|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | On the origin and continuing evolution of SARS-CoV-2显示文摘The SARS-Co V-2 epidemic started in late December 2019 in Wuhan, China, and has since impacted a large portion of China and raised major global concern. Herein, we investigated the extent of molecular divergence between SARS-CoV-2 and other related coronaviruses. Although we found only 4% variability in genomic nucleotides between SARS-CoV-2 and a bat SARS-related coronavirus(SARSr-CoV;Ra TG13), the difference at neutral sites was 17%, suggesting the divergence between the two viruses is much larger than previously estimated. Our results suggest that the development of new variations in functional sites in the receptor-binding domain(RBD) of the spike seen in SARS-Co V-2 and viruses from pangolin SARSr-Co Vs are likely caused by natural selection besides recombination. Population genetic analyses of 103 SARS-CoV-2 genomes indicated that these viruses had two major lineages(designated L and S), that are well defined by two different SNPs that show nearly complete linkage across the viral strains sequenced to date. We found that L lineage was more prevalent than the S lineage within the limited patient samples we examined. The implication of these evolutionary changes on disease etiology remains unclear.These findings strongly underscores the urgent need for further comprehensive studies that combine viral genomic data, with epidemiological studies of coronavirus disease 2019(COVID-19). | Xiaolu Tang Changcheng Wu Xiang Li Yuhe Song Xinmin Yao Xinkai Wu Yuange Duan Hong Zhang Yirong Wang Zhaohui Qian Jie Cui Jian Lu | 2020 | National Science Review2020，7，6： | 67 |
| 2 | Identification of a Stable Quantitative Trait Locus for Percentage Grains with White Chalkiness in Rice (Oryza sativa)显示文摘High chalkiness is a major problem in many rice-producing areas of the world, especially in hybrid rice (Oryza sativa L.) in China. We previously showed a major quantitative trait locus for the percentage of grains with white chalkiness (QTLqPGWC-8) in the interval G1149-R727 on chromosome 8 using a chromosome segment substitution line (CSSL). Here, we selected the line-CSSL50 harboring the QTLqPGWC-8 allele from the CSSLs derived from a cross between Asominori (as a recurrent parent) and IR24 (as a donor parent), which had higher percentage chalkiness, markedly different from that of Asominori. There were also significant differences in starch granules, appearance of amylose content (AAC) and milling qualities between Asominori and CSSL50, but not in grain size or thousand grain weight (TGW). The BC4F2 and BC4F3 populations from a cross between CSSL50 and Asominori were used for fine mapping of qPGWC-8. We narrowed down the location of this QTL to a 142 kb region between Indel markers 8G-7 and 8G-9. QTLqPGWC-8 accounted for 50.9% of the difference in PGWC between the parents. The markers tightly linked to qPGWC-8 should facilitate cloning of the gene underlying this QTL and will be of value for marker-assisted selection in breeding rice varieties with better grain quality. | Tao Guo Xiaolu Liu Xiangyuan Wan Jianfeng Weng Shijia Liu Xi Liu Mingjiang Chen Jingjing Li Ning Su Fuqing Wu Zhijun Cheng Xiuping Guo Cailin Lei Jiulin Wang Ling jiang Jianmin Wan | 2011 | Journal of Integrative Plant Biology2011，53，8： | 25 |
| 3 | Effects of protein sources and levels in antibiotic-free diets on diarrhea,intestinal morphology, and expression of tight junctions in weaned piglets显示文摘This study examined effects of dietary protein sources and levels on intestinal health of 21 to 35 d-old weaned piglets fed antibiotics-free diets. A total of 150 weaned piglets(21 d of age) were allotted to 5 dietary treatment groups. Diets were formulated, based on corn-soybean meal, with different protein sources(fish meal and soy protein concentrate) to provide different dietary CP levels. Piglets within 5 dietary treatments were fed diets as follows, respectively: 1) control diet of 17% CP(control); 2) 19% CP diets formulated with more soy protein concentrate(SPC19); 3) fish meal(FM19); 4) 23.7% CP diets formulated with more soy protein concentrate(SPC23); 5) fish meal(FM23). The results showed that piglets from control group had higher ADG and lower incidence of diarrhea compared with those of other groups(P < 0.05). The incidence of diarrhea of piglets in FM19 group was lower than those from SPC23 group and FM23 group(P < 0.05). With the higher CP levels, villous height and villous height to crypt depth ratio of piglets in the duodenum and jejunum were decreased(P < 0.05), but crypt depth was increased(P < 0.05). Comparing control group and other groups, we found the expression of inflammatory cytokines interleukin-1β(IL-1β) and interferon-γ(IFN-γ) were increased(P < 0.05) in the jejunum and colon of piglets, as did cystic fibrosis transmembrane conductance regulators(CFTR) in the distal colon. The relative transcript abundance of Zonula occludens-1(ZO-1) in the jejunum, and occludin in the jejunum and ileum of piglets fed 23.7% CP diets were reduced compared with those fed control diet(P < 0.05). In conclusion, the 17% CP diet without in-feed antibiotics helped improve growth performance and relief of diarrhea of 21 to 35 d-old weaned piglets. Dietary CP level, rather than its source(either fish meal or soy protein concentrate), has more significant impacts on the growth performance and intestinal health of 21 to 35 d-old weaned piglets when fed antibiotics-free diets. | Yunpeng Wu Zongyong Jiang Chuntian Zheng Li Wang Cui Zhu Xuefen Yang Xiaolu Wen Xianyong Ma | 2015 | Animal Nutrition2015，，3： | 22 |
| 4 | Promotive Effects of Alginate-Derived Oligosaccharides on the Inducing Drought Resistance of Tomato显示文摘In order to determine the role of alginate-derived oligosaccharides (ADO) in drought stress resistance of tomato (Ly-copersicon esculentum Miller) seedlings, the leaves were exposed to different concentrations of ADO (0.05%, 0.10%, 0.20%, 0.30% and 0.50%) after drought stress was simulated by exposing the roots to 0.6 molL-1 PEG-6000 solution for 6 h. Changes in biomass, electrolyte leakage and malondialdehyde (MDA), free proline, total soluble sugars (TSS) and abscisic acid (ABA), the enzyme activities of catalase (CAT), superoxide dismutase (SOD), peroxidase (POD) and phenylalanine ammonia-lyase (PAL) were measured to investigate the effects of ADO treatment. The results showed that the treatment with an ADO concentration of 0.20% exhibited the highest performance of drought stress resistance in the tomato seedlings by decreasing the electrolyte leakage and the concentration of MDA, increasing the contents of free proline, TSS and ABA, and increasing the activities of CAT, SOD, POD and PAL after treatment with ADO. It is suggested that changes in electrolyte leakage, MDA, osmotic solutes, ABA, anti-oxidative enzyme and PAL activities were responsible for the increased drought stress resistance in tomato seedlings. To our best knowledge, this is the first report of the effect of ADO treatment on enhancing the drought stress resistance of tomato seedlings. | LIU Ruizhi JIANG Xiaolu GUAN Huashi LI Xiaoxia DU Yishuai WANG Peng MOU Haijin | 2009 | Journal of Ocean University of China2009，8，3： | 16 |
| 5 | Fecal scores and microbial metabolites in weaned piglets fed different protein sources and levels显示文摘This experiment studied the effects of dietary protein sources and levels on the gut health of piglets,p H value,and concentrations of microbial metabolites(ammonia-N,volatile fatty acids [VFA],and polyamines) in the distal colonic and proximal colonic digesta of piglets weaned at 21 d of age.A total of 150 early-weaned piglets were allotted randomly to 5 diets: 1) control diet(CT; 17% CP),2) CT formulated with more soy protein concentrate(SPC19; 19% CP),3) more fish meal(FM19; 19% CP),4) CT formulated with more soy protein concentrate(SPC23; 23% CP),and 5) more fish meal(FM23; 23%CP).Results showed high protein level increased fecal score(P < 0.05),but different protein sources did not(P > 0.05).The p H value and ammonia-N concentration of digesta in the proximal and distal colon of FM23 were significantly higher(P < 0.05) than those of CT.Acetic acid,propionic acid,butyric acid and valeric acid concentrations in the proximal colon of FM23 exceeded those of CT,SPC19,and FM19(P < 0.05);however,isobutyric acid and isovaleric acid were not affected(P > 0.05).Histamine and spermidine concentrations of FM23 were higher than those of other treatments(P < 0.05).Propionic acid and butyric acid concentrations in the distal colon were higher of FM23 than of FM19(P < 0.05); putrescine,histamine and spermidine were higher of FM23 than of LP and FM19(P < 0.05).It was concluded that high dietary CP content increased microbial metabolites(ammonia-N,histamine,putrescine) in colonic digesta and aggravated piglets' diarrhea. | Xiaolu Wen Li Wang Chuntian Zheng Xuefen Yang Xianyong Ma Yunpeng Wu Zhuang Chen Zongyong Jiang | 2018 | Animal Nutrition2018，，1： | 14 |
| 6 | Orderly Porous Covalent Organic Frameworks-based Materials:Superior Adsorbents for Pollutants Removal from Aqueous Solutions显示文摘Covalent organic frameworks(COFs)are a new type of crystalline porous polymers known for chemical stability,excellent structural regularity,robust framework,and inherent porosity,making them promising materials for capturing various types of pollutants from aqueous solutions.This review thoroughly presents the recent progress and advances of COFs and COF-based materials as superior adsorbents for the efficient removal of toxic heavy metal ions,radionuclides,and organic pollutants.Information about the interaction mechanisms between various pollutants and COF-based materials are summarized from the macroscopic and microscopic standpoints,including batch experiments,theoretical calculations,and advanced spectroscopy analysis.The adsorption properties of various COF-based materials are assessed and compared with other widely used adsorbents.Several commonly used strategies to enhance COF-based materials’adsorption performance and the relationship between structural property and sorption ability are also discussed.Finally,a summary and perspective on the opportunities and challenges of COFs and COF-based materials are proposed to provide some inspiring information on designing and fabricating COFs and COF-based materials for environmental pollution management. | Xiaolu Liu Hongwei Pang Xuewei Liu Qian Li Ning Zhang Liang Mao Muqing Qiu Baowei Hu Hui Yang Xiangke Wang | 2021 | The Innovation2021，2，1： | 12 |
| 7 | Lactate metabolism in human health and disease显示文摘The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism,as identified by studies on the Warburg effect.The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates signaling among different cells,organs and tissues.Lactylation is a posttranslational modification initially reported by Professor Yingming Zhao’s research group in 2019.Subsequent studies confirmed that lactylation is a vital component of lactate function and is involved in tumor proliferation,neural excitation,inflammation and other biological processes.An indispensable substance for various physiological cellular functions,lactate plays a regulatory role in different aspects of energy metabolism and signal transduction.Therefore,a comprehensive review and summary of lactate is presented to clarify the role of lactate in disease and to provide a reference and direction for future research.This review offers a systematic overview of lactate homeostasis and its roles in physiological and pathological processes,as well as a comprehensive overview of the effects of lactylation in various diseases,particularly inflammation and cancer. | Xiaolu Li Yanyan Yang Bei Zhang Xiaotong Lin Xiuxiu Fu Yi An Yulin Zou Jian-Xun Wang Zhibin Wang Tao Yu | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 9 |
| 8 | Diamond Discovered in High-Al Chromitites of the Sartohay Ophiolite,Xinjiang Province,China显示文摘In recent years diamonds and other exotic minerals have been recovered from mantle peridotites and high-Cr chromitites of a number of ophiolites of different age and different tectonic environments. Here we report a similar collection of minerals from the Sartohay ophiolite of Xinjiang Province,western China,which is characterized by having high-Al chromitites. Several samples of massive podiform chromitite with an aggregate weight of nearly 900 kg yielded diamonds,moissanite and other highly reduced minerals,as well as common crustal minerals. Thus far,more than 20 grains each of diamond and moissanite have been recovered from heavy mineral separates of the chromitites. The diamonds are all 100-200 μm in size and range in color from pale yellow to reddish-orange to colorless. Most of the grains are anhedral to subhedral octahedra,commonly with elongate forms exhibiting well-developed striations. They all display characteristic Raman spectra with shifts between 1325 cm-1 and 1333 cm-1,mostly 1331.51 cm-1 or 1326.96 cm-1. The moissanite grains are light blue to dark blue,broken crystals,50-150 μm across,commonly occurring as small flakes or fragments. Their typical Raman spectra have shifts at 762 cm-1,785 cm-1,and 966 cm-1. This investigation extends the occurrence of diamonds and moissanite to a Paleozoic ophiolite in the Central Asian Orogenic Belt and demonstrates that these minerals can also occur in high-Al chromitites. We conclude that diamonds and moissanite are likely to be ubiquitous in ophiolitic mantle peridotites and chromitites. | TIAN Yazhou YANG Jingsui Paul T.ROBINSON XIONG Fahui LI Yuan ZHANG Zhongming LIU Zhao LIU Fei NIU Xiaolu | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 9 |
| 9 | Early Eocene Radiolarian Fauna from the Sangdanlin, Southern Tibet: Constraints on the Timing of Initial India-Asia Collision显示文摘This is a new report on the early Eocene radiolarian fauna from the Sangdanlin section in the Gyirong region, along the southern margin of the Yarlung Zangbo Suture Zone. The Sangdanlin section measured in this study is divided into three lithostratigraphic units from bottom to top: the Zongzhuo, Sangdanlin, and Zheya formations. Abundant radiolarian fossils were obtained from the Sangdanlin section and 54 species of 30 genera were identified and assigned as follows: Cryptamphorella conara-C. macropora the late Cretaceous Zone and Amphisphaera coronate, Buryella tetradica-Bekoma campechensis, and B.bidartensis-B. divaricata the Paleocene-early Eocene Interval Zones. The Paleocene–early Eocene radiolarian zones are comparable to the radiolarian zones RP4-RP8 in New Zealand. Based on the data of radiolaria and lithofacies, it is suggested that the Zongzhuo Formation should be deposited along the base of the north-facing, continental slope of the Greater Indian continental margin, and the Sangdanlin Formation should be a deep marine, sedimentary sequence located in a foreland basin. The early Eocene radiolarian fauna in the Sangdanlin Formation constrains the initial age of the India-Asia collision to no later than 53.6 Ma. | WANG Tianyang LI Guobiao LI Xinfa NIU Xiaolu | 2017 | Acta Geologica Sinica(English Edition)2017，91，6： | 9 |
| 10 | Graphene-enabled electrically controlled terahertz meta-lens显示文摘Metasurfaces have become a new photonic structure for providing potential applications to develop integrated devices with small thickness, because they can introduce an abrupt phase change by arrays of scatterers. To be applied more widely, active metasurface devices are highly desired. Here, a tunable terahertz meta-lens whose focal length is able to be electrically tuned by ~4.45λ is demonstrated experimentally. The lens consists of a metallic metasurface and a monolayer graphene. Due to the dependence of the abrupt phase change of the metasurface on the graphene chemical potential, which can be modulated using an applied gate voltage, the focal length is changed from 10.46 to 12.24 mm when the gate voltage increases from 0 to 2.0 V. Experimental results are in good agreement with the theoretical hypothesis. This type of electrically controlled meta-lens could widen the application of terahertz technology. | WEIGUANG LIU BIN HU ZONGDUO HUANG HONGYU GUAN HETING LI XINKE WANG YAN ZHANG HONGXING YIN XIAOLU XIONG JUAN LIU YONGTIAN WANG | 2018 | Photonics Research2018，6，7： | 8 |
| 11 | Molten salt synthesis of porous carbon and its application in supercapacitors: A review显示文摘Carbon materials have taken an important role in supercapacitor applications due to their outstanding features of large surface area,low price,and stable physicochemical properties.Considerable research efforts have been devoted to the development of novel synthesis strategy for the preparation of porous carbon materials in recent years.In particular,molten salt strategy represents an emerging and promising method,whereby it has shown great potential in achieving tailored production of porous carbon.It has been proved that the molten salt-assisted production of carbon via the direct carbonization of carbonaceous precursors is an effective approach.Furthermore,with the incorporation of electrochemical technology,molten salt synthesis of porous carbon has become flexible and diversiform.Here,this review focuses on the mainstream molten salt synthesis strategies for the production of porous carbon materials,which includes direct molten salt carbonization process,capture and electrochemical conversion of CO_(2)to value-added carbon,electrochemical exfoliation of graphite to graphene-based materials,and electrochemical etching of carbides to new-type carbide-derived carbon materials.The reaction mechanisms and recent advances for these strategies are reviewed and discussed systematically.The morphological and structural properties and capacitive performances of the obtained carbon materials are summarized to reveal their appealing points for supercapacitor applications.Moreover,the opportunities and challenges of the molten salt synthesis strategy for the preparation of carbon materials are also discussed in this review to provide inspiration to the future researches. | Zhongya Pang Guangshi Li Xiaolu Xiong Li Ji Qian Xu Xingli Zou Xionggang Lu | 2021 | Journal of Energy Chemistry2021，30，10： | 7 |
| 12 | Ultrasmall Fe-doped carbon dots nanozymes for photoenhanced antibacterial therapy and wound healing显示文摘Pathogenic bacteria pose a devastating threat to public health.However,because of the growing bacterial antibiotic resistance,there is an urgent need to develop alternative antibacterial strategies to the established antibiotics.Herein,iron-doped carbon dots(Fe-CDs,~3 nm)nanozymes with excellent photothermal conversion and photoenhanced enzyme-like properties are developed through a facile one-pot pyrolysis approach for synergistic efficient antibacterial therapy and wound healing.In particular,Fe doping endows CDs with photoenhanced peroxidase(POD)-like activity,which lead to the generation of heat and reactive oxygen species(ROS)for Gram-positive and Gram-negative bacteria killing.This study demonstrates Fe-CDs have significant wound healing efficiency of Fe-CDs by preventing infection,promoting fibroblast proliferation,angiogenesis,and collagen deposition.Furthermore,the ultrasmall size of Fe-CDs possesses good biocompatibility favoring clinical translation.We believe that the nanozyme-mediated therapeutic platform presented here is expected to show promising applications in antibacterial. | Yunhang Liu Bolong Xu Mingzhu Lu Shanshan Li Juan Guo Fangzhou Chen Xiaolu Xiong Zhe Yin Huiyu Liu Dongsheng Zhou | 2022 | Bioactive Materials2022，7，6： | 7 |
| 13 | Development and Preliminary Evaluation of a Double-cell Ozonesonde显示文摘Ozonesondes are widely used to obtain ozone concentration profiles from the surface to the upper atmosphere. A kind of double-cell ozonesonde has been developed at the Institute of Atmospheric Physics(IAP), Chinese Academy of Sciences(named the 'IAP ozonesonde') based on previous experience over the past 20 years of developing the singlecell GPSO3 ozonesonde. The IAP ozonesonde is of the Electrochemical Concentration Cell(ECC) type. A detailed description of the IAP ozonesonde is firstly provided in the present paper, followed by a presentation of results from a series of launches carried out to evaluate its performance. The analysis involved comparing its observations with measurements from the GPSO3 and ECC ozonesondes(Model type ENSCI-Z) as well as a Brewer spectrophotometer. The results showed that the IAP ozonesonde is a vast improvement over the GPSO3 ozonesonde, able to capture vertical ozone structures very well and in good agreement with ECC ozonesonde measurements. The average difference in the ozone partial pressure between the IAP and ECC ozonesondes was 0.3 mPa from the surface to 2.5 km, close to zero from 2.5 to 9 km and generally less than 1 mPa for layers higher than 9 km. The apparent deviation is likely caused by a decreasing pump flow rate in the IAP ozonesonde which needs further improvement. The total ozone amounts measured by the IAP ozonesonde profiles were highly comparable with the Brewer data with a relative difference of 6%. The development of the IAP ozonesonde and its strong performance will surely accelerate the process of conventional observations of ozone profiles over China in the near future as well as provide more data for ozone research in general. | ZHANG Jinqiang XUAN Yuejian YAN Xiaolu LIU Mingyuan TIAN Hongmin XIA Xiang'ao PANG Li ZHENG Xiangdong | 2014 | Advances in Atmospheric Sciences2014，31，4： | 7 |
| 14 | Gut microbiome alterations and its link to corticosteroid resistance in immune thrombocytopenia显示文摘Quantitative metagenomic studies have linked the gut microbiota to autoimmune disorders.Here,we performed deep shotgun metagenomic sequencing of fecal samples from 99 immune thrombocytopenia(ITP)patients and 52 healthy controls.Dysbiosis in the gut microbiome of ITP was detected phylogenetically and functionally,and classifier based on species markers distinguished individuals with ITP from healthy controls.In particular,the abundance of Ruminococcus gnavus,Bifidobacterium longum and Akkermansia muciniphila was markedly increased in treatment-na?ve ITP patients,and the alterations of microbial species were correlated with clinical indices.Functionally,the secondary bile acid biosynthesis and flagellar assembly were depleted in the gut microbiota of ITP,which may contribute to the onset of ITP by affecting the immune system.Furthermore,we found that corticosteroid treatment affected the gut microbiome of ITP.Compared with corticosteroid-sensitive ITP patients,we identified that the corticosteroid-resistant ITP patients displayed a distinct gut microbiome,which was different from that of the treatment-na?ve ITP patients.Together,we provided support for the critical role of gut microbiota in the development of ITP and established a foundation for further research characterizing gut microbiota in relation to corticosteroid resistance of ITP. | Yanan Wang Fengqi Liu Gaochao Zhang Yan Su Xueyan Sun Qi Chen Chencong Wang Haixia Fu Yun He Xiaolu Zhu Xiao Liu Meng Lv Xiangyu Zhao Xiaosu Zhao Yueying Li Qianfei Wang Xiaojun Huang Xiaohui Zhang | 2021 | Science China(Life Sciences)2021，64，5： | 6 |
| 15 | Quantitative analysis of distributed and centralized development of renewable energy显示文摘Global renewable energy has maintained a steady growth in recent years, mainly fostered by national policies and increasing demand. Analyzing the experience of renewable energy development in developed countries can be important to provide reference and guidance for its adoption in other countries. First, we compare and summarize definitions of distributed generation from 18 leading countries and organizations in renewable energy. On this basis, we provide three basic characteristics for successful distributed generation using renewable resources. Then, we empirically analyze the distributed and centralized development of renewable energy in Germany with focus on wind and photovoltaic power. We determined that 95% of the photovoltaic generation and 85% of the wind power generation is distributed in Germany, suggesting that the most suitable generation mode for renewable energy is the distributed approach. | Xiaolu Wang Nana Li Wei Sun Shan Xu Zedong Zhang | 2018 | Global Energy Interconnection2018，1，5： | 6 |
| 16 | Three-Dimensional Modelling of a Multi-Layer Sandstone Reservoir: the Sebei Gas Field, China显示文摘Multi-layer sandstone reservoirs occur globally and are currently in international production.The 3D characteristics of these reservoirs are too complicated to be accurately delineated by general structural-facies-reservoir modelling.In view of the special geological features,such as the vertical architecture of sandstone and mudstone interbeds,the lateral stable sedimentation and the strong heterogeneity of reservoir poroperm and fluid distribution,we developed a new three-stage and six-phase procedure for 3D characterization of multi-layer sandstone reservoirs.The procedure comprises two-phase structural modelling,two-phase facies modelling and modeUing of two types of reservoir properties.Using this procedure,we established models of the formation structure,sand body structure and microfacies,reservoir facies and properties including porosity,permeability and gas saturation and provided a 3D fine-scale,systematic characterization of the Sebei multi-layer sandstone gas field,China.This new procedure,validated by the Sebei gas field,can be applied to characterize similar multi-layer sandstone reservoirs. | OU Chenghua WANG Xiaolu LI Chaochun HE Yan | 2016 | Acta Geologica Sinica(English Edition)2016，90，1： | 5 |
| 17 | Peripheral Lymphocyte Subsets as a Marker of Parkinson's Disease in a Chinese Population显示文摘In this study, we conducted a clinical analysis of lymphocyte subtypes in 268 patients with Parkinson's disease(PD) to assess their clinical impact as a potential marker of advanced PD in Chinese patients. The participants comprised 268 sporadic PD patients and 268 healthy controls. The numbers of natural killer(NK) cells and CD3+, CD3+CD4+, CD3+CD8+, and CD19+ lymphocytes from peripheral blood were determined by immunostaining and flow cytometric analysis and the percentages of these CD+ T cells were calculated. The ratio of regulatory T(Treg)/helper T 17(Th17) lymphocytes from 64 PD patients and 46 controls was determined by flow cytometric analysis.The results showed that the percentage of NK cells was higher in advanced PD patients than in controls(22.92% ±10.08% versus 19.76% ± 10.09%, P = 0.006), while CD3+ T cells are decreased(62.93% ± 9.27% versus65.75% ± 9.13%, P = 0.005). The percentage of CD19+B cells in male patients was lower(P = 0.021) than in female patients, whereas NK cells were increased(P \ 0.0001). The scores on the Unified Parkinson's Disease Rating Scale(UPDRS) and the Non-Motor Symptoms Scale in late-onset PD patients were significantly higher than those in earlyonset patients(P = 0.024 and P = 0.007, respectively). The percentage of CD19+ B cells in patients with UPDRS scores[24 was lower than in those with scores \24(10.17% ±4.19% versus 12.22% ± 5.39%, P = 0.009). In addition, the Treg/Th17 ratio in female patients was higher than that in female controls(13.88 ± 6.32 versus 9.94 ± 4.06, P =0.042). These results suggest that the percentages of NK cells,CD3+ T cells, and CD19+ B cells along with the Treg/Th17 ratio in peripheral blood may be used to predict the risk of PD in Chinese individuals and provide fresh avenues for novel diagnostic biomarkers and therapeutic designs. | Luan Cen Chaohao Yang Shuxuan Huang Miaomiao Zhou Xiaolu Tang Kaiping Li Wenyuan Guo Zhuohua Wu Mingshu Mo Yousheng Xiao Xiang Chen Xinling Yang Qinhui Huang Chaojun Chen Shaogang Qu Pingyi Xu | 2017 | Neuroscience Bulletin2017，33，5： | 5 |
| 18 | Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin显示文摘Isolation rearing(IR) enhances aggressive behavior, and the central serotonin(5-hydroxytryptamine,5-HT) system has been linked to IR-induced aggression.However, whether the alteration of central serotonin is the cause or consequence of enhanced aggression is still unknown. In the present study, using mice deficient in central serotonin Tph2-/-and Lmx1 b-/-, we examined the association between central serotonin and aggression with or without social isolation. We demonstrated that central serotonergic neurons are critical for the enhanced aggression after IR. 5-HT depletion in wild-type mice increased aggression. On the other hand, application of 5-HT in Lmx1 b-/-mice inhibited the enhancement of aggression under social isolation conditions. Dopamine was downregulated in Lmx1 b-/-mice. Similar to 5-HT, L-DOPA decreased aggression in Lmx1 b-/-mice. Our results linkthe serotoninergic system directly to aggression and this may have clinical implications for aggression-related human conditions. | Yiqiong Liu Yunong Sun Xiaoyan Zhao Ji-Young Kim Lu Luo Qian Wang Xiaolu Meng Yonghui Li Nan Sui Zhou-Feng Chen Chuxiong Pan Liang Li Yan Zhang | 2019 | Neuroscience Bulletin2019，35，5： | 5 |
| 19 | MYH7B variants cause hypertrophic cardiomyopathy by activating the Ca MK-signaling pathway显示文摘Hypertrophic cardiomyopathy(HCM) is a common genetic disease, predominantly caused by mutations in cardiac sarcomere genes;however, whether MYH7 B causes HCM is not known. In this study, 549 unrelated patients with HCM and 500 healthycontrols were screened using targeted sequencing and whole exome sequencing together. We observed seven variants in MYH7 B causing HCM in 8/549 patients, which accounted for 1.46% of HCM cases. Of these seven variants, three likely pathogenic variants in MYH7 B co-segregating with 5 HCM patients were identified in three HCM pedigrees without other HCM-associated variants. Myh7 b knockout rats were generated and cardiac functions were detected by Millar pressure-volume catheterization and echocardiography. Spontaneous HCM phenotypes, cellular disarray and cardiac fibrosis were observed in both Myh7 b^+/–/Myh7 b^–/–rats. Transcriptome sequencing showed that calcium is the key mediator of cardiac hypertrophy in Myh7 b knockout. Subsequent analysis confirmed over-activation of Ca MK-signaling pathway in cardiomyocytes of Myh7 b^–/–rats.Furthermore, MYH7 B expression in human and rat hearts was identified and micro RNA-208 a and micro RNA-499 levels are unchanged in HCM patients and Myh7 b^+/–/Myh7 b^–/–rats. This study is the first to identify MYH7 B variants as cause of HCM,which account for 1.46% of pathogenesisin HCM patients. Activation of Ca MK-signaling pathway may be involved in its pathophysiology. | Peng Chen Zongzhe Li Jiali Nie Hong Wang Bo Yu Zheng Wen Yang Sun Xiaolu Shi Li Jin Dao-Wen Wang | 2020 | Science China(Life Sciences)2020，63，9： | 5 |
| 20 | Application of next-generation sequencing to screen for pathogenic mutations in 123 unrelated Chinese patients with Marfan syndrome or a related disease显示文摘Marfan syndrome(MFS) is a systemic connective tissue disease principally affecting the ocular, skeletal and cardiovascular systems. This autosomal dominant disorder carries a prevalence of 1:3,000 to 1:5,000. This study aims to define the mutational spectrum of MFS related genes in Chinese patients and to establish genotype-phenotype correlations in MFS. Panel-based targeted next-generation sequencing was used to analyze the FBN1, TGFBR1 and TGFBR2 genes in 123 unrelated Chinese individuals with MFS or a related disease. Genotype-phenotype correlation analyses were performed in mutation-positive patients. The results showed that 97 cases/families(78.9%;97/123) harbor at least one(likely) pathogenic mutation, most of which were in FBN1;four patients had TGFBR1/2 mutations;and one patient harbored a SMAD3 mutation. Three patients had two FBN1 mutations, and all patients showed classical MFS phenotypes. Patients with a dominant negative-FBN1 mutation had a higher prevalence of ectopia lentis(EL). Patients carrying a haploinsufficiency-FBN1 mutation tended to have aortic dissection without EL. This study extends the spectrum of genetic backgrounds of MFS and enriches our knowledge of genotype-phenotype correlations. | Jiacheng Li Chaoxia Lu Wei Wu Yaping Liu Rongrong Wang Nuo Si Xiaolu Meng Shuyang Zhang Xue Zhang | 2019 | Science China(Life Sciences)2019，62，12： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员