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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | Nanostructured Bi2S3 encapsulated within three- dimensional N-doped graphene as active and flexible anodes for sodium-ion batteries显示文摘 | Chen Lu Zhenzhu Li Lianghao Yu Li Zhang Zhou Xia Tao Jiang Wanjian Yin Shixue Dou Zhongfan Liu Jingyu Sun | 2018 | Nano Research2018，11，9： | 9 |
| 3 | Confining MOF-derived SnSe nanoplatelets in nitrogen-doped graphene cages via direct CVD for durable sodium ion storage显示文摘Tin-based compounds are deemed as suitable anode candidates affording promising sodium-ion storages for rechargeable batteries andhybrid capacitors.However,synergistically tailoring the electrical conductivity and structural stability of tin-based anodes to attain durablesodium-ion storages remains challenging to date for its practical applications.Herein,metal-organic framework(MOF)derived SnSe/C wrappedwithin nitrogen-doped graphene(NG@SnSe/C)is designed targeting durable sodium-ion storage.NG@SnSe/C possesses favorable electricalconductivity and structure stability due to the'inner'carbon framework from the MOF thermal treatment and'outer'graphitic cage from thedirect chemical vapor deposition synthesis.Consequently,NG@SnSe/C electrode can obtain a high reversible capacity of 650 mAh·g^-1 at 0.05 A·g^1,a favorable rate performance of 287.8 mAh·g^1 at 5 A·g^1 and a superior cycle stability with a negligible capacity decay of 0.016%percycle over 3,200 cycles at 0.4 A·g^1.Theoretical calculations reveal that the nitrogen-doping in graphene can stabilize the NG@SnSe/Cstructure and improve the electrical conductivity.The reversible Na-ion storage mechanism of SnSe is further investigated by in-situ X-raydiffraction/ex-s/tu transmission electron microscopy.Furthermore,assembled sodium-ion hybrid capacitor full-cells comprising our NG@SnSe/Canode and an active carbon cathode harvest a high energy/power density of 115.5 Wh·kg^-1/5,742 W·kg^-1,holding promise for next-generationen ergy storages. | Chen Lu Zhenzhu Li Zhou Xia Haina Ci Jingsheng Cai Yingze Song Lianghao Yu Wanjian Yin Shixue Dou Jingyu Sun Zhongfan Liu | 2019 | Nano Research2019，12，12： | 7 |
| 4 | Precise synthesis of N-doped graphitic carbon via chemical vapor deposition to unravel the dopant functions on potassium storage toward practical K-ion batteries显示文摘Nitrogen doped carbon is a burgeoning anode candidate for potassium-ion battery(PIBs)owing to its outstanding attributes.It is imperative to grasp further insight into specific effects of different nitrogen dopants in carbon anode toward advanced K-ion storage.However,the prevailing fabrication method is plagued by the fact that considerable variations in the total N-doping concentration occur in the course of regulating the type of nitrogen dopants,incapable of distinguishing the certain roles of them under similar conditions.Herein,throughout the precise preparation of high edge-N doped carbon(HENC)and high graphitic-N doped carbon(HGNC)harnessing basically identical N-doping levels(5.78 at.%for HENC;5.07 at.%for HGNC)via chemical vapor deposition route,the effects of edge-N and graphitic-N in the carbon anode on K-ion storage are revisited,offering guidance into the design of low-cost and high-performance PIB systems. | Yu Zhao Zhongti Sun Yuyang Yi Chen Lu Menglei Wang Zhou Xia Xueyu Lian Zhongfan Liu Jingyu Sun | 2021 | Nano Research2021，14，5： | 4 |
| 5 | Commuting dual Toeplitz operators on the harmonic Bergman space显示文摘We completely characterize commuting dual Toeplitz operators with bounded harmonic symbols on the harmonic Bergman space of the unit disk. We show that for harmonic ■ and ψ, S■Sψ= SψS■ on(L2h)⊥if and only if ■ and ψ satisfy one of the following conditions:(1) Both ■ and ψ are analytic on D.(2) Both ■ and ψ are anti-analytic on D.(3) There exist complex constants α and β, not both 0, such that ■ = αψ + β.Furthermore, we give the necessary and sufficient conditions for S■Sψ= S■ψ. | YANG JingYu LU YuFeng | 2015 | Science China Mathematics2015，58，7： | 4 |
| 6 | A new method of developing elastic-plastic-viscous constitutive model for clays显示文摘A new method is presented to develop the existing elastic-plastic constitutive model into an elastic-plastic-viscous one for clays.The actual loading process is divided into an instant process and a delayed process denoting the elastic-plastic strain and viscous strain, respectively. The elastic-plastic strain is determined by either an elastic-plastic model for overconsolidated clays or an improved model based on the elastic-plastic model for normally consolidated clays. In order to calculate viscous strain, a reference state line is defined based on the actual loading path. Combining the reference state line, an existing elastic-plastic model can be conveniently developed into an elastic-plastic-viscous model. Furthermore, using the proposed method, the modified cam clay model is extended into an elastic-plastic-viscous model. Comparisons with test results demonstrate that the extended model can capture the main time-dependent behaviours of clays, including creep, stress relaxation and strain rate effects. | LU DeChun MIAO JinBo DU XiuLi LIANG JingYu | 2020 | Science China(Technological Sciences)2020，63，2： | 3 |
| 7 | Algebraic Properties of Toeplitz Operators on the Harmonic Bergman Space显示文摘In this paper, we first investigate the finite-rank product problem of several Toeplitz operators with quasihomogeneous symbols on the harmonic Bergman space. Next, we characterize finite rank commutators and semi-commutators of two Toeplitz operators with quasihomogeneous symbols. | Jingyu YANG Yufeng LU Xiaoying WANG | 2016 | Journal of Mathematical Research with Applications2016，36，4： | 2 |
| 8 | Reasoning about knowledge, belief and certainty in hierarchical multi-agent systems显示文摘 | Lijun WU Kaile SU Yabiao HAN Jingyu CHEN Xiangyu LU | 2017 | Frontiers of Computer Science2017，11，3： | 2 |
| 9 | Straight line feature based image distortion correction显示文摘An image distortion correction method is proposed, which uses the straight line features. Many parallel lines of different direction from different images were extracted, and then were used to optimize the distortion parameters by nonlinear least square. The thought of step by step was added when the optimization method working. 3D world coordination is not need to know, and the method is easy to implement. The experiment result shows its high accuracy. | Zhang Haofeng Zhao Chunxia Lu Jianfeng Tang Zhenmin Yang Jingyu | 2008 | Engineering Sciences2008，6，2： | 1 |
| 10 | Detection of EGFR on living human gastric cancer BGC823 cells using surface plasmon resonance phase sensing显示文摘 | Fangfang Liu Jingyu Zhang Yan Deng Daqian Wang Youyong Lu Xinglong Yu | 2010 | Chemical2010，，2： | 1 |
| 11 | Influences of permeation of vanadium ions through PVDF-g-PSSA membranes on performances of vanadium redox flow batteries 显示文摘 | Luo Xuanli Lu Zhengzhong Xi Jingyu | 2005 | Journal of Phys Chem B2005，109，20： | 1 |
| 12 | Metabolic reprogramming and redox adaptation in sorafenib-resistant leukemia cells:detected by untargeted metabolomics and stable isotope tracing analysis显示文摘Background:Internal tandem duplications(ITD)within the juxtamembrane domain of FMS-like tyrosine kinase 3(FLT3)represent a poor prognostic indicator in acute myeloid leukemia(AML).Therapeutic benefits of tyrosine kinase inhibitors,such as sorafenib,are limited due to the emergence of drug resistance.While investigations have been con-ducted to improve the understanding of the molecular mechanisms underlying the resistance to this FLT3 inhibitor,a profile of cell functioning at the metabolite level and crosstalk between metabolic pathways has yet to be created.This study aimed to elucidate the alteration of metabolomic profile of leukemia cells resistant to the FLT3 inhibitor.Methods:We established two sorafenib-resistant cell lines carrying FLT3/ITD mutations,namely the murine BaF3/ITD-R and the human MV4-11-R cell lines.We performed a global untargeted metabolomics and stable isotope-labe-ling mass spectrometry analysis to identify the metabolic alterations relevant to the therapeutic resistance.Results:The resistant cells displayed fundamentally rewired metabolic profiles,characterized by a higher demand for glucose,accompanied by a reduction in glucose flux into the pentose phosphate pathway(PPP);and by an increase in oxidative stress,accompanied by an enhanced glutathione synthesis.We demonstrated that the highest scoring network of altered metabolites in resistant cells was related to nucleotide degradation.A stable isotope tracing experiment was performed and the results indicated a decrease in the quantity of glucose entering the PPP in resistant cells.Further experiment suggested that the inhibition of major enzymes in the PPP consist of glucose-6-phosphate dehydrogenase deficiency(G6PD)in the oxidative arm and transketolase(TKT)in the non-oxidative arm.In addition,we observed that chronic treatment with sorafenib resulted in an increased oxidative stress in FLT3/ITD-positive leu-kemia cells,which was accompanied by decreased cell proliferation and an enhanced antioxidant response.Conclusions:Our data regarding comparative metabolomics characterized a distinct metabolic and redox adaptation that may contribute to sorafenib resistance in FLT3/ITD-mutated leukemia cells. | Xin You Weiye Jiang Wenhua Lu Hui Zhang Tiantian Yu Jingyu Tian Shijun Wen Guillermo Garcia-Manero Peng Huang Yumin Hu | 2019 | Cancer Communications2019，39，1： | 1 |
| 13 | Evaluation of software of four-parameter sine wave curve-fit显示文摘 | LIANG Zhiguo LU Kejie SUN Jingyu | 2000 | Transaction of Nanjing University of Aeronautics and Astronautics2000，17，1： | 1 |
| 14 | Annual Operation Status of SECRAL in 2009显示文摘 | Lu Wang Sun Liangting Feng Yucheng Guo Xiaohong Zhang Xuezheng Li Jingyu Cao Yun Wang Hui Ma Baohua Shang Yong Sha Shan Ma Hongyi Li Xixia Lin Shuhao Zhang Wenhui Jin Tao Zhao Huanyu Zhao Hongwei | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 1 |
| 15 | Association of Ala589Ser polymorphism of WNK4 gene with essential hypertension in a high-risk Chinese population显示文摘 | SUN Zhijun LI Yan LU Jingyu | 2009 | JPhysiolSci2009，59，2： | 1 |
| 16 | Understanding the dynamical-microphysical-electrical processes associated with severe thunderstorms over the Beijing metropolitan region显示文摘The Dynamical-microphysical-electrical Processes in Severe Thunderstorms and Lightning Hazards(STORM973)project conducted coordinated comprehensive field observations of thunderstorms in the Beijing metropolitan region(BMR)during the warm season from 2014 to 2018.The aim of the project was to understand how dynamical,microphysical and electrical processes interact in severe thunderstorms in the BMR,and how to assimilate lightning data in numerical weather prediction models to improve severe thunderstorm forecasts.The platforms used in the field campaign included the Beijing Lightning Network(BLNET,consisting of 16 stations),2 X-band dual linear polarimetric Doppler radars,and 4 laser raindrop spectrometers.The collaboration also made use of the China Meteorological Administration’s mesoscale meteorological observation network in the Beijing-Tianjin-Hebei region.Although diverse thunderstorm types were documented,it was found that squall lines and multicell storms were the two major categories of severe thunderstorms with frequent lightning activity and extreme rainfall or unexpected local short-duration heavy rainfall resulting in inundations in the central urban area,influenced by the terrain and environmental conditions.The flash density maximums were found in eastern Changping District,central and eastern Shunyi District,and the central urban area of Beijing,suggesting that the urban heat island effect has a crucial role in the intensification of thunderstorms over Beijing.In addition,the flash rate associated with super thunderstorms can reach hundreds of flashes per minute in the central city regions.The super(5%of the total),strong(35%),and weak(60%)thunderstorms contributed about 37%,56%,and 7%to the total flashes in the BMR,respectively.Owing to the close connection between lightning activity and the thermodynamic and microphysical characteristics of the thunderstorms,the lightning flash rate can be used as an indicator of severe weather events,such as hail and short-duration heavy rainfall.Lightning data can also be assimilated into numerical weather prediction models to help improve the forecasting of severe convection and precipitation at the cloud-resolved scale,through adjusting or correcting the thermodynamic and microphysical parameters of the model. | Xiushu QIE Shanfeng YUAN Zhixiong CHEN Dongfeng WANG Dongxia LIU Mengyu SUN Zhuling SUN Abhay SRIVASTAVA Hongbo ZHANG Jingyu LU Hui XIAO Yongheng BI Liang FENG Ye TIAN Yan XU Rubin JIANG Mingyuan LIU Xian XIAO Shu DUAN Debin SU Chengyun SUN Wenjing XU Yijun ZHANG Gaopeng LU Da-Lin ZHANG Yan YIN Ye YU | 2021 | Science China Earth Sciences2021，64，1： | 1 |
| 17 | Controllable growth and flexible optoelectronic devices of regularly-assembled Bi2S3 semiconductor nanowire bifurcated junctions and crosslinked networks显示文摘Regularly assembled structures of nanowires, such as aligned arrays, junctions and interconnected networks, have great potential for the applications in logical circuits, address decoders, photoelectronic devices and transparent electrodes. However, for now it is still lack of effective approaches for constructing nanowire bifurcated junctions and crosslinked networks with ordered orientations and high quality. Herein, we report the controlled growth of Bi2S3 semiconductor nanowire bifurcated junctions and crosslinked networks with well-aligned directions and high crystalline degree by utilizing the proportional lattice match between nanowires and substrates. Taking advantages of the “tip-to-stem splice” assembly of individual nanowires, the precise orientation alignments of Bi2S3 semiconductor nanowire bifurcated junctions and crosslinked networks were successfully realized. The controlled growth mechanism and structural evolution process have been elucidated by detailed atomic structure characterizations and modeling. The highly crystal quality and direct energy bandgap of as-assembled photodetectors based on individual bismuth sulfide nanowires enabled high photoresponsivity and fast switch time under light illumination. The three-terminal devices based on nanowire bifurcated junctions present rapid carrier transport across the junction. The flexible photodetectors based on nanowire crosslinked networks show very minimal decay of photocurrent after long-term bending test. This work may provide new insights for the guided construction and regular assembly of low-dimensional ordered functional nanostructures towards advanced nanotechnologies. | Yi Hu Lingyun Mao Xin Yuan Jingyu Lu Renpeng Chen Tao Chen Wenjun Zhang Xiaolan Xue Wen Yan Mohammadreza Shokouhimehr Xiao Li Zhang Zhong Jin | 2020 | Nano Research2020，13，8： | 1 |
| 18 | An Efficient Renovation on Kernel Fisher Discriminant Analysis and Face Recognition Experiments显示文摘 | Xu Yong Yang Jingyu Lu Jianfeng | | 0，，10： | 1 |
| 19 | Evaluation of Software of Four-Parameter Sine Wave Curve-fit显示文摘 | Liang Zhiguo Lu Kejie Sun Jingyu | 2000 | Transa-ction of Nanjing University of Aeronautics & Astronautics2000，17，1： | 1 |
| 20 | miR-214 inhibits epithelial–mesenchymal transition of breast cancer cells via downregulation of RNF8显示文摘MicroRNAs(miRNAs)are a class of endogenous noncoding genes that regulate gene expression at the posttranscriptional level.In recent decades,miRNAs have been reported to play important roles in tumor growth and metastasis,while some reported functions of a specific miRNA in tumorigenesis are contradictory.In this study,we reevaluated the role of miR-214,which has been reported to serve as an oncogene or anti-oncogene in breast cancer metastasis.We found that miR-214 inhibited breast cancer via targeting RNF8,a newly identified regulator that could promote epithelial–mesenchymal transition(EMT).Specifically,the survival rate of breast cancer patients was positively correlated with miR-214 levels and negatively correlated with RNF8 expression.The overexpression of miR-214 inhibited cell proliferation and invasion of breast cancer,while suppression of miR-214 by chemically modified antagomir enhanced the proliferation and invasion of breast cancer cells.Furthermore,miR-214 could modulate the EMT process via downregulating RNF8.To our knowledge,this is the first report that reveals the role of the miR-214–RNF8 axis in EMT,and our results demonstrate a novel mechanism for miR-214 acting as a tumor suppressor through the regulation of EMT. | Lu Min Chuanyang Liu Jingyu Kuang Xiaomin Wu Lingyun Zhu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，8： | 1 |
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