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| 1 | The ultraviolet photoconductive detector based on Al-doped ZnO thin film with fast response显示文摘We report fabrication and characterization of metal-semiconductor-metal photoconductive detectors based on Al-doped ZnO thin films fabricated by radio frequency magnetron sputtering.Optical and structural properties of the thin films were characterized using various techniques.At 6 V bias,a responsivity higher than 4 A/W in the wavelength shorter than 350 nm was obtained,and this responsibility dropped quickly and reached the noise floor in the visible region.Transient response measurement revealed that the detector had a fast photoresponse with a rise time of 9 ns and a fall time of 1.2 μs. | SUN Jian DAI Qian LIU FengJuan HUANG HaiQin LI ZhenJun ZHANG XiQing WANG YongSheng | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，1： | 4 |
| 2 | A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis显示文摘Hypoxia-inducible factor 1(HIF-1) attenuates amyloid-beta protein neurotoxicity and decreases apoptosis induced by oxidative stress or hypoxia in cortical neurons. In this study, we constructed a recombinant adeno-associated virus(rAAV) vector expressing the human HIF-1α gene(rAAV-HIF-1α), and tested the assumption that rAAV-HIF-1α represses hippocampal neuronal apoptosis induced by amyloid-beta protein. Our results confirmed that rAAV-HIF-1α significantly reduces apoptosis induced by amyloid-beta protein in primary cultured hippocampal neurons. Direct intracerebral rAAV-HIF-1α administration also induced robust and prolonged HIF-1α production in rat hippocampus. Single rAAV-HIF-1α administration resulted in decreased apoptosis of hippocampal neurons in an Alzheimer's disease rat model established by intracerebroventricular injection of aggregated amyloid-beta protein(25–35). Our in vitro and in vivo findings demonstrate that HIF-1 has potential for attenuating hippocampal neuronal apoptosis induced by amyloid-beta protein, and provides experimental support for treatment of neurodegenerative diseases using gene therapy. | Xiqing Chai Weina Kong Lingyun Liu Wenguo Yu Zhenqing Zhang Yimin Sun | 2014 | Neural Regeneration Research2014，9，11： | 4 |
| 3 | Interference management in 6G space and terrestrial integrated networks: Challenges and approaches显示文摘The Space-Terrestrial Integrated Network(STIN)is considered to be a promising paradigm for realizing worldwide wireless connectivity in sixth-Generation(6G)wireless communication systems.Unfortunately,excessive interference in the STIN degrades the wireless links and leads to poor performance,which is a bottleneck that prevents its commercial deployment.In this article,the crucial features and challenges of STIN-based interference are comprehensively investigated,and some candidate solutions for Interference Management(IM)are summarized.As traditional IM techniques are designed for single-application scenarios or specific types of interference,they cannot meet the requirements of the STIN architecture.To address this issue,we propose a self-adaptation IM method that reaps the potential benefits of STIN and is applicable to both rural and urban areas.A number of open issues and potential challenges for IM are discussed,which provide insights regarding future research directions related to STIN. | Shi Yan Xueyan Cao Zile Liu Xiqing Liu | 2020 | Intelligent and Converged Networks2020，1，3： | 3 |
| 4 | Channel Estimation for Reconfigurable Intelligent Surface Assisted Wireless Communication Systems in Mobility Scenarios显示文摘Reconfigurable intelligent surface(RIS)can manipulate the wireless propagation environment by smartly adjusting the amplitude/phase in a programmable panel,enjoying the improved performance.The accurate acquisition of the instantaneous channel state information(CSI)in the cascaded RIS chain makes an indispensable contribution to the performance gains.However,it is quite challenging to estimate the CSI in a time-variant scenario due to the limited signal processing capability of the passive elements embedded in a RIS pannel.In this work,a channel estimation scheme for the RIS-assisted wireless communication system is proposed,which is demonstrated to perform well in a time-variant scenario.The cascaded RIS channel is modeled as a state-space model based upon the mobility situations.In addition,to fully exploit the time correlation of channel,Kalman filter is employed by taking the prior information of channels into account.Further,the optimal reflection coefficients are derived according to the minimum mean square error(MMSE)criterion.Numerical results show that the proposed methods exhibit superior performance if compared with a conventional channel estimation scheme. | Zhendong Mao Mugen Peng Xiqing Liu | 2021 | China Communications2021，18，3： | 3 |
| 5 | Structural basis and binding properties of the second bromodomain of Brd4 with acetylated histone tails显示文摘 | Liu Ying Wang Xiqing Zhang Jiahai | 2008 | Biochemistry2008，47，24： | 1 |
| 6 | Sulfonated ordered mesoporous carbon for catalytic preparation of biodiesel 显示文摘 | Liu Rui Wang Xiqing Zhao Xiang | 2008 | Carbon2008，，46： | 1 |
| 7 | Sulfonated ordered mesoporous carbon for catalytic preparation of biodiesel显示文摘 | Rui Liu Xiqing Wang Xiang Zhao Pingyun Feng | 2008 | Carbon2008，，13： | 1 |
| 8 | Nitrogen-doped mesoporous carbon for energy storage in vanadium redox flow batteries显示文摘 | Yuyan Shao Xiqing Wang Mark Engelhard Chongmin Wang Sheng Dai Jun Liu Zhenguo Yang Yuehe Lin | 2010 | Journal of Power Sources2010，，13： | 1 |
| 9 | Study on prediction of noise produced by stern wake-duct-propeller interaction显示文摘The mechanism and prediction methods of low-frequency discrete spectrum noise of ducted propellers are studied.The acoustic pressure field of ducted propellers is divided into the propeller radiated field and the duct scattered field based on the linear acoustic theory. First of all,the flow field is analyzed with unsteady panel method to get the unsteady force, and then the pressure data are used as the sources for Ffowcs Williams-Hawings formulation to predict the propeller radiated field,meanwhile,the duct scattered field is obtained by Kirchoff integral equation.Through the analysis and calculation of a ducted propeller case,it is found that the duct scattered sound field is a small quantity compared with propeller radiated sound field under low-frequency and short duct condition;Also the predicted discrete spectrum noise level of ducted propellers is compared with that of full-scale propellers by experiment,verifying the predicted results are able to reflect the full-scale propellers' discrete spectrum noise level properly. | XIONG Ziying ZHU Xiqing LIU Xiaolong LI Ya | 2010 | Chinese Journal of Acoustics2010，29，2： | 1 |
| 10 | A novel ultrafine leady oxide prepared from spent lead pastes for application as cathode of lead acid battery显示文摘 | Danni Yang Jianwen Liu Qin Wang Xiqing Yuan Xinfeng Zhu Lei Li Wei Zhang Yucheng Hu Xiaojuan Sun R. Vasant Kumar Jiakuan Yang | 2014 | Journal of Power Sources2014，，： | 1 |
| 11 | Ultrasensitive quantification of trace amines based on N-phosphorylation labeling chip 2D LC-QQQ/MS显示文摘Trace amines(TAs)are metabolically related to catecholamine and associated with cancer and neurological disorders.Comprehensive measurement of TAs is essential for understanding pathological processes and providing proper drug intervention.However,the trace amounts and chemical instability of TAs challenge quantification.Here,diisopropyl phosphite coupled with chip two-dimensional(2D)liquid chromatography tandem triple-quadrupole mass spectrometry(LC-QQQ/MS)was developed to simultaneously determine TAs and associated metabolites.The results showed that the sensitivities of TAs increased up to 5520 times compared with those using nonderivatized LC-QQQ/MS.This sensitive method was utilized to investigate their alterations in hepatoma cells after treatment with sorafenib.The significantly altered TAs and associated metabolites suggested that phenylalanine and tyrosine metabolic pathways were related to sorafenib treatment in Hep3B cells.This sensitive method has great potential to elucidate the mechanism and diagnose diseases considering that an increasing number of physiological functions of TAs have been discovered in recent decades. | Xiqing Bian Yida Zhang Na Li Menglin Shi Xiaolin Chen Hui-Lu Zhang Jie Liu Jian-Lin Wu | 2023 | Journal of Pharmaceutical Analysis2023，13，3： | 0 |
| 12 | HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation显示文摘Bone marrow mesenchymal stem cell(BMSC)osteogenic differentiation and osteoblast function play critical roles in bone formation,which is a highly regulated process.Long noncoding RNAs(lncRNAs)perform diverse functions in a variety of biological processes,including BMSC osteogenic differentiation.Although several studies have reported that HOX transcript antisense RNA(HOTAIR)is involved in BMSC osteogenic differentiation,its effect on bone formation in vivo remains unclear.Here,by constructing transgenic mice with BMSC(Prx1-HOTAIR)-and osteoblast(Bglap-HOTAIR)-specific overexpression of HOTAIR,we found that Prx1-HOTAIR and Bglap-HOTAIR transgenic mice show different bone phenotypes in vivo.Specifically,Prx1-HOTAIR mice showed delayed bone formation,while Bglap-HOTAIR mice showed increased bone formation.HOTAIR inhibits BMSC osteogenic differentiation but promotes osteoblast function in vitro.Furthermore,we identified that HOTAIR is mainly located in the nucleus of BMSCs and in the cytoplasm of osteoblasts.HOTAIR displays a nucleocytoplasmic translocation pattern during BMSC osteogenic differentiation.We first identified that the RNA-binding protein human antigen R(HuR)is responsible for HOTAIR nucleocytoplasmic translocation.HOTAIR is essential for osteoblast function,and cytoplasmic HOTAIR binds to miR-214 and acts as a ceRNA to increase Atf4 protein levels and osteoblast function.BglapHOTAIR mice,but not Prx1-HOTAIR mice,showed alleviation of bone loss induced by unloading.This study reveals the importance of temporal and spatial regulation of HOTAIR in BMSC osteogenic differentiation and bone formation,which provides new insights into precise regulation as a target for bone loss. | Yuheng Li Weijia Sun Jianwei Li Ruikai Du Wenjuan Xing Xinxin Yuan Guohui Zhong Dingsheng Zhao Zizhong Liu Xiaoyan Jin Junjie Pan Youyou Li Qi Li Guanghan Kan Xuan Han Shukuan Ling Xiqing Sun Yingxian Li | 2023 | Bone Research2023，11，4： | 0 |
| 13 | Joint uplink and downlink resource allocation for low-latency mobile virtual reality delivery in fog radio access networks显示文摘Fog radio access networks(F-RANs),in which the fog access points are equipped with communication,caching,and computing functionalities,have been anticipated as a promising architecture for enabling virtual reality(VR)applications in wireless networks.Although extensive research efforts have been devoted to designing efficient resource allocation strategies for realizing successful mobile VR delivery in downlink,the equally important resource allocation problem of mobile VR delivery in uplink has so far drawn little attention.In this work,we investigate a mobile VR F-RAN delivery framework,where both the uplink and downlink transmissions are considered.We first characterize the round-trip latency of the system,which reveals its dependence on the communication,caching,and computation resource allocations.Based on this information,we propose a simple yet efficient algorithm to minimize the round-trip latency,while satisfying the practical constraints on caching,computation capability,and transmission capacity in the uplink and downlink.Numerical results show that our proposed algorithm can effectively reduce the round-trip latency compared with various baselines,and the impacts of communication,caching,and computing resources on latency performance are illustrated. | Tian DANG Chenxi LIU Xiqing LIU Shi YAN | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，1： | 0 |
| 14 | Software defined intelligent satellite-terrestrial integrated networks:Insights and challenges显示文摘Satellite-Terrestrial integrated Networks(STNs)have been advocated by both academia and industry as a promising network paradigm to achieve service continuity and ubiquity.However,STNs suffer from problems including poor flexibility of network architecture,low adaptability to dynamic environments,the lack of network intelligence,and low resource utilization.To handle these challenges,a Software defined Intelligent STN(SISTN)architecture is introduced.Specifically,the hierarchical architecture of the proposal is described and a distributed deployment scheme for SISTNs controllers is proposed to realize agile and effective network management and control.Moreover,three use cases in SISTNs are discussed.Meanwhile,key techniques and their corresponding solutions are presented,followed by the identification of several open issues in SISTNs including compatibility with existing networks,the tradeoff between network flexibility and performance,and so on. | Shuo Yuan Mugen Peng Yaohua Sun Xiqing Liu | 2023 | Digital Communications and Networks2023，9，6： | 0 |
| 15 | How to Comprehensively Utilize the Discarded Fresh Tobacco Leaf ?显示文摘This paper aims to explore comprehensive utilization way of discarded fresh tobacco leaf. Based on modern tobacco demands on green,environmental protection and sustainable development,as well as actual situation of biogas production facility in some villages of local tobacco area,this paper selects Longwan Village of Fengshiyan Town as the experimental site and explores the rational way of discarded fresh tobacco leaf biogas fermentation. Results show that cutting and fermentation of discarded fresh tobacco leaf before adding into biogas digester is conductive to improving p H in fermentation process,reducing crust amount,and effectively improving biogas production amount and rate. The study can provide reference for effective processing and rational utilization of discarded fresh tobacco leaf. | Xiqing LIU Weiping FENG Zhifu XU Dongyang HU Zairan DENG Wenyu LI | 2015 | Asian Agricultural Research2015，7，12： | 0 |
| 16 | Biological Characterization and Whole Genome Sequencing of a Genotype VII Newcastle Disease Virus Strain显示文摘[Objective] The aim of this paper was to study the genotype, pathogenicity and nucleotide difference between Newcastle disease virus(NDV) isolates and traditional NDV vaccine strain(La Sota). [Method] A suspected NDV strain was isolated from a chicken farm. The isolate was preliminarily determined by HA and HI tests. A pair of primers was designed based on the partial sequence of NDV F gene published in GenBank(accession No. JF950510.1). F gene was amplified by RT-PCR, cloned and sequenced. The sequencing result was compared with the F gene sequences published in GenBank, and the phylogenetic tree was constructed to analyze the genotypes. The pathogenicity of the virus was determined by mean death time(MDT) of chicken embryos, intracerebral pathogenicity index(ICPI) of one-day-old chicks and intravenous pathogenicity index(IVPI) of six-week-old chickens, respectively. Based on the NDV genome sequence published in GenBank(accession No. JF950510.1), nine pairs of primers were designed to amplify the genome sequence of the isolate, and its structure was analyzed. [Result] The length of F gene was about 500 bp, and a NDV strain of genotype VII was isolated. The MDT, ICPI and IVPI were 52.8 h, 1.675 and 2.46, respectively, indicating the isolate was a virulent strain. The whole genome sequence analysis results showed that the full genome length of the isolate was 15 192 bp, which had 6 more nu-cleotides than that of La Sota strain, and the homology between the two strains was 82.8%. [Conclusion] A virulent NDV strain of genotype Ⅶ was isolated, with low homology to La Sota strain in nucleotide sequence. | Sun Hualu Li Xiqing Bi Yunying Yu Zekun Li Sifei Liu Yang Li Mingyi Cui Xianlan | 2018 | Animal Husbandry and Feed Science2018，10，5： | 0 |
| 17 | Clinical Effects of the COVID-19 Pandemic Among the Uninfected Pregnant Women—6 PLADs,China,2019−2020显示文摘Summary What is already known about this topic?The coronavirus disease 2019(COVID-19)pandemic potentially affected prenatal care quality and maternal and fetal outcomes globally.What is added by this report?During COVID-19 pandemic period,the rates of caesarean sections(CS)and preterm birth for uninfected pregnant women increased slightly in areas that were relatively severely impacted by the pandemic in China. | Bin Wang Hang An Huanqing Hu Wei Zhao Bahabaike Jiangtulu Shuo Wang Jiamei Wang Junxi Chen Manman Long Zewu Li Yu Jin Yuhuan Li Huiting Chen Tao Xue Xiqing Li Kexin Li Wei Du Suhong Gao Jiangli Di Xiaohong Liu Rongwei Ye Zhiwen Li | 2021 | China CDC weekly2021，3，10： | 0 |
| 18 | Characterization of the core microflora and nutrient composition in packaged pasteurized milk products during storage显示文摘Pasteurized milk contains complex microbial communities affected by sterilization and storage conditions.This complex microflora may be the possible reason that pasteurized dairy products are highly prone to spoilage.In this study,packaged pasteurized milk products collected from dairy processing factories in China were stored at 0,4,10,15,and 25℃ for 0−15 days and subjected to microbial identification using high-throughput sequencing.Accordingly,6 phyla and 44 genera were identified as the dominant microbiota.Moreover,the changes in nutritional composition of the pasteurized milk,including in 16 free amino acids,7 taste values,and 8 chemical constituents,were analyzed using principal component and multi-factor analyses.The Pearson correlation analysis identified Pseudomonas,Aeromonas,Paenibacillus,and Serratia genera as the core functional microbiota that significantly affects the nutritional composition of pasteurized milk.Hence,the results provide a comprehensive understanding of the safety and shelf-life of stored pasteurized milk. | Ruixue Ding Shanshan Yang Lijuan Geng Yumeng Liu Baoping He Liyun Liu Xiqing Yue Rina Wu Junrui Wu | 2023 | Food Science and Human Wellness2023，12，4： | 0 |
| 19 | Gas diffusion in catalyst layer of flow cell for CO_(2) electroreduction toward C_(2+) products显示文摘The use of gas diffusion electrode(GDE)based flow cell can realize industrial-scale CO_(2) reduction reactions(CO_(2)RRs).Controlling local CO_(2) and CO intermediate diffusion plays a key role in CO_(2)RR toward multi-carbon(C_(2+))products.In this work,local CO_(2) and CO intermediate diffusion through the catalyst layer(CL)was investigated for improving CO_(2)RR toward C_(2+)products.The gas permeability tests and finite element simulation results indicated CL can balance the CO_(2) gas diffusion and residence time of the CO intermediate,leading to a sufficient CO concentration with a suitable CO_(2)/H_(2)O supply for high C_(2+)products.As a result,an excellent selectivity of C_(2+)products~79%at a high current density of 400 mA·cm^(-2) could be obtained on the optimal 500 nm Cu CL(Cu500).This work provides a new insight into the optimization of CO_(2)/H_(2)O supply and local CO concentration by controlling CL for C_(2+)products in CO_(2)RR flow cell. | Xiqing Wang Qin Chen Yajiao Zhou Yao Tan Ye Wang Hongmei Li Yu Chen Mahmoud Sayed Ramadan A.Geioushy Nageh K.Allam Junwei Fu Yifei Sun Min Liu | 2024 | Nano Research2024，17，3： | 0 |
| 20 | A prospective cohort study of the presence of SARS-CoV-2 in clinical samples from multiple bodily sites:implications for transmission routes of COVID-19显示文摘Objective: The coronavirus disease 2019 (COVID-19) epidemic resulting from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has still spread globally. The occurrence of the Delta variant, which is more infectious and spreads faster than earlier forms of the virus that causes COVID-19, makes infection prevention more challenging. Therefore, this study aimed to gain a comprehensive insight into the transmission routes of SARS-CoV-2 for curbing the propagation of SARS-CoV-2 in human populations.Methods: We studied a prospective cohort of 576 patients admitted consecutively to the First Affiliated Hospital of Guangzhou Medical University from January 21 to June 8, 2020. These patients were chosen based on their similar clinical phenotypes or imaging findings. There were 21 (3.6%) laboratory-confirmed COVID-19 patients (16 severe and 5 mild cases) and 555 non-COVID-19 patients. The antibody response and routes and duration of viral shedding were systematically evaluated in serial clinical specimens. Moreover, SARS-CoV-2 RNA was also detected in a mouth rinse, urine, and tear samples. This study was approved by the Medical Ethical Committee of The First Affiliated Hospital of Guangzhou Medical University (approval No. 2020-77).Results: SARS-CoV-2 mainly existed in sputum, nasal and throat swabs, and feces samples. Virus latency was longer in sputum and feces samples than in nasopharyngeal samples. IgG antibody response in respiratory samples was related to disease severity. Although droplets and aerosols are the major transmission routes for COVID-19, covert routes of transmission from asymptomatic patients, contaminated surfaces, and wastewater are also of interest.Conclusion: Our findings provide a solid foundation for developing prophylactic measures against SARS-CoV-2. | Meixian Liu Huimin Huang Xiqing Bian Zhiyuan Zheng Na Li Baoqing Sun Jian-Lin Wu | 2022 | Journal of Bio-X Research2022，5，1： | 0 |
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