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| 1 | Correlation of MRI-determined small bowel Crohn’s disease categories with medical response and surgical pathology显示文摘AIM: To determine whether magnetic resonance imaging (MRI) can be used to categorize small bowel Crohn's disease (SB CD) into groups that correlate with response to medical therapy and surgical pathology.METHODS: Data was collected from all patients with MRI evidence of SB CD without significant colonic disease over a 32-mo period. Two radiologists, blinded to clinical findings, evaluated each MRI and grouped them based on bowel wall thickness and wall enhancement. These categories were: (1) 'fibrosis', (2) 'mild segmental hyper-enhancement and mild wall thickening', (3) 'mild segmental hyper-enhancement and marked wall thickening', (4) 'marked segmental transmural hyper-enhancement'. Patient response to additional medical therapy post-MRI was prospectively determined at 8-wk. Non-responders underwent endoscopy and were offered therapeutic endoscopy or surgery. Surgical pathology was assessed against the MRI category. RESULTS: Fifty-five patients were included. Females and category '2' patients were more likely, and patients with luminal narrowing and hold-up less likely, to respond to medical therapy (P < 0.05). Seventeen patients underwent surgery. The surgical pathologicalfindings of fibrosis and the severity of inflammation correlated with the MRI category in all cases.CONCLUSION: Our fi ndings suggest that SB CD can be grouped by the MRI f indings and that these groups are associated with patients more likely to respond to continued medical therapy. The MRI categories also correlated with the presence and level of intestinal inflammation and fibrosis on surgical pathology, and may be of prognostic use in the management of CD patients. | Ian Craig Lawrance Christopher J Welman Peter Shipman Kevin Murray | 2009 | World Journal of Gastroenterology2009，15，27： | 12 |
| 2 | Pre-hospital assessment with ultrasound in emergencies: implementation in the field显示文摘BACKGROUND: Point-of-care ultrasound(US) is a proven diagnostic imaging tool in the emergency department(ED). Modern US devices are now more compact, affordable and portable, which has led to increased usage in austere environments. However, studies supporting the use of US in the prehospital setting are limited. The primary outcome of this pilot study was to determine if paramedics could perform cardiac ultrasound in the fi eld and obtain images that were adequate for interpretation. A secondary outcome was whether paramedics could correctly identify cardiac activity or the lack thereof in cardiac arrest patients.METHODS: We performed a prospective educational study using a convenience sample of professional paramedics without ultrasound experience. Eligible paramedics participated in a 3-hour session on point-of-care US. The paramedics then used US during emergency calls and saved the scans for possible cardiac complaints including: chest pain, dyspnea, loss of consciousness, trauma, or cardiac arrest.RESULTS: Four paramedics from two distinct fire stations enrolled a total of 19 unique patients, of whom 17 were deemed adequate for clinical decision making(89%, 95%CI 67%–99%). Paramedics accurately recorded 17 cases of cardiac activity(100%, 95%CI 84%–100%) and 2 cases of cardiac standstill(100%, 95%CI 22%–100%).CONCLUSION: Our pilot study suggests that with minimal training, paramedics can use US to obtain cardiac images that are adequate for interpretation and diagnose cardiac standstill. Further large-scale clinical trials are needed to determine if prehospital US can be used to guide care for patients with cardiac complaints. | Kevin P. Rooney Sari Lahham Shadi Lahham Craig L. Anderson Bryan Bledsoe Bryan Sloane Linda Joseph Megan B. Osborn John C. Fox | 2016 | World Journal of Emergency Medicine2016，7，2： | 5 |
| 3 | The amazing potential of fungi:50 ways we can exploit fungi industrially显示文摘Fungi are an understudied,biotechnologically valuable group of organisms.Due to the immense range of habitats that fungi inhabit,and the consequent need to compete against a diverse array of other fungi,bacteria,and animals,fungi have developed numerous survival mechanisms.The unique attributes of fungi thus herald great promise for their application in biotechnology and industry.Moreover,fungi can be grown with relative ease,making production at scale viable.The search for fungal biodiversity,and the construction of a living fungi collection,both have incredible economic potential in locating organisms with novel industrial uses that will lead to novel products.This manuscript reviews fifty ways in which fungi can potentially be utilized as biotechnology.We provide notes and examples for each potential exploitation and give examples from our own work and the work of other notable researchers.We also provide a flow chart that can be used to convince funding bodies of the importance of fungi for biotechnological research and as potential products.Fungi have provided the world with penicillin,lovastatin,and other globally significant medicines,and they remain an untapped resource with enormous industrial potential. | Kevin D.Hyde Jianchu Xu Sylvie Rapior Rajesh Jeewon Saisamorn Lumyong Allen Grace T.Niego Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahamanage Siraprapa Brooks Amornrat Chaiyasen K.W.Thilini Chethana Putarak Chomnunti Clara Chepkirui Boontiya Chuankid Nimali I.de Silva Mingkwan Doilom Craig Faulds Eleni Gentekaki Venkat Gopalan Pattana Kakumyan Dulanjalee Harishchandra Hridya Hemachandran Sinang Hongsanan Anuruddha Karunarathna Samantha C.Karunarathna Sehroon Khan Jaturong Kumla Ruvishika S.Jayawardena Jian-Kui Liu Ningguo Liu Thatsanee Luangharn Allan Patrick G.Macabeo Diana S.Marasinghe Dan Meeks Peter E.Mortimer Peter Mueller Sadia Nadir Karaba N.Nataraja Sureeporn Nontachaiyapoom Meghan O’Brien Watsana Penkhrue Chayanard Phukhamsakda Uma Shaanker Ramanan Achala R.Rathnayaka Resurreccion B.Sadaba Birthe Sandargo Binu C.Samarakoon Danushka S.Tennakoon Ramamoorthy Siva Wasan Sriprom T.S.Suryanarayanan Kanaporn Sujarit Nakarin Suwannarach Thitipone Suwunwong Benjarong Thongbai Naritsada Thongklang Deping Wei S.Nuwanthika Wijesinghe Jake Winiski Jiye Yan Erandi Yasanthika Marc Stadler | 2019 | Fungal Diversity2019，，4： | 3 |
| 4 | Cell:癌基因“遗传平衡”或会影响患者对癌症疗法的反应显示文摘进行癌症疗法的选择越来越需要确定肿瘤细胞中是否含有一些特殊突变的癌基因会驱动癌细胞异常生长。并且确定是否癌细胞会对特殊药物耐受或敏感.近日来自加州大学旧金山分校的研究人员就通过研究发现。以常见的癌基因KRAs突变为例。患者对疗法的反应往往会随着肿瘤的不断进化而发生改变。相关研究刊登于国际杂志Cell上。 | Michael R. Burgess Eugene Hwang Rana Mroue Craig M. Bielski Anica M. Wandler Benjamin J. Huang Ari J. Firestone Amy Young Jennifer A. Lacap Lisa Crocker Saurabh Asthana Elizabeth M. Davis Jin Xu Keiko Akagi Michelle M. Le Beau Qing Li Benjamin Haley David Stokoe Deepak Sampath Barry S. Taylor Marie Evangelista Kevin Shannon | 2017 | 现代生物医学进展2017，17，18： | 2 |
| 5 | Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity显示文摘 | Daniel J. Antoine Rosalind E. Jenkins James W. Dear Dominic P. Williams Mitchell R. McGill Matthew R. Sharpe Darren G. Craig Kenneth J. Simpson Hartmut Jaeschke B. Kevin Park | 2012 | Journal of Hepatology2012，，5： | 2 |
| 6 | 99mTc-Labeled Small-Molecule Inhibitors of Prostate-Specific Membrane Antigen for Molecular Imaging of Prostate Cancer显示文摘 | Shawn M. Hillier Kevin P. Maresca Genliang Lu Ross D. Merkin John C. Marquis Craig N. Zimmerman William C. Eckelman John L. Joyal John W. Babich | 2013 | Journal of Nuclear Medicine2013，，8： | 2 |
| 7 | Spinal Pedicle Fixation: Reliability and Validity of Roentgenogram-Based Assessment and Surgical Factors on Successful Screw Placement显示文摘 | JAMES N. WEINSTEIN KEVIN F. SPRATT DAN SPENGLER CRAIG BRICK STANLEY REID | 1988 | Spine1988，，9： | 2 |
| 8 | On-hardware optimization of stepper-motor system dynamics显示文摘 | Rogers John R Kevin Craig | 2005 | Mechatronics2005，15，： | 1 |
| 9 | On-hardware optimization of stepper motor system dynamics显示文摘 | Jihn R Kevin Craig | 2005 | Mechatronics2005，15，7： | 1 |
| 10 | Chemotherapy-induced mesenchymal stem cell damage in patients with hematological malignancy显示文摘 | Kevin Kemp Ruth Morse Sarah Wexler Christine Cox Elizabeth Mallam Jill Hows Craig Donaldson | 2010 | Annals of Hematology2010，，7： | 1 |
| 11 | Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodystrophy显示文摘 | Kevin J Martin Klaus Olgaard Jack W Coburn Giorgio M Coen Masafumi Fukagawa Craig Langman Hartmut H Malluche James T McCarthy Shaul G Massry Otto Mehls Isidro B Salusky Justin M Silver Miroslaw T Smogorzewski Eduardo M Slatopolsky Linda McCann | 2004 | American Journal of Kidney Diseases2004，，3： | 1 |
| 12 | Ultrastructure of the Ovary and Oogenesis in the Methane-Seep Mollusc Bathynerita naticoidea (Gastropoda: Neritidae) from the Louisiana Slope显示文摘 | Kevin J E Craig M Y | 1997 | Invertebrate Biology1997，116，4： | 1 |
| 13 | Recommendations for autonomous underway pCOe measuring systems and data reduction routines显示文摘 | Denis Pierrot Craig Neill Kevin Sullivan | 2009 | Deep-Sea Research 112009，56，： | 1 |
| 14 | Characteristics of Track Cycling显示文摘 | NEIL P CRAIG KEVIN I N | 2000 | Sports Med2000，31，7： | 1 |
| 15 | Is Anything Really New in Mechatronics Education? 显示文摘 | Kevin Craig | 2001 | IEEE Robotics & Automation Magazine2001，8，2： | 1 |
| 16 | Association of classical semen parameters, sperm DNA fragmentation index, lipid peroxidation and antioxidant enzymatic activity of semen in ram-lambs显示文摘 | Ramanathan Kasimanickam Kevin D. Pelzer Vanmathy Kasimanickam William S. Swecker Craig D. Thatcher | 2005 | Theriogenology2005，，7： | 1 |
| 17 | Islet graft function:Comparison of portal versus systemic venous insulin delivery显示文摘 | Susan K Kevin J | 1988 | Transplantion1988，45，： | 1 |
| 18 | Ultrastructure of the ovary and oogenesis in the methane-seep mollusk Batbynerita naticoi dea ( Gastropoda : Neri- tidae) from the Louisiana Slope显示文摘 | Kevin J Craig M | 1997 | Invertebr Biol1997，116，4： | 1 |
| 19 | Mitochondrial DNA mutations in individuals occupationally exposed to ionizing radiation显示文摘 | Craig S W Kevin C E Janet T C | 2006 | Radiat Res2006，165，2： | 1 |
| 20 | The learning library incontext:community, integration, and influence显示文摘 | Kevin Simons James Young Craig Gibson | 2000 | Research Strategies2000，，7： | 1 |
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