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| 1 | Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration显示文摘房间通过 secreting 和释放蛋白质和泡与对方一起交流。许多房间能移居。在这研究,我们报导 migracytosis,为释放细胞的内容的房间迁居依赖者机制,和 migrasomes 的发现,调停的小囊的结构 migracytosis。当移居的房间移动,他们离开长管状的海滨,叫的收回纤维,在他们后面。大泡,包含众多的更小的泡,在收回纤维的尖端和交叉上成长。这些纤维,与主要房间身体连接泡,最后,裂缝,和泡被释放直到细胞外的空间或直接由包围房间收起。因为这些泡的形成是迁居依赖者,我们把他们称为 “ migrasomes”。我们也发现 cytosolic 内容能被搬运进 migrasomes 并且通过 migrasomes 免除了房间。我们把这迁居依赖者版本机制称为 “ migracytosis”。 | Liang Ma Ying Li Junya Peng Danni Wu Xiaoxin Zhao Yitong Cui Lilian Chen Xiaojun Yan Yanan Du Li Yu | 2015 | Cell Research2015，25，1： | 21 |
| 2 | Dapper1 promotes autophagy by enhancing the Beclinl -Vps34-Atg14L complex formation显示文摘 | Benvu Ma Weipeng Cao Wenxia Li Chan Gao Zhen Qi Yan Zhao Jun Du Hua Xue Junya Peng Jun Wen Hua Chen Yuanheng Ning Lei Huang Hong Zhang Xiang Gao Li Yu Ye-Guang Chen | 2014 | Cell Research2014，24，8： | 12 |
| 3 | SKIP Confers Osmotic Tolerance during Salt Stress by Controlling Alternative Gene Splicing in Arabidopsis显示文摘译解位于下面的机制种回答到不能生活的应力为改进植物压力抵抗是关键的。大部分在 transcriptional 水平响应盐应力对基因表示的规定被知道;然而,很少在 posttranscriptional 水平对这个过程被知道。最近,我们证明那个翻斗车是与钟基因 pre-mRNAs 交往并且为调整他们拼接的选择和 mRNA 成熟是必要的 spliceosome 的一个部件。在这研究,我们发现 skip-1 植物对盐和渗透的压力过分敏感,并且那个翻斗车为拼接的选择和几咸忍耐的基因的 mRNA 成熟被要求,包括 NHX1, CBL1, P5CS1, RCI2A,和 PAT10。染色体宽的分析表明那个翻斗车调停在咸压力的条件下面许多基因拼接的选择,和在 skip-1 的其他的拼接事件的那个大多数包含 intron 保留和罐头 generatea 在抄录 mRNA 的早熟的结束 codon。翻斗车也控制由 modulating 的其他的拼接 5 和 3 的识别或劈开拼接在咸压力的条件下面的施主和领受人地点。因此,这研究探讨的基本问题拼接的 mRNA 在植物的机械在 posttranscriptional 水平贡献咸压力的回答,并且提供在其他的拼接和盐忍耐之间的一个连接。 | Jinlin Feng dingjing Li Zhaoxu Gao Yaru Lu Junya Yu Qian Zheng Shuning Yan Wenjiao Zhang Hang He Ligeng Ma Zhengge Zhu | 2015 | Molecular Plant2015，8，7： | 10 |
| 4 | Atg5 regulates late endosome and lysosome biogenesis显示文摘Autophagy is an evolutionarily conserved lysosome-based degradation process.Atg5 plays a very important role in autophagosome formation.Here we show that Atg5 is required for biogenesis of late endosomes and lysosomes in an autophagy-independent manner.In Atg5 cells,but not in other essential autophagy genes defecting cells,recycling and retrieval of late endosomal components from hybrid organelles are impaired,causing persistent hybrid organelles and defective formation of late endosomes and lysosomes.Defective retrieval of late endosomal components from hybrid organelles resulting from impaired recruitment of a component of V1-ATPase to acidic organelles blocks the pH-dependent retrieval of late endosomal components from hybrid organelles.Lowering the intracellular pH restores late endosome/lysosome biogenesis in Atg5 cells.Our data demonstrate an unexpected role of Atg5 and shed new light on late endosome and lysosome biogenesis. | PENG JunYa ZHANG Ran CUI YiTong LIU HaoDong ZHAO XiaoXin HUANG Lei HU MingXu YUAN XiaoXi MA BenYu MA XiaoWei TAKASHI Ueno MASAAKI Komatsu LIANG XingJie YU Li | 2014 | Science China(Life Sciences)2014，57，1： | 6 |
| 5 | Influence of heating rate on reactivity and surface chemistry of chars derived from pyrolysis of two Chinese low rank coals显示文摘A series of char samples were derived from pyrolysis of two typical low-rank coals in China(Shengli lignite and Shenmu bituminous coal) at low, medium and fast heating rates, respectively, to the same pyrolysis temperature 750 °C. Then these chars were characterized by means of thermogravimetric analysis and Fourier transform infrared spectrometer with the aim to investigate the influence of heating rate in pyrolysis process on gasification reactivity and surface chemistry of them. Besides, a homogeneous model was used to quantitatively analyze the activation energy of gasification reaction. The results reveal that Shengli lignite and its derived chars behave higher gasification reactivity and have less content of oxygen functional groups than Shenmu coal and chars. Meanwhile, chars derived from Shengli lignite at 50 °C/min and Shenmu coal at 200 °C/min have the greatest gasification reactivity, respectively. The oxygen functional groups in Shengli lignite are easily thermo-decomposed, and they are less affected by the heating rate, while that in Shenmu coal have a significant change with the variation of heating rate.In addition, there is no good correlation between the change of oxygen functional groups and that of the gasification reactivity of the derived chars from pyrolysis at different heating rates. | Liang Dingcheng Xie Qiang Li Guangsheng Cao Junya Zhang Jun | 2018 | International Journal of Mining Science and Technology2018，28，4： | 6 |
| 6 | Genome wide association study identifies SNPs associated with fatty acid composition in Chinese Wagyu cattle显示文摘Background: Fatty acids are important traits that affect meat quality and nutritive values in beef cattle. Detection of genetic variants for fatty acid composition can help to elucidate the genetic mechanism underpinning these traits and promote the improvement of fatty acid profiles. In this study, we performed a genome-wide association study(GWAS) on fatty acid composition using high-density single nucleotide polymorphism(SNP) arrays in Chinese Wagyu cattle.Results: In total, we detected 15 and 8 significant genome-wide SNPs for individual fatty acids and fatty acid groups in Chinese Wagyu cattle, respectively. Also, we identified nine candidate genes based on 100 kb regions around associated SNPs. Four SNPs significantly associated with C14:1 cis-9 were embedded with stearoyl-CoA desaturase(SCD), while three SNPs in total were identified for C22:6 n-3 within Phospholipid scramblase family member 5(PLSCR5), Cytoplasmic linker associated protein 1(CLASP1), and Chymosin(CYM). Notably, we found the top candidate SNP within SCD can explain ~ 7.37% of phenotypic variance for C14:1 cis-9.Moreover, we detected several blocks with high LD in the 100 kb region around SCD. In addition, we found three significant SNPs within a 100 kb region showing pleiotropic effects related to multiple FA groups(PUFA,n-6, and PUFA/SFA), which contains BAI1 associated protein 2 like 2(BAIAP2 L2), MAF bZIP transcription factor F(MAFF),and transmembrane protein 184 B(TMEM184 B).Conclusions: Our study identified several significant SNPs and candidate genes for individual fatty acids and fatty acid groups in Chinese Wagyu cattle, and these findings will further assist the design of breeding programs for meat quality in cattle. | Zezhao Wang Bo Zhu Hong Niu Wengang Zhang Ling Xu Lei Xu Yan Chen Lupei Zhang Xue Gao Huijiang Gao Shengli Zhang Lingyang Xu Junya Li | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 4 |
| 7 | Combined effects of interface modification and micro-filler reinforcements on the thermal and tribological performances of fabric composites显示文摘The high specific‐strength of glass fibers and exceptional self‐lubrication of polytetrafluoroethylene(PTFE)fibers promote the potential application of hybrid PTFE/glass fabric composites in the tribological field,but their weak interfacial adhesion and inferior thermal properties significantly inhibit their tribological performance and reliability.Herein,a hybrid of polydopamine/silicon carbide/polyethyleneimine(PDA/SiC/PEI)functional coating was co‐deposited onto the hybrid PTFE/glass fabric surface through a one‐step impregnation method,leading to increased surface roughness and abundant amine groups.Tensile and peeling tests showed that this functional coating offered 47.8%enhancement in the fabric/matrix interfacial adhesion without compromising the strength of the pristine fabric.Moreover,the additional incorporation of WS_(2),and aluminum nitride(AlN)micro‐fillers contributed to the development of a high‐quality tribofilm and improved the thermal properties of fabric composites.The results of wear tests proved that the hybrid‐fabric composites,after the introduction of functional coating and micro‐fillers,exhibited outstanding tribological performance,which was attributed to the superior interfacial adhesion as well as the synergistic enhancement effects between WS2 and AlN micro‐fillers. | Junya YUAN Zhaozhu ZHANG Mingming YANG Xin ZHAO Liangfei WU Peilong LI Wei JIANG Xuehu MEN Weimin LIU | 2021 | Friction2021，9，5： | 3 |
| 8 | Tissue expression,association analysis between three novel SNPs of the RXRαgene and growth traits in Chinese indigenous cattle显示文摘Retinoid X receptor(RXR) α is a member of the nuclear hormone receptor superfamily that mediates the biological effects on several hormones,vitamins,and regulates lipid,glucose and energy metabolism.In this study,the tissue expression profiles of the bovine RXRαgene and association analysis of single nucleotide polymorphisms(SNPs) with growth traits were carried out in 413 Chinese native cattle.The expression profile was analysed in ten Jiaxian cattle tissues by real-time PCR,and the results showed that RXRαgene was abundantly expressed in adipose tissue and spleen,moderately expressed in heart,liver,lung,kidney,muscle and testis.Meanwhile,three SNPs(T27919A,T28139C and G28142A) and five haplotypes were identified.Haplotype with TTG was dominant with frequency of 69.1%.Chi-square test showed all populations were in Hardy-Weinberg equilibrium(P>0.05) at the three sites except Jiaxian cattle at G28142A site and Qinchuan cattle at T27919A site.Statistical analysis of combined sites showed that the individuals with TTGA genotype had significantly higher heart girth than those with TAGG genotype(P<0.05) and the animals with AAGA genotype had higher body weight than those with TAGG genotype(P<0.05) in T27919A-G28142A site.Heart girth,abdominal circumference and body weight of individuals with TCAG genotype were exceedingly higher than those with TTGG(P<0.01),TTGA and TCGG(P<0.05) in T28139C-G28142A site.For T27919A-T28139C site,the individuals of TCTA and TCTT genotype had significantly higher heart girth and lower height at hip cross than those with TTTA(P<0.05),and the body weight of TCAA and TCTT genotype individuals was higher than those with TTTA(P<0.05).In conclusion,these results provided evidence that the polymorphisms of RXRαgene were associated with growth traits and might apply to Chinese indigenous yellow cattle breeding program as a possible candidate for marker-assisted selection(MAS). | MA Yun GAO HanTing LIN Feng CHEN NingBo XU YongJie JIANG JinHang LI Fen LU FangRu ZHAO Man SHI KuiLin CHENG Ni LI JunYa | 2013 | Chinese Science Bulletin2013，58，18： | 1 |
| 9 | Delaminated layered double hydroxide delivers DNA molecules as sandwich nanostructure into cells via a non-endocytic pathway显示文摘Layered double hydroxides(LDHs) are effective molecular carriers in cytological research, gene therapy,and transgenic applications. Herein, we investigated the internalization behavior of the LDH-DNA bioconjugates via a microscopic approach and analyzed the internalization pathway by dissipative particle dynamics(DPD) simulations. We experimentally found that LDH can efficiently carry DNA into the nucleus of cell in BY-2 suspension cells. Furthermore, atomic force microscopy and X-ray diffraction analysis demonstrated that the LDH-DNA bioconjugates mainly exist as a DNA-LDH-DNA sandwich complex,while the LDH-DNA-LDH sandwich complex and DNA-LDH complex cannot be excluded. The DPD simulations further indicated that only the DNA-LDH-DNA sandwich structure could penetrate the plasma membrane(PM), while PM is impermeable to the LDH-DNA-LDH sandwich complex and the DNA-LDH complex. This work provides novel perspective for understanding the membrane penetration mechanism of LDH nano-sheets and new insights into the design of novel molecular delivery systems.ó 2017 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved. | Ye Li Wenlong Bao Hongyang Wu Junya Wang Yu Zhang Yinglang Wan Dapeng Cao Dermot O'Hare Qiang Wang | 2017 | Science Bulletin2017，62，10： | 1 |
| 10 | Wilms’ tumor gene WT1-shRNA as a potent apoptosis-inducing agent forsolid tumors显示文摘 | Naoya Tatsumi Yusuke Oji Naoko Tsuji Asako Tsuda Mari Higashio Sayaka Aoyagi Ikuyo Fukuda Ken Ito Junya Nakamura Satoshi Takashima Yayoi Kitamura Saori Miyai Tanyarat Jomgeow Zheyu Li Toshiaki Shirakata Sumiyuki Nishida Akihiro Tsuboi Yoshihiro Oka Haruo | 2008 | International Journal of Oncology2008，，： | 1 |
| 11 | Incorporating kernelized multi-omics data improves the accuracy of genomic prediction显示文摘Background:Genomic selection(GS)has revolutionized animal and plant breeding after the first implementation via early selection before measuring phenotypes.Besides genome,transcriptome and metabolome information are increasingly considered new sources for GS.Difficulties in building the model with multi-omics data for GS and the limit of specimen availability have both delayed the progress of investigating multi-omics.Results:We utilized the Cosine kernel to map genomic and transcriptomic data as n×n symmetric matrix(G matrix and T matrix),combined with the best linear unbiased prediction(BLUP)for GS.Here,we defined five kernel-based prediction models:genomic BLUP(GBLUP),transcriptome-BLUP(TBLUP),multi-omics BLUP(MBLUP,M=ratio×G+(1-ratio)×T),multi-omics single-step BLUP(mss BLUP),and weighted multi-omics single-step BLUP(wmss BLUP)to integrate transcribed individuals and genotyped resource population.The predictive accuracy evaluations in four traits of the Chinese Simmental beef cattle population showed that(1)MBLUP was far preferred to GBLUP(ratio=1.0),(2)the prediction accuracy of wmss BLUP and mss BLUP had 4.18%and 3.37%average improvement over GBLUP,(3)We also found the accuracy of wmss BLUP increased with the growing proportion of transcribed cattle in the whole resource population.Conclusions:We concluded that the inclusion of transcriptome data in GS had the potential to improve accuracy.Moreover,wmss BLUP is accepted to be a promising alternative for the present situation in which plenty of individuals are genotyped when fewer are transcribed. | Mang Liang Bingxing An Tianpeng Chang Tianyu Deng Lili Du Keanning Li Sheng Cao Yueying Du Lingyang Xu Lupei Zhang Xue Gao Junya Li Huijiang Gao | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 0 |
| 12 | Targeted B-domain deletion restores F8 function in human endothelial cells and mice显示文摘Dear Editor,Hemophilia A(HA)is the most common genetic bleeding disorders and affects 1 in 5000 male births.1 HA patients suffer spontaneous soft-tissue and joint bleeding or life-threatening intracranial hemorrhage.The main clinical treatment for severe HA patients is life-long maintenance of protein replacement therapy,which increase the risks of infection and induce FVIII inhibitors.Gene therapy is expected to cure HA,however,the current AAVbased gene addition strategy is limited by its loading capacity,immunogenicity of capsids,and the risk of insertional mutagenesis.2 Therefore,the aim of this study is to overcome these limitations by a combination of gene editing and ex vivo strategy for HA gene therapy. | Zhiqing Hu Zhuo Li Yong Wu Junya Zhao Lingqian Wu Miaojin Zhou Desheng Liang | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
| 13 | Adaptive Fitting Capacity Prediction Method for Lithium‑Ion Batteries显示文摘Lithium-ion batteries have become the mainstream power source for electric vehicles because of their excellent performance.However,lithium-ion batteries still experience aging and capacity attenuation during usage.It is therefore critical to accu-rately predict battery remaining capacity for increasing battery safety and prolonging battery life.This paper first adopts the metabolism grey algorithm and a simplified electrochemical model to predict battery capacity under different operating conditions.To improve the prediction performance where the capacity changes nonlinearly,a decoupling analysis of battery capacity loss is then conducted based on the simplified electrochemical model.Finally,an adaptive fitting method is devel-oped for capacity prediction,aiming at improving the prediction accuracy at the inflection point of battery capacity diving.The prediction results indicate that the developed adaptive fitting method can achieve high prediction accuracy under battery capacity attenuation at different discharge stages with errors lower than 2.2%.And the battery capacity decay shows linear variation,and the proposed method effectively forecast the inflection point of battery capacity diving. | Xiao Chu Fangyu Xue Tao Liu Junya Shao Junfu Li | 2022 | Automotive Innovation2022，5，4： | 0 |
| 14 | Bovine HSD17B8 gene and its relationship with growth and meat quality traits显示文摘17 b-Hydroxysteroid dehydrogenase type 8(HSD17B8) is an important regulator of lipid and steroid metabolism. In the present study, we aimed to assess the effects of HSD17B8 on growth and meat quality traits in cattle. Transcription profile analysis showed that HSD17B8 was primarily expressed in the salpinx, liver, and testis.Meanwhile, we identified three SNPs(SNP1: intron1-A91G; SNP2: exon 1-A90G; and SNP3: intron 8-A86G)of the bovine HSD17B8 gene and investigated its haplotype frequencies and linkage disequilibrium. The detected SNPs were found associated with growth traits(body weight,body length, height at withers, heart girth, hip width, and average daily gain) in native cattle populations(Nanyangand Jiaxian) as well as the meat quality traits(Warner–Bratzler shear force, rib area, dressing percentage, carcass weight, and backfat thickness) in commercial breeds(Angus, Hereford, Limousin, Luxi, Simmental, and Jinnan).Our results provided evidence that polymorphisms in the HSD17B8 gene were associated with growth traits and meat quality traits. Moreover, our findings might be used for marker-assisted selection in beef cattle breeding program. | Yun Ma Ningbo Chen Fen Li Weiwei Fu Yapeng Han Yanlin Chang Xiangxiang Jiang Junya Li Yueyu Bai Xuxin Tan | 2015 | Science Bulletin2015，60，18： | 0 |
| 15 | Single-cell transcriptomic analysis uncovers intratumoral heterogeneity and drug-tolerant persister in ALK-rearranged lung adenocarcinoma显示文摘Dear Editor,Non-small cell lung carcinoma(NSCLC)accounts for more than 85%of all lung cancers[1].Lung adenocarcinomas(ADCs)arising from never-smokers have been frequently found to be associated with oncogenic driver mutations,including anaplastic lymphoma kinase(ALK)rearrangement.Echinoderm microtubule-associated protein-like 4(EML4)is the most common fusion partner of the ALK gene[2].Tyrosine kinase inhibitors(TKIs)are currently the first-line treatment for advanced EML4-ALKrearranged lung ADC. | Hoi-Hin Kwok Huiyu Li Jiashuang Yang Junyang Deng Nerissa Chui-Mei Lee Timmy Wing-Kuk Au Alva Ko-Yung Sit Michael Kuan-Yew Hsin Stephanie Kwai-Yee Ma LydiaWai-Ting Cheung Luc Girard Junya Fujimoto Ignacio Ivan Wistuba Boning Gao John Dorrance Minna David Chi-Leung Lam | 2023 | Cancer Communications2023，43，8： | 0 |
| 16 | Halloysite‒gold core‒shell nanosystem synergistically enhances thermal conductivity and mechanical properties to optimize the wear-resistance of a pheonlic-PBO/PTFE textile composite liner显示文摘Polymer-textile liner composites have potential applications in aerospace applications for reducing the abrasion damage of moving parts during operation owing to their self-lubrication,light weight,and high loading capacity.Herein,Au nanoparticles(AuNPs)are successfully loaded into the lumen of halloysite nanotubes(HNTs)to construct an HNTs‒Au peasecod core‒shell nanosystem to optimize the wear resistance of phenolic resin-based poly(p-phenylene benzobisoxazole)(PBO)/polytetrafluoroethylene(PTFE)textile composites.Transmission electron microscope(TEM)characterization reveals that the AuNPs are well-dispersed inside the HNTs,with an average diameter of 6‒9 nm.The anti-wear performance of the HNTs and Au-reinforced PBO/PTFE composites is evaluated using a pin-on-disk friction tester at 100 MPa.Evidently,the addition of HNTs‒Au induces a 27.9%decrease in the wear rate of the composites.Possible anti-wear mechanisms are proposed based on the analyzed results of the worn surface morphology and the cross-section of the tribofilm obtained by focused ion beam transmission electron microscopy. | Yanling WANG Zhaozhu ZHANG Meng LIU Yaohui HE Peilong LI Junya YUAN Mingming YANG Weimin LIU | 2023 | Friction2023，11，12： | 0 |
| 17 | Consensus on diagnostic criteria for Yin deficiency syndrome in hypertension:a modified Delphi study显示文摘OBJECTIVE:To reach consensus on the diagnostic criteria for Yin deficiency syndrome in hypertension(YDSH)patients by a modified Delphi method.METHODS:Our study was consistent with T/CACM 1032-2017.The methodology of RAND/UCLA appropriateness was used to develop consensus guidance statements.A nationwide panel of experienced clinical experts from 19 provinces was constructed.These experts were all prominent in Traditional Chinese Medicine(TCM)of cardiovascular diseases.This consensus process consisted of two rounds of questionnaires and a final round of consultation to analyze the weight score of each item.Moreover,the data extraction process is carried out independently by third-party researchers(LIANG Junya,SUN Yang,and DU Xiaona).When there is disagreement in all three rounds,the expert panel group(odd number)are invited to vote,and the one with more votes wins.In the questionnaires,participants were asked to rate the appropriateness of each syndrome item using a nine-point Likert scale.The consensus was defined as a panel median rating 1-3 or 7-9 without disagreement.And then the diagnostic criteria of YDSH were formed according to the weight score in the final round.RESULTS:Twenty-eight experts(84.8%)participated in the first round,and thirty-one(93.9%)finished the second round.After two rounds,the consensus of YDSH was reached on 11 items(25.6%),including symptoms,signs,and pulse condition.Twenty-one experts(63.6%)completed the final round in which they used a grading system for each item.Red tongue with scanty fur had the highest weighting(22.8%),followed by heat in the palms and soles(20.1%).CONCLUSIONS:The consensus-based diagnostic criteria for YDSH,formed by a modified Delphi method,can be widely incorporated in TCM.A further clinical study will be conducted to analyze the diagnosis value and cut-off score of our YDSH criteria. | HE Yun HE Jing XU Xiangru LI Haixiao SHI Rongwei LIANG Junya ZHOU Ying ZHU Yao CHEN Xiaohu TANG Shuhua XIAO Min ZHAN Libin PEI Yinghao JIANG Weimin | 2023 | Journal of Traditional Chinese Medicine2023，43，1： | 0 |
| 18 | Surface modification of YS-20 with polydopamine for improving the tribological properties of polyimide composites显示文摘Recently,great effort has been devoted to prepare various reinforce fillers to improve polymer performances,but ignoring the importance of raw polymer powders which are indispensable parts of hot-pressed polymer composites.Herein,we engineer raw polyimide(PI)powders with the assistance of polydopamine(PDA)in aqueous solutions.After the modification,polymer powders change from hydrophobic to hydrophilic,which makes it is possible to further modification of polymer powders in liquid phase.During the curing process of modified polymer powders,the partial dehydration of the catechol groups and crosslinking of PDA via C–O–C bonds are confirmed.Based on the features of PDA,a non-destructive mixing method is utilized to realize homogeneous dispersion of multi-walled carbon nanotubes(MWCNTs)in polymer matrix.In comparison with ball milling method,this way can preserve the integrated innate structure of MWCNTs effectively.Besides,by taking full advantage of the reducing and metal-coordination capability of PDA,Cu2+is successfully loaded onto the surfaces of polymer powders.The related characterizations demonstrate that Cu2+in situ converts to metallic copper rather than copper oxide during the hot pressing process.The tribological properties of corresponding polymer composites are also studied.These results indicate that modifying polymer powders with PDA is multi-profit and presents practical application prospect. | Liangfei WU Zhaozhu ZHANG Mingming YANG Junya YUAN Peilong LI Zujun CHEN Xuehu MEN | 2022 | Friction2022，10，3： | 0 |
| 19 | Study on Spray Characteristics of Dimethyl Carbonate Blended Fuel in IC Engines显示文摘The spray characteristics of the blended fuel composed of biodiesel and dimethyl carbonate were compared with those of biodiesel and diesel.The macroscopic spray characteristic parameters including spray tip penetration,maximum spray width,average spray cone angle,and peak tip velocity were used to evaluate the spray characteristics of the blended fuel.The results showed that the spray tip penetration of blended fuel was lower than that of biodiesel,while the spray cone angle and maximum spray width of blended fuel were both larger than that of biodiesel.On the basis of the Hiroyasu and Arai mathematical model combined with the actual working conditions of this experiment,including physical parameters such as the viscosity and density of the fuel,a correct model of spray penetration was established,and the experimental results were compared. | Fu Wei Zhou Kun Liu Junya Xie Hongxi Li Yayun Lu Lei Bao Jihu Cheng Yunlang | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，4： | 0 |
| 20 | Novel technologies in cfDNA analysis and potential utility in clinic显示文摘The profiling of plasma cell-free DNA(cfDNA)is becoming a valuable tool rapidly for tumor diagnosis,monitoring and prognosis.Diverse plasma cfDNA technologies have been in routine or emerging use,including analyses of mutations,copy number alterations,gene fusions and DNA methylation.Recently,new technologies in cfDNA analysis have been developed in laboratories,and potentially reflect the status of epigenetic modification,the immune microenvironment and the microbiome in tumor tissues.In this review,the authors discuss the principles,methods and effects of the current cfDNA assays and provide an overview of studies that may inform clinical applications in the near future. | Jie Li Mengyue Xu Junya Peng Jingqiao Wang Yupei Zhao Wenming Wu Xun Lan | 2021 | Chinese Journal of Cancer Research2021，33，6： | 0 |
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