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| 1 | An Analytical Method for Calculating the Shielding Effectiveness of an Enclosure with an Oblique Rectangular Aperture显示文摘An efficient analytical method is proposed to calculate the Shielding effectiveness(SE)of an enclosure with an oblique rectangular aperture.This enclosure was first decomposed into two ones with horizontal rectangular apertures through mirror image and Green function theories.The SE of each decomposed enclosure was calculated by the Robinson’s method.The relationship between the SE of the original cavity and those of the decomposed ones was also derived analytically.The SE of the original cavity could be directly obtained from this analytical relationship.The accuracy of the proposed method was validated with measurements and the Transmission line matrix(TLM)solver.The results show that the efficiency was largely improved compared with the TLM solver. | SU Donglin LIU Hongyi YANG Shunchuan ZHAO Zihua SUI Donghai | 2019 | Chinese Journal of Electronics2019，28，4： | 5 |
| 2 | An adaptive scaled boundary finite element method by subdividing subdomains for elastodynamic problems显示文摘The scaled boundary finite element method(SBFEM) is a semi-analytical numerical method,which models an analysis domain by a small number of large-sized subdomains and discretises subdomain boundaries only.In a subdomain,all fields of state variables including displacement,stress,velocity and acceleration are semi-analytical,and the kinetic energy,strain energy and energy error are all integrated semi-analytically.These advantages are taken in this study to develop a posteriori h-hierarchical adaptive SBFEM for transient elastodynamic problems using a mesh refinement procedure which subdivides subdomains.Because only a small number of subdomains are subdivided,mesh refinement is very simple and efficient,and mesh mapping to transfer state variables from an old mesh to a new one is also very simple but accurate.Two 2D examples with stress wave propagation were modelled.The results show that the developed method is capable of capturing propagation of steep stress regions and calculating accurate dynamic responses,using only a fraction of degrees of freedom required by adaptive finite element method. | ZHANG ZiHua 1,2,YANG ZhenJun 2,LIU GuoHua 1 & HU YunJin 1 1 College of Civil Engineering and Architecture,Zhejiang University,Hangzhou 310058,China 2 School of Engineering,University of Liverpool,L69 3GQ,UK | 2011 | Science China(Technological Sciences)2011，54，S1： | 4 |
| 3 | Experimental study of structural damage identification based on modal parameters and decay ratio of acceleration signals显示文摘A novel damage assessment method based on the decay ratio of acceleration signals(DRAS)was proposed.Two experimental tests were used to show the efficiency.Three beams were gradually damaged,and then the changes of dynamic parameters were monitored from initial to failure state.In addition,a new method was compared with the linear modal-based damage assessment using wavelet transform(WT).The results clearly show that DRAS increases in linear elasticity state and microcrack propagation state,while DRAS decreases in macrocrack propagation state.Preliminary analysis was developed considering the beat phenomenon in the nonlinear state to explain the turn point of DRAS.With better sensibility of damage than modal parameters,probably DRAS is a promising damage indicator in damage assessment. | Zhigen WU Guohua LIU Zihua ZHANG | 2011 | Frontiers of Structural and Civil Engineering2011，5，1： | 3 |
| 4 | Downregulation of thioredoxin reductase 1 expression in the substantia nigra pars compacta of Parkinson's disease mice显示文摘Because neurons are susceptible to oxidative damage and thioredoxin reductase 1 is extensively distributed in the central nervous system and has antioxidant properties,we speculated that the enzyme may be involved in the pathogenesis of Parkinson’s disease.A Parkinson’s disease model was produced by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into C57BL/6 mice.Real-time reverse transcription-PCR,western blot analysis and colorimetric assay showed that the levels of thioredoxin reductase 1 mRNA and protein were decreased,along with a significant reduction in thioredoxin reductase activity,in the midbrain of Parkinson’s disease mice compared with normal mice.Immunohistochemical staining revealed that the number of thioredoxin reductase 1-positive neurons in the substantia nigra pars compacta of Parkinson’s disease mice was significantly decreased compared with normal mice.These experimental findings suggest that the expression of thioredoxin reductase 1 in the substantia nigra pars compacta of Parkinson’s disease mice is significantly decreased,and that the enzyme may be associated with disease onset. | Zihua Liu Yuhong Jing Jie Yin Jiying Mu Tingting Yao Liping Gao | 2013 | Neural Regeneration Research2013，8，35： | 2 |
| 5 | Characterization of Early Fatigue Microstructure in AISI 321 Steel Using Eddy Current Non-destructive Methodology显示文摘Accumulative damage during early stage of fatigue in AISI 321 steel was investigated by eddy current test, atomic force microscopy, X-ray diffraction and transmission electron microscopy. Surface slip, dislocation, and strain-induced martensite were determined as the main damage types. Moreover, damage during the fatigue was found to be increased with the increasing fatigue cycles and load amplitude. The contribution of strain-induced martensite to the total eddy current amplitude(V max) was enhanced with the increase in its volume fraction. Finally, a linear relationship between V slip and the height of surface slip was established. | LIU Kunpeng ZHAO Zihua ZHANG Zheng | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，6： | 1 |
| 6 | Research on the Rules of Short Video Online Reviews in Mainstream Media显示文摘With the continuous optimization of mobile intelligent mode,the internet has gradually entered the era of visualization.This paper briefly summarizes the reasons and current situation of the rapid development of mainstream media short films,analyzes the composition and functions of mainstream media short video online reviews,and probes into the rules of mainstream media short video online reviews. | Zihua Zhan Yajuan Liu | 2021 | Proceedings of Business and Economic Studies2021，4，2： | 0 |
| 7 | 3-Hydroxybutyrate ameliorates insulin resistance by inhibiting PPARγSer273 phosphorylation in type 2 diabetic mice显示文摘3-Hydroxybutyrate(3HB)is a small ketone body molecule produced endogenously by the body in the liver.Previous studies have shown that 3HB can reduce blood glucose level in type 2 diabetic(T2D)patients.However,there is no systematic study and clear mechanism to evaluate and explain the hypoglycemic effect of 3HB.Here we demonstrate that 3HB reduces fasting blood glucose level,improves glucose tolerance,and ameliorates insulin resistance in type 2 diabetic mice through hydroxycarboxylic acid receptor 2(HCAR2).Mechanistically,3HB increases intracellular calcium ion(Ca^(2+))levels by activating HCAR2,thereby stimulating adenylate cyclase(AC)to increase cyclic adenosine monophosphate(cAMP)concentration,and then activating protein kinase A(PKA).Activated PKA inhibits Raf1 proto-oncogene serine/threonine-protein kinase(Raf1)activity,resulting in a decrease in extracellular signal-regulated kinases 1/2(ERK1/2)activity and ultimately inhibiting peroxisome proliferator-activated receptorγ(PPARγ)Ser273 phosphorylation in adipocytes.Inhibition of PPARγSer273 phosphorylation by 3HB altered the expression of PPARγregulated genes and reduced insulin resistance.Collectively,3HB ameliorates insulin resistance in type 2 diabetic mice through a pathway of HCAR2/Ca^(2+)/cAMP/PKA/Raf1/ERK1/2/PPARγ. | Yudian Zhang Zihua Li Xinyi Liu Xinyu Chen Shujie Zhang Yuemeng Chen Jiangnan Chen Jin Chen Fuqing Wu Guo-Qiang Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 8 | Simple nucleophile/H_(2)O promoted defluorinative ring-opening of gem-difluorocyclopropenes显示文摘A novel defluorinative ring-opening of gem-difluorocyclopropenes is presented,providing a concise and efficient method for accessing 2-fluoropropenals and 2-fluorobuta-1,3-dienes in moderate to good yields with excellent regio-and stereoselectivities.The reaction is performed under mild conditions with no need of using an excess amount of nucleophilic reagents.Water plays a crucial role in this transformation. | Yimiao He Jingwen Yuan Wen-Xin Lv Peng Liu Fan Teng Qijin Mo Zihua Wu Chusheng Huang Qianwen Liu Honggen Wang | 2024 | Green Synthesis and Catalysis2024，5，1： | 0 |
| 9 | Synthesis of Novel Bifunctional Chelator for (177)~Lu Labelling显示文摘The research of(177)^Lu labelled radiopharmaceuticals attracted much attention in recent years.The most widely used bifunctional chelators are DOTA and DTPA.However,the labelling procedure of DOTA needs heating(40-90℃)and extends reaction time(30-180min),and these conditions are typically required for quantitative radiolabelling,which can be incompatible with antibodies and other biomolecules.DTPA will successfully radiolabel these isotopes in 10-15min at ambient temperature.However,the in vivo stability is less optimal than that of DOTA.So it’s important to develop novel bifunctional chelator with better properties for the labelling of 177Lu. | FAN Caiyun WANG Yue LI Fenglin XIE Qinghua LIU Zihua | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 10 | Antioxidant activity of the thioredoxin system显示文摘The thioredoxin system is composed of thioredoxin(Trx),thioredoxin reductase(TR)and reduced nicotinamide adenine dinucleotide phosphate.Trx is an important antioxidant molecule that can resist cell death caused by various stresses and plays a prominent role in redox reactions.TR is a protein that contains selenium(selenocysteine),in three main forms,namely,TR1,TR2 and TR3.TR1,TR2 and TR3 are mainly distributed in the cytoplasm,mitochondria,and testes,respectively.TR can regulate cell growth and apoptosis.After a cell becomes cancerous,the expression of TR is increased to promote cell growth and metastasis.The Trx system is closely related to neurodegenerative diseases,parasitic infec-tions,acquired immunodeficiency syndrome,rheumatoid arthritis,hypertension,myocarditis,and so on.In addition,the Trx system can remove the reactive oxygen species in the body and keep the inside and outside of the cell in a balanced state.In summary,the Trx system is an important target for the drug treatment of many diseases. | Zihua Liu | 2023 | Biophysics Reports2023，9，1： | 0 |
| 11 | Clinical Application of PES Membrane Dialyzer显示文摘Objective The dialysate membrane can be classified into acetate membrane and synthetic membrane,while the latter can be further divided into polysulfone,polyacrylonitrile,etc.Polyethersulfone membrane is high molecular membrane material with excellent biocompatibility,stable mechanical properties,high temperature and pressure resistance,and good cleaning performance,which has been applied for more than 10 years.This trial is to assess the safety and efficacy of hollow polysulfone membrane fiber dialyzer with pattern number Enttex^(TM)-16LF(E60)for hemodialysis in patients with acute or chronic renal failure due to multiple factors.Methods Totally 76 patients receiving maintenance hemodialysis were included in a two-site,random,open label,two-stage,positive crossover and non inferiority validation study.The clinical efficacy and safety of the test device were observed,which was a hollow fiber dialyzer produced by Guangzhou Enttex Medical Products Co.,Ltd.,with polyethersulfone membrane imported from Germany.It was a low flux dialyzer with the pattern number of EnttexTM-16LF(E60).Inclusion criteria:①patients with acute or chronic renal failure due to various reasons who needed hemodialysis;②18 to 80 years old,gender unlimited;③patients who received stable dialysis for more than 3 months,regular hemodialysis 3 times a week,4 h at each time,blood flow rate of 200~350ml/min;④using bicarbonate dialysate at a flow rate of 500ml/min;⑤patients with arteriovenous fistula or who received artificial blood vessel puncture dialysis;received anticoagulation by heparin or low molecular weight heparin.Exclusion criteria:①patients needing heparin free dialysis for severe anemia,tumor and active bleeding;②patients with severe cardiac(gradeⅢcardiac function),hepatic(severe hepatitis and cirrhosis)and pulmonary diseases(severe respiratory failure).Results Comparison of parameters,including the changes of Kt/V,general creatinine and urea clearance rates and URR(urea reduction rate)shows no statistical significance in differences between the two devices,indicating that the test and control devices can equally and effectively eliminate toxins including creatinine and urea,etc.PPP and MITTP results are consistent.Comparison of ultrafiltration rates between two groups of patients shows no statistical difference.PPP and MITTP results are consistent,indicating that both the test device and control device can effectively eliminate water.In MITTP,electrolytes including K^+,Na^+,Cl^-,Ca^2+,HCO3^-,etc.show no statistical significance in difference between the test and control devices before and after dialysis(P>0.05).After treating by using test and control devices,body weight,serum potassium and phos-phorus all significantly decrease(P<0.001);serum Ca^2+,PO2,PCO2and HCO3^-all significantly increase(P<0.001).These results indicate that both the test and control devices can effectively eliminate serum potassium and phosphorus,and eliminate excess water in body,maintain the balance between liquid and electrolytes in patients.PPP and MITTP results are consistent.Conclusion This clinical trial confirms that hollow polyethersulfone membrane fiber dialyzer can be safely and effectively used in hemodialysis therapy. | YUN Chen YANG Peidian LIANG Wenxue CHEN Yu CHEN Gangyi LIU Hongping OUYANG Zihua SONG Huifeng LI Yunyi YU Zongchao GUAN Baozhang DONG Xiangnan LIU Huanhuan Cao Rui ZHANG Zeyu FAN Lijing HU Bo HE Yongcheng SHI Mingjie XU Jun Yang Lifeng TANG Shuifu | 2019 | 临床医学工程2019，26，S01： | 0 |
| 12 | The Static Solution for the Layered Piezoelectric Bounded Domain with Side Face Load by the Modified SBFEM显示文摘The static response of two-dimensional horizontal layered piezoelectric bounded domain with side face load was investigated.In this paper,the modified scaled boundary finite element method(SBFEM)is provided as an effective semi analytical methodology.The method is used to solve the static problem for the layered piezoelectric bounded domain.The scaling line definition extends the SBFEM to be more suitable for analyzing the multilayered piezoelectric bounded domain.It avoids the limitations of original SBFEM in modeling the horizontal layered bounded domain.The modified SBFEM governing equation with piezoelectric medium is derived by introducing Duality variable in the Hamilton system.This derivation technology makes the progress be concise.The novel displacement and electric governing equations of the modified SBFEM is given together by the first time.The node forces can be expressed as power exponent function with radial coordinate by introducing the auxiliary variable and using the eigenvalue decomposition.The novel modified SBFEM solution of layered bounded domain with piezoelectric medium is solved.The new power expansion function of layered piezoelectric medium with side face load is proposed.This technology significantly extends the application range of modified SBFEM.The novel treatment of side face load for the layered piezoelectric bounded domain is proposed.Numerical studies are conducted to demonstrate the accuracy of proposed technique in handling with the static problem of layered bounded domain with piezoelectric medium for side face load.The influence of the side face load type and depth are discussed in detail. | Shan Lu Jun Liu Gao Lin Zihua Zhang Pengchong Zhang | 2018 | Advances in Applied Mathematics and Mechanics2018，10，1： | 0 |
| 13 | Advances and outlook of TE-PCM system:a review显示文摘This review reports the most recent developments of thermoelectric(TE)system coupled with phase change material(PCM)and its promising integration options within various PCM deployment and structure design.These innovative TE coupled with PCM(TE-PCM)systems provide heat/cold energy with additional electric power which implies better harnessing of multiform energy.Fundamentals of TE-PCM system including thermoelectric effect are presented along with a basic mathematical formulation of the physical problem.The classification principles and configuration types of such systems are also summarized.The most representative studies related to the utilization of TE-PCM system in diversified application scenarios and their compatibility with other energy systems have been comprehensively reviewed and analyzed,including the component and structure optimization.In-depth analysis of the main technical and operational challenges in the future has been carried out,and the prospective development of more efficient TEPCM system and its hybrid configurations are projected based on the current technological level. | Anbang Liu Huaqing Xie Zihua Wu Yuanyuan Wang | 2022 | Carbon Neutrality2022，1，1： | 0 |
| 14 | Research progress and development direction of low-temperature drilling fluid for Antarctic region显示文摘By combing the characteristics of drilling in Antarctic region, performance requirements on drilling fluid for Antarctic low temperature conditions, and research progress of low temperature drilling fluid, current problems of the drilling fluid have been sorted out, and the development direction of the drilling fluid has been pointed out. Drilling in the Antarctic region mainly includes drilling in snow, ice and subglacial rock formations, and drilling in Antarctic low temperature conditions will face problems in four aspects:(1) low temperature and large temperature changes in the drilling area;(2) likely well leakage and drillstring-sticking in the snow layer, creep in the ice layer, ice chip gathering jamming in the warm ice layer, well wall collapse in the subglacial rock formations;(3) lack of infrastructure and difficulty in logistical support;(4) fragile environment and low carrying capacity. After years of development, progresses have been made on low-temperature drilling fluids for the Antarctic region. Low-temperature petroleum-based drilling fluid, ethanol/ethylene glycol-based drilling fluid, ester-based drilling fluid and silicone oil-based drilling fluid have been developed. However, these drilling fluids have problems such as insufficient low-temperature tolerance, low environmental performance and weak wellbore stability, etc. In order to meet the performance requirements of drilling fluid under low-temperature conditions in Antarctic region, the working mechanisms of low-temperature drilling fluid must be examined in depth;environment-friendly low-temperature base fluid of drilling fluid and related additives must be developed to prepare environmentally friendly low temperature drilling fluid systems;multi-functional integrated adjustment method for drilling fluid must be worked out to ensure well wall stability and improve cutting-carry capacity when drilling ice formations and ice-rock interlayers;and on-site support operation codes must be established to provide technical support for Antarctic drilling. | SUN Jinsheng WANG Zonglun LIU Jingping LYU Kaihe HUANG Xianbin ZHANG Xianfa SHAO Zihua HUANG Ning | 2022 | Petroleum Exploration and Development2022，49，5： | 0 |
| 15 | Particle motion trajectory tracking based on fiber optic tweezers显示文摘A biosensor based on single-fiber optical tweezers is proposed,which can detect the motion trajectory of cells based on the stable capture and transmission of silica microspheres as well as biological yeast cells by using a tapered optical fiber as a sensing element.The interference cavity is formed by using the fiber tip and the target particle,the detected interference signal is demodulated using Hilbert transform,and the displacement curve of the particle is plotted to realize the particle motion trajectory tracking.This method provides potential technical support for process monitoring of targeted drug delivery in biomedicine. | ZHAO Cun DONG Taiji GAO Bingkun LIU Xu ZHANG Zihua | 2023 | Optoelectronics Letters2023，19，8： | 0 |
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