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| 1 | Percutaneous coronary intervention for chronic total occlusion in 1263 patients:a single-center report显示文摘背景冠的长期的全部的吸藏(CTO ) 在 interventional 心病学仍然是最挑战性的损害子集之一,甚至与医药设备和操作符专家知识的开发。这研究被进行检验在损害特征和程序的成功和在里面医院的发生之间的关系在为在沈阳经历了在1995年6月和2005年12月之间的一种总线标准的有 CTO 的 1263 个病人的 CTO.Methods 临床、冠的 angiographic 数据的经皮的冠的干预(一种总线标准)以后的主要不利心脏的事件(向) PLA 的医院将军是回顾地在那里的 analyzed.Results 是与吝啬的吸藏 tim 位于 1596 个容器的 1625 CTO 损害1647 冠的 stents 的一个总数被植入到目标损害。全面病人和损害成功率分别地是 90.8 %(1147/1263 ) 和 88.9 %(1445/1625 ) 。一种总线标准的成功率与吸藏的长持续时间被拒绝,突然的错过树桩,衔接担保在堵塞长度的 15 公里,对严重石灰化或扭曲和 ostial 或 CTO 损害(P 0.05 ) 的远侧的地点中等。程序的失败发生在 116 个病人,由指南电线(81.0%) 或汽球(19.0%) 的不可能引起了通过 occlusion.There 不在过程期间是死亡,但是 2 个病人患了尖锐 stent 血栓,另外的 9 个病人有尖锐或迟了的心囊的穿孔。那些复杂并发症都成功地被对待。在过程以后, 3patients 死了,因为稍尖的 stent 血栓和 1underwent, 4 经历了迫切目标容器 revascularization 冠在在里面医院期间由于冠的管绕过接枝外科时期。全面在里面医院向率是 0.6%(8/1263 ) 。没有在里面医院 MACE.Conclusions, Drug-eluting stents 在一个富有经验的心中心在 198 个病人被使用,与冠的 CTO 损害为病人获得一种总线标准和有利临床的结果的相对高的成功率是可能的。 | HAN Ya-ling WANG Shou-li JING Quan-min LI Yi ZHANG Jian MA Ying-yan LUAN Bo | 2006 | Chinese Medical Journal2006，，14： | 18 |
| 2 | FERONIA Receptor Kinase Controls Seed Size in Arabidopsis thaliana显示文摘Dear Editor, Plants have evolved elaborate mechanisms by which cell elongation regulation is coupled to the environmental signals.The plasma membrane receptor kinase FERONIA (FER) has emerged as an important regulatory node in controlling cell elongation and hormone crosstalk (Guo et al.,2009;Deslauriers and Larsen,2010;Duan et al.,2010;Yu et al.,2012).Initially reported to inhibit pollen tube elongation during fertilization (Escobar-Restrepo et al.,2007),FER has been since found to promote cell elongation in leaves and root hairs (Guo et al.,2009;Duan et al.,2010). | Feng Yu Jian Li Yuan Huang Li Liu Dongping Li Liangbi Chen Sheng Luan | 2014 | Molecular Plant2014，7，5： | 16 |
| 3 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 4 | Magnesium transporter AtMGT9 is essential for pollen development in Arabidopsis显示文摘镁(Mg2+) 充满工厂房间并且在许多生理的过程起一个关键作用。A 10 成员基因家庭 AtMGT (也作为 AtMRS2 知道) 在 Arabidopsis 被识别,它属于 CorA 总科的一个优核质子集,作为 Mg2+ transporters 工作。一些家庭成员(AtMGT1 和 AtMGT10 ) 作为高亲密关系的 Mg2+ transporter 工作并且能补充缺乏 Mg2+ 运输能力的细菌的异种或酵母异种。这里,我们报导一个 AtMGT 家庭成员, AtMGT9,作为低亲密关系的 Mg2+ transporter 工作,并且为花粉开发是必要的。在沙门氏菌变异的紧张 MM281 的功能的互补试金证明 AtMGT9 能够调停在 Mg2+ 的 sub-millimolar 范围的 Mg2+ 举起。AtMGT9 基因在成熟花药最强烈被表示并且在叶子的脉管的纸巾,并且在年轻的根也是可检测的。AtMGT9 基因表示的混乱在异质接合的变异的 +/mgt9 导致了成熟花粉谷物的一半的流产,并且没有同型结合的变异的植物在 selfed +/mgt9 植物的子孙被获得。在这些异质接合的植物表示 AtMGT9 的转基因的植物能恢复花粉显型到野类型。另外, AtMGT9 RNAi 转基因的植物也显示出类似的未成功的花粉显型到变异的 +/mgt9。一起,我们的结果证明 AtMGT9 作为在男配偶体开发和男富饶起一个关键作用的低亲密关系的 Mg2+ transporter 工作。 | Jian Chen Le-gong Li Zhen-hua Liu Yu-ju Yuan Li-lin Guo Dan-dan Mao Lian-fu Tian Liang-bi Chen Sheng Luan Dong-ping Li | 2009 | Cell Research2009，19，7： | 10 |
| 5 | Long-term outcomes of drug-eluting versus bare-metal stent implantation in patients with chronic total coronary artery occlusions显示文摘在那里的背景为长期的全部的吸藏(CTO ) 的治疗是 drug-eluting stents (DES ) 的功效上的有限数据。学习的目的是与赤裸金属的 stent ( BMS )相比为 CTO 评估 DES 培植的长期的临床的结果在1995年6月和2006年12月之间的 implantation.Methods ,有至少一 de novo CTO 损害的成功的开运河的 1184 个病人的一个总数连续地被登记,包括 660 (55.7%)经历了 DES 并且 524 (44.3%)经历了 BMS 培植。所有病人被跟随在上面为为主要不利心脏的事件(向) 的出现的多达 5 年。长期的幸存率与临床的 Kaplan-Meier method.Results 基线被估计,除了在 DES 组的病人收到了更长双的 antiplatelet 治疗之外, angiographic 特征在二个组之间是可比较的((7.4 ??????????????? 陈 ? 陈吗?? | HAN Ya-ling ZHANG Jian LI Yi WANG Shou-li JING Quan-min YI Xian-hua MA Ying-yan LUAN Bo WANG Geng WANG Bin | 2009 | Chinese Medical Journal2009，，6： | 9 |
| 6 | Treatment of drug-resistant epilepsy with vagus nerve stimulation m review of 45 cases显示文摘背景迷走神经神经刺激( VNS )是为 .The 学习试图探索预后的潜在的因素的药抵抗的癫痫( DRE )的其他的治疗,在有 DRE.Methods 的病人的 VNS 治疗的安全和效果我们回顾地检验了从2004年6月在我们的中心接受了 VNS 治疗到2010年6月并且分析了参数的 DRE 的 45 个盒子(耐心的收到的年龄 VNS ,在 VNS 以及治疗持续时间前后的抓住频率)由学生的 t 测试,菲希尔是准确的并且 | BAO Min ZHOU Jian LUAN Guo-ming | 2011 | Chinese Medical Journal2011，，24： | 9 |
| 7 | AtMGT7:An Arabidopsis Gene Encoding a Low-Affinity Magnesium Transporter显示文摘Magnesium(Mg2+) is one of the essential cations in all cells. Although the Mg2+ transport mechanism has been welldocumented in bacteria,less is known about Mg2+ transporters in eukaryotes. The AtMGT gene family encoding putative magnesium transport proteins had been described previously. We report here that one of the Arabidopsis MGT family members,the AtMGT7 gene,encodes two mRNAs that have resulted from alternative splicing variants,designated AtMGT7a and AtMGT7b. Interestingly,the two mRNA variants were expressed with different patterns with AtMGT7a expressing in all organs,but AtMGT7b appearing only in root and flowers. The AtMGT7a variant functionally complemented a bacterial mutant lacking Mg2+ transport capacity,whereas AtMGT7b did not. The 63Ni2+ tracer uptake analysis in the bacterial model showed that AtMGT7a mediated low-affinity transport of Mg2+. Consistent with the complementation assay result,63Ni2+ tracer uptake analysis revealed that AtMGT7b did not transport Mg2+. This study therefore has identified from a higher plant the first low-affinity Mg2+ transporter encoded by a gene with alternatively spliced transcripts that produce proteins with distinct functions. | Dan-Dan Mao Lian-Fu Tian Le-Gong Li Jian Chen Pei-Yi Deng Dong-Ping Li Sheng Luan | 2008 | Journal of Integrative Plant Biology2008，50，12： | 8 |
| 8 | In vitro and in vivo investigation of bacterial cellulose dressing containing uniform silver sulfadiazine nanoparticles for burn wound healing显示文摘Silver sulfadiazine(SSD) particles in homogeneous dispersion state were prepared by an ultrasonic method and then nano- and microparticles were separated using centrifugation. SSD particles with narrow size distribution were impregnated with bacterial cellulose(BC) to produce BC–SSD composite membrane used as burn wound dressing. A scanning electron microscope(SEM) was used to examine the surface morphology of BC–SSD membranes. The incorporation of SSD in BC–SSD was confirmed by X-ray diffraction(XRD). Antimicrobial tests in vitro indicated that BC–SSD showed excellent antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. The effects of BC–SSD on burn wound healing were assessed by rat models. The comparative study confirmed that the wound treated with BC–SSD showed high healing rate. The bacteria count in BC–SSD group was far less than control group. Histological analysis showed that epithelialization progressed better in wound treated with BC–SSD. These values demonstrated that the BC–SSD composite membrane could be a promising wound dressing for burn. | Xiaoxiao Wen Yudong Zheng Jian Wu Lina Yue Cai Wang Jiabin Luan Zhigu Wu Kaisheng Wang | 2015 | Progress in Natural Science:Materials International2015，25，3： | 6 |
| 9 | Biofilm-inspired adhesive and antibacterial hydrogel with tough tissue integration performance for sealing hemostasis and wound healing显示文摘Uncontrolled bleeding and infection can cause significant increases in mortalities.Hydrogel sealants have attracted extensive attention for their ability to control bleeding.However,because interfacial water is a formidable barrier to strong surface bonding,a challenge remains in finding a product that offers robust tissue adhesion combined with anti-infection properties.Inspired by the strong adhesive mechanism of biofilm and mussels,we report a novel dual bionic adhesive hydrogel(DBAH)based on chitosan grafted with methacrylate(CS-MA),dopamine(DA),and N-hydroxymethyl acrylamide(NMA)via a facile radical polymerization process.CS-MA and DA were simultaneously included in the adhesive polymer for imitating the two key adhesive components:polysaccharide intercellular adhesin(PIA)of staphylococci biofilm and 3,4-dihydroxy-L-phenylalanine(Dopa)of mussel foot protein,respectively.DBAH presented strong adhesion at 34 kPa even upon three cycles of full immersion in water and was able to withstand up to 168 mm Hg blood pressure,which is significantly higher than the 60–160 mm Hg measured in most clinical settings.Most importantly,these hydrogels presented outstanding hemostatic capability under wet and dynamic in vivo movements while displaying excellent antibacterial properties and biocompatibility.Therefore,DBAH represents a promising class of biomaterials for high-efficiency hemostasis and wound healing. | Wei Han Bo Zhou Kai Yang Xin Xiong Shifang Luan Yu Wang Zheng Xu Peng Lei Zhengshan Luo Jian Gao Yijing Zhan Guopu Chen Lei Liang Rui Wang Sha Li Hong Xu | 2020 | Bioactive Materials2020，5，4： | 6 |
| 10 | Literature-based analysis on relationship of symptoms,drugs and therapies in treatment of intestinal diseases显示文摘OBJECTIVE:To evaluate clinical articles published in the past 30 years using the Traditional Chinese Medicine(TCM)theory of the lung being connected with large intestine to treat intestinal diseases.We also analyzed the relationship between symptoms,drugs and therapies with data-excavating technology to aid management.METHODS:After retrieving relevant clinical articles,we set up a database,used Microsoft Structured Query Language Server 2005 Analysis Services as a data-excavating tool,and applied the association rule to study the relationship between the symptoms,drugs and therapies of intestinal diseases.RESULTS:The key symptoms of dyschesia,constipation,abdominal fullness,fatigue and pale tongue could be treated with Kuxingren(Semen Armeniacae Amarum),Huangqi(Radix Astragali Mongolici)and Gualou(Fructus et Semen Trichosanthis)to invigorate Qi and moisten the intestine.Among these agents,Kuxingren(Semen Armeniacae Amarum)was used most frequently.Clearing Fu-organs was the most prevalent therapy for abdominal fullness,dyschesia,constipation and red tongue.Clearing Fu-organs could be achieved with Kuxingren(Semen Armeniacae Amarum)and Gualou(Fructus et Semen Trichosanthis),whereas Qi could be invigorated using Huangqi(Radix Astragali Mongolici),Gancao(Radix Glycyrrhizae),Baizhu(Rhizoma Atractylodis Macrocephalae)and Kuxingren(Semen Armeniacae Amarum).Moistening the intestine was possible with Kuxingren(SemenArmeniacae Amarum),Huomaren(Fructus Cannabis)and Jiegeng(Radix Platycodi).Also,moistening the lungs was done with Kuxingren(Semen Armeniacae Amarum),ventilating the lungs with Kuxingren(Semen Armeniacae Amarum)and Gualou(Fructus et Semen Trichosanthis),and nourishing the lungs with Huangqi(Radix Astragali Mongolici),Gancao(Radix Glycyrrhizae)and Kuxingren(Semen Armeniacae Amarum).These data demonstrated that Kuxingren(SemenArmeniacaeAmarum)was a key agent.CONCLUSION:Our analyses of the literature showed clear relationships between symptoms(constipation,dyschesia,abdominal fullness),drugs[Gualou(Fructus et Semen Trichosanthis),Kuxingren(Semen Armeniacae Amarum),Huangqi(Radix Astragali Mongolici)]and therapies(moistening the intestine,clearing Fu-organs,invigorating Qi,ventilating the lungs). | Luan Gao Jian Wang Yong Deng Fenggang Li Sihua Gao | 2014 | Journal of Traditional Chinese Medicine2014，34，1： | 5 |
| 11 | Visualization of aging-associated chromatin alterations with an engineered TALE system显示文摘在实时房间的特定的 genomic loci 的可视化在多样的生物过程期间是为在染色质建筑学的动态变化的调查的一个前提,例如细胞的老化。然而,当前的精确 genomic 成像方法被缺乏妨碍荧光灯有高特性和 signal-to-noise 的探针形成对照。我们发现那常规抄写像使活跃之物的受动器(故事) 趋于形成蛋白质总数,从而在成像应用程序损害他们的性能。通过屏蔽,我们发现有故事的那熔化 thioredoxin 阻止了总数形成,开基于故事的 genomic 成像的完整的力量。用熔化 thioredoxin 的故事(TTALE ) ,我们在各种各样的 genomic loci 完成了高质量的成像并且观察联系老化(epi ) 在在人和老鼠早衰模型的 telomeres 和着丝点的 genomic 改变。重要地,我们鉴别 ribosomal DNA 的摩擦为人的老化作为一个分子的标记重复。我们的学习为精确在 vitro 并且在 vivo 监视染色质动力学建立一个简单、柔韧的成像方法。 | Ruotong Ren Liping Deng Yanhong Xue Keiichiro Suzuki Weiqi Zhang Yang Yu Jun Wu Liang Sun Xiaojun Gong Huiqin Luan Fan Yang Zhenyu Ju Xiaoqing Ren Si Wang Hong Tang Lingling Geng Weizhou Zhang Jian Li Jie Qiao Tao Xu Jing Qu Guang-Hui Liu | 2017 | Cell Research2017，27，4： | 4 |
| 12 | Nematode-Encoded RALF Peptide Mimics Facilitate Parasitism of Plants through the FERONIA Receptor Kinase显示文摘The molecular mechanism by which plants defend against plant root-knot nematodes(RKNs)is largely unknown.The plant receptor kinase FERONIA and its peptide ligands,rapid alkalinization factors(RALFs),regulate plant immune responses and cell expansion,which are two important factors for successful RKN parasitism.In this study,we found that mutation of FERONIA in Arabidopsis thaliana resulted in plants showing low susceptibility to the RKN Meloidogyne incognita.To identify the underlying mechanisms associated with this phenomenon,we identified 18 novel RALF-likes from multiple species of RKNs and showed that two RALF-likes(i.e.,MiRALF1 and MiRALF3)from M.incognita were expressed in the esophageal gland with high expression during the parasitic stages of nematode development.These nematode RALF-likes also possess the typical activities of plant RALFs and can directly bind to the extracellular domain of FERONIA to modulate specific steps of nematode parasitism-related immune responses and cell expansion.Genetically,both MiRALF1/3 and FERONIA are required for RKN parasitism in Arabidopsis and rice.Collectively,our study suggests that nematode-encoded RALFs facilitate parasitism via plant-encoded FERONIA and provides a novel paradigm for studying host-pathogen interactions. | Xin Zhang Huan Peng Sirui Zhu Junjie Xing Xin Li Zhaozhong Zhu Jingyuan Zheng Long Wang Bingqian Wang Jia Chen Zhenhua Ming Ke Yao Jinzhuo Jian Sheng Luan Devin Coleman-Derr Hongdong Liao Yousong Peng Deliang Peng Feng Yu | 2020 | Molecular Plant2020，13，10： | 3 |
| 13 | Molecular Epidemiology and Clinical Features of Haemophilus influenzae among Hospitalized Children with Community-acquired Pneumonia in Chengde,China显示文摘Community-acquired pneumonia(CAP)is an acute lung infection that is caused by several different pathogens and is associated with significant morbidity and mortality.The high global incidence of CAP poses a heavy disease and economic burden to patients,especially children.Respiratory illnesses such as pneumonia and influenza are the fourth leading cause of death in China[1].The top 3 etiologic pathogens of CAP in the Asia-Pacific region are Streptococcus pneumoniae,Haemophilus influenzae(H.influenzae),and Mycoplasma pneumoniae(M.pneumoniae). | LI Dan WANG Qian SU Meng WANG Ling Ling ZHANG Qing WANG Chun Yang WANG Jiang Li DU Luan Ying LIU Jian Ying XIE Guang Cheng | 2020 | Biomedical and Environmental Sciences2020，33，8： | 3 |
| 14 | Analysis on clinically drug-used law for lung-intestine related diseases显示文摘OBJECTIVE:To analyze the application laws of clinical drugs by descriptive statistical method with the clinical literatures guided by 'lung being connected with large intestine' used as the object.METHODS:Retrievepubliclypublishedclinicalliteratures about 'lung being connected with large intestine'inrecent30years,establishthedatabaseofclinical literature,and study on the clinically drug-used lawsbydescriptivestatisticalanalyticmethod.RESULTS:The common high frequent drugs used for the lung-intestine related diseases were Gualou(Ructus Trichsanthis),Dahuang(Radix et Rhizoma),Kuxingren(Semen Armeniacae Amarum),Gancao(Radix Glycyrrhizae),Houpu(Cortex Magnoliae Officinalis),Zhishi(Fructus Aurantii Immaturus).For the different clinical syndrome types,in the commonly used drugs there were different characteristics,reflecting the principle of TCM syndrome differentiation treatment.CONCLUSION:The common high frequent drugs used for the lung-intestine related diseases are Gualou(Fructus Trichsanthis),Dahuang(Radix et Rhizoma),Kuxingren(Semen Armeniacae Amarum),Gancao(Radix Glycyrrhizae),Houpu(Cortex Magnoliae Officinalis),Zhishi(Fructus Aurantii Immaturus),which are commonly-used drugs for the lung-intestine related diseases,with differences for different syndrome types. | Luan Gao Jian Wang Fenggang Li Sihua Gao Yong Deng | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 3 |
| 15 | Long-term efficacy and safety of drug-eluting stent implantation for patients with multiple coronary chronic total occlusions显示文摘为多重冠的长期的全部的吸藏(CTO ) 的治疗的 drug-eluting stent (DES ) 的功效和安全上的背景数据损害是贫乏的。现在的学习的目的是为我们分析了的多重冠的 CTO lesions.Methods 比较 DES 对赤裸的金属 stent (BMS ) 培植的长期的结果从 2000 年 11 月在我们的中心为至少二 de novo CTO 损害经历了冠的 stenting 到 2006 年 11 月的 188 个病人。在他们之中, 118 个病人(62.8%) 收到了 DES, 70 个病人(37.2%) 为 CTO 损害在开运河以后收到了 BMS 培植。所有病人被跟随在上面为为主要不利心脏的事件(向) 的出现的多达 5 年。长期的幸存率与有的 Kaplan-Meier method.Results 被估计在临床的特征和程序的成功在 DES 组和 BMS 之间评估的基线的重要差别都不组织。与 BMS 组相比, DES 组显示出长 CTO (15 公里) 的显著地更高的率(62.0% 对 50.6% , P=0.023 ) 。stents 的数字每损害(1.39 ???????( | ZHANG Jian HAN Ya-ling LI Yi WANG Shou-li JING Quan-min WANG Xiao-zeng MA Ying-yan LUAN Bo WANG Geng WANG Bin | 2010 | Chinese Medical Journal2010，，7： | 3 |
| 16 | Sustainable Synthesis of Core-Shell Structured ZSM-5@Silicalite-1 Zeolite显示文摘Core-shell structured ZSM-5@Silicalite-1 zeolite could effectively hinder the deactivation of catalyst surface. Currently, organic structure directing agents(OSDAs) are necessary in the conventional route for the synthesis of this core-shell zeolite under hydrothermal conditions, which is costly and environmental-unfriendly. In this research, a synthesis of the core-shell structured ZSM-5@Silicalite-1 zeolite with a strategy of alcohol filling and zeolite seeding without any organic template or solvent is exhibited. The obtained products are well characterized by X-ray powder diffractometer(XRD), scanning electron microscopy(SEM), transmission electron microscopy(TEM), N2 sorption isotherms, solid magic angle spinning(MAS) NMR, temperature-programmed-desorption of ammonia(NH3-TPD), and X-ray photoelectron spectroscopy(XPS) techniques, in order to confirm the core-shell structure. More importantly, the core-shell structured ZSM-5@Silicalite-1 zeolite exhibits a long lifetime and a high p-xylene selectivity in the alkylation of toluene with methanol, compared with the conventional ZSM-5 catalyst. | LUAN Huimin WU Qinming ZHANG Jian WANG Yeqing MENG Xiangju XIAO Feng-Shou | 2022 | Chemical Research in Chinese Universities2022，38，1： | 3 |
| 17 | BMAL1 functions as a cAMP-responsive coactivator of HDAC5 to regulate hepatic gluconeogenesis显示文摘 | Jian Li Sihan Lv Xinchen Qiu Jiamin Yu Junkun Jiang Yalan Jin Wenxuan Guo| Ruowei Zhao Zhen-Ning Zhang Chao Zhang Bing Luan | 2018 | Protein & Cell2018，9，11： | 3 |
| 18 | Treatment of Epilepsy with Bipolar Electro-coagulation: An Analysis of Cortical Blood Flow and Histological Change in Temporal Lobe显示文摘 | Zhi-Qiang Cui Guo-Ming Luan Jian Zhou Feng Zhai Yu-Guang Guan Min Bao | 2015 | Chinese Medical Journal2015，，2： | 3 |
| 19 | The Influence of Diabetes, Hypertension, and Hyperlipidemia on the Onset of Age-Related Macular Degeneration in North China: The Kailuan Eye Study显示文摘Objective To analyze the prevalence of dry and wet age-related macular degeneration(AMD)in patients with diabetes,hypertension and hyperlipidemia,and to analyze the risk factors for AMD.Methods A population-based cross-sectional epidemiologic study was conducted involving 14,440 individuals.We assessed the prevalence of dry and wet AMD in diabetic and non-diabetic subjects and analyzed the risk factors for AMD.Results The prevalence of wet AMD in diabetic and non-diabetic patients was 0.3%and 0.5%,respectively,and the prevalence of dry AMD was 17%and 16.4%,respectively.The prevalence of wet AMD in healthy,hypertensive,hyperlipidemic,and hypertensive/hyperlipidemic populations was 0.5%,0.3%,0.2%,and 0.7%,respectively.The prevalence of dry AMD in healthy,hypertensive,hyperlipidemic,and hypertensive/hyperlipidemic populations was 16.6%,16.2%,15.2%,and 17.2%,respectively.Age,sex,body mass index,and use of hypoglycemic drugs or lowering blood pressure drugs were corrected in the risk factor analysis of AMD.Diabetes,diabetes/hypertension,diabetes/hyperlipidemia,and diabetes/hypertension/hyperlipidemia were analyzed.None of the factors analyzed in the current study increased the risk for the onset of AMD.Conclusion There was no significant difference in the prevalence of wet and dry AMD among diabetic and non-diabetic subjects.Similarly,there was no significant difference in the prevalence of wet and dry AMD among subjects with hypertension and hyperlipidemia.Diabetes co-existing with hypertension and hyperlipidemia were not shown to be risk factors for the onset of dry AMD. | ZHANG Yong Peng WANG Ya Xing ZHOU Jin Qiong WANG Qian YAN Yan Ni YANG Xuan YANG Jing Yan ZHOU Wen Jia WANG Ping SHEN Chang YANG Ming LUAN Ya Nan WANG Jin Yuan WU Shou Ling CHEN Shuo Hua WANG Hai Wei FANG Li Jian WAN Qian Qian ZHU Jing Yuan NIE Zi Han CHEN Yu Ning XIE Ying JONAS JB WEI Wen Bin | 2022 | Biomedical and Environmental Sciences2022，35，7： | 2 |
| 20 | Shikonin alleviates collagen-induced arthritis mice by inhibiting M1 macrophage polarization显示文摘OBJECTIVE: To investigate the effects of shikonin(SKN) on M1 and M2 polarization of macrophages both in vitro and in vivo. METHODS: Collagen-induced arthritis(CIA) in male DBA/1 mice were treated with a dose of 4 mg/kg/day of SKN for 23 d(n = 6/group). The histopathology of inflamed joints in CIA mice was evaluated to test the antiarthritic effect of SKN. M1/M2 polarization of macrophages induced by lipopolysaccharide(LPS) and interferon(IFN)-γ or interleukin(IL)-4 and IL-13, were used to assess the effect of SKN(0.05, 0.1, and 0.2 μM). The effect of SKN on the protein expression of nitric oxide synthase, arginase, CD68, and CD206 was evaluated using western blot analysis. RESULTS: The results of this study revealed that SKN delayed the arthritis feet symptom score, reduced the incidence rate of arthritis, and relieved the inflammation of joints in CIA mice. SKN inhibited M1 macrophage polarization but did not affect M2 macrophage polarization in the joints of CIA mice. Moreover, SKN inhibited M1 polarization induced by LPS and IFN-γ, but did not affect M2 polarization induced by IL-4 and IL-13. CONCLUSION: These findings suggest that SKN alleviated CIA through inhibiting M1 macrophage polarization and has great potential as a new drug for RA treatment. | HE Lianhua LUAN Huijie QIN Qingxia HE Juan CHEN Jian HU Yiping CAI Yueming SUN Desheng SHI Yu WANG Qingwen | 2022 | Journal of Traditional Chinese Medicine2022，42，6： | 2 |
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