|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | TGF-β family co-receptor function and signaling显示文摘转变生长因素 --(TGF-) 家庭成员,它包括 TGF-s, activins 和骨头形态基因的蛋白质,是多种的 cytokines 得到细胞类型特定的效果在一高度在许多不同纸巾的上下文依赖者举止。经由 single-transmembrane 类型的这些分泌蛋白质 ligands 信号我和类型 II serine/threonine kinase 受体和细胞内部的 SMAD 抄写因素。在发信号的解除管制在疾病的一个宽广数组被含有,并且含有对复杂罚款在细胞的发信号的回答调节的需要。TGF- 家庭受体发信号紧张,持续时间,特性和差异被调整或调停的一重要出现机制通过房间表面合作受体。这里,我们提供为 TGF- 家庭成员被识别了的合作受体的概述。当一些看起来对 TGF- 家庭成员特定时,其它与另外的小径被分享并且为信号集成提供可能的方法。这评论集中于 TGF- 家庭合作受体的新奇功能,它继续发现。 | Joachim Nickel Peter ten Dijke Thomas D. Mueller | 2018 | Acta Biochimica et Biophysica Sinica2018，50，1： | 26 |
| 2 | VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab. | Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann | 2008 | World Journal of Gastroenterology2008，14，26： | 15 |
| 3 | Increased liver stiffness in alcoholic liver disease:Differentiating fibrosis from steatohepatitis显示文摘AIM:To test if inflammation also interferes with liver stiffness (LS) assessment in alcoholic liver disease (ALD) and to provide a clinical algorithm for reliable fibrosis assessment in ALD by FibroScan (FS).METHODS:We first performed sequential LS analysis before and after normalization of serum transaminases in a learning cohort of 50 patients with ALD admitted for alcohol detoxification. LS decreased in almost all patients within a mean observation interval of 5.3 d. Six patients (12%) would have been misdiagnosed with F3and F4 fibrosis but LS decreased below critical cut-off values of 8 and 12.5 kPa after normalization of trans-aminases. RESULTS:Of the serum transaminases,the decrease in LS correlated best with the decrease in glutamic oxaloacetic transaminase (GOT). No significant chang-es in LS were observed below GOT levels of 100 U/L. After establishing the association between LS and GOT levels,we applied the rule of GOT < 100 U/L for reliable LS assessment in a second validation cohort of 101 patients with histologically confi rmed ALD. By ex-cluding those patients with GOT > 100 U/L at the time of LS assessment from this cohort,the area under the receiver operating characteristic (AUROC) for cirrhosis detection by FS improved from 0.921 to 0.945 while specificity increased from 80% to 90% at a sensitivity of 96%. A similar AUROC could be obtained for lower F3 fibrosis stage if LS measurements were restricted to patients with GOT < 50 U/L. Histological grading of inflammation did not further improve the diagnostic accuracy of LS.CONCLUSION:Coexisting steatohepatitis markedly increases LS in patients with ALD independent of fibrosis stage. Postponing cirrhosis assessment by FS during alcohol withdrawal until GOT decreases to < 100 U/mL signif icantly improves the diagnostic accuracy. | Sebastian Mueller Gunda Millonig Lucie Sarovska Stefanie Friedrich Frank M Reimann Maria Pritsch Silke Eisele Felix Stickel Thomas Longerich Peter Schirmacher Helmut Karl Seitz | 2010 | World Journal of Gastroenterology2010，16，8： | 10 |
| 4 | The amazing potential of fungi:50 ways we can exploit fungi industrially显示文摘Fungi are an understudied,biotechnologically valuable group of organisms.Due to the immense range of habitats that fungi inhabit,and the consequent need to compete against a diverse array of other fungi,bacteria,and animals,fungi have developed numerous survival mechanisms.The unique attributes of fungi thus herald great promise for their application in biotechnology and industry.Moreover,fungi can be grown with relative ease,making production at scale viable.The search for fungal biodiversity,and the construction of a living fungi collection,both have incredible economic potential in locating organisms with novel industrial uses that will lead to novel products.This manuscript reviews fifty ways in which fungi can potentially be utilized as biotechnology.We provide notes and examples for each potential exploitation and give examples from our own work and the work of other notable researchers.We also provide a flow chart that can be used to convince funding bodies of the importance of fungi for biotechnological research and as potential products.Fungi have provided the world with penicillin,lovastatin,and other globally significant medicines,and they remain an untapped resource with enormous industrial potential. | Kevin D.Hyde Jianchu Xu Sylvie Rapior Rajesh Jeewon Saisamorn Lumyong Allen Grace T.Niego Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahamanage Siraprapa Brooks Amornrat Chaiyasen K.W.Thilini Chethana Putarak Chomnunti Clara Chepkirui Boontiya Chuankid Nimali I.de Silva Mingkwan Doilom Craig Faulds Eleni Gentekaki Venkat Gopalan Pattana Kakumyan Dulanjalee Harishchandra Hridya Hemachandran Sinang Hongsanan Anuruddha Karunarathna Samantha C.Karunarathna Sehroon Khan Jaturong Kumla Ruvishika S.Jayawardena Jian-Kui Liu Ningguo Liu Thatsanee Luangharn Allan Patrick G.Macabeo Diana S.Marasinghe Dan Meeks Peter E.Mortimer Peter Mueller Sadia Nadir Karaba N.Nataraja Sureeporn Nontachaiyapoom Meghan O’Brien Watsana Penkhrue Chayanard Phukhamsakda Uma Shaanker Ramanan Achala R.Rathnayaka Resurreccion B.Sadaba Birthe Sandargo Binu C.Samarakoon Danushka S.Tennakoon Ramamoorthy Siva Wasan Sriprom T.S.Suryanarayanan Kanaporn Sujarit Nakarin Suwannarach Thitipone Suwunwong Benjarong Thongbai Naritsada Thongklang Deping Wei S.Nuwanthika Wijesinghe Jake Winiski Jiye Yan Erandi Yasanthika Marc Stadler | 2019 | Fungal Diversity2019，，4： | 3 |
| 5 | Utility of Absolute and Relative Changes in Cardiac Troponin Concentrations in the Early Diagnosis of Acute Myocardial Infarction显示文摘 | Tobias Reichlin Affan Irfan Raphael Twerenbold Miriam Reiter Willibald Hochholzer Hanna Burkhalter Stefano Bassetti Stephan Steuer Katrin Winkler Federico Peter Julia Meissner Philip Haaf Mihael Potocki Beatrice Drexler Stefan Osswald Christian Mueller | 2011 | Circulation2011，，2： | 2 |
| 6 | 2-Year Follow-Up of Patients Undergoing Transcatheter Aortic Valve Implantation Using a Self-Expanding Valve Prosthesis显示文摘 | Lutz Buellesfeld Ulrich Gerckens Gerhard Schuler Raoul Bonan Jan Kovac Patrick W. Serruys Marino Labinaz Peter den Heijer Michael Mullen Wayne Tymchak Stephan Windecker Ralf Mueller Eberhard Grube | 2011 | Journal of the American College of Cardiology2011，，16： | 1 |
| 7 | Differential expression of chemokines in normal pancreas and in chronic pancreatitis显示文摘 | Leslie Saurer Peter Reber Thomas Schaffner Markus W. Büchler Caroline Buri Andreas Kappeler Alfred Walz Helmut Friess Christoph Mueller | 2000 | Gastroenterology2000，，2： | 1 |
| 8 | Late Clinical Events After Clopidogrel Discontinuation May Limit the Benefit of Drug-Eluting Stents显示文摘 | Matthias Pfisterer Hans Peter Brunner-La Rocca Peter T. Buser Peter Rickenbacher Patrick Hunziker Christian Mueller Raban Jeger Franziska Bader Stefan Osswald Christoph Kaiser | 2006 | Journal of the American College of Cardiology2006，，12： | 1 |
| 9 | High miR‐21 expression from FFPE tissues is associated with poor survival and response to adjuvant chemotherapy in colon cancer显示文摘 | Naohide Oue Katsuhiro Anami Aaron J. Schetter Markus Moehler Hirokazu Okayama Mohammed A. Khan Elise D. Bowman Annett Mueller Arno Schad Manabu Shimomura Takao Hinoi Kazuhiko Aoyagi Hiroki Sasaki Masazumi Okajima Hideki Ohdan Peter R. Galle Wataru Yasui C | 2014 | Int. J. Cancer2014，，： | 1 |
| 10 | Differential expression of chemokines in normal pancreas and in chronic pancreatitis显示文摘 | Leslie Saurer Peter Reber Thomas Schaffner Markus W. Büchler Caroline Buri Andreas Kappeler Alfred Walz Helmut Friess Christoph Mueller | 2000 | Gastroenterology2000，，2： | 1 |
| 11 | Radiofrequency ablation of hepatic tumours: effect of post-ablation margin on local tumour progression显示文摘 | Chang-Hsien Liu Ronald S. Arellano Raul N. Uppot Anthony E. Samir Debra A. Gervais Peter R. Mueller | 2010 | European Radiology2010，，4： | 1 |
| 12 | Donor evaluation, donor risks, donor outcome, and donor quality of life in adult-to-adult living donor liver transplantation显示文摘 | Andreas Pascher Igor M. Sauer Marc Walter Enrique Lopez-Haeninnen Tom Theruvath Antonino Spinelli Ruth Neuhaus Utz Settmacher Andrea R. Mueller Thomas Steinmueller Peter Neuhaus | 2002 | Liver Transplantation2002，，9： | 1 |
| 13 | Radiofrequency tissue ablation: Increased lesion diameter with a perfusion electrode显示文摘 | S. Nahum Goldberg G. Scott Gazelle Luigi Solbiati William J. Rittman Peter R. Mueller | 1996 | Academic Radiology1996，，8： | 1 |
| 14 | Long-Term Oncologic Outcomes After Radiofrequency Ablation for T1 Renal Cell Carcinoma显示文摘 | Sarah Psutka Adam S. Feldman W. Scott McDougal Francis J. McGovern Peter Mueller Debra A. Gervais | 2012 | European Urology2012，，： | 1 |
| 15 | MRI Contrast Agents for Evaluating Focal Hepatic Lesions显示文摘 | Mukesh G. Harisinghani Kartik S. Jhaveri Ralph Weissleder Wolfgang Schima Sanjay Saini Peter F. Hahn Peter R. Mueller | 2001 | Clinical Radiology2001，，9： | 1 |
| 16 | Huge primitive neuroectodermal tumor of the pancreas:Report of a case and review of the literature显示文摘Primitive neuroectodermal tumor (PNET) of the pancreas is an extremely rare tumor that usually occurs in children or young adults. We report a case of a 33-year-old male patient with an 18 cm × 18 cm × 16 cm mass arising from the pancreatic body and tail with a one- day history of abdominal pain. Initial CT scan showed no signs of metastatic tumor spread. The tumor caused intrabdominal bleeding and the patient underwent primary tumor resection including partial gastrectomy, left pancreatic resection and splenectomy. Diagnosis of PNET was confi rmed by histology, immunohistochemistry and FISH analysis. All neoplastic cells were stained positive for MIC2-protein (CD99). Approximately one month after surgery, several liver metastases were observed and the patient underwent chemotherapy according to the Euro- Ewing protocol. Subsequent relaparotomy excluded any residual hepatic or extrahepatic abdominal metastases. Although PNET in the pancreas is an extremely rare entity, it should be considered in the diffential diagnosis of pancreatic masses, especially in young patients. This alarming case particularly illustrates that PNET in the pancreas although in an advanced stage can present with only a short history of mild symptoms. | Thilo Welsch Gunhild Mechtersheimer Sebastian Aulmann Sascha A Mueller Markus W Buechler Jan Schmidt Peter Kienle | 2006 | World Journal of Gastroenterology2006，12，37： | 1 |
| 17 | Fluoride and calcium-phosphate coated sponges of the magnesium alloy AX30 as bone grafts: a comparative study in rabbits显示文摘 | Mareike Lalk Janin Reifenrath Nina Angrisani Alexandr Bondarenko Jan-Marten Seitz Peter P. Mueller Andrea Meyer-Lindenberg | 2013 | Journal of Materials Science: Materials in Medicine2013，，2： | 1 |
| 18 | Studies on the protein composition and baking quality of einkorn lines显示文摘 | Herbert Wieser Karl-Josef Mueller Peter Koehler | 2009 | European Food Research and Technology2009，，3： | 1 |
| 19 | p73 induces apoptosis by different mechanisms显示文摘 | Saafa Ramadan Alessandro Terrinoni Maria Valeria Catani A. Emre Sayan Richard A. Knight Martina Mueller Peter H. Krammer Gerry Melino Eleonora Candi | 2005 | Biochemical and Biophysical Research Communications2005，，3： | 1 |
| 20 | Nitric oxide is induced by wounding and influences jasmonic acid signaling in Arabidopsis thaliana显示文摘 | Xi Huang Kurt Stettmaier Christa Michel Peter Hutzler Martin J. Mueller J?rg Durner | 2004 | Planta2004，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员