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| 1 | Solar activity effects of the ionosphere: A brief review显示文摘Solar radiation, which varies over multiple temporal scales, modulates remarkably the evolution of the ionosphere. The solar activity dependence of the ionosphere is a key and fundamental issue in ionospheric physics, providing information essential to understanding the variations in the ionosphere and its processes. Selected recent studies on solar activity effects of the ionosphere are briefly reviewed in this report. This report focuses on (1) observations of solar irradiance at X-ray and extreme ultraviolet wavelengths and the outstanding problems of solar proxies, in the view of ionospheric studies, (2) new findings and improved representations of the features of the solar activity dependence of ionospheric key parameters and the corresponding physical processes, (3) possible phenomena in the ionosphere under extremely high and low solar activity conditions that are unique, as indicated by historical solar datasets and the deep solar minimum of solar cycle 23/24, and (4) statistical studies and model simulations of the ionosphere response to solar flares. The above-mentioned studies provide new clues for comprehensively explaining basic processes in the ionosphere and improving the prediction capability of ionospheric models and related applications. | LIU LiBo WAN WeiXing CHEN YiDing LE HuiJun | 2011 | Chinese Science Bulletin2011，56，12： | 45 |
| 2 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 3 | Catgut implantation at acupoints increases the expression of glutamate aspartate transporter and glial glutamate transporter-1 in the brain of rats with spasticity after stroke显示文摘Catgut implantation at acupoints has been shown to alleviate spasticity after stroke in rats.However,the underlying mechanisms are poorly understood.In this study,we used the rat middle cerebral artery occlusion model of stroke.Three days after surgery,absorbable surgical catgut sutures were implanted at Dazhui(GV14),Jizhong(GV6),Houhui,Guanyuan(CV4)and Zhongwan(CV12).The Zea Longa score was used to assess neurological function.The Modified Ashworth Scale was used to evaluate muscle tension.The 2,3,5-triphenyl-tetrazolium chloride assay was used to measure infarct volume.Immunohistochemical staining was performed for glutamate aspartate transporter(GLAST)and glial glutamate transporter-1(GLT-1)expression.Western blot assay was used to analyze the expression of GLAST and GLT-1.Reverse transcription and polymerase chain reaction were carried out to assess the expression of GLAST and GLT-1m RNAs.After catgut implantation at the acupoints,neurological function was substantially improved,muscle tension was decreased,and infarct volume was reduced in rats with spasticity after stroke.Furthermore,the expression of GLAST and GLT-1 m RNAs was increased on the injured(left)side.Our findings demonstrate that catgut implantation at acupoints alleviates spasticity after stroke,likely by increasing the expression of GLAST and GLT-1. | Rui-Qing Li Ming-Yue Wan Jing Shi Hui-Ling Wang Fei-Lai Liu Cheng-Mei Liu Jin Huang Ren-Chao Liu Le Ma Xiao-Dong Feng | 2018 | Neural Regeneration Research2018，13，6： | 10 |
| 4 | Development of a middle and low latitude theoretical ionospheric model and an observation system data assimilation experiment显示文摘On the basis of previous work, we develop a middle and low latitude theoretical ionospheric model in this paper, named Theoretical Ionospheric Model of the Earth in the Institute of Geology and Geophysics, Chinese Academy of Sciences (TIME-IGGCAS). TIME-IGGCAS solves the equations of mass continuity, motion and energy of electron and ions self-consistently and uses an eccentric dipole field approxima-tion to the Earth’s magnetic field. We combine the Eulerian and Lagrangian approaches in the model and take account of the plasma E×B drift velocity. Calculation results reveal that the model is steady and credible and can reproduce most large-scale features of ionosphere. By using TIME-IGGCAS, we carried out an observation system data assimilation experiment. Assimilation results show that the E×B drift velocity can be accurately estimated by ingesting the observed foF2 and hmF2 into the model ap-plying nonlinear least-square fit method. We suggest that this work is of great significance in the de-velopment of ionospheric data assimilation model to give better nowcast and forecast of ionosphere. | YUE XinAn WAN WeiXing LIU LiBo LE HuiJun CHEN YiDing YU Tao | 2008 | Chinese Science Bulletin2008，53，1： | 7 |
| 5 | Whole-genome sequencing provides insights into the genetic diversity and domestication of bitter gourd(Momordica spp.)显示文摘Bitter gourd(Momordica charantia)is a popular cultivated vegetable in Asian and African countries.To reveal the characteristics of the genomic structure,evolutionary trajectory,and genetic basis underlying the domestication of bitter gourd,we performed whole-genome sequencing of the cultivar Dali-11 and the wild small-fruited line TR and resequencing of 187 bitter gourd germplasms from 16 countries.The major gene clusters(Bi clusters)for the biosynthesis of cucurbitane triterpenoids,which confer a bitter taste,are highly conserved in cucumber,melon,and watermelon.Comparative analysis among cucurbit genomes revealed that the Bi cluster involved in cucurbitane triterpenoid biosynthesis is absent in bitter gourd.Phylogenetic analysis revealed that the TR group,including 21 bitter gourd germplasms,may belong to a new species or subspecies independent from M.charantia.Furthermore,we found that the remaining 166 M.charantia germplasms are geographically differentiated,and we identified 710,412,and 290 candidate domestication genes in the South Asia,Southeast Asia,and China populations,respectively.This study provides new insights into bitter gourd genetic diversity and domestication and will facilitate the future genomics-enabled improvement of bitter gourd. | Junjie Cui Yan Yang Shaobo Luo Le Wang Rukui Huang Qingfang Wen Xiaoxia Han Nansheng Miao Jiaowen Cheng Ziji Liu Changyuan Zhang Chengcheng Feng Haisheng Zhu Jianwen Su Xinjian Wan Fang Hu Yu Niu Xiaoming Zheng Yulan Yang Dai Shan Zhensheng Dong Weiming He Narinder P.S.Dhillon Kailin Hu | 2020 | Horticulture Research2020，7，1： | 7 |
| 6 | Score model for predicting acute-on-chronic liver failure risk in chronic hepatitis B显示文摘AIM: To establish a clinical scoring model to predict risk of acute-on-chronic liver failure(ACLF) in chronic hepatitis B(CHB) patients.METHODS: This was a retrospective study of 1457 patients hospitalized for CHB between October 2008 and October 2013 at the Beijing Ditan Hospital, Capital Medical University, China. The patients were divided into two groups: severe acute exacerbation(SAE) group(n = 382) and non-SAE group(n = 1075). The SAE group was classified as the high-risk group based on the higher incidence of ACLF in this group than in the non-SAE group(13.6% vs 0.4%). Two-thirds of SAE patients were randomly assigned to risk-model derivation and the other one-third to model validation. Univariate risk factors associated with the outcome were entered into a multivariate logistic regression model for screening independent risk factors. Each variable was assigned an integer value based on the regression coefficients, and the final score was the sum of these values in the derivation set. Model discrimination and calibration were assessed using area under the receiver operating characteristic curve and the Hosmer-Lemeshow test. RESULTS: The risk prediction scoring model includedthe following four factors: age ≥ 40 years, total bilirubin ≥ 171 μmol/L, prothrombin activity 40%-60%, and hepatitis B virus DNA > 107 copies/m L. The sum risk score ranged from 0 to 7; 0-3 identified patients with lower risk of ACLF, whereas 4-7 identified patients with higher risk. The Kaplan-Meier analysis showed the cumulative risk for ACLF and ACLF-related death in the two risk groups(0-3 and 4-7 scores) of the primary cohort over 56 d, and log-rank test revealed a significant difference(2.0% vs 33.8% and 0.8% vs 9.4%, respectively; both P < 0.0001). In the derivation and validation data sets, the model had good discrimination(C index = 0.857, 95% confidence interval: 0.800-0.913 and C index = 0.889, 95% confidence interval: 0.820-0.957, respectively) and calibration demonstrated by the Hosmer-Lemeshow test(χ2 = 4.516, P = 0.808 and χ2 = 1.959, P = 0.923, respectively).CONCLUSION: Using the scoring model, clinicians can easily identify patients(total score ≥ 4) at high risk of ACLF and ACLF-related death early during SAE. | Fang-Yuan Gao Yao Liu Xiao-Shu Li Xie-Qiong Ye Le Sun Ming-Fan Geng Rui Wang Hui-Min Liu Xiao-Bing Zhou Li-Li Gu Yan-Min Liu Gang Wan Xian-Bo Wang | 2015 | World Journal of Gastroenterology2015，21，27： | 5 |
| 7 | Catalytic microwave assisted pyrolysis of aspen显示文摘The effect of catalysts on the microwave pyrolysis of aspen pellets was studied.A range of chlorides,nitrates and metal-oxides were added at 2%of the aspen mass(air dry aspen pellet weight basis).Chlorides in particular were found to favor liquid yield,especially the yield of water phase residue.Average liquid yield with added chlorides was 41%mass of the total biomass input,compared to 35%mass without catalyst.Metal-oxides were found to favor pyrolysis heavy oil,and thus total oil yield,since the yield of light oils seemed to be fairly constant.Nitrates were found to favor pyrolysis gas production.Pure light oils and light oils blended with diesel were found to be a potential diesel fuel substitute. | Johannes Moen Changyan Yang Bo Zhang Hanwu Lei Kevin Hennessy Yiqin Wan Zhiping Le Yuhuan Liu Paul Chen Roger Ruan | 2009 | International Journal of Agricultural and Biological Engineering2009，2，4： | 5 |
| 8 | Heritability of growth traits in the Asian seabass (Lates calcarifer)显示文摘Growth is an economically important trait in aquaculture.To improve growth trait of the Asian seabass(Lates calcarifer)we have been carrying out,since 2004,a selective breeding program.This study focuses on growth traits in the F2 fish generation,comprised of offspring from 23 mass crosses from 383 F_(1) brooders.Using genotyping analysis for 10 microsatellites from both brood stock and progeny we have reconstructed the pedigree of each mass-cross.For F_(2) generation at 90 days post hatch(dph),we have recorded body weight(BW)for 12,117 individuals and total length(TL),standard length(SL)and condition factor(K_(tl) and K_(sl))for 3530 individuals;and all five traits for 2136 individuals at 270 dph.At 90 dph the average BW was 46.88±20.95 g.Combining pedigree information,recorded growth traits and Restricted Maximum Likelihood method,we have estimated that the narrow sense heritability(h^(2))in F_(1) fish for BW,TL,SL,K_(tl) and K_(sl) was at,90 dph,0.12±0.03,0.11±0.03,0.10±0.03,0.20±0.04 and 0.11±0.03,respectively and,at 270 dph,0.34±0.07,0.32±0.07,0.30±0.06,0.13±0.04 and 0.11±0.04,respectively.At 90 dph the realised heritability for BW was 0.13.Comparing with F_(1) generation,the growth performance of F_(2) fish was increased by 14.4%.Heritability of growth traits will be useful for future genetic improvement programmes of the Asian seabass. | Baoqing Ye Ziyi Wan Le Wang Hongyan Pang Yanfei Wen Huiming Liu Bing Liang Huan Sein Lim Junhui Jiang Genhua Yue | 2017 | Aquaculture and Fisheries2017，2，3： | 4 |
| 9 | Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits显示文摘Displaced fractures of patella often require open reduction surgery and internal fixation to restore the extensor continuity and articular congruity.Fracture fixation with biodegradable magnesium(Mg)pins enhanced fracture healing.We hypothesized that fixation with Mg pins and their degradation over time would enhance healing of patellar fracture radiologically,mechanically,and histologically.Transverse patellar fracture surgery was performed on thirty-two 18-weeks old female New Zealand White Rabbits.The fracture was fixed with a pin made of stainless steel or pure Mg,and a figure-of-eight stainless steel band wire.Samples were harvested at week 8 or 12,and assessed with microCT,tensile testing,microindentation,and histology.Microarchitectural analysis showed that Mg group showed 12%higher in the ratio of bone volume to tissue volume at week 8,and 38.4%higher of bone volume at week 12.Tensile testing showed that the failure load and stiffness of Mg group were 66.9%and 104%higher than the control group at week 8,respectively.At week 12,Mg group was 60.8%higher in ultimate strength than the control group.Microindentation showed that,compared to the Control group,Mg group showed 49.9%higher Vickers hardness and 31%higher elastic modulus at week 8 and 12,respectively.At week 12,the new bone of Mg group remodelled to laminar bone,but those of the control group remained woven bone-like.Fixation of transverse patellar fracture with Mg pins and its degradation enhanced new bone formation and mechanical properties of the repaired patella compared to the Control group. | Dick Ho Kiu Chow Jiali Wang Peng Wan Lizhen Zheng Michael Tim Yun Ong Le Huang Wenxue Tong Lili Tan Ke Yang Ling Qin | 2021 | Bioactive Materials2021，6，11： | 3 |
| 10 | Quercetin promotes human epidermal stem cell proliferation through the estrogen receptor/β-catenin/c-Myc/cyclin A2 signaling pathway显示文摘Skin epidermal stem cells(EpSCs)play an important role in wound healing.Quercetin is a phytoestrogen reported to accelerate skin wound healing,but its effect on EpSCs is unknown.In this study,we investigated the effect of quercetin on human EpSC proliferation and explored the underlying mechanisms.We found that quercetin at 0.1~1μM significantly promoted EpSC proliferation and increased the number of cells in S phase.The pro-proliferative effect of quercetin on EpSCs was confirmed in cultured human skin tissue.Mechanistic studies showed that quercetin significantly upregulated the expressions ofβ-catenin,c-Myc,and cyclins A2 and E1.Inhibitor forβ-catenin or c-Myc significantly inhibited quercetin-induced EpSC proliferation.Theβ-catenin inhibitor XAV-939 suppressed quercetin-induced expressions ofβ-catenin,c-Myc,and cyclins A2 and E1.The c-Myc inhibitor 10058-F4 inhibited the upregulation of c-Myc and cyclin A2 by quercetin.Pretreatment of EpSCs with estrogen receptor(ER)antagonist ICI182780,but not the G protein-coupled ER1 antagonist G15,reversed quercetin-induced cell proliferation and upregulation ofβ-catenin,c-Myc,and cyclin A2.Collectively,these results indicate that quercetin promotes EpSC proliferation through ER-mediated activation ofβ-catenin/c-Myc/cyclinA2 signaling pathway and ER-independent upregulation of cyclin E1 and that quercetin may accelerate skin wound healing through promoting EpSC proliferation.As EpSCs are used not only in clinic to treat skin wounds but also as seed cells in skin tissue engineering,quercetin is a useful reagent to expand EpSCs for basic research,skin wound treatment,and skin tissue engineering. | Zhaodong Wang Guangliang Zhang Yingying Le Jihui Ju Ping Zhang Dapeng Wan Qiang Zhao Guangzhe Jin Hao Su Jinwei Liu Jiaxuan Feng Yi Fu Ruixing Hou | 2020 | Acta Biochimica et Biophysica Sinica2020，52，10： | 3 |
| 11 | Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle显示文摘Whether glucose is predomi nantly metabolized via oxidative phosphorylati on or glycolysis differs between quiesce nt versus proliferating cells,iincluding tumor cells.However,how glucose metabolism is coordinated with cell cycle in mammalian cells remains elusive.Here,we report that mammalian cells predominantly utilize the tricarboxylic acid(TCA)cycle in G1 phase,but prefer glycolysis in S phase.Mechanistically,coupling cell cycle with metabolism is largely achieved by timely destruction of IDH1/2,key TCA cycle enzymes,in a Skp2-dependent manner.As such,depleting SKP2 abolishes cell cycle-dependent fluctuation of IDH1 protein abundance,leading to reduced glycolysis in S phase.Furthermore,elevated Skp2 abundance in prostate cancer cells destabilizes IDH1 to favor glycolysis and subsequent tumorigenesis.Therefore,our study reveals a mechanistic link between two cancer hallmarks,aberrant cell cycle and addiction to glycolysis,and provides the underlying mechanism for the coupling of metabolic fluctuation with periodic cell cycle in mammalian cells. | Jing Liu Yunhua Peng Le Shi Lixin Wan Hiroyuki Inuzuka Jiangang Long Jianping Guo Jinfang Zhang Min Yuan Shuangxi Zhang Xun Wang Jing Gao Xiangpeng Dai Shozo Furumoto Lijun Jia Pier Paolo Pandolfic John M.Asara William G.Kaelin Jr. Jjankang Liu Wenyi Wei | 2021 | Cell Research2021，31，1： | 2 |
| 12 | Thermal-Hydraulic Calculation and Analysis on Evaporator System of a 1000 MW Ultra-Supercritical Pulverized Combustion Boiler with Double Reheat显示文摘A double reheat ultra-supercritical boiler is an important development direction for high-parameter and large-capacity coal-fired power plants due to its high thermal efficiency and environmental value.China has developed a 1000 MW double reheat ultra-supercritical boiler with steam parameters of 35 MPa at 605℃/613℃/613℃.Reasonable water wall design is one of the keys to safe and reliable operation of the boiler.In order to examine the thermal-hydraulic characteristics of the double reheat ultra-supercritical boiler,the water wall system was equivalent to a flow network comprising series-parallel circuits,linking circuits and pressure nodes,and a calculation model was built on account of the conservation equations of energy,momentum and mass.Through the iterative solving of nonlinear equations,the prediction parameters of the water wall at boiler maximum continue rate(BMCR),75%turbine heat-acceptance rate(THA)and 30%THA loads,including total pressure drops,flow distribution,outlet steam temperatures,fluid and metal temperatures were gotten.The results of calculation exhibit excellent thermal-hydraulic characteristics and substantiate the feasibility of the water wall design of the double reheat ultra-supercritical boiler. | WAN Li YANG Dong ZHOU Xihong DONG Le LI Juan | 2021 | Journal of Thermal Science2021，30，3： | 2 |
| 13 | Prognostic role of neutrophil‐to‐lymphocyte ratio in colorectal cancer: A systematic review and meta‐analysis显示文摘 | Mu‐Xing Li Xue‐Min Liu Xu‐Feng Zhang Jian‐Fei Zhang Wan‐Li Wang Ying Zhu Jian Dong Ji‐Wen Cheng Zheng‐Wen Liu Le Ma Yi Lv | 2014 | Int. J. Cancer2014，，10： | 2 |
| 14 | Four COVID-19 Cases of New Variant B.1.351 First Emerging in South Africa in Chinese Passengers on Same Flight-Shenzhen,China,January 2021显示文摘At 04∶50 on January 1,2021,a 36-year-old Chinese project manager(Case A),a 29-year-old Chinese worker(Case B),and a 53-year-old Chinese businessman(Case C)returned from Africa(Case A and B from South Africa and Case C from Lesotho)on the same flight and tested coronavirus disease 2019(COVID-19)RNA positive by real-time polymerase chain reaction(PCR)by Baoan District People’s Hospital.Shenzhen CDC received their oral nasopharyngeal swabs packages from the hospital and retested COVID-19 RNA positive at 09∶50.Meanwhile,Case D. | Cong Cheng Lei Wang Ziquan Lyu Bo Peng Yinghui Li Dongfeng Kong Le Zuo Xiaomin Zhang Chao Yang Weiwen Liu Jia Wan Yijun Tang Junjia He Ying Wen Shule Xu Weihua Wu Ying Chen Guangnan Liu Junjie Xia Xuan Zou Renli Zhang Qinghua Hu Shujiang Mei Tiejian Feng | 2021 | China CDC weekly2021，3，8： | 2 |
| 15 | The nucleocapsid protein of rice stripe virus in cell nuclei of vector insect regulates viral replication显示文摘Rice stripe virus(RSV)transmitted by the small brown planthopper causes severe rice yield losses in Asian countries.Although viral nuclear entry promotes viral replication in host cells,whether this phenomenon occurs in vector cells remains unknown.Therefore,in this study,we systematically evaluated the presence and roles of RSV in the nuclei of vector insect cells.We observed that the nucleocapsid protein(NP)and viral genomic RNAs were partially transported into vector cell nuclei by utilizing the importin a nuclear transport system.When blocking NP nuclear localization,cytoplasmic RSV accumulation significantly increased.In the vector cell nuclei,NP bound the transcription factor YY1 and affected its positive regulation to FAIM.Subsequently,decreased FAIM expression triggered an antiviral caspase-dependent apoptotic reaction.Our results reveal that viral nuclear entry induces completely different immune effects in vector and host cells,providing new insights into the balance between viral load and the immunity pressure in vector insects. | Wan Zhao Junjie Zhu Hong Lu Jiaming Zhu Fei Jiang Wei Wang Lan Luo Le Kang Feng Cui | 2022 | Protein & Cell2022，13，5： | 2 |
| 16 | Correlation between CT attenuation value and iodine concentration in vitro : Discrepancy between gemstone spectral imaging on single‐source dual‐energy CT and traditional polychromatic X‐ray imaging显示文摘 | Le Wang Bin Liu Xing‐wang Wu Jie Wang Yong Zhou Wan‐qin Wang Xiao‐hong Zhu Yong‐qiang Yu Xiao‐hu Li Shuai Zhang Yun Shen | 2012 | Journal of Medical Imaging and Radiation Oncology2012，，4： | 2 |
| 17 | Inflammatory response to cardiopulmonary bypass显示文摘 | Wan S Le Clerc JL Vincent JL | 1997 | Chest1997，112，3： | 1 |
| 18 | The ionospheric responses to the 11 August 1999 solar eclipse:observations and modeling显示文摘 | LE H LIU L YUE X WAN W | | 0，，： | 1 |
| 19 | Proliferation and differentiation of human mesenchymal stem cel encapsulate d in polyelectrolyte complexation fibrous scaffold显示文摘 | Yim EK Wan AC Le Visa ge C | | 0，，36： | 1 |
| 20 | Capillary dectrophoretic immunoassays for digoxin and gentamicin with laser- induced fluorescene polarization detection 显示文摘 | Wan Q H Le C X | 1999 | Journal of Chromatography B1999，734，： | 1 |
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