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| 1 | Characteristics of paleoflood deposits archived in unit T0403 of Yuxi Site in the Three Gorges reservoir areas,China显示文摘Based on the detailed analyses,multi-proxies such as AMS 14 C dating,grain size,component and morphology of heavy minerals,micromorphology of zircon,magnetic susceptibility,Rb/Sr and Hg content are used to research the paleoflood sediments archived in the Yuxi Site.The research indicates that, since 7.6 kaBP,at least 16 times of paleoflood with water level above Wusong Elevation 147.024 m(a.s.l.) left deposits in the Neolithic layers of unit T0403 from the Yuxi Site.The results are induced from the following aspects:(1)The plaeoflood sediments take on great similarities with modern flood sediments in the Yuxi Site and Zhongba Site in probability cumulative curves which mainly show a pattern of 3 segments in fluvial pattern.(2)There is some resemblance between the heavy mineral components and the zircon shape characteristics of paleoflood deposits and those of modern flood deposits.(3) Magnetic susceptibility values(40.44―70.10SI)are lower than those of sediments from cultural layers (59.59―188.68SI).(4)Hg values(290.71―742.51 ng/g)are lower than those of sediments from cultural layers(344.16―10518.17 ng/g).(5)Rb/Sr values are higher than those of sediments from cultural layers, while those of the 4th,5th,6th,7th,8th cultural layers are high,which shows that they are inundated by paleoflood.The reason for many flood deposits existing is related to the site situated on the first terrace where the Yuxi River joins with the Yangtze River.As there are some similarities between the plaeoflood sediments and those of the Zhongba Site,it is feasible to confirm the existence of paleoflood sediments based on the above points. | ZHU Cheng MA ChunMei XU WeiFeng BAI JiuJiang ZHENG ChaoGui ZHU GuangYao WANG HuiLin CHEN Ye LU XueFeng | 2008 | Chinese Science Bulletin2008，53，S1： | 16 |
| 2 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 3 | Proanthocyanidins Inhibit Seed Germination by Maintaining a High Level of Abscisic Acid in Arabidopsis thaliana显示文摘Proanthocyanidins (PAs) are the main products of the flavonoid biosynthetic pathway in seeds, but their biological function during seed germination is still unclear. We observed that seed germination is delayed with the increase of exogenous PA concentration in Arabidopsis. A similar inhibitory effect occurred in peeled Brassica napus seeds, which was observed by measuring radicle elongation. Using abscisic acid (ABA), a biosynthetic and metabolic inhibitor, and gene expression analysis by real-time polymerase chain reaction, we found that the inhibitory effect of PAs on seed germination is due to their promotion of ABA via de novo biogenesis, rather than by any inhibition of its degradation. Consistent with the relationship between PA content and ABA accumulation in seeds, PA-deficient mutants maintain a lower level of ABA compared with wild-types during germination. Our data suggest that PA distribution in the seed coat can act as a doorkeeper to seed germination. PA regulation of seed germination is mediated by the ABA signaling pathway. | Liguo Jia Qiuyu Wu Nenghui Ye Rui Liu Lu Shi Weifeng Xu Hui Zhi A. N. M. Rubaiyath Bin Rahman Yiji Xia Jianhua Zhang | 2012 | Journal of Integrative Plant Biology2012，54，9： | 9 |
| 4 | Mechanistic studies of the transport of peimine in the Caco-2 cell model显示文摘Fritillaria thunbergii Miq. has been widely used in traditional Chinese medicine for its expectorant, antitussive, antiinflammatory and analgesic properties. Moreover, modern pharmacological studies have demonstrated that F. thunbergii Miq. has efficacy in the treatment of leukemia and cancers of the liver and cervix. Although the alkaloid, peimine, is largely responsible for these pharmacological effects, it has very low oral bioavailability. The aim of this study was to investigate the intestinal absorption of peimine in Caco-2 cell monolayers. Having demonstrated that peimine is non-toxic to Caco-2 cells at concentrations o200 μmol/L, the effect of peimine concentration, p H, temperature, efflux transport protein inhibitors and EDTA-Na_2 on peimine transport were studied. The results show that peimine transport is concentration-dependent; that at p H 6.0 and 7.4, the P_(app(AP-BL))of peimine is not significantly different but the Papp(BL-AP)) is; that both Papp(AP-BL)and P_(app(BL-AP))at 4 1C are significantly higher than their corresponding values at 37 1C; that the P-glycoprotein(P-gp) inhibitors, verapamil and cyclosporin A, increase absorption of peimine; and that EDTA-Na2 has no discernible effect. In summary,the results demonstrate that the intestinal absorption of peimine across Caco-2 cell monolayers involves active transport and that peimine is a substrate of P-gp. | Lihua Chen Xueping Lu Xinli Liang Dandan Hong Zhiyu Guan Yongmei Guan Weifeng Zhu | 2016 | Acta Pharmaceutica Sinica B2016，6，2： | 8 |
| 5 | Estimating genetic diversity and sampling strategy for a wild soybean (Glycine soja) population based on different molecular markers显示文摘Genetic diversity is the basic and most important component of biodiversity. It is essential for the effective conservation and utilization of genetic resources to accurately estimate genetic diversity of the targeted species and populations. This paper reports analyses of genetic diversity of a wild soy-bean population using three molecular marker tech-nologies (AFLP, ISSR and SSR), and computer simulation studies of randomly selected subsets with different sample size (5―90 individuals) drawn 50 times from a total of 100 wild soybean individuals. The variation patterns of genetic diversity indices, including expected heterozygosity (He), Shannon diversity index (I), and percentage of polymorphic loci (P), were analyzed to evaluate changes of genetic diversity associated with the increase of individuals in each subset. The results demonstrated that (1) val-ues of genetic diversity indices of the same wild soybean population were considerably different when estimated by different molecular marker techniques; (2) genetic diversity indices obtained from subsets with different sample sizes also diverged considera-bly; (3) P values were relatively more reliable for comparing genetic diversity detected by different molecular marker techniques; and (4) different diver-sity indices reached 90% of the total genetic diversity of the soybean population quite differently in terms of the sample size (number of individuals) analyzed. When using the P value as a determinator, 30―40individuals could capture over 90% of the total ge-netic diversity of the wild soybean population. Results from this study provide a strong scientific basis for estimating genetic diversity and for strategic conser-vation of plant species. | ZHAO Ru CHENG Zhou LU Weifeng LU Baorong | 2006 | Chinese Science Bulletin2006，51，10： | 7 |
| 6 | Express,on of the novel adipokine ClqTNF-related protein 4 (CTRP4) suppresses colitis and colitis- associated colorectal cancer in mice显示文摘 | Yang Luo Xiaotong Wu Zhuang Ma Weifeng Tan Lanlan Wang Daxiang Na Guoying Zhang Ang Yin He Huang Dan Xia Yingmei Zhang Xueying Shi Lu Wang | 2016 | Cellular & Molecular Immunology2016，13，5： | 6 |
| 7 | A general bimetal-ion adsorption strategy to prepare nickel single atom catalysts anchored on graphene for efficient oxygen evolution reaction显示文摘Single-atom catalysts (SACs) supported on two-dimensional (2D) materials are highly attractive for maximizing their catalytic activity.However,graphene based SACs are primarily bonded with nitrogen and carbon sites,resulting in poor performance for the oxygen evolution reaction (OER).Herein,we develop a general bimetal-ion adsorption strategy for the synthesis of individually dispersed Ni SACs anchored on the oxygenated sites of ultrathin reduced graphene oxide as efficient OER electrocatalysts.The resultant Ni SACs for OER in alkaline electrolyte exhibit a highly stable overpotential of 328 mV at the current density of 10 mA cm^-2,and Tafel slope of 84 mV dec^-1 together with long-term durability and negligible degradation for 50 h,which is greatly outperform its counterparts of nitrogen bonded Ni SACs (564 mV,364 mV dec^-1) and Ni(OH)2 nanoparticles anchored on graphene (450 mV,142 mV dec^-1),and most reported Ni based OER electrocatalysts.Furthermore,the extended X-ray absorption fine structure at the Ni K-edge and theoretical simulation reveal that the nickel-oxygen coordination significantly boost OER performance.Therefore,this work will open numerous opportunities for creating novel-type 2D SACs via oxygen-metal bonding as highly robust OER catalysts. | Yingqi Xu Weifeng Zhang Yaguang Li Pengfei Lu Zhong-Shuai Wu | 2020 | Journal of Energy Chemistry2020，29，4： | 3 |
| 8 | Subcarrier Requirement Analysis for Downlink OFDMA Cellular System显示文摘In Orthogonal frequency division multiple access(OFDMA) cellular system,the user at the different location requires different number of subcarriers to satisfy the data rate requirement.We determine average subcarrier requirement for downlink OFDMA cellular system without power control based on the Interference to signal ratio(ISR).A typical downlink OFDMA cellular system model is proposed.Based on this model,we calculate the Cumulative distribution function(CDF) of ISR,and obtain the analytical expression of the average number of subcarriers required in the whole cell.Through numerical calculation and Monte-Carlo simulations,we analyze the impact of the various parameters on the average number of subcarriers required of the downlink OFDMA cellular system in random subcarrier allocation policy.And the results are compared with that in grouping subcarrier allocation and adaptive subcarrier allocation.These study results are useful in the performance evaluation,design,planning of resources and call admission control of OFDMA cellular networks like LTE. | LU Weifeng GU Mengmeng YANG Luxi | 2017 | Chinese Journal of Electronics2017，26，5： | 3 |
| 9 | Association of ABCB1 Gene Polymorphisms with Efficacy and Adverse Reaction to Risperidone or Paliperidone in Han Chinese Schizophrenic Patients显示文摘Dear editor,P-glycoprotein(P-gp,also known as ATP-binding cassette transport sub-family B member 1,ABCB1)is a potent ATP-dependent efflux pump for a wide variety of drugs.Although studies of its substrates are abundant[1,2],and ABCB1 is a well-conserved gene,there is increasing evidence that its polymorphisms affect substrate specificity[3].A previous study reported that the synonymous | Weifeng Mi Feihu Liu Yongqiao Liu Bo Du Weidong Xiao Lingzhi Li Lan Huang Tianlan Lu Jia He Le Shi Weihua Yue Hongyan Zhang | 2016 | Neuroscience Bulletin2016，32，6： | 3 |
| 10 | Evaluation of Intensive Urban Land Use Based on an Artificial Neural Network Model:A Case Study of Nanjing City,China显示文摘In this paper, the artificial neural network(ANN) model was used to evaluate the degree of intensive urban land use in Nanjing City, China. The construction and application of the ANN model took into account the comprehensive, spatial and complex nature of urban land use. Through a preliminary calculation of the degree of intensive land use of the sample area, representative sample area selection and using the back propagation neural network model to train, the intensive land use level of each evaluation unit is finally determined in the study area. Results show that the method can effectively correct the errors caused by the limitations of the model itself and the determination of the ideal value and weights when the multifactor comprehensive evaluation is used alone. The ANN model can make the evaluation results more objective and practical. The evaluation results show a tendency of decreasing land use intensity from the core urban area to the periphery and the industrial functional area has relatively low land use intensity compared with other functional areas. Based on the evaluation results, some suggestions are put forward, such as transforming the mode of urban spatial expansion, strengthening the integration and potential exploitation of the land in the urban built-up area, and strengthening the control of the construction intensity of protected areas. | QIAO Weifeng GAO Junbo LIU Yansui QIN Yueheng LU Cheng JI Qingqing | 2017 | Chinese Geographical Science2017，27，5： | 2 |
| 11 | Opposed multi-burner gasification technology:Recent process of fundamental research and industrial application显示文摘Opposed multi-burner(OMB)gasification technology is the first large-scale gasification technology developed in China with completely independent intellectual property rights.It has been widely used around the world,involving synthetic ammonia,methanol,ethylene glycol,coal liquefaction,hydrogen production and other fields.This paper summarizes the research and development process of OMB gasification technology from the perspective of the cold model experiment and process simulation,pilotscale study and industrial demonstration.The latest progress of fundamental research in nozzle atomization and dispersion,mixing enhancement of impinging flow,multiscale reaction of different carbonaceous feedstocks,spectral characteristic of impinging flame and particle characteristics inside gasifier,and comprehensive gasification model are reviewed.The latest industrial application progress of ultralarge-scale OMB gasifier and radiant syngas cooler(RSC)combined with quenching chamber OMB gasifier are introduced,and the prospects for the future technical development are proposed as well. | Fuchen Wang Guangsuo Yu Haifeng Liu Weifeng Li Qinghua Guo Jianliang Xu Yan Gong Hui Zhao Haifeng Lu Zhongjie Shen | 2021 | Chinese Journal of Chemical Engineering2021，34，7： | 2 |
| 12 | Emerging role of tumor cell plasticity in modifying therapeutic response显示文摘Resistance to cancer therapy is a major barrier to cancer management.Conventional views have proposed that acquisition of resistance may result from genetic mutations.However,accumulating evidence implicates a key role of non-mutational resistance mechanisms underlying drug tolerance,the latter of which is the focus that will be discussed here.Such non-mutational processes are largely driven by tumor cell plasticity,which renders tumor cells insusceptible to the drug-targeted pathway,thereby facilitating the tumor cell survival and growth.The concept of tumor cell plasticity highlights the significance of re-activation of developmental programs that are closely correlated with epithelial–mesenchymal transition,acquisition properties of cancer stem cells,and transdifferentiation potential during drug exposure.From observations in various cancers,this concept provides an opportunity for investigating the nature of anticancer drug resistance.Over the years,our understanding of the emerging role of phenotype switching in modifying therapeutic response has considerably increased.This expanded knowledge of tumor cell plasticity contributes to developing novel therapeutic strategies or combination therapy regimens using available anticancer drugs,which are likely to improve patient outcomes in clinical practice. | Siyuan Qin Jingwen Jiang Yi Lu Edouard CNice Canhua Huang Jian Zhang Weifeng He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 13 | A 0.19 ppm/°C bandgap reference circuit with high-PSRR显示文摘A high-order curvature-compensated CMOS bandgap reference(BGR) topology with a low temperature coefficient(TC) over a wide temperature range and a high power supply reject ratio(PSRR) is presented.High-order correction is realized by incorporating a nonlinear current INL, which is generated by ?V_(GS) across resistor into current generated by a conventional first-order current-mode BGR circuit. In order to achieve a high PSRR over a broad frequency range, a voltage pre-regulating technique is applied. The circuit was implemented in CSMC 0.5 μm 600 V BCD process. The experimental results indicate that the proposed topology achieves TC of0.19 ppm/°C over the temperature range of 165 °C(-40 to 125 °C), PSRR of-123 d B @ DC and-56 d B @ 100 k Hz. In addition, it achieves a line regulation performance of 0.017%/V in the supply range of 2.8–20 V. | Jing Leng Yangyang Lu Yunwu Zhang Huan Xu Kongsheng Hu Zhicheng Yu Weifeng Sun Jing Zhu | 2018 | Journal of Semiconductors2018，39，9： | 2 |
| 14 | Clinical relevance of angiographic coronary collaterals during primary coronary intervention for acute ST-elevation myocardial infarction显示文摘 | Shen Ying Wu Feng Pan Chunzang Zhu Tianqi Zhang Qi Zhang Ruiyan Ding Fenghua Lu Lin Hu Jian Yang Zhenkun Shen Weifeng Wu Zonggui | 2014 | Chinese Medical Journal2014，，1： | 2 |
| 15 | Kinetic Study of Formic Acid Oxidation on Highly DispersedCarbon Supported Pd-TiO2 Electrocatalyst显示文摘 | Weifeng Xu Ying Gao Tianhong Lu et a/ | 2009 | Catal Lett2009，130，： | 1 |
| 16 | A 3D Ba-MOF for selective adsorption of CO_(2)/CH_(4)and CO_(2)/N_(2)显示文摘An unexpected in-situ hydrolysis reaction occurred during the solvothermal reaction of N,N’-bis(4-carboxy-2-methylphenyl)pyromellitic di-imide)and Ba(NO3)2,and a novel porous Ba-MOF,[H_(2)N(CH_(3))_(2)]_(0.5)[Ba_(1.5)(L)(DMA)]·1.5 DMA·1.5 H_(2)O(UPC-70,H_(3)L=2-(4-ca rboxy-2-methylphenyl)-1,3-dioxoisoindoline-5,6-dicarboxylic acid,DMA=N,N-dimethylacetamide),was obtained on the basis of the partial hydrolysate.The as-synthesized 3 D network with 1 D open channels of different sizes(24 A and 10 A)contains abundant open metal sites after removal of solvents,which is conducive to the preferential adsorption of CO_(2).The subsequent gas sorption measurement reveals the high separation selectivity of UPC-70 for CO_(2)/CH_(4)(15)and CO_(2)/N_(2)(32)at ambient conditions,and GCMC theoretical simulation provides good verification of the experimental results,indicating that UPC-70 is a potential candidate for CO_(2)capture from flue gas and natural gas. | Xiaokang Wang Yutong Wang Kebin Lu Weifeng Jiang Fangna Dai | 2021 | Chinese Chemical Letters2021，32，3： | 1 |
| 17 | Polymorphisms of β-adrenoceptor and Natriuretic Peptide Receptor Genes Influence the Susceptibility to and the Severity of Idiopathic Dilated Cardiomyopathy in a Chinese Cohort显示文摘 | Lingjie Wang Lin Lu Fengru Zhang Qiujing Chen Weifeng Shen | 2010 | Journal of Cardiac Failure2010，，1： | 1 |
| 18 | Synergistic antitumor efficacy by combining adriamycin with recombinanthuman endostatin in an osteosarcoma model显示文摘 | Hairong Xu Xiaohui Niu Qing Zhang Lin Hao Yi Ding Weifeng Liu Lu Yao | 2011 | Oncology Letters2011，，5： | 1 |
| 19 | Autofluorescence imaging endoscopy for predicting acid reflux in patients with gastroesophageal reflux disease显示文摘 | Weifeng Wang Noriya Uedo Yunsheng Yang Lihua Peng Diane Bai Zhongsheng Lu Kaichun Fan Juan Wang Xiaoxiao Wang Yunlong Zhao Zhiping Yu | 2014 | J Gastroenterol Hepatol2014，，7： | 1 |
| 20 | Bubble Formation in an Annular Granular Jet Dispersed by a Central Air Round Jet显示文摘 | Lu Hui Liu Haifeng Li Weifeng | 2013 | AIChEJ2013，59，6： | 1 |
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