|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | ZmCOL3, a CCT gene represses flowering in maize by interfering with the circadian clock and activating expression of ZmCCT显示文摘Flowering time is a trait vital to the adaptation of flowering plants to different environments.Here, we report that CCT domain genes play an important role in flowering in maize(Zea mays L.).Among the 53 CCT family genes we identified in maize, 28 were located in flowering time quantitative trait locus regions and 15 were significantly associated with flowering time, based on candidate-gene association mapping analysis.Furthermore, a CCT gene named ZmCOL3 was shown to be a repressor of flowering.Overexpressing ZmCOL3 delayed flowering time by approximately 4 d, in either long-day or short-day conditions.The absence of one cytosine in the ZmCOL3 3'UTR and the presence of a 551 bp fragment in the promoter region are likely the causal polymorphisms contributing to the maize adaptation from tropical to temperate regions.We propose a modified model of the maize photoperiod pathway, wherein ZmCOL3 acts as an inhibitor of flowering either by transactivating transcription of ZmCCT, one of the key genes regulating maize flowering, or by interfering with the circadian clock. | Minliang Jin Xiangguo Liu Wei Jia Haijun Liu Wenqiang Li Yong Peng Yanfang Du Yuebin Wang Yuejia Yin Xuehai Zhang Qing Liu Min Deng Nan Li Xiyan Cui Dongyun Hao Jianbing Yan | 2018 | Journal of Integrative Plant Biology2018，60，6： | 14 |
| 2 | Antigenically dominant proteins within the human liver mitochondrial proteome identified by monoclonal antibodies显示文摘Analysis of the mitochondrial proteome would provide valuable insight into the function of this important organelle, which plays key roles in energy metabolism, apoptosis, free radical production, thermogenesis, and calcium signaling. It could also increase our understanding about the mechanisms that promote mitochondrial disease. To identify proteins that are antigenically dominant in human liver mitochondria, we generated >240 hybridoma cell lines from native mitochondrial proteins after cell fusion, screening, and cloning. Antibodies that recognized mitochondrial proteins were identified by screening human liver cDNA expression libraries. In this study, we identified 6 major antigens that were recognized by at least 2 different monoclonal antibodies (mAbs). The proteins that were antigenically dominant were: acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase), aldehyde dehydrogenase 1 family member A1, carbamoyl phosphate synthetase 1, dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex), enoyl coenzyme A hydratase 1, and hydroxysteroid (11-beta) dehydrogenase 1. We also determined the subcellular localizations of these enzymes within the mitochondria using immunohistocytochemistry. We believe that these well-characterized antibodies will provide a valuable resource for the Human Liver Proteome Project (HLPP), and will make studies aimed at investigating liver mitochondrial function far easier to perform in future. Our results provide strong evidence that, (i) depletion of dominant proteins from liver mitochondrial samples is possible and, (ii) the approaches adopted in this study can be used to explore or validate protein-protein interactions in this important organelle. | JU YanFang YANG JinJu LIU Rong LIU XiaoLan DU XueMei LIU Li CHEN ZhiCheng CHI Jun LIU ShuEr GAO Yuan GAO JianEn JIAO ShunChang HE FuChu SUN QiHong | 2011 | Science China(Life Sciences)2011，54，1： | 6 |
| 3 | Substantial transition to clean household energy mix in rural China显示文摘The household energy mix has significant impacts on human health and climate,as it contributes greatly to many health-and climate-relevant air pollutants.Compared to the well-established urban energy statistical system,the rural household energy statistical system is incomplete and is often associated with high biases.Via a nationwide investigation,this study revealed high contributions to energy supply from coal and biomass fuels in the rural household energy sector,while electricity comprised∼20%.Stacking(the use of multiple sources of energy)is significant,and the average number of energy types was 2.8 per household.Compared to 2012,the consumption of biomass and coals in 2017 decreased by 45%and 12%,respectively,while the gas consumption amount increased by 204%.Increased gas and decreased coal consumptions were mainly in cooking,while decreased biomass was in both cooking(41%)and heating(59%).The time-sharing fraction of electricity and gases(E&G)for daily cooking grew,reaching 69%in 2017,but for space heating,traditional solid fuels were still dominant,with the national average shared fraction of E&G being only 20%.The non-uniform spatial distribution and the non-linear increase in the fraction of E&G indicated challenges to achieving universal access to modern cooking energy by 2030,particularly in less-developed rural and mountainous areas.In some non-typical heating zones,the increased share of E&G for heating was significant and largely driven by income growth,but in typical heating zones,the time-sharing fraction was<5%and was not significantly increased,except in areas with policy intervention.The intervention policy not only led to dramatic increases in the clean energy fraction for heating but also accelerated the clean cooking transition.Higher income,higher education,younger age,less energy/stove stacking and smaller family size positively impacted the clean energy transition. | Guofeng Shen Rui Xiong Yanlin Tian Zhihan Luo Bahabaike Jiangtulu Wenjun Meng Wei Du Jing Meng Yuanchen Chen Bing Xue Bin Wang Yonghong Duan Jia Duo Fenggui Fan Lei Huang Tianzhen Ju Fenggui Liu Shunxin Li Xianli Liu Yungui Li Mu Wang Ying Nan Bo Pan Yanfang Pan Lizhi Wang Eddy Zeng Chao Zhan Yilin Chen Huizhong Shen Hefa Cheng Shu Tao | 2022 | National Science Review2022，9，7： | 4 |
| 4 | The norepinephrine transporter gene is associated with the retardation symptoms of major depressive disorder in the Han Chinese population显示文摘The norepinephrine transporter plays an important role in the pathophysiology and pharmacological treatment of major depressive disorder.Consequently,the norepinephrine transporter gene is an attractive candidate in major depressive disorder research.In the present study,we evaluated the depression symptoms of subjects with major depressive disorder,who were all from the North of China and of Han Chinese origin,using the Hamilton Depression Scale.We examined the rela-tionship between two single nucleotide polymorphisms in the norepinephrine transporter,rs2242446 and rs5569,and the retardation symptoms of major depressive disorder using quantitative trait testing with the UNPHASED program.rs5569 was associated with depressed mood,and the GG genotype may be a risk factor for this;rs2242446 was associated with work and interest,and the TT genotype may be a risk factor for loss of interest.Our findings suggest that rs2242446 and rs5569 in the norepinephrine transporter gene are associated with the retardation symptoms of depression in the Han Chinese population. | Xinrong Li Ning Sun Yong Xu Yanfang Wang Suping Li Qiaorong Du Juyi Peng Jinxiu Luo Kerang Zhang | 2012 | Neural Regeneration Research2012，7，25： | 3 |
| 5 | Heat Dissipation Performance of Porous Copper with Elongated Cylindrical Pores显示文摘The purpose of this paper is to investigate heat dissipation performance of porous copper with long cylindrical pores fabricated by a unidirectional solidification method.Three samples with porosity of 29.87%,34.47%and 50.98%were chosen and cut into size of 60 mm(length)26 mm(width)2 mm(thickness)along the vertical direction of pore axis.Their heat dissipation performance was evaluated by a nonsteady method in air and compared to those of not only bulk copper but also bored coppers with porosity of 30.61%and32.20%.It is found that the porous copper dissipated heat faster by a forced air convection than that by natural convection from 80 C to room temperature and both porosity and pore size play an important role in the performance for the porous copper.Furthermore,the heat dissipation rate is higher when the forced air was circulated along the specimens than that perpendicular to the specimens for the porous copper.It is revealed that porous copper with bigger porosity and a proper pore size possesses a higher heat dissipation rate.It is concluded that the porous copper with elongated cylindrical pores has larger heat dissipation performance than both the bulk copper and the bored copper,which is attributed to its higher specific surface area.Application of the porous copper for heat dissipation is promising. | Hao Du Dongzhu Lu Jianzhong Qi Yanfang Shen Lisong Yin Yuan Wang Zhongguang Zheng Tianying Xiong | 2014 | Journal of Materials Science & Technology2014，30，9： | 3 |
| 6 | Structural Characterization of Glucan Produced by Lactobacillus sake L-7 from Sausage显示文摘A linear glucan was produced by Lactobacillus sake L-7 isolated from homemade sausage. Cultivation of the strain in Man–Rogosa–Sharpe(MRS) medium containing 50 g/L sucrose yielded 5.3 g/L of purified exopolysaccharide(EPS). The EPS was characterized by gas chromatography(GC), Fourier-transform infrared(FT-IR) spectroscopy, high-performance sizeexclusion chromatography(HPSEC), nuclear magnetic resonance(NMR) spectroscopy, and scanning electron microscopy(SEM). The monosaccharide composition of the EPS was glucose, and its molecular weight was 1 × 10~7 Da. The FT-IR and NMR spectra revealed that the L-7 EPS was a linear glucan with α-(1 → 6) glucosidic bonds. SEM images of the dried EPS revealed a hollow tubular structure. The water solubility index and water holding capacity of L-7 EPS were 96 and 272%, respectively. The results of hydrolysis indicated that L-7 EPS was not susceptible to hydrolysis by physiological barriers and can be used as a soluble dietary fiber with health benefits. All these characteristics suggest that L-7 EPS might have potential applications in the food, cosmetic, and pharmaceutical industries. | Fang Feng Qingqing Zhou Yanfang Yang Fangkun Zhao Renpeng Du Ye Han Zhijiang Zhou | 2019 | Transactions of Tianjin University2019，25，1： | 3 |
| 7 | Isolation, Purification, and Characterization of Exopolysaccharide Produced by Leuconostoc Citreum N21 from Dried Milk Cake显示文摘A strain with high production of exopolysaccharide(EPS) was isolated from dried milk cake(a traditional fermented food from Inner Mongolia). The strain was called N21 and later identified as Leuconostoc citreum( Leu. citreum). The strain was cultured in Man-Rogosa-Sharpe medium containing 50 g/L of sucrose for 48 h at 30 °C and the EPS purified, with a yield of 24.5 g/L. An average molecular weight of 6.07 × 10~6 g/mol was determined by high-performance size-exclusion chromatography. The structure of the purified EPS was investigated through gas chromatography, ~1H and ^(13)C nuclear magnetic resonance spectroscopy, and Fourier transform infrared spectroscopy. The results demonstrated a polysaccharide composed of D-glucopyranose units in a linear chain with consecutive α(1 → 6) linkages. No branching was found in the structure of the exopolysaccharide. The purified EPS showed high water solubility and emulsibility. Based on the thermogravimetric curve, the degradation temperature of the EPS was 308.47 °C, which suggested that the dextran in the study exhibited high thermal stability. The results indicated that Leu. citreum N21 could be widely used to produce linear EPS and that the EPS has potential applications in food science and processing as a food additive. | Yanfang Yang Fang Feng Qingqing Zhou Fangkun Zhao Renpeng Du Zhijiang Zhou Ye Han | 2019 | Transactions of Tianjin University2019，25，2： | 2 |
| 8 | Selective Synthesis of Fe2O3 and Fe3O4 Nanowires Via a Single Precursor: A General Method for Metal Oxide Nanowires显示文摘 | Ning Du Yanfang Xu Hui Zhang Chuanxin Zhai Deren Yang | 2010 | Nanoscale Research Letters2010，，8： | 1 |
| 9 | Anti-inflammatory Effects of Rebamipide According to Helicobacter pylori Status in Patients with Chronic Erosive Gastritis: A Randomized Sucralfate-Controlled Multicenter Trial in China—STARS Study显示文摘 | Yiqi Du Zhaoshen Li Xianbao Zhan Jie Chen Jun Gao Yanfang Gong Jianlin Ren Liping He Zhijian Zhang Xiaozhong Guo Jianshen Wu Zibin Tian Ruihua Shi Bo Jiang Dianchun Fang Youming Li | 2008 | Digestive Diseases and Sciences2008，，11： | 1 |
| 10 | JUDICIAL ADJUDICATION RULES AND ENLIGHTENMENT ON THE CASE SERIES OF ADMINISTRATIVE DISPUTES OVER THE TRADEMARK OF "QIAODAN"显示文摘In the process of interest balancing and value selecting in the theoretical research and practice of the Intellectual Property Law,the proper balance between the judicial policy and value of'stringent judicial protection'and'balancing of interest'should be seriously taken into account.One of the typical representatives is the interest dispute and balance between the obligee of the prior right | Tao Kaiyuan Wang Chuang Xia Junli Wang Yanfang Du Weike Liu Jiajia | 2017 | China Legal Science2017，5，2： | 1 |
| 11 | Preparation and curing kinetics of bisphenol A type novolac epoxy resins显示文摘 | Liu Yanfang Zhang Chen Du Zhongjie | 2006 | Journal of Applied Polymer Science2006，99，3： | 1 |
| 12 | Nanoporous PtRu Alloy enhanced nonenzymatic immunosensor for ultrasensitive detection of microcystin-LR显示文摘 | WEI QIN ZHAO YANFANG DU BIN | 2011 | Advanced Functional Materials2011，21，21： | 1 |
| 13 | Morphology and properties of bisphenol A novolac epoxy resin with polysulfone blends显示文摘 | Liu Zhao Liu Yanfang Du Zhongjie | 2011 | International Journal of Polymer Analysis and Characterization2011，16，5： | 1 |
| 14 | Morphology and pro- perties of hisphenol-A novolac epoxy resin with polysulforte blends显示文摘 | Liu Zhao Liu Yanfang Du Zhongjie | 2011 | Int J Polym Anal2011，16，： | 1 |
| 15 | Sphere-like kesterite Cu2ZnSnS4 nanoparticles synthesized by a facile solvothermal method显示文摘 | Zhou Yanli Zhou Wenhui Du Yanfang | 2011 | Mater Lett2011，65，： | 1 |
| 16 | Decreased regional homogeneity in insula and cerebellum: A resting-state fMRI study in patients with major depression and subjects at high risk for major depression显示文摘 | Zhifen Liu Cheng Xu Yong Xu Yanfang Wang Bing Zhao Yating Lv Xiaohua Cao Kerang Zhang Chongxi Du | 2010 | Psychiatry Research: Neuroimaging2010，，3： | 1 |
| 17 | Electrosynthesis of poly( o-phenylenediamine) in ionic liquid and its properties显示文摘Ionic liquid 1-ethyl-3-methylimidazolium bromide (EMIMBr) and N-methylimidazolium tetrafluorobo-rate (HMIMBF4) have been used as solvent and electrolyte for the electropolymerization of o-phenylenediamine at glassy carbon electrode by cyclic voltammetry. It was found that monomer was more easily oxidized in ionic liquid than acidic aqueous solution,and oxidative potential was reduced by 0.725 and 0.455 V,respectively. Electrode modified with poly(o-phenylenediamine) (PPD) has obvi-ous electrochemical activity in acid solution (pH 1-4). The apparent diffusion coefficient (Dapp) of PPD film is measured by chronocoulometry and chronoamperometry. The polymer structure is measured by UV and IR. IR spectrometry reveals that poly(o-phenylenediamine) has phenazine ring structure. The heat stability of polymer is observed from thermogravimetry. | DU YanFang WANG Huan ZHANG AiJian LU JiaXingt | 2007 | Chinese Science Bulletin2007，52，16： | 1 |
| 18 | Apoptosis induced by trimethyltin chloride in human neureblastoma cells SY5Y is regulated by a balance and cross-talk between NF-jB and MAPKs sig- naling pathways 显示文摘 | Qing Yan Liang Yanfang Du Qingqing | 2013 | Arch Toxicol2013，87，7： | 1 |
| 19 | Bisulfite-free mapping of DNA cytosine modifications:challenges and perspectives显示文摘The mapping of DNA cytosine modifications is crucial for understanding the dynamic landscape of epigenetic regulation.While bisulfite sequencing has been the gold standard for decades,it suffers from limitations such as DNA degradation and low library quality due to harsh chemical treatment.In recent years,bisulfite-free methods have emerged as promising alternatives for detecting and quantifying DNA cytosine modifications.These methods employ enzymatic and chemical strategies to investigate cytosine modifications without the need for bisulfite treatment.This review provides an overview of the historical context of bisulfite-based methods and presents the current landscape of bisulfite-free methods.The advantages and limitations of each approach are discussed,along with insights into their applications.Furthermore,the review explores the existing challenges in the field and presents future perspectives and potential directions for advancing bisulfite-free mapping methods.The continued progress in bisulfite-free techniques holds great promise for unraveling the intricate nature of DNA cytosine modifications and their functional implications in diverse biological processes and diseases. | Yanfang Du Ying Tang Bingqian Lin Xiaochen Xue Yafen Wang Yibin Liu | 2023 | Science China Chemistry2023，66，11： | 0 |
| 20 | Flammulina velutipes polysaccharide-iron (Ⅲ) complex used to treat iron deficiency anemia after being absorbed via GLUT2 and SGLT1 transporters显示文摘Iron deficiency anemia(IDA)is a common nutritional problem, but traditional iron supplements cause many adverse reactions. Thus, the development of a novel iron supplement might be significant for the treatment of IDA. This study aimed to study the transport mechanism of Flammulina velutipes polysaccharide-iron complex(FVP1-Fe(Ⅲ))in Caco-2 cells and the therapeutic effect on IDA rats, as well as the influence on gut microbiota in vivo. These results showed that in vitro, the uptake of FVP1-Fe(Ⅲ)was mediated by sodium-dependent glucose transporter-1(SGLT1)and facilitated glucose transporter-2(GLUT2)and GLUT2 played a dominant function. The multidrug resistance-associated protein-2(MRP-2)was involved in the efflux of FVP1-Fe(Ⅲ)across the Caco-2 cells. In vivo, FVP1-Fe(Ⅲ)had a better restorative effect on blood parameters and iron status indicators in rats with IDA as compared with FeSO_4 and exerted this effect by downregulating the expression of hepcidin. FVP1-Fe(Ⅲ)could also regulate gut microbiota dysbiosis in iron deficiency rats by returning the relative abundance of gut microbiota to the normal level. Besides, as a dietary factor, vitamin C(vit C)could enhance the therapeutic effect of FVP1-Fe(Ⅲ). These present findings showed that FVP1-Fe(Ⅲ)could be exploited as a novel iron supplement to treat IDA. | Chenying Shi Chen Cheng Xiaotong Lin Yanfang Qian Yufeng Du Guitang Chen | 2023 | Food Science and Human Wellness2023，12，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员