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| 1 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 2 | Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study显示文摘 | Mark S Pearce Jane A Salotti Mark P Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola L Howe Cecile M Ronckers Preetha Rajaraman Alan W Craft Louise Parker Amy Berrington de González | 2012 | The Lancet . 2012 (9840)2012，，： | 3 |
| 3 | Review: Improving our knowledge of male mosquito biology in relation to genetic control programmes显示文摘 | Rosemary Susan Lees Bart Knols Romeo Bellini Mark Q. Benedict Ambicadutt Bheecarry Hervé Christophe Bossin Dave D. Chadee Jacques Charlwood Roch K. Dabiré Luc Djogbenou Alexander Egyir-Yawson René Gato Louis Clément Gouagna Mo’awia Mukhtar Hassan Shakil A | 2013 | Acta Tropica2013，，： | 2 |
| 4 | 妊娠与乳腺癌显示文摘妊娠期乳腺癌与非妊娠期乳腺癌的预后相似终止妊娠改麦乳腺癌预后的证据不足罹患乳腺癌后妊娠不影响治疗的结果乳腺癌治疗后与再次妊娠之间理想的时间同隔尚不清楚 | Ludger Barthelmes Louise A Davidson Christopher Gaffney Christopher A Gateley 赵卫红 | 2005 | 英国医学杂志中文版2005，8，6： | 2 |
| 5 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 6 | Severe Hand, Foot, and Mouth Disease Associated with Coxsackievirus A6 - Alabama, Connecticut, California, and Nevada, November 201 1 - February 2012显示文摘 | McIntyre Mary G Stevens Kelly M Davidson Sherri Pippin Tina Magill Dagny Kulhanjian Julie A Kelly Daniel Greenhow Tara L Salas Maria L Yagi Shigeo Padilla Tasha Berumen Ricardo Glaser Carol Landry Marie Louise Lott Jason Chen Lei Paulson | 2012 | EN2012，，12： | 2 |
| 7 | The aesthetics of ecological design : seeing science as culture 显示文摘 | LOUISE A MOZINGO | 1997 | Landscape Journal1997，16，1： | 1 |
| 8 | Neuroendocrine pharmacology of stress显示文摘 | Gonzalo A Carrasco Louis D Van de Kar | 2003 | European Journal of Pharmacology2003，，1： | 1 |
| 9 | Tumor necrosis factor gene polymorphism influences TNF alpha produc-tion in LPS-stimulated whole blood cell culture in healthy humans显示文摘 | Louis E Franchimont D Piron A | | 0，，3： | 1 |
| 10 | Functional electrical stimulation improves activity after stroke :a systematic review with meta-analysis 显示文摘 | Howlett OA Lannin NA Louise A | 2015 | Arch Phys Med Rehabil2015，96，5： | 1 |
| 11 | Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody显示文摘 | Kenneth A Foon Xiao-Dong Yang Louis M Weiner Arie S Belldegrun Robert A Figlin Jeffrey Crawford Eric K Rowinsky Janice P Dutcher Nicholas J Vogelzang Jared Gollub John A Thompson Garry Schwartz Ronald M Bukowski Lorin K Roskos Gisela M Schwab | 2004 | International Journal of Radiation Oncology Biology Physics2004，，3： | 1 |
| 12 | Accurate quantitation of Leishmania infection in cultured cells by flow cytometry 显示文摘 | Guinet F Louise A Jouin H | 2000 | Cytometry2000，39，3： | 1 |
| 13 | MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions显示文摘 | du Rieu Ma?l Chalret Torrisani Jér?me Selves Janick Al Saati Talal Souque Anny Dufresne Marlène Tsongalis Gregory J Suriawinata Arief A Carrére Nicolas Buscail Louis Cordelier Pierre | 2010 | Clinical Chemistry2010，，： | 1 |
| 14 | Centennial review of corneal transplantation显示文摘 | S Louise Moffatt BSc Victoria A Cartwright BA Thomas H Stumpf | 2005 | Clinical and Experimental Ophthalmology2005，33，： | 1 |
| 15 | Cell attachment and biocompatibility of polytetrafluoroethylene (PTFE) treated with glow-discharge plasma of mixed ammonia and oxygen显示文摘 | Meng Chen Paul O. Zamora Prantika Som Louis A. Pe?a Shigemasa Osaki | 2003 | Journal of Biomaterials Science Polymer Edition2003，，9： | 1 |
| 16 | Transformational Leadership and Ambidex-terity in the Context of An Acquisition显示文摘 | Louise A N Dusya V | 2009 | The Leadership Quarter-ly2009，20，： | 1 |
| 17 | Adult degenerative scoliosis显示文摘 | Tambe AD Louis A Michael R | | 0，，： | 1 |
| 18 | Sedation for endoscopy: The safe use of propofol by general practitioner sedationists显示文摘 | CLARKE A C LOUISE C HILLMAN L C | 2002 | Medical Journal of Australia2002，176，4： | 1 |
| 19 | Effects of two proteinase inhibitors on the digestive enzymes and survival of honey bees (Apis mellifera L)显示文摘 | ELISABETH P J B LOUISE A M JOHN T | 1996 | Journal of Insect Physiology1996，9，42： | 1 |
| 20 | Task Force 1: the changing profile of congenital heart disease in adult life显示文摘 | Carole A Warnes Richard Liberthson Gordon K Danielson Annie Dore Louise Harris Julien I.E Hoffman Jane Somerville Roberta G Williams Gary D Webb | 2001 | Journal of the American College of Cardiology2001，，5： | 1 |
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