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| 1 | Roles of miR319-regulated TCPs in plant development and response to abiotic stress显示文摘Elaborate regulation of gene expression is required for plants to maintain normal growth,development,and reproduction.MicroRNAs(miRNAs)and transcription factors are key players that control gene expression in plant regulatory networks.The TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR(TCP)family comprises plantspecific transcription factors that contain a conserved TCP domain of 59 amino acids.Some members of this family are targeted by miR319,one of the most ancient and evolutionarily conserved miRNAs in plants.Accumulating evidence has revealed that miR319-regulated TCP(MRTCP)genes participate extensively in plant development and responses to environmental stress.In this review,the structural characteristics and classifications of TCP transcription factors and the regulatory relationships between TCP transcription factors and miRNAs are introduced.Current knowledge of the regulatory functions of MRTCP genes in multiple biological pathways including leaf development,vascular formation,flowering,hormone signaling,and response to environmental stresses such as cold,salt,and drought is summarized.This review will be beneficial for understanding the roles of the MRTCP-mediated regulatory network and its molecular mechanisms in plant development and stress response,and provides a theoretical basis for plant genetic improvement. | Yujie Fang Yuqian Zheng Wei Lu Jian Li Yujing Duan Shuai Zhang Youping Wang | 2021 | The Crop Journal2021，9，1： | 4 |
| 2 | Automatic segmentation of foveal avascular zone based on adaptive watershed algorithm in retinal optical coherence tomography angiography images显示文摘The size and shape of the foveal avascular zone(FAZ)have a strong positive correlation with several vision-threatening ret inovascular diseases.The identification,segmentation and analysis of FAZ are of great significance to clinical diagnosis and treatment.We presented an adaptive watershed algorithm to automatically extract F AZ from retinal optical coherence tomography angiography(OCTA)images.For the traditional watershed algorithm,'over-segmentation'is the most common problem.FAZ is often incorrectly divided into multiple regions by redundant'dams'.This paper analyzed the relationship between the'dams'length and the maximum inscribed circle radius of FAZ,and proposed an adaptive watershed algorithm to solve the problem of'over-segmentation'.Here,132 healthy retinal images and 50 diabetic retinopathy(DR)images were used to verify the accuracy and stability of the algorithm.Three ophthal-mologists were invited to make quan titative and qualitative evaluations on the segmentation results of this algorithm.The quantitative evaluation results show that the correlation coffi-cients between the automatic and manual segmentation results are 0.945(in healthy subjects)and 0.927(in DR patients),respectively.For qualitative evaluation,the percentages of'perfect segmentation'(score of 3)and'good segmentation'(score of 2)are 99.4%(in healthy subjects)and 98.7%(in DR patients),respectively.This work promotes the application of watershed algorithm in FAZ segmentation,making it a useful tool for analyzing and diagnosing eye diseases. | Jian Liu Shixin Yan Nan Lu Dongni Yang Chunhui Fan Hongyu Lv Shuanglian Wang in Zhu Yuqian Zhao Yi Wang Zhenhe Ma Yao Yu | 2022 | Journal of Innovative Optical Health Sciences2022，15，1： | 3 |
| 3 | On Mineralize-halo-forming Mechanism of Sareke Glutenite-type Copper Deposit in Xinjiang显示文摘1 Introduction Sareke glutenite-type copper deposit is located in the Sarekebayi basin,a sub-basin of southwest margin of the Tuoyun Mesozoic hinterland basin in the northwestern part of the Tarim Basin.The Tuoyun Mesozoic | YU Wangjie FANG Weixuan Guo Yuqian Wang Lei Li Tiancheng Lu Jia | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 3 |
| 4 | Porous nitrogen-enriched hollow carbon nanofibers as freestanding electrode for enhanced lithium storage显示文摘Onedimensional porous carbons bearing high surface areas and sufficient heteroatom doped functionalities are essential for advanced electrochemical energy storage devices,especially for developing freestanding film electrodes.Here we develop a porous,nitrogenenriched,freestanding hollow carbon nanofiber(PNFHCF)electrode material via filtration of polypyrrole(PPy)hollow nanofibers formed by in situ selfdegraded templateassisted strategy,followed by NH3assisted carbonization.The PNFHCF retains the freestanding film morphology that is composed of threedimensional networks from the entanglement of 1D nanofiber and delivers 3.7fold increase in specific surface area(592 m^(2)g^(-1))compared to the carbon without NH_(3)treatment(FHCF).In spite of the enhanced specific surface area,PNFHCF still exhibits comparable high content of surface N functionalities(8.8%,atom fraction)to FHCF.Such developed hierarchical porous structure without sacrificing N doping functionalities together enables the achievement of high capacity,highrate property and good cycling stability when applied as selfsupporting anode in lithiumion batteries,superior to those of FHCF without NH3 treatment. | Xiaosa Xu Yuqian Qiu Jianping Wu Baichuan Ding Qianhui Liu Guangshen Jiang Qiongqiong Lu Jiangan Wang Fei Xu Hongqiang Wang | 2021 | Chinese Journal of Chemical Engineering2021，34，4： | 3 |
| 5 | Relationship between time in range and corneal nerve fiber loss in asymptomatic patients with type 2 diabetes显示文摘Background: Corneal confocal microscopy (CCM) is a noninvasive technique to detect early nerve damage of diabetic sensorimotor polyneuropathy (DSPN). Time in range (TIR) is an emerging metric of glycemic control which was reported to be associated with diabetic complications. We sought to explore the relationship between TIR and corneal nerve parameters in asymptomatic patients with type 2 diabetes (T2DM).Methods: In this cross-sectional study, 206 asymptomatic inpatients with T2DM were recruited. After 7 days of continuous glucose monitoring, the TIR was calculated as the percentage of time in the glucose range of 3.9 to 10.0 mmol/L. CCM was performed to determine corneal nerve fiber density, corneal nerve branch density, and corneal nerve fiber length (CNFL). Abnormal CNFL was defined as ≤15.30 mm/mm2.Results: Abnormal CNFL was found in 30.6% (63/206) of asymptomatic subjects. Linear regression analyses revealed that TIR was positively correlated with CCM parameters both in the crude and adjusted models (all P< 0.05). Each 10% increase in TIR was associated with a 28.2% (95% CI: 0.595–0.866,P = 0.001) decreased risk of abnormal CNFL after adjusting for covariates. With the increase of TIR quartiles, corneal nerve fiber parameters increased significantly (allP for trend <0.01). The receiver operating characteristic curve indicated that the optimal cutoff point of TIR was 77.5% for predicting abnormal CNFL in asymptomatic patients.Conclusions: There is a significant independent correlation between TIR and corneal nerve fiber loss in asymptomatic T2DM patients. TIR may be a useful surrogate marker for early diagnosis of DSPN. | Wejing Zhao Jingyi Lu Lei Zhang Wei Lu Wei Zhu Yuqian Bao Jjian Zhou | 2022 | Chinese Medical Journal2022，135，16： | 2 |
| 6 | Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer显示文摘Oxaliplatin is widely used in the frontline treatment of colorectal cancer(CRC),but an estimated 50%of patients will eventually stop responding to treatment due to acquired resistance.This study revealed that diminished MEIS1 expression was detected in CRC and harmed the survival of CRC patients.MEIS1 impaired CRC cell viabilities and tumor growth in mice and enhanced CRC cell sensitivity to oxaliplatin by preventing DNA damage repair.Mechanistically,oxaliplatin resistance following MEIS1 suppression was critically dependent on enhanced FEN1 expression.Subsequently,we confirmed that EZH2-DNMT3a was assisted by lncRNA ELFN1-AS1 in locating the promoter of MEIS1 to suppress MEIS1 transcription epigenetically.Based on the above,therapeutics targeting the role of MEIS1 in oxaliplatin resistance were developed and our results suggested that the combination of oxaliplatin with either ELFN1-AS1 ASO or EZH2 inhibitor GSK126 could largely suppress tumor growth and reverse oxaliplatin resistance.This study highlights the potential of therapeutics targeting ELFN1-AS1 and EZH2 in cell survival and oxaliplatin resistance,based on their controlling of MEIS1 expression,which deserve further verification as a prospective therapeutic strategy. | Yimin Li Yaqi Gan Jiaxin Liu Juanni Li Zhengwei Zhou Ruotong Tian Ruizheng Sun Jiaqi Liu Qing Xiao Yuanyuan Li Pengyan Lu Yulong Peng Yuqian Peng Guang Shu Gang Yin | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 7 | Humans Are Not Machines—Anthropocentric Human–Machine Symbiosis for Ultra-Flexible Smart Manufacturing显示文摘1.Introduction The real question is not whether machines think but whether men do.Burrhus Frederic Skineer Dedicated manufacturing systems are fading out as future manufacturing(i.e.,Industry 4.0[1])demands ultra-flexible smart manufacturing systems that can self-adapt to production process changes resulting from the varied batch sizes of personalized products[2–4].The manufacturing shop-floor can become an unstructured environment where manufacturing systems and processes change their configurations dynamically via adaptive near-real-time decision-making.One emerging trend to make manufacturing flexible and reconfigurable is to introduce collaborative machines that work alongside humans with high productivity[5-7]. | Yuqian Lu Juvenal Sastre Adrados Saahil Shivneel Chand Lihui Wang | 2021 | Engineering2021，7，6： | 2 |
| 8 | Chemotherapy of cerebral gliomas directed by the chemosensitivity test in vitro: a clinical study显示文摘Objective: To evaluate correlation between chemosensitivity of tumor cells in vitro and their clinical responsive- ness in vivo by comparing the difference of curative effect between chemotherapy of cerebral gliomas directed by chemo- sensitivity test in vitro and its routine chemotherapy. Methods: Sixty-two patients with cerebral gliomas were recruited as the experiment group, who had received total resection or subtotal resection of the tumor. The resected tumor cells were cultured in vitro, followed by chemosensitivity test using colorimetric MTT assay. Finally, chemotherapeutic protocol was made based on the results of the chemosensitivity test. Fifty patients with cerebral gliomas subjected to the routine chemotherapeutic protocol were simultaneously recruited as the control group, whose age, gender, survival functional status and operational fashion were matched with the experiment group. The two groups were equally followed up for the survival functional status, recurrence and death. All data were analyzed using SPSS 10.0 software. Results: At the time of evaluation, KPS values of 64.52 ± 35.84 were seen in the experiment group, and 33.60 ± 36.24 in the control group, showing statistical difference between the two groups (t = 4.5163, P = 0.000). During 2–4 years of follow up, a recurrence rate of 32.26% was seen in the experimental group, and 60.00% in the control group, showing a statistical difference between the two groups (χ2 = 8.620, P = 0.003). The fatality was 22.58% in the experiment group, and 48.00% in the control group, showing a statistical difference between the two groups (χ2 = 7.978, P = 0.005). The survival rate of the experimental group was higher than that of the control group, showing a statistical differences between the two groups (χ2 = 7.29, P = 0.0069). Conclusion: Chemotherapy of glio- mas under the guidance of chemosensitivity test in vitro contributes to obvious improvement on the current survival functional status, a clear decline of the recurrence rates and fatality rate, and raised survival rates of the patients. A close correlation between the chemosensitivity in vitro and clinical responsiveness in vivo is observed. | Chaochun Yu Fanmin Zhou Yuqian Wang Ping Zhong Guanfu Jiang Aichi Miao Hao Lu | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，3： | 2 |
| 9 | Optimisation for subcritical fluid extraction of 17-methyltestosterone with 1,1,1,2-tetrafluoroethane for HPLC analysis显示文摘 | Yuqian Han Qinchuan Ma Jie Lu Yong Xue Changhu Xue | 2012 | Food Chemistry2012，，4： | 1 |
| 10 | Diethylstilbestrol in Fish Tissue Determined Through Subcritical Fluid Extraction and with GC-MS显示文摘As the key point in sex hormone analysis, sample pre-treatment technology has attracted scientists' attention all over the world, and the development trend of sample preparation forwarded to faster and more efficient technologies. Taking economic and environmental concerns into account, subcritical fluid extraction as a faster and more efficient method has stood out as a sample pre-treatment technology. This new extraction technology can overcome the shortcomings of supercritical fluid and achieve higher extraction efficiency at relatively low pressures and temperatures. In this experiment, a simple, sensitive and efficient method has been developed for the determination of diethylstilbestrol(DES) in fish tissue using subcritical 1,1,1,2-tetrafluoroethane(R134a) extraction in combination with gas chromatography-mass spectrometry(GC-MS). After extraction, freezing-lipid filtration was utilized to remove fatty co-extract. Further purification steps were performed with C_(18) and NH_2 solid phase extraction(SPE). Finally, the analyte was derived by heptafluorobutyric anhydride(HFBA), followed by GC-MS analysis. Response surface methodology(RSM) was employed to optimizing the extraction condition, and the optimized was as follows: extraction pressure, 4.3 MPa; extraction temperature, 26℃; amount of co-solvent volume, 4.7 m L. Under this condition, at a spiked level of 1, 5, 10 μg kg^(-1), the mean recovery of DES was more than 90% with relative standard deviations(RSDs) less than 10%. Finally, the developed method has been successfully used to analyzing the real samples. | QIAO Qinghui SHI Nianrong FENG Xiaomei LU Jie HAN Yuqian XUE Changhu | 2016 | Journal of Ocean University of China2016，15，3： | 1 |
| 11 | Research on Comprehensive Control of Power Quality of Port Distribution Network Considering Large-Scale Access of Shore Power Load显示文摘In view of the problem of power quality degradation of port distribution network after the large-scale application of shore power load,a method of power quality management of port distribution network is proposed.Based on the objective function of the best power quality management effect and the smallest investment cost of the management device,the optimization model of power quality management in the distribution network after the large-scale application of large-capacity shore power is constructed.Based on the balance between the economic demand of distribution network resources optimization and power quality management capability,the power quality of distribution network is considered comprehensively.The proposed optimization algorithm for power quality management based on Matlab and OpenDSS is proposed and analyzed for port distribution networks.The simulation results show that the proposed optimizationmethod can maximize the power qualitymanagement capability of the port distribution network,and the proposed optimization algorithm has good convergence and global optimization finding capability. | Yuqian Qi Mingshui Li Yu Lu Baitong Li | 2023 | Energy Engineering2023，120，5： | 1 |
| 12 | Sampled-Data H_(∞)Dynamic Output Feedback Controller Design for Fuzzy Markovian Jump Systems显示文摘This paper considers the issue of H_(∞)dynamic output feedback controller design for T-S fuzzy Markovian jump systems under time-varying sampling with known upper bound on the sampling intervals.The main aim is to realize sampled-data fuzzy dynamic output feedback control so as to demonstrate the stochastic stability and H_(∞)performance index of the closed-loop sampled-data fuzzy Markovian jump systems.Then,by making the most of the information within the sampling interval,a suitable closed-loop function is constructed and the integral terms are handled by using free weighted matrix method and improved integral inequality technique.Numerical example and single-link robot arm are presented to show the effectiveness of the developed method. | LIN Yuqian ZHUANG Guangming XIA Jianwei CHEN Guoliang LU Junwei | 2023 | Journal of Systems Science & Complexity2023，36，1： | 1 |
| 13 | A single-cell transcriptome atlas of the aging human and macaque retina显示文摘The human retina is a complex neural tissue that detects light and sends visual information to the brain.However,the molecular and cellular processes that underlie aging primate retina remain unclear.Here,we provide a comprehensive transcriptomic atlas based on 119520 single cells of the foveal and peripheral retina of humans and macaques covering different ages.The molecular features of retinal cells differed between the two species,suggesting distinct regional and species specializations of the human and macaque retinae.In addition,human retinal aging occurred in a region-and cell-type-specific manner.Aging of human retina exhibited a foveal to peripheral gradient.MYO9A-rods and a horizontal cell subtype were greatly reduced in aging retina,indicating their vulnerability to aging.Moreover,we generated a dataset showing the cell-type-and region-specific gene expression associated with 55 types of human retinal disease,which provides a foundation to understanding of the molecular and cellular mechanisms underlying human retinal diseases.Such datasets are valuable to understanding of the molecular characteristics of primate retina,as well as molecular regulation of aging progression and related diseases. | Wenyang Yi Yufeng Lu Suijuan Zhong Mei Zhang Le Sun Hao Dong Mengdi Wang Min Wei Haohuan Xie Hongqiang Qu Rongmei Peng Jing Hong Ziqin Yao Yunyun Tong Wei Wang Qiang Ma Zeyuan Liu Yuqian Ma Shouzhen Li Chonghai Yin Jianwei Liu Chao Ma Xiaoqun Wang Qian Wu Tian Xue | 2021 | National Science Review2021，8，4： | 1 |
| 14 | Computer-integrated manufacturing, cyber-physical systems and cloud manufacturing- concepts and relationships显示文摘 | YU Chunyang XU Xun LU Yuqian | 2015 | Manufacturing Letters2015，6，： | 1 |
| 15 | Heavy metal pollution risk of desulfurized steel slag as a soil amendment in cycling use of solid wastes显示文摘The by-product of wet flue gas desulfurization,desulfurized steel slag(DS),had chemical characteristics like natural gypsum that can be used to improve saline-sodic soil.However,contamination risk of heavy metals for cycling utilization of DS in agriculturewas concerned mostly.Both pot and field experiments were conducted for evaluating the potential pollution risk of DS as the amendment of saline-sodic soil.Results showed that application of DS decreased the contents of Cd,Cu,Zn,and Pb,while significantly increasing chromium(Cr)content in DS-amended soils.The field experiment demonstrated that the migration of heavy metals(Cd,Zn,Cu,and Pb)in the soil profile was negligible.The application of DS at the dosage of 22.5–225 tons/ha significantly increased the Cr content in alfalfa(Medicago sativa L.)but lower than the national standard for feed in China(GB 13078-2017).DS altered the chemical fraction of heavy metals(Zn,Cu,and Pb),transferred exchangeable,reducible into oxidizable and residual forms in DS-amended soil.Application of DS combined with fulvic acid(FA)could effectively reduce the movement of heavy metals in soil and the accumulation of Cr in alfalfa.Based on our results,DS was a safe and feasible material for agricultural use and presented relatively little pollution risk of heavy metals.However,the results also showed that DS to a certain extent had a potential environmental risk of Cr if larger dosages of DS were used. | Fanyi Kong Yuqian Ying Shenggao Lu | 2023 | Journal of Environmental Sciences2023，，5： | 1 |
| 16 | Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial显示文摘Lifestyle interventions,including dietary adjustments and exercise,are important for obesity management.This study enrolled adults with overweight or obesity to explore whether either low-carbohydrate diet(LCD)or exercise is more effective in metabolism improvement.Forty-five eligible subjects were randomly divided into an LCD group(n=22)and an exercise group(EX,n=23).The subjects either adopted LCD(carbohydrate intake<50 g/day)or performed moderate-to-vigorous exercise(≥30 min/day)for 3 weeks.After the interventions,LCD led to a larger weight loss than EX(−3.56±0.37 kg vs.−1.24±0.39 kg,P<0.001),as well as a larger reduction in fat mass(−2.10±0.18 kg vs.−1.25±0.24 kg,P=0.007)and waist circumference(−5.25±0.52 cm vs.−3.45±0.38 cm,P=0.008).Both interventions reduced visceral and subcutaneous fat and improved liver steatosis and insulin resistance.Triglycerides decreased in both two groups,whereas low-density lipoprotein cholesterol increased in the LCD group but decreased in the EX group.Various glycemic parameters,including serum glycated albumin,mean sensor glucose,coefficient of variability(CV),and largest amplitude of glycemic excursions,substantially declined in the LCD group.Only CV slightly decreased after exercise.This pilot study suggested that the effects of LCD and exercise are similar in alleviating liver steatosis and insulin resistance.Compared with exercise,LCD might be more efficient for weight loss and glucose homeostasis in people with obesity. | Lingli Cai Jun Yin Xiaojing Ma Yifei Mo Cheng Li Wei Lu Yuqian Bao Jian Zhou Weiping Jia | 2021 | Frontiers of Medicine2021，15，3： | 1 |
| 17 | Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated with deteriorating glucose regulation显示文摘Most information used to evaluate diabetic statuses is collected at a special time-point,such as taking fasting plasma glucose test and providing a limited view of individual’s health and disease risk.As a new parameter for continuously evaluating personal clinical statuses,the newly developed technique“continuous glucose monitoring”(CGM)can characterize glucose dynamics.By calculating the complexity of glucose time series index(CGI)with refined composite multi-scale entropy analysis of the CGM data,the study showed for the first time that the complexity of glucose time series in subjects decreased gradually from normal glucose tolerance to impaired glucose regulation and then to type 2 diabetes(P for trend<0.01).Furthermore,CGI was significantly associated with various parameters such as insulin sensitivity/secretion(all P<0.01),and multiple linear stepwise regression showed that the disposition index,which reflectsβ-cell function after adjusting for insulin sensitivity,was the only independent factor correlated with CGI(P<0.01).Our findings indicate that the CGI derived from the CGM data may serve as a novel marker to evaluate glucose homeostasis. | Cheng Li Xiaojing Ma Jingyi Lu Rui Tao Xia Yu Yifei Mo Wei Lu Yuqian Bao Jian Zhou Weiping Jia | 2023 | Frontiers of Medicine2023，17，1： | 0 |
| 18 | Mineral Geochemical Characteristics and Indication Significance of Biotite-Rutile in the Gabbro Intrusions in the Yinmin Iron-Copper District, Yunnan显示文摘1 Introduction After the Dongchuan Orogenic movement(Hudsonian Orogeny,ca.1800 Ma±),the tectonic basement layer of the continental crust on the Yangtze massif could have been formed.And then tectonic-magmatic | SUN Zijian FANG Weixuan Lu Jia GUO Yuqian SONG Lihong | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 0 |
| 19 | Transcript profile of CLSTN3B gene in human white adipose tissue is associated with obesity and mitochondrial gene program显示文摘Dear Editor,Obesity is a major health issue with global prevalence and increases the risk of many metabolic diseases.Of particular con-cern is the increasing incidence of type 2 diabetes,the primary causes of which are obesity-driven insulin resistance in white adipose tissue(WAT),skeletal muscle,and liver,and decreased insulin secretion by pancreaticβ-cells[1]. | Ningning Bai Xuhong Lu Yansu Wang Xiaoya Li Rong Zhang Haoyong Yu Cheng Hu Xiaojing Ma Yuqian Bao Ying Yang | 2023 | Life Metabolism2023，2，6： | 0 |
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