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| 1 | Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas显示文摘Invasive nonfunctional pituitary adenomas(NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery.Currently,no medications are clinically effective in the control of NFPA.Although radiation therapy and radiosurgery are useful to prevent tumor regrowth,they are frequently withheld because of severe complications.Boron neutron capture therapy(BNCT) is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue.Folate receptor(FR)-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis.In this study,FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas.After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons,the cell viability of NFPAs was significantly decreased,while apoptotic cells were simultaneously increased.However,cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells.The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT.In conclusion,FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs cells for BNCT.Furthermore,our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy,while exploring these new applications of BNCT for tumors,especially benign tumors. | DAI CongXin CAI Feng HWANG Kuo Chu ZHOU YongMao ZHANG ZiZhu LIU XiaoHai MA SiHai YANG YaKun YAO Yong FENG Ming BAO XinJie LI GuiLin WEI JunJi JIAO YongHui WEI ZhenQing MA WenBin WANG RenZhi | 2013 | Science China(Life Sciences)2013，56，2： | 8 |
| 2 | Periodical characteristics of baseflow in the source region of the Yangtze River显示文摘Baseflow,which represents the drainage of groundwater aquifers,is an essential component of runoff in hydrological basins.In the source region of the Yangtze River,the change of baseflow typically reflects the interactions between groundwater system and climatic factors in cold and arid areas.With modified Kalinen separation method,annual baseflow between 1957 and 2009 in this region was estimated and calculated.In comparison with the inner-annual variations of total streamflow,baseflow showed a weaker fluctuation.Before the 1980s,it was in a steady state;and after then,it demonstrated dramatic variations and large amplitudes.Based on the calculation results of baseflow,the real Morlet wavelet method was applied to reveal the periodical characteristics of baseflow as well as the precipitation and air temperature in the study area.It was found that annual baseflow has a 43-year trend as well as a 21-year period and a 7-year period.The 21-year period is most significant,with its wavelet coefficient having the largest fluctuation and amplitude.Summation of wavelet coefficients on these periods exhibits a similar change pattern with respect to that of annual baseflow.The summation curve takes a'W'shape,which means that the baseflow follows a four-stage sequence of descending–ascending–descending–ascending.As analyzed,the relationship among baseflow,precipitation and temperature is implied in the correlation between their normalized wavelet coefficients at different temporal scales.By the significant positive linear correlations both between precipitation and baseflow(correlation coefficient is 0.98)and between temperature and baseflow(correlation coefficient is 0.90)for the 43-year wavelet coefficients,it is suggested that the long-term increasing trends of precipitation and air temperature will lead to an increasing trend of baseflow.For wavelet coefficients of 21-year and 7-year periods,the positive linear correlation between precipitation and baseflow is significant.However,the correlation between air temperature and baseflow is not so evident,especially for the 21-year period.As a conclusion, correlation analysis with normalized wavelet coefficients showed that the change of annual baseflow was contributed mostly by the change of precipitation and secondly by the change of temperature. | KaiZhu QIAN Li WAN XuSheng WANG JingJing LV SiHai LIANG | 2012 | Journal of Arid Land2012，4，2： | 7 |
| 3 | China Digital Ocean Prototype System显示文摘Digital Ocean is a new research domain of Digital Earth.Because of the spatiotemporal,three-dimensional(3D)and intrinsically dynamic nature of ocean data,it is more difficult to make a breakthrough in this domain.The construction of the China Digital Ocean Prototype System(CDOPS)pushes Digital Ocean a step forward from its operation as a mere concept to its achievement as a realistic system.In this paper,the technical framework of the CDOPS is discussed,including its data,function,and application layers.Then,two key technologies are studied in detail that will enable the construction of the 3D ocean environment and the visualization of the ocean model output data.Practical demonstrations show that the CDOPS provides a technical reference for the development of Digital Ocean.This paper is based on an ongoing research project of the development of CDOPS that aims at the facilitation,integration,sharing,accessing,visualization,and use of the ocean data and model computing data from the Digital Earth perspective. | Xin Zhang Wen Dong Sihai Li Jiancheng Luo Tianhe Chi | 2011 | International Journal of Digital Earth2011，4，3： | 7 |
| 4 | Are academic independent directors punished more severely when they engage in violations?显示文摘We use a sample of Chinese A-share listed companies from 2003 to 2013 to explore the reputation damage and overflow effect of academic independent directors who have received supervisory punishment. We find that when companies violate information disclosure rules, the market punishes academic independent directors more severely than nonacademic independent directors for these violations. Furthermore, companies employing punished academic directors face greater declines in their stock price than companies employing punished nonacademic independent directors during a relatively short window before or after the punishment is announced. The punishment of academic independent directors influences the employment of other scholars in the same field and results in a negative overflow effect. This study provides evidence of the market's differential reactions to independent directors with different backgrounds; the findings reflect the double-edged sword of one individual's reputation on organizations. | Yi Quan Sihai Li | 2017 | China Journal of Accounting Research2017，，1： | 5 |
| 5 | Effect of AAPH oxidation on digestion characteristics of seed watermelon(Citrullus lanatus var)kernels protein isolates显示文摘Seed watermelon kernel is a typical complex food with high fat and protein contents.During storage and processing,it is often affected by various factors to undergo interactions between components,which lead to its quality change.In this experiment,seed watermelon kernels were used as research objects,and the effects of 2-Azobis(2-amidinopropane)dihydrochloride(AAPH)on seed watermelon kernel protein isolates(WMP)were investigated.The structure and digestion characteristics of WMP after oxidation were studied.The results showed that with the increase of AAPH concentration(0.05−5 mol/L),WMP showed obvious aggregation,and its solubility decreased from 6.76 mg/mL to 9.59 mg/mL.The free sulfhydryl content of WMP was 18.24 mmol/g decreased to 11.25 mmol/g,α-helix decreased andβ-sheet decreased in secondary structure,and its disulfide bond increased by 43.06 mmol/g from 39.57 mmol/g,enthalpy(H)and denaturation temperature increased(Td)(P<0.05).By mass spectrometry results of simulated gastric digestion products,it was found that oxidation adversely affected the digestion characteristics of WMP.It can be seen that the lipid oxidation product APPH of seed watermelon kernel can significantly affect the structure and function of the protein extracted from the seed kernel. | Shugang Li Zhihao Li Xiuting Li Ping Wang Xiongwei Yu Qinli Fu Sihai Gao | 2020 | Food Science and Human Wellness2020，9，4： | 3 |
| 6 | Oxygen Isotope Characteristics of the Footwall Alteration Zones in the Hongtoushan Volcanogenic Massive Sulfide Deposit,Liaoning Province,China and Restoration of Their Formation Temperatures显示文摘Hongtoushan Volcanogenic 巨大的硫醚存款(VMSD ) 发生在 Hunbei 花岗石绿岩岩层,辽宁省, NE 中国。在采矿区域的岩石在以前的调查在在 600posit 之间的温度在 3.02.8 Ga 附近被变形了到上面的角闪岩外形因为矿石身体在正直的褶层的过渡地点和谐地发生。Re 和 O 为有从矿石身体的闪锌矿和方铅矿的 paragenetic 黄铁矿的同位素的分析被用来决定预定矿化作用并且跟踪 metallogenic 材料的来源。四个黄铁矿的 ReOs 同位素的数据取样构造 isochron,产出 226 攠敮杲敩 ? 景映牯慭楴湯漠 ? 桴 ? 牴癩污湥 ? 慣楴湯 ? 牡 ?湫睯n 的加权的平均年龄吗? | ZHENG Yuanchuan GU Lianxing TANG Xiaoqian LIU Sihai WU Changzhi LI Chunhai | 2011 | Acta Geologica Sinica(English Edition)2011，85，3： | 2 |
| 7 | Novel sol-gel material for fabrication of a long period waveguide grating filter as a precise thermometer显示文摘A new kind of organic-inorganic hybrid HfO 2/SiO 2 sol-gel material with a large thermo-optic coefficient and a wide linear tunable temperature range has been developed for fabrication of a long period waveguide grating (LPWG) filter,whose parameters were optimized and designed by using finite difference time domain (FDTD) simulations.The LPWG filter,a periodic rectangle-corrugated grating structure,was easily fabricated with soft-lithography technique.At a temperature range from 19°C to 70°C,the fabricated LPWG filter element demonstrated a high temperature sensitivity of about 6.5 nm/°C and a wide linear tunable temperature range of 51°C,so that it can be used as a precise thermometer.Our results are useful for the designs of LPWG filters for the implementation of a wide range of thermo-optic functions. | WANG Xin LI XiaoChan ZHANG Tao HU CanDong ZHU QiuXiang CHEN SiHai LI Yun XU Jia HE Miao NIU QiaoLi ZHAO LingZhi LI ShuTi ZHANG Yong | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，11： | 2 |
| 8 | Effect of Lactobacillus acidophilus 1.1878 on sIgA Content in the Intestinal Mucous and Antioxidant Capacity of Broiler Chicks显示文摘[Objective] The paper was to study the immune activities of Lactobacillus acidophilus 1.1878 and its effect on antioxidant capacity of broiler chicks.[Methods]Samples of intestinal mucous,serum and liver were collected from broiler chicks after oral administration of L. acidophilus 1.1878. Secretory immunoglobulin A( sIgA) content in the intestinal mucous,total antioxidant capacity( T-AOC),level of MDA and activity of SOD and GSH-Px were determined,respectively. [Result] Oral administration of L. acidophilus 1.1878 significantly improved the s Ig A content in jejunum and ileum mucous( P < 0.05). No significant differences were observed in GSH-Px activity between treatment group and control group. The concentration of T-AOC and activity of SOD in serum and liver increased significantly( P < 0.05),while the level of MDA reduced significantly after oral administration of L. acidophilus 1.1878( P < 0.05). [Conclusion]L. acidophilus 1.1878 can enhance the immune function of intestinal mucous and antioxidant capacity of broiler chicks. | Li Jianmin Cao Li Han Sihai | 2017 | Animal Husbandry and Feed Science2017，9，4： | 2 |
| 9 | Curved microlens array for bionic compound eye 显示文摘 | Li Feng Chen Sihai Luo Huan el al | 2013 | Light andElectron Optics2013，，6： | 1 |
| 10 | Fabrication and characterization of polydimethylsiloxane concave microlens array显示文摘 | Li Feng Chen Sihai Luo Huan Zhou Yifan Lai Jianjun Gao Yiqing | 2011 | Optics and Laser Technology2011，，4： | 1 |
| 11 | Hybrid integration between long focus microlens array and IR detector array显示文摘 | Chen Sihai Yi Xinjian Li Yi | 2001 | International J Infrared and Millimeter Waves2001，22，3： | 1 |
| 12 | Temporal and Quantitative Analysis of Atherosclerotic Lesions in Diet-Induced Hypercholesterolemic Rabbits显示文摘 | Qi Yu Yafeng Li Ahmed Bilal Waqar Yanli Wang Bingqiao Huang Yulong Chen Sihai Zhao Peigang Yang Jianglin Fan Enqi Liu George E. Plopper | 2012 | Journal of Biomedicine and Biotechnology2012，，： | 1 |
| 13 | Expression of TRPV1 in rabbits and consuming hot pepper affects its body weight显示文摘 | Qi Yu Yanli Wang Ying Yu Yafeng Li Sihai Zhao Yulong Chen Ahmed Waqar Jianglin Fan Enqi Liu | 2012 | Molecular Biology Reports2012，，7： | 1 |
| 14 | Unique evolutionary pattern of numbers of gramineous NBS–LRR genes显示文摘 | Jing Li Jing Ding Wen Zhang Yuanli Zhang Ping Tang Jian-Qun Chen Dacheng Tian Sihai Yang | 2010 | Molecular Genetics and Genomics2010，，5： | 1 |
| 15 | Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers显示文摘 | Xiaohui Yan Zhongyi Hu Yi Feng Xiaowen Hu Jiao Yuan Sihai D. Zhao Youyou Zhang Lu Yang Weiwei Shan Qun He Lingling Fan Lana E. Kandalaft Janos L. Tanyi Chunsheng Li Chao-Xing Yuan Dongmei Zhang Huiqing Yuan Keqin Hua Yiling Lu Dionyssios Katsaros Qihong H | 2015 | Cancer Cell2015，，4： | 1 |
| 16 | Oleic acid reduces steroidogenesis by changing the lipid type stored in lipid droplets of ovarian granulosa cells显示文摘Background:Oleic acid is an abundant free fatty acid present in livestock that are in a negative energy-balance state,and it may have detrimental effects on female reproduction and fertility.Oleic acid induces lipid accumulation in bovine granulosa cells,which leads to a foam cell-like morphology and reduced steroidogenesis.However,why oleic acid increases lipid accumulation but decreases steroidogenesis remains unclear.This study focused on oleic acid’s effects on lipid type and steroidogenesis.Results:Oleic acid increased the lipid accumulation in a concentration-dependent manner and mainly increased the triglyceride level and decreased the cholesterol ester level.Oleic acid also led to a decline in estradiol and progesterone production in porcine granulosa cells in vitro.In addition,oleic acid up-regulated the expression of CD36 and diacylglycerol acyltransferase 2,but down-regulated the expression of 3-hydroxy-3-methylglutarylcoenzyme A reductase,scavenger receptor class B member 1 and acetyl-Coenzyme A acetyltransferase 2,as well as steroidogenesis-related genes,including cytochrome P450 family 11 subfamily A member 1,cytochrome P450family 19 subfamily A member 1 and 3 as well as steroidogenic acute regulatory protein at the mRNA and protein levels.An oleic acid-rich diet also enhanced the triglyceride levels and reduced the cholesterol levels in ovarian tissues of female mice,which resulted in lower estradiol levels than in control-fed mice.Compared with the control,decreases in estrus days and the numbers of antral follicles and corpora lutea,as well as an increase in the numbers of the atretic follicles,were found in the oleic acid-fed female mice.Conclusions:Oleic acid changed the lipid type stored in lipid droplets of ovarian granulosa cells,and led to a decrease in steroidogenesis.These results improve our understanding of fertility decline in livestock that are in a negative energy-balance state. | Xiaoge Zhou Zhaoyi Mo Yankun Li Liang Huang Sihai Yu Lan Ge Yamei Hu Shengjie Shi Lutong Zhang Liguang Wang Lei Gao Gongshe Yang Guiyan Chu | 2022 | Journal of Animal Science and Biotechnology2022，13，3： | 1 |
| 17 | Intact Polar and Core Tetraether Lipids in Sediments from the Haiyang 4 Cold-seep of the Northern South China Sea and their Implications显示文摘A number of cold seeps have been discovered in the northern South China Sea(SCS) including the Haiyang 4 cold-seep area where Core 973-5 was collected. Intact polar lipids(IPLs) and core lipids(CLs) were analyzed separately in sediments from Core 973-5. The most abundant lipid biomarkers were isoprenoidal GDGTs(iso GDGTs), with Crenarchaeol and GDGT-0 predominating. IPL-iso GDGTs and CL-iso GDGTs were mainly derived from Thaumarchaeota. IPL-iso GDGTs were mainly produced and retained in situ thus containing most of the in situ microbiological information. Branched GDGTs were predominantly derived from generated in marine production, and mixed with some terrestrial inputs. All IPLs groups presented a high value in the sulfate-methane transition zone(SMTZ). Furthermore, IPL and CL-MI, IPL-R;showed the highest values within the SMTZ, while IPL and CL-R;had the lowest values at the SMTZ, suggesting that the contribution of Methanophila and methanogenic to GDGTs increased, while the contribution of ammonia-oxidizing Archaea to GDGTs decreased at the SMTZ. | LI Yuejiao SU Xin JIAO Lu CHEN Fang CHENG Sihai | 2022 | Acta Geologica Sinica(English Edition)2022，96，2： | 1 |
| 18 | Erratum to:Borates as a new direction in the design of oxide ion conductors(vol 65,issue 10,page 2737,2022)显示文摘In the version of the article originally published in the volume 62,issue 10,2022 of Sci.china Mater.(page 2737-2745,http://gffzzd3cc09b8251d45dfscpqcu6obxwk56qnb.ffgz.tsg.suse.edu.cn/10.1007/s40843-022-2044-3).The chemical shift reported in Figure 5f for the^(11)B solid-state NMR spectra is incorrect because no parameter correction was performed during data processing. | Xiaohui Li Li Yang Zhenyu Zhu Xiaoge Wang Bohua Chen Senchuan Huang Xianyi Wei Guohong Cai Pascal Manuel Sihai Yang Jianhua Lin Xiaojun Kuang Junliang Sun | 2022 | Science China Materials2022，65，11： | 0 |
| 19 | Porous framework materials for energy&environment relevant applications:A systematic review显示文摘Carbon peaking and carbon neutralization trigger a technical revolution in energy&environment related fields.Development of new technologies for green energy production and storage,industrial energy saving and efficiency reinforcement,carbon capture,and pollutant gas treatment is in highly imperious demand.The emerging porous framework materials such as metal–organic frameworks(MOFs),covalent organic frameworks(COFs)and hydrogen-bonded organic frameworks(HOFs),owing to the permanent porosity,tremendous specific surface area,designable structure and customizable functionality,have shown great potential in major energy-consuming industrial processes,including sustainable energy gas catalytic conversion,energy-efficient industrial gas separation and storage.Herein,this manuscript presents a systematic review of porous framework materials for global and comprehensive energy&environment related applications,from a macroscopic and application perspective. | Yutao Liu Liyu Chen Lifeng Yang Tianhao Lan Hui Wang Chenghong Hu Xue Han Qixing Liu Jianfa Chen Zeming Feng Xili Cui Qianrong Fang Hailong Wang Libo Li Yingwei Li Huabin Xing Sihai Yang Dan Zhao Jinping Li | 2024 | Green Energy & Environment2024，9，2： | 0 |
| 20 | Corporate Donations in China: A Strategic- Political Perspective显示文摘这份报纸探索优秀经理的政治身份怎么影响社团的捐赠,基于上面的军队飞机理论(UET ) 。结果证明优秀经理的政治身份在一个公司的捐赠行为上有重要影响,特别在有差的机构的环境的区域。社团的捐赠取决于优秀经理是否有政治身份而且这身份的类型不仅。而且,影响与不同所有权结构在公司之间显著地不同。这研究由证明社团的捐赠惯例被上下文的因素的一个范围塑造充实我们社团的慈善的知识。在象中国那样的新兴的经济的社团的给行为不同地根据他们的机构的背景的根本上不同的方面被激发。 | Sihai Li Wenbin Long Xianzhong Song | 2015 | Frontiers of Business Research in China2015，9，4： | 0 |
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