|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinically relevant factors associated with quantitative optical coherence tomography angiography metrics in deep capillary plexus in patients with diabetes显示文摘Background:To test clinically relevant factors associated with quantitative artifact-free deep capillary plexus(DCP)metrics in patients with diabetes mellitus(DM).Methods:563 eligible eyes(221 with no diabetic retinopathy[DR],135 with mild DR,130 with moderate DR,and 77 with severe DR)from 334 subjects underwent optical coherence tomography-angiography(OCT-A)with a swept-source OCT(Triton DRI-OCT,Topcon,Inc.,Tokyo,Japan).Strict criteria were applied to exclude from analysis those DCP images with artifacts and of poor quality,including projection artifacts,motion artifacts,blurriness,signal loss,B-scan segmentation error,or low-quality score.A customized MATLAB program was then used to quantify DCP morphology from the artifact-free DCP images by calculating three metrics:foveal avascular zone(FAZ),vessel density(VD),and fractal dimension(FD).Results:166(29.5%)eyes were excluded after quality control,leaving in the analysis 397 eyes(170 with no DR,101 with mild DR,90 with moderate DR,36 with severe DR)from 250 subjects.In the multiple regression models,larger FAZ area was associated with more severe DR(β=0.687;p=0.037),shorter axial length(AL)(β=−0.171;p=0.003),thinner subfoveal choroid thickness(β=−0.122;p=0.031),and lower body mass index(BMI)(β=−0.090;p=0.047).Lower VD was associated with more severe DR(β=−0.842;p=0.001),shorter AL(β=0.107;p=0.039),and poorer visual acuity(VA)(β=−0.133;p=0.021).Lower FD was associated with more severe DR(β=−0.891;p<0.001)and with older age(β=−0.142;p=0.004).Conclusions:Quantitative artifact-free DCP metrics are associated with VA,DR severity,AL,subfoveal choroidal thickness,age,and BMI in diabetic patients.The effects of ocular and systemic factors should be considered for meaningful interpretations of DCP changes in DM patients. | Fang Yao Tang Erica O.Chan Zihan Sun Raymond Wong Jerry Lok Simon Szeto Jason C.Chan Alexander Lam Clement C.Tham Danny S.Ng Carol Y.Cheung | 2020 | Eye and Vision2020，7，1： | 7 |
| 2 | Clinicopathological significance of synchronous carcinoma in colorectal cancer显示文摘 | Alfred King-Yin Lam Robert Carmichael Petra Gertraud Buettner Vinod Gopalan Yik-Hong Ho Simon Siu | 2011 | The American Journal of Surgery2011，，1： | 4 |
| 3 | Entecavir Monotherapy Is Effective in Suppressing Hepatitis B Virus After Liver Transplantation显示文摘 | James Fung Cindy Cheung See–Ching Chan Man–Fung Yuen Kenneth S.H. Chok William Sharr Wing–Chiu Dai Albert C.Y. Chan Tan–To Cheung Simon Tsang Banny Lam Ching–Lung Lai Chung–Mau Lo | 2011 | Gastroenterology2011，，4： | 3 |
| 4 | Oncogene GAEC1 regulates CAPN10 expression which predicts survival in esophageal squamous cell carcinoma显示文摘AIM: To identify the downstream regulated genes of GAEC1 oncogene in esophageal squamous cell carcinoma and their clinicopathological significance. METHODS: The anti-proliferative effect of knocking down the expression of GAEC1 oncogene was stud-ied by using the RNA interference (RNAi) approach through transfecting the GAEC1 -overexpressed esophageal carcinoma cell line KYSE150 with the pSilencer vector cloned with a GAEC1 -targeted sequence, followed by MTS cell proliferation assay and cell cycle analysis using flow cytometry. RNA was then extracted from the parental, pSilencer-GAEC1 -targeted sequence transfected and pSilencer negative control vector transfected KYSE150 cells for further analysis of different patterns in gene expression. Genes differentially expressed with suppressed GAEC1 expression were then determined using Human Genome U133 Plus 2.0 cDNA microarray analysis by comparing with the parental cells and normalized with the pSilencer negative control vector transfected cells. The most prominently regulated genes were then studied by immunohistochemical staining using tissue microarrays to determine their clinicopathological correlations in esophageal squamous cell carcinoma by statistical analyses. RESULTS: The RNAi approach of knocking down gene expression showed the effective suppression of GAEC1 expression in esophageal squamous cell carcinoma cell line KYSE150 that resulted in the inhibition of cell proliferation and increase of apoptotic population. cDNA microarray analysis for identifying differentially expressed genes detected the greatest levels of downregulation of calpain 10 (CAPN10 ) and upregulation of trinucleotide repeat containing 6C (TNRC6C ) transcripts when GAEC1 expression was suppressed. At the tissue level, the high level expression of calpain 10 protein was significantly associated with longer patient survival (month) of esophageal squamous cell carcinoma compared to the patients with low level of calpain 10 expression (37.73 ± 16.33 vs 12.62 ± 12.44, P = 0.032). No significant correction was observed among the TNRC6C protein expression level and the clinocopathologcial features of esophageal squamous cell carcinoma. CONCLUSION: GAEC1 regulates the expression of CAPN10 and TNRC6C downstream. Calpain 10 expression is a potential prognostic marker in patients with esophageal squamous cell carcinoma. | Dessy Chan Miriam Yuen-Tung Tsoi Christina Di Liu SauHing Chan Simon Ying-Kit Law Kwok-Wah Chan Yuen-Piu Chan Vinod Gopalan Alfred King-Yin Lam Johnny Cheuk-On Tang | 2013 | World Journal of Gastroenterology2013，19，18： | 2 |
| 5 | Metachronous carcinomas in colorectum and its clinicopathological significance显示文摘 | Alfred Lam Vinod Gopalan Robert Carmichael Petra Buettner Melissa Leung Robert Smith Cu-Tai Lu Yik-Hong Ho Simon Siu | 2012 | International Journal of Colorectal Disease2012，，10： | 1 |
| 6 | FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis显示文摘 | Pauline Andreu Magnus Johansson Nesrine I. Affara Ferdinando Pucci Tingting Tan Simon Junankar Lidiya Korets Julia Lam David Tawfik David G. DeNardo Luigi Naldini Karin E. de Visser Michele De Palma Lisa M. Coussens | 2010 | Cancer Cell2010，，2： | 1 |
| 7 | Esteem maintenance among groups:Laboratory and field studies of group performance cognitions显示文摘 | Simon SK Lam John Schaubroeck Andrew D Brown | 2004 | Organizational Behavior and Human Decision Process2004，94，： | 1 |
| 8 | Group Citizenship Behaviour: Conceptualization and Preliminary Tests of its Antecedents and Consequences 显示文摘 | Chen X P Simon S K Lam | 2005 | Management and Organization Review2005，1，2： | 1 |
| 9 | Effects of 4E-BPI expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival 显示文摘 | Barnhart BC Lam JC Young RM Houghton PJ Keith B Simon MC | 2008 | Cancer Biol Ther2008，7，9： | 1 |
| 10 | Pathogen-induced programmed cell death in tobacco显示文摘 | MITTLER R SIMON L LAM E | 1997 | J Cell Sci1997，110，： | 1 |
| 11 | Analysis of gene expression data using BRB-ArrayTools显示文摘 | Simon R Lam A Li MC | 2007 | Cancer Inform2007，3，： | 1 |
| 12 | The Investment Opportunity Set, Director Ownership, and Corporate Policies, Evidence from an Emerging Market 显示文摘 | Simon S M Ho Kevin C K Lam Heibatollah Sami | 2004 | Journal of Corporate Finance2004，，10： | 1 |
| 13 | The effects of job complexity and autonomy on cohesiveness in collectivistic and individualistic work groups : a cross cultural analysis显示文摘 | Derek C Man and Simon S K Lam | 2003 | Journal of Organizational Behavior2003，24，： | 1 |
| 14 | Entecavir Monotherapy Is Effective in Suppressing Hepatitis B Virus After Liver Transplantation显示文摘 | James Fung Cindy Cheung See–Ching Chan Man–Fung Yuen Kenneth S.H. Chok William Sharr Wing–Chiu Dai Albert C.Y. Chan Tan–To Cheung Simon Tsang Banny Lam Ching–Lung Lai Chung–Mau Lo | 2011 | Gastroenterology2011，，4： | 1 |
| 15 | Analysis of gene expression da ta using BRB-Array Tools显示文摘 | Simon R Lam A Li M C | 2007 | Cancer Inform2007，3，： | 1 |
| 16 | Entecavir Monotherapy Is Effective in Suppressing Hepatitis B Virus After Liver Transplantation显示文摘 | James Fung Cindy Cheung See–Ching Chan Man–Fung Yuen Kenneth S.H. Chok William Sharr Wing–Chiu Dai Albert C.Y. Chan Tan–To Cheung Simon Tsang Banny Lam Ching–Lung Lai Chung–Mau Lo | 2011 | Gastroenterology2011，，4： | 1 |
| 17 | Digital Signatures for Flows and Multicasts显示文摘 | Chung Kei Wong Simon s Lam | 1999 | IEEE/ACM Transactions on networking1999，7，4： | 1 |
| 18 | The investment opportunity set, director ownership, and corporate policies: evidence from an emerging market 显示文摘 | Simon S M Ho Kevin C K Lam Heibatollah Sami | 2004 | Journal of Corporate Finance2004，，10： | 1 |
| 19 | Establishment, characterization, karyotyping, and comparative genomic hybridization analysis of HKESC-2 and HKESC-3显示文摘 | Ying Chuan Hu King Y. Lam Simon Y. Law Thomas S.K. Wan Edmond S.K. Ma Yok Lam Kwong Li C. Chan John Wong Gopesh Srivastava | 2002 | Cancer Genetics and Cytogenetics2002，，2： | 1 |
| 20 | Use of flow cytometry in the analysis of stage Ⅲ squamous cell carcinoma of the oesophagus and its association with MIB-1 显示文摘 | KY Lam Lily Ma Simon Y K Law | 1996 | J Clin Pathol1996，49，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员