are extremely rare disease entities, and the extraluminal type is difficult to diagnose. These tumors have been misdiagnosed as pancreatic tumors; hence, pancreaticoduodenectomy has been performed, although partial duodenectomy can be performed if accurately diagnosed. Developing a diagnostic methodology including endoscopic ultrasonography(EUS) and fine-needle aspiration(FNA) has allowed us to diagnose the tumor directly through the duodenum. Here, we present a case of a 50-year-old woman with a 27-mm diameter tumor in the pancreatic uncus on computed tomography scan. EUS showed a well-defined hypoechoic mass in the pancreatic uncus that connected to the duodenal proper muscular layer and was followed by endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA). Histological examination showed spindle-shaped tumor cells positively stained for c-kit. Based on these findings, the tumor was finally diagnosed as a duodenal GIST of the extraluminal type, and the patient underwent successful mass resection with partial resection of the duodenum. This case suggests that EUS and EUS-FNA are effective for diagnosing the extraluminal type of duodenal GISTs, which is difficult to differentiate from pancreatic head tumor, and for performing the correct surgical procedure. | Kazunao Hayashi Kenya Kamimura Kazunori Hosaka Satoshi Ikarashi Junji Kohisa Kazuya Takahashi Kentaro Tominaga Kenichi Mizuno Satoru Hashimoto Junji Yokoyama Satoshi Yamagiwa Kazuyasu Takizawa Toshifumi Wakai Hajime Umezu Shuji Terai | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，12： | 1 |
| 4 | Inhibitory effects of total flavones of Hippophae Rhamnoides L on thrombosis in mouse femoral artery and in vitro platelet aggregation 显示文摘 | Cheng JY Kazunao Kondo Yasuhiro Suzuki | 2003 | Life Sci2003，72，20： | 1 |
| 5 | Inhibitory Effects of Total Flavones of Hippophae Rhamnoides Lon Thrombosis in Mouse Femoral Artery and in Vitro Platelet Aggregation显示文摘 | Cheng JY Kazunao K Suzuki Y | 2003 | Life Sc&nces2003，72，5： | 1 |
| 6 | A single recessive gene controls cadmium translocation in the cadmium hyperaccumulating rice cultivar Cho-Ko-Koku显示文摘 | Kouichi Tezuka Hidenori Miyadate Kazunao Katou Ikuko Kodama Shinichi Matsumoto Tomohiko Kawamoto Satoshi Masaki Hideki Satoh Masayuki Yamaguchi Kenji Sakurai Hidekazu Takahashi Namiko Satoh-Nagasawa Akio Watanabe Tatsuhito Fujimura Hiromori Akagi | | 0，2010，： | 1 |
| 7 | Dietary supplementation with fermented soybeans suppresses intimal thickening 显示文摘 | Yasuhiro S Kazunao K Hideyuki I | 2003 | Nutrition2003，19，3： | 1 |
| 8 | Dietary supplementation with fermented soybeans suppresses intimal thickening显示文摘 | Yasuhiro Suzuki Kazunao Kondo Hideyuki Ichise Yoshinori Tsukamoto Tetsumei Urano Kazuo Umemura | 2003 | Nutrition2003，，3： | 1 |
| 9 | Dietary supplementation with fermented soybeans suppresses Intimal thickening显示文摘 | YASUHIRO S KAZUNAO K HIDEYUKI I | 2003 | Basic Nutrition Investigation2003，19，3： | 1 |
| 10 | Combination of a free radical scavenger and heparin reduces cerebral hemorrhage after heparin treatment in a rabbit middle cerebral artery occlusion model显示文摘 | Bing-Qiao Zhao Yasuhiro Suzuki Kazunao Kondo | 2001 | Stroke2001，32，9： | 1 |
| 11 | Coagulation/Fibrinolysis Disorder in Patients with Severe Preeclampsia显示文摘 | Takao Kobayashi Naoki Tokunaga Motoi Sugimura Kazunao Suzuki Naohiro Kanayama Tomizo Nishiguchi Toshihiko Terao | 1999 | Semin Thromb Hemost1999，，05： | 1 |
| 12 | Inhibitory effects of total flavones of Hippophae Rhamnoides L on thrombosis in mouse femoral artery and in vitro platelet aggregation显示文摘 | Cheng Jiayi Kondo Kazunao Suzuki Yasuhiro | 2003 | Life Sciences2003，72，20： | 1 |
| 13 | Inhibitory effects of total flavones of Hippophae Rhamnoides L on thrombosis in mouse femoral artery and in vitro platelet aggregation显示文摘 | Jiayi C Kazunao K Yasuhiro S | 2003 | Life Sciences2003，72，： | 1 |
| 14 | Dietary supplementation of fermented soybean,natto,suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery显示文摘 | Yasuhiro Suzuki Kazunao | 2003 | Life Sciences2003，73，： | 1 |
| 15 | Usefulness of ultrasonography to assess the response to steroidal therapy for the rare case of type 2b immunoglobulin G4-related sclerosing cholangitis without pancreatitis:A case report显示文摘BACKGROUND A type 2b immunoglobulin G4(IgG4)-related sclerosing cholangitis(SC)without autoimmune pancreatitis is a rare condition with IgG4-SC.While the variety of the imaging modalities have tested its usefulness in diagnosing the IgG4-SC,however,the usage of ultrasonography for the assessment of the response to steroidal therapy on the changes of bile duct wall thickness have not been reported in the condition.Therefore,the information of our recent case and reported cases have been summarized.CASE SUMMARY We report the case of an 82-year-old Japanese man diagnosed with isolated IgG4-related SC based on the increase of serum IgG4,narrowing of the bile duct,its wall thickness,no complication of autoimmune pancreatitis,and IgG4 positive inflammatory cell infiltration to the wall with the fibrotic changes.The cholangiogram revealed type 2b according to the classification.Corticosteroid treatment showed a favorable effect,with the smooth decrease in serum IgG4 and the improvement of the bile duct wall thickness.CONCLUSION As isolated type 2b,IgG4-SC is rare,the images,histological findings,and clinical course of our case will be helpful for physicians to diagnose and treat the new cases appropriately. | Yuto Tanaka Kenya Kamimura Ryota Nakamura Marina Ohkoshi-Yamada Yohei Koseki Takeshi Mizusawa Satoshi Ikarashi Kazunao Hayashi Hiroki Sato Akira Sakamaki Junji Yokoyama Shuji Terai | 2020 | World Journal of Clinical Cases2020，8，22： | 0 |
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