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| 1 | Inhibition of temperature-sensitive TRPV3 channel by two natural isochlorogenic acid isomers for alleviation of dermatitis and chronic pruritus显示文摘Genetic gain-of-function mutations of warm temperature-sensitive transient receptor potential vanilloid 3(TRPV3)channel cause Olmsted syndrome characterized by severe itching and keratoderma,indicating that pharmacological inhibition of TRPV3 may hold promise for therapy of chronic pruritus and skin diseases.However,currently available TRPV3 tool inhibitors are either nonselective or less potent,thus impeding the validation of TRPV3 as therapeutic target.Using whole-cell patch-clamp and single-channel recordings,we report the identification of two natural dicaffeoylquinic acid isomers isochlorogenic acid A(IAA)and isochlorogenic acid B(IAB)that selectively inhibit TRPV3 currents with IC50 values of 2.7±1.3 and 0.9±0.3μmol/L,respectively,and reduce the channel open probability to 3.7±1.2%and 3.2±1.1%from 26.9±5.5%,respectively.In vivo evaluation confirms that both IAA and IAB significantly reverse the ear swelling of dermatitis and chronic pruritus.Furthermore,the isomer IAB is able to rescue the keratinocyte death induced by TRPV3 agonist carvacrol.Molecular docking combined with site-directed mutations reveals two residues T636 and F666 critical for the binding of the two isomers.Taken together,our identification of isochlorogenic acids A and B that act as specific TRPV3 channel inhibitors and gating modifiers not only provides an essential pharmacological tool for further investigation of the channel pharmacology and pathology,but also holds developmental potential for treatment of dermatitis and chronic pruritus. | Hang Qi Yuntao Shi Han Wu Canyang Niu Xiaoying Sun KeWei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 3 |
| 2 | Advanced noble-metal-free bifunctional electrocatalysts for metal-air batteries显示文摘The sluggish reaction kinetics at the oxygen cathode is one of the important issues hindering the commercialization of the metal-air batteries.Although the noble metal can be used as the high-efficiency electrocatalyst to solve the problems to some extent,the high cost and scarcity of these noble-metal catalysts have limited their application in electrocatalysis.In this review,we discussed the mecha-nisms of the ORR and OER,and proposed the principles for the bifunctional electrocatalysts firstly,and then the state-of-the-art bifunctional catalysts,including carbon-based materials and transition-metal-based materials.On the basis of that,the self-supporting 3D noble-metal-free bifunctional ORR/OER catalysts were also discussed.Finally,the perspectives for the bifunctional electrocatalysts were discussed. | Wenhao Tang Boya Li Kewei Teng Xiaodong Wang Ruiping Liu Mengwei Wu Lei Zhang Pengfei Ren Junqing Zhang Ming Feng | 2022 | Journal of Materiomics2022，8，2： | 2 |
| 3 | Oncostatin M inhibits myoblast differentiation and regulates muscle regeneration显示文摘Oncostatin M (OSM ) 是 interleukin-6 家庭的 cytokine 并且在发炎期间起重要作用。然而,它在 myoblast 区别的角色和肌肉新生仍然保持未经勘探。我们这里证明 OSM potently 主要由激活 JAK1/STAT1/STAT3 小径禁止了 myoblast 区别。OSM downregulated myocyte 提高有约束力的因素 2A (MEF2A ) , upregulated Id1 和 Id2 的表示,并且禁止了 MyoD 和 MEF2 的 transcriptional 活动。另外, OSM 也提高了 STAT3 和 OSM 受体的表示,它组成了一个积极反馈环进一步放大导致 OSM 的发信号。而且,我们发现身体上与 MEF2 联系并且镇压的那 STAT1 它的 transcriptional 活动,它能说明 MEF2 的调停 OSM 的压抑。尽管在在 vivo 的正常肌肉无法发现, OSM 很快在肌肉损害上然后即时被导致就在 myoblasts 的多数前的 downregulated 区分。没有影响 myoblast 增长,在肌肉的 OSM 的延长表示损害了新生进程,建议 OSM 工作阻止增殖的 myoblasts 在肌肉新生的早阶段期间的早熟的区别。 | Fang Xiao Haixia Wang Xinrong Fu Yanfeng Li Kewei Ma Luguo Sun Xiang Gao Zhenguo Wu | 2011 | Cell Research2011，21，2： | 2 |
| 4 | Computational Identification of Small Interfering RNA Targets in SARS CoV-2显示文摘Dear Editor,At the end of 2019,a new virus,called Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)was reported(Benvenuto et al.2020;Zhu et al.2020).The sequences of SARS-CoV-2 reported by different research groups demonstrated that it is a positive strand RNA virus.The sequence of SARS-CoV-2 is approximately 30 kb long,and could encodes spike,envelope,membrane,nucleocapsid proteins,etc.(Phan 2020).These proteins are responsible for replicating the viral genome as well as generating nested transcripts that are used in the synthesis of the viral proteins. | Wei Chen Pengmian Feng Kewei Liu Meng Wu Hao Lin | 2020 | Virologica Sinica2020，35，3： | 2 |
| 5 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 6 | Enrichment-induced exercise to quantify the effect of different housing conditions: A tool to standardize enriched environment protocols显示文摘 | Hongyu Xie Yi Wu Jie Jia Gang Liu Qi Zhang Kewei Yu Zhenzhen Guo Li Shen Ruiping Hu | 2013 | Behavioural Brain Research2013，，： | 1 |
| 7 | Enriched environment induces angiogenesis and improves neural function outcomes in rat stroke model显示文摘 | Kewei Yu Yi Wu Qi Zhang Hongyu Xie Gang Liu Zhenzhen Guo Fang Li Jie Jia Shenyi Kuang Ruiping Hu | 2014 | Journal of the Neurological Sciences2014，，： | 1 |
| 8 | Photoluminescence studies of red-emitting NaEu(WO4)2 as a near-UV or blue convertible phosphor显示文摘 | Shao Qiyue Li Huijuan Wu Kewei | 2009 | J Lumin2009，129，： | 1 |
| 9 | Proton-pump inhibitors can decrease gastrointestinal bleeding after percutaneous coronary intervention显示文摘 | Zongdan Jiang Hailu Wu Zhaotao Duan Zhibing Wang Kewei Hu Fei Ye Zhenyu Zhang | 2013 | Clinics and Research in Hepatology and Gastroenterology2013，，： | 1 |
| 10 | Kinetics of desensitization and recovery from desensitization for human α4β2-nicotinic acetylcholine receptors stably expressed in SH-EP1 cells显示文摘 | Kewei D YU Qjang LIU Jie WU Ronald J LUKA | 2009 | Acta Pharmacologica Sinica2009，30，6： | 1 |
| 11 | Binswanger's disease:progressive subcortical encephalopathy or multi-infarct dementia显示文摘 | Lijuan Wu Yi Luo | 1985 | Can J Neurol Sci1985，12，： | 1 |
| 12 | X-ray diffraction measurement of residual stress and crystal orientation in Au/NiCr/Ta films prepared by plating显示文摘 | TANG Wu DENG Longjiang XU Kewei | 2007 | Surface & Coatings Technology2007，201，1： | 1 |
| 13 | Differences between laminar convections through parallel plain planes with uniform wall temperature and heat flux in terms of process parameter显示文摘Using the process parameter description,we analyzed the difference between the characteristics of laminar convections through parallel plain planes with uniform temperature and heat flux.The results show the following.(1)On the wall surface of the developing region,under uniform heat flux boundary condition,the heat flux normal to the wall surface is transported through a convection process although the velocity is zero;the velocity gradient contributes to this transport,but under uniform temperature boundary condition,the heat flux normal to the wall surface is transported through a difussion process.(2)Inside the flow of the developing region,whether under uniform temperature or heat flux boundary condition,the heat flux along the main flow direction and the heat flux normal to the wall surface are transported through a convection process,and the contributions of velocity and velocity gradient are dependent on the thermal boundary condition.(3)On the wall surface of the fully developed region,under uniform heat flux boundary condition,the heat flux normal to the wall surface is transported through a convection process;the velocity gradient contributes to this transport,but under uniform temperature boundary condition,the heat flux normal to the wall surface is transported through a diffusion process.(4)Inside the flow of the fully developed region,under uniform temperature boundary condition,the heat flux along the main flow direction and the heat flux normal to the wall surface are transported through a convection process,and the velocity and velocity gradient contribute to these transports;under uniform heat flux boundary condition,the heat flux along the main flow direction and the heat flux normal to the wall surface are transported through a convection process.Furthermore,the transport of the heat flux along the main flow direction is a no-net convection process;the velocity gradient contributes to the transport of the heat flux only in the normal direction of the wall surface.(5)Simply because the maximum velocity gradient component on the wall surface contributes to the transport of the heat flux normal to the wall surface under uniform heat flux boundary condition,it does not contribute to this transport under uniform temperature boundary condition;thus,the heat transfer intensity under uniform heat flux boundary condition is stronger than that under uniform temperature boundary condition. | WANG LiangBi,LIN ZhiMin,WU Xiang&SONG KeWei School of Mechatronic Engineering,Lanzhou Jiaotong University,Lanzhou 730070,China | 2010 | Science China(Technological Sciences)2010，53，3： | 0 |
| 14 | Fluorinated Covalent Organic Frameworks Coupled with Molecular Cobalt Cocatalysts for Efficient Photocatalytic CO_(2)Reduction显示文摘The combination of covalent organic framework(COF)photosensitizers with molecular cocatalysts is a promising avenue for photocatalytic carbon dioxide(CO_(2))reduction.Here,a series of isostructural COFs was synthesized using linkers of different lengths,with or without partial fluorination.These COFs were investigated for photocatalytic CO_(2)reduction under visible-light irradiation when combined with cobalt(II)bipyridine complexes as a cocatalyst.Fluorination was found to enhance both CO_(2)affinity and catalytic activity,and a partially fluorinated COF,FBP-COF,achieved the highest CO_(2)-to-CO conversion efficiency,showing a carbon monoxide(CO)generation rate of 2.08 mmol h−1 g−1 and a 90%CO selectivity.FBP-COF also showed good stability under sacrificial conditions,generating CO for 50 h with a turnover number of 91.5.This activity is much higher than a homogeneous system using ruthenium bipyridine complexes as the photosensitizer combined with the same cobalt bipyridine complexes. | Zhiwei Fu Chang Shu Xiaoyan Wang Linjiang Chen Xue Wang Lunjie Liu Kewei Wang Rob Clowes Samantha Y.Chong Xiaofeng Wu Andrew I.Cooper | 2023 | CCS Chemistry2023，5，10： | 0 |
| 15 | Effects of Standardized Rehabilitation on Quality of Life of Stroke Patients at Convalescence and Sequelae Stages显示文摘Objective:To explore the effects of standardized rehabilitation on quality of life (QOL) of stroke patients at convalescence and sequelae stages. Method:A total of 251 stroke patients were randomly divided into a standardized rehabilitation group and a control group. The simplified Fugl-Meyer assessment(FMA) scale, the 36-item short-form health survey questionnaire (SF-36) and functional comprehensive assessment (FCA) were administered before as well as after 3, 6 and at 12 months a follow-up study respectively. Statistical analysis was conducted based on the evaluations at 4 testing time points. Result:There was no significant difference in FMA,SF-36 and FCA scores of the two groups before and after 3 months treatments, while FMA,SF-36 and FCA scores of the rehabilitation group were obviously higher than those of the control group either after 6 months treatments or of followup study. Moreover, after 6 months treatments FMA score was apparently higher than the score at the beginning and after 3 months treatments. The FMA, SF36 and FAC scores during the followup visit decreased when compared with scores after 6 months treatments, but increased significantly when compared with the scores at the beginning and after 3 months treatments. Conclusion:Standardized tertiary rehabilitation (STR) at convalescence and sequelae stages can significantly improve motor functions and QOL of stroke patients. | XU Dongyan JIA Jie WU Yi LI Mingfen XIE Hongyu YU Kewei GUO Zhenzhen | 2013 | 中国康复医学杂志2013，28，6： | 0 |
| 16 | A Test Program of MSC1210 Intelligence Controller显示文摘 | Jiang Ziyun Zhang Wei Gu Kewei Chen Yun Wu Junqi Yang Feng An Shi Liu Xiaojun | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 17 | Design of Testing Program for Gateway显示文摘 | Liu Xiaojun Zhang Wei Gu Kewei Chen Yun Jiang Ziyun Wu Junqi An Shi Yang Feng | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 18 | 5-32 Network Communicating between IPC and Multimeter Based on LabView显示文摘The output stability of power supply for Heavy Ion Research Facility of Lanzhou (HIRFL) is signicant. Powersupply provides currents to magnets which produce the magnetic eld to constraint particles. So the output stabilityof power supply has a great signicance to the quality of beams. In order to test the stability of power supply, weuse a Fluke 8846A digit precision multimeter based on LabView platform of National Instrument Corporation.Remote operation of 8846A Digital Multimeter from a host, that is a terminal, controller, PC, or computer, isaccomplished by sending commands to it through one of its remote interfaces. The Multimeter is controlled remotelyusing Standard Commands for Programmable Instruments (SCPI), Fluke 45 or Fluke 8842A (8840A and 8842A)commands. The meter can be remotely controlled through the LAN port on the Meter's rear panel[1] We can sendSCPI commands to the Meter using network communicating controls provided by LabView[2]. This program couldbe used to test output stability of power supply of HIRFL. | Wang Pengpeng Zhang Wei An Shi Liu Xiaojun Gu Kewei Chang Jianjun Wu Junqi Chen Yun | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 19 | 白介素25介导的自分泌循环在银屑病发育中的促炎功能与机制研究显示文摘文章简介银屑病是一种由免疫系统所介导的临床上的自身免疫性皮肤疾病,具体表现为皮肤表皮增厚、银屑形成、真皮炎症细胞浸润等,且伴随一系列的并发症,全世界大约1%~2%的人受到该疾病的困扰。虽然从淋巴细胞中产生的白介素17已经被证实在银屑病的发育过程中起到关键作用. | 徐妙 Huiping Lu Young-Hee Lee Yelin Wu Kewei Liu Yuling Shi Haoran An Jingren Zhang Xiaohu Wang 赖玉平 董晨 | 2019 | 科学新闻2019，0，2： | 0 |
| 20 | LiZr_(2)(PO_(4))_(3)surface coating towards stable layer structure Li_(1.2)Mn_(0.54)Ni_(0.13)Co_(0.13)O_(2)cathode materials with long cycle performance显示文摘Li-rich manganese-based materials are considered to be the mainstream cathode materials for next-generation lithium-ion batteries due to high discharge capacity and low cost,but poor cycle life and high temperature performance limit their development.Herein,LiZr_(2)(PO_(4))_(3)(LZPO)is coated on the surface of spherical Li_(1.2)Mn_(0.54)Ni_(0.13)Co_(0.13)O_(2)(LMNCO)material by a simple wet chemical method.The LZPO layer not only has the function of traditional coating layer to inhibit the occurrence of side reactions between electrolyte and LMNCO surface but also promotes the formation of spinel phase in the layered structure,increases the content of lattice oxygen,and reduces the content of absorbed oxygen.Thus,LZPO coated LMNCO has a more stable layered structure during cycling compared pure LMNCO,which improves effectively its long life and high temperature performance.The capacity loss rate of LZPO coated LMNCO is only 16.2%and 11.9%after 350 cycles at 25℃and 200 cycles at 50℃,respectively.Moreover,the capacity retention rate of the full cell composed of LZPO coated LMNCO and graphite is 70.7%after 200 cycles at 1.0 C.The coating layer toward stable surface structure can provide an idea for the modification of cathode materials,especially for Li-rich manganese-based materials. | Hao Yang Jie Wang Changsheng Xu Kewei Wu Fangfang Zou Xuebu Hu Zhongli Hu | 2023 | Nano Research2023，16，2： | 0 |
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