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| 1 | Prevalence and Factors Associated with Female Sexual Dysfunction in Beijing, China显示文摘 | Wen-Jia Lou Bo Chen Lan Zhu Shao-Mei Han Tao Xu Jing-He Lang Lei Zhang | 2017 | Chinese Medical Journal2017，，12： | 25 |
| 2 | An-Luo-Hua-Xian Pill Improves the Regression of Liver Fibrosis in Chronic Hepatitis B Patients Treated with Entecavir显示文摘Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and cancer.As the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-Hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,2020.Demographic,laboratory,and liver histology data before and after 78 weeks of treatment were collected.The Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after treatment.Results:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX group.After 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=0.035.The percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=0.056.Logistic regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients. | Yi-Qi Liu Chi Zhang Jia-Wen Li Li-Hua Cao Zhan-Qing Zhang Wei-Feng Zhao Qing-Hua Shang Da-Zhi Zhang An-Lin Ma Qing Xie Hong-Lian Gui Guo Zhang Ying-Xia Liu Jia Shang Shi-Bin Xie Jun Li Xu-Qing Zhang Zhi-Qiang Zou Yu-Ping Chen Zong Zhang Ming-Xiang Zhang Jun Cheng Fu-Chun Zhang Li-Hua Huang Jia-Bin Li Qing-Hua Meng Hai-Bin Yu Yu-Qiang Mi Yan-Zhong Peng Zhi-Jin Wang Li-Ming Chen Fan-Ping Meng Wan-Hua Ren Lang Bai Yi-Lan Zeng Rong Fan Xian-Zhi Lou Wei-Feng Liang Hui Liu Hui Zhuang Hong Zhao Gui-Qiang Wang | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 7 |
| 3 | Effectiveness of flesh-moistening paste in psoriasis vulgaris patients with symptom pattern of blood stasis:a randomized and parallel-controlled trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of flesh-moistening paste for treating psoriasis vulgaris in patients with blood stasis pattern in terms of Traditional Chinese Medicine(TCM).METHODS:Eudipleural rashes on both the left and right side of the same patients with psoriasis vulgaris,diagnosed via TCM as blood stasis pattern,were selected as the targeted skin lesions.A randomized,double-blind,parallel-controlled,multicenter controlled trial was conducted.The targeted skin lesions were categorized into either the treatment or control group.The treatment group used the flesh-moistening paste;the control group used a placebo.Both the paste and the placebo were topically applied twice daily for eight weeks.The patients were examined biweekly to evaluate the effects.The two groups were compared in terms of the psoriasis area and severity index(PASI)of the targeted skin lesions,which is scored according to erythema,desquamation,infiltration,area,pruritus,and improvement of skin barrier function.Adverse events were recorded during the study period.SPSS 21.0 was used to analyze the data.RESULTS:Fifty-six patients were enrolled between February 2016 and October 2017.Two were complicated by cardio-cerebrovascular disease and were excluded;thus,54 outpatients were finally enrolled in the study.Four dropped out during the study period:three failed to complete their follow-up visits for unknown reasons,and one exited due to an adverse event.The final trial comprised 50 of the 56 originally selected patients,with a 92.6%completion rate.After 8 weeks of treatment,the targeted skin lesion scores differed significantly(P<0.05).The PASI scores of the targeted skin lesions differed significantly beginning at week 6(P<0.05).The treatment group presented better results than those of the control group.Only one patient had an adverse reaction associated with the treatment.Improvements in skin barrier function differed significantly(P<0.05).CONCLUSION:The flesh-moistening paste demonstrated a reliable curative effect and safety for treating psoriasis vulgaris in patients with blood stasis patterns.The topical paste improved the barrier function of the skin lesions. | Guo Xinwei Lang Na Li Guanru Li Ping Qu Jianhua Zhou Dongmei Wang Ping Cang Zhang Deng BingXu Lou Weihai Xu Jingna Lan Haibing Liu Yumin Zhang Weishu Sun Liyun | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 4 |
| 4 | Mechanism of the Effect of Bacillus coagulans on Production Performance of Laying Hens in Late Laying Period显示文摘[Objective]The paper was to investigate the mechanism of Bacillus coagulans preparation in improving production performance of laying hens in late period of laying.[Method]A total of 648 individuals of'Jingfen 1'laying hens(66 weeks of age)in late period of laying were randomly divided into four groups,six replicates each group,and each group had 27 individuals of laying hens.The laying hens in control group were fed with basal diet,and those in experimental groupsⅠ,Ⅱ and Ⅲ were fed with the basal diets added with 3.33×10^6,1×10^7,3.33×10^7 CFU/g B.coagulans,respectively.The pretrial lasted one week,and the formal test lasted eight weeks.[Result]Compared with the control group,the laying rate in group Ⅰ increased significantly,and the feed-gain ratio in experimental group Ⅱ decreased noticeably while the spleen index increased remarkably;the alkaline phosphatase activities and blood calcium content in experimental groups Ⅰ,Ⅱ and Ⅲ increased significantly(P<0.05),while the triglyceride content decreased remarkably(P<0.05);the urea content in experimental groups Ⅰ and Ⅱ decreased obviously(P<0.05).Adding B.coagulans significantly increased the specific activity of amylase,lipase and protease in various intestinal mucosa of small intestine(P<0.05);adding B.coagulans significantly increased the content of follicle-stimulating hormone(FSH)and estradiol(E2),and significantly increased the mRNA expression of follicle stimulating hormone receptor gene(FSHR).[Conclusion]B.coagulans preparation could significantly improve the production performance of laying hens in late period of laying;appropriately enhance the immune capacity of laying hens;improve the serum biochemical indicators;increase the activity of digestive enzymes in the small intestine;and promote the release of gonadal hormone and the mRNA expression of FSHR gene in the ovary. | Xing Guanrun Lang Xinrui Wu Ji’an Lou Hongxing Liu Wenqiang Zhang Hengshuo Dong Xinyang Pan Xiaoliang Wang Youming | 2019 | Animal Husbandry and Feed Science2019，11，5： | 2 |
| 5 | Quantum-enhanced stochastic phase estimation with the Su(1,1)interferometer显示文摘Quantum stochastic phase estimation has many applications in the precise measurement of various physical parameters.Similar to the estimation of a constant phase,there is a standard quantum limit for stochastic phase estimation,which can be obtained with the Mach-Zehnder interferometer and coherent input state.Recently,it has been shown that the stochastic standard quantum limit can be surpassed with nonclassical resources such as squcezed light.However,practical methods to achieve quantum enhancement in the stochastic phase estimation remain largely unexplored.Here we propose a method utilizing the SU(1,1)interferometer and coherent input states to cstimate a stochastic optical phase.As an example,we investigate the Ornstcin-Uhlenback stochastic phase.We analyze the performance of this method for three key estimation problems:prediction,tracking,and smoothing.The results show significant reduction of the mean square error compared with the Mach-Zehnder interferometer under the same photon number flux inside the interferometers.In particular,we show that the method with the SU(1,1)interferometer can achieve fundamental quantum scaling,achieve stochastic Heisenberg scalinga and surpass the precision of the canonical measurement. | KAIMIN ZHENG MINGHAO MI BEN WANG LANG XU LIYUN HU SHENGSHUAI LIU YANBO LOU JETAI JING LIJIAN ZHANG | 2020 | Photonics Research2020，8，10： | 2 |
| 6 | Electrical, Thermal, and Mechanical Properties of Cu/Ti3AlC2 Functional Gradient Materials Prepared by Low-temperature Spark Plasma Sintering显示文摘Cu/Ti3AlC2 composite and functional-gradient materials with excellent electrical conductivity and thermal conductivity as well as good flexural properties were prepared by low-temperature spark plasma sintering of Cu and Ti3AlC2 powder mixtures. The phase compositions of the materials were analyzed by X-ray diffraction, and their microstructure was characterized by scanning electron microscopy and energy dispersive X-ray spectroscopy. Further, the electrical conductivity, thermal conductivity, and flexural properties of the materials were tested. Results show that, for the composite materials, the resistivity rises from 0.75 × 10^-7 Ω·m only to 1.32 × 10^-7 Ω·m and the thermal diffusivity reduces from 82.5 mm^2/s simply to 39.8 mm^2/s, while the flexural strength improves from 412.9 MPa to 471.3 MPa, as the content of Ti3AlC2 is increased from 5 wt%to 25 wt%. Additionally, the functional-gradient materials sintered without interface between the layers exhibit good designability, and their overall electrical conductivity, thermal conductivity, and flexural strength are all higher than those of the corresponding uniform composite material. | 陈艳林 PENG Hang LOU Lang HUANG Kang YAN Ming 吴崇刚 | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，4： | 1 |
| 7 | HPLC analysis of ginsenosides in Panax ginseng,Panax quinquefolium and Panax notoginseng显示文摘 | Lou ZC But PH | 1993 | J Chinese Pharmaceutical Sci1993，2，2： | 1 |
| 8 | Multi-Target Track Initiation in Heavy Clutter显示文摘In the heavy clutter environment, the information capacity is large,the relationships among information are complicated, and track initiationoften has a high false alarm rate or missing alarm rate. Obviously, it is adifficult task to get a high-quality track initiation in the limited measurementcycles. This paper studies the multi-target track initiation in heavy clutter.At first, a relaxed logic-based clutter filter algorithm is presented. In thealgorithm, the raw measurement is filtered by using the relaxed logic method.We not only design a kind of incremental and adaptive filtering gate, but alsoadd the angle extrapolation based on polynomial extrapolation. The algorithm eliminates most of the clutter and obtains the environment with highdetection rate and less clutter. Then, we propose a fuzzy sequential Houghtransform-based track initiation algorithm. The algorithm establishes a newmeshing rule according to system noise to balance the relationship between thegrid granularity and the track initiation quality. And a flexible superpositionmatrix based on fuzzy clustering is constructed, which avoids the transformation error caused by 0–1 voting method in traditional Hough transform.In addition, the algorithm allows the superposition matrixes of nonadjacentcycles to be associated to overcome the shortcoming that the track can’t beinitiated in time when the measurements appear in an intermittent way. Anda slope verification method is introduced to detect formation-intensive serialtracks. Last, the sliding window method is employed to feedback the trackinitiation results timely and confirm the track. Simulation results verify thatthe proposed algorithms can initiate the tracks accurately in heavy clutter. | Li Xu Ruzhen Lou Chuanbin Zhang Bo Lang Weiyue Ding | 2022 | Computers, Materials & Continua2022，，9： | 0 |
| 9 | An ultra-sensitive metasurface biosensor for instant cancer detection based on terahertz spectra显示文摘Metasurface biosensors have become the core label-free and rapid-detection technology in bioanalysis.Lung cancer and brain cancer are the first leading causes of cancer death among adults and adolescents,respectively,where poor early diagnosis results from expensive detection costs and time consumption.To tackle the above problems,here,we introduce a terahertzdomain metasurface biosensor for cancer diagnosis,relying on a perfectly symmetrical periodic surface structure,which significantly exhibits polarization-insensitivity at 2.05 THz and the high-sensitivity of 504 GHz/RIU(RIU=refractive index unit).According to the frequency shifts and transmittance variations,four cell types are successfully distinguished from each other.The minimum number of cells is required for thousands of cells to display the differences of spectra,which is 1/30 of clinical methods.Furthermore,the results were consistent with pathological results(the gold standard in clinic)by Gaussian curve fitting.The proposed biosensor has really achieved the characterization of cells in normal and cancerous state.This detection strategy dramatically reduced the cost of detection by reuse and time consumption was reduced to 1/20 of the pathology testing.In addition,it is flexible to set samples and easy to realize automatic operation due to the great polarization-insensitivity of the proposed biosensor,which can further reduce labor costs in the future.It is envisioned that the proposed biosensor will present immense potential in the fields of cancer detection,distinguishing different cancers,identifying primary lesion cancer or metastatic cancer. | Peiliang Wang Jing Lou Yun Yu Lang Sun Lan Sun Guangyou Fang Chao Chang | 2023 | Nano Research2023，16，5： | 0 |
| 10 | 畅享自然——让老年人乐享幸福生活的生态社区公园设计显示文摘为了更好地照顾老年人,护理模式正在一步步由家庭护理向社区护理转变。该项目以自然恢复、低影响发展、自我维持的生态社区为设计理念,旨在创造一个健康舒适的户外空间,为老年人提供互动、娱乐和教育服务,加强老年人与家人之间的联系,并完善社区内外的社交网络。项目地址位于安徽省合肥市中心的仙桥社区。该社区占地0.46平方公里,有6个相对独立的居民区。原有社区景观设计陈旧,建筑密度高,仅有一个公共广场和一个袖珍公园,区域内居民很少有接触到绿色和自然的机会。 | Peng Chen Yichen Lou Kun Qian Zhengwei Xing Yunxin Han Wenjun Liu Hongbo Chen Wenqi Chen Xinmiao Zhu Lang Qin Xueying Liu Yu Leng Xinya Hu Suheng Yao | 2023 | 工业设计2023，，9： | 0 |
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