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| 1 | 全球生物制药领域研发态势分析显示文摘1引言生物制药(即生物治疗药物)指运用重组DNA技术制造或提纯于生物来源的一类用于疾病预防、治疗和诊断的制品,主要包括大分子物质(如蛋白质和核酸)、疫苗和经基因工程改造后的细胞,具体包括疫苗、治疗性抗体、重组蛋白(包括融合蛋白)、基因治疗药物、细胞治疗药物、抗菌肽、细胞因子、蛋白类激素和酶等。因其具备药理活性高、毒副作用小、靶向性强等显著优点,在疾病治疗中得到愈来愈多的应用。 | 谢华玲 陈芳 Cynthia Liu Yingzhu Li Yi Deng 韩涛 余敏 杨艳萍 王学昭 | 2019 | 中国生物工程杂志2019，39，5： | 9 |
| 2 | 基于二模复杂网络的隐性知识发现方法研究——以潜在药物靶点挖掘为例显示文摘[目的/意义]通过构建二模复杂网络模型,揭示隐藏在海量文献中的隐性知识。[方法/过程]通过NetworkX复杂网络工具包,依据任意两个节点的共现关系构建二模复杂网络模型;对网络模型中节点的共现关系进行加权,计算网络的拓扑信息并进行AP聚类,提取节点间的直接关系;采用AUC方法对AA、JC、加权改进的wAA和wJC等4种链路预测算法进行评价,遴选出最合适的预测算法,并对复杂网络的隐性关系进行预测分析。[结果/结论]以潜在药物靶点挖掘为例进行的实证研究结果表明,wAA链路预测算法为最优的链路预测算法;二模复杂网络模型、指标和方法体系在美国化学文摘社数据库中的药物靶点挖掘中具有一定的有效性。下一步计划在其他数据库中或其他研究领域中进行尝试,以进一步验证该模型的通用性和有效性。 | 李东巧 陈芳 韩涛 杨艳萍 王学昭 王燕鹏 Cynthia Liu Yingzhu Li | 2020 | 图书情报工作2020，64，21： | 6 |
| 3 | UV-B-induced photomorphogenesis in Arabidopsis显示文摘Ultraviolet-B(UV-B)is a relatively minor component of sunlight,but can induce stress-related physiological pro-cesses or UV-B-specifi c photomorphogenic responses in plants.In the last decade,signifi cant progress has been made in understanding the UV-B photomorphogenic pathway,including identifi cation of the key components in the pathway,molecular characterization of UV-B pho-toreceptor and perception mechanism,and elucidation of the signal transduction mechanisms from the photo-activated UV-B receptor to downstream gene expression.This review summarizes the key players identifi ed to date in the UV-B photomorphogenic pathway and their roles in mediating UV-B signal transduction. | Jigang Li Li Yang Dan Jin Cynthia D.Nezames William Terzaghi Xing Wang Deng | 2013 | Protein & Cell2013，4，7： | 4 |
| 4 | 全球疫苗研发态势分析显示文摘1引言自1796年全球首个用于天花预防的牛痘疫苗诞生以来,疫苗已有200多年的发展历史,其研发与应用是20世纪公共卫生领域最伟大的成就之一[1]。在此期间,得益于疫苗的接种,世界卫生组织(WHO)在1979年宣布消灭了天花,2015宣布消灭了II型脊灰野病毒[2]。 | 谢华玲 陈芳 Cynthia Liu Yingzhu Li Yi Deng Jeffrey Smoot Linda Carter 韩涛 杨艳萍 王学昭 | 2019 | 中国生物工程杂志2019，39，5： | 4 |
| 5 | Short-term environmental enrichment exposure induces proliferation and maturation of doublecortin-positive cells in the prefrontal cortex显示文摘Previous studies have demonstrated that doublecortin-positive immature neurons exist predominantly in the superficial layer of the cerebral cortex of adult mammals such as guinea pigs, and these neurons exhibit very weak properties of self-proliferation during adulthood under physiological conditions. To verify whether environmental enrichment has an impact on the proliferation and maturation of these immature neurons in the prefrontal cortex of adult guinea pigs, healthy adult guinea pigs were subjected to short-term environmental enrichment. Animals were allowed to play with various cognitive and physical stimulating objects over a period of 2 weeks, twice per day, for 60 minutes each. Immunofluorescence staining results indicated that the number of doublecortin-positive cells in layer II of the prefrontal cortex was significantly increased after short-term environmental enrichment exposure. In addition, these doublecortin-positive cells co-expressed 5-bromo-2-deoxyuridine(a marker of cell proliferation), c-Fos(a marker of cell viability) and NeuN(a marker of mature neurons). Experimental findings showed that short-term environmental enrichment can induce proliferation, activation and maturation of doublecortin-positive cells in layer II of the prefrontal cortex of adult guinea pigs. | Chunling Fan Mengqi Zhang Lei Shang Ngobe Akume Cynthia Zhi Li Zhenyu Yang Dan Chen Jufang Huang Kun Xiong | 2014 | Neural Regeneration Research2014，9，3： | 4 |
| 6 | 基因治疗及细胞治疗发展态势分析显示文摘基因治疗是将目的基因导入患者的特定组织或细胞进行适当有调控的表达,以纠正或补偿因基因缺陷或异常而引起的疾病,从而达到治疗疾病的目的[1-2]。基因治疗可以被用于治疗血友病等单基因遗传性疾病以及癌症、神经退行性疾病、眼科疾病和心血管疾病等多基因疾病。 | 迟培娟 陈芳 Cynthia Liu Qiongqiong Zhou YiDeng Yingzhu Li 韩涛 余敏 杨艳萍 王学昭 | 2019 | 中国生物工程杂志2019，39，5： | 3 |
| 7 | Dietary Bacillus spp.enhanced growth and disease resistance of weaned pigs by modulating intestinal microbiota and systemic immunity显示文摘Background:Previous research has shown that dietary supplementation of Bacillus spp.probiotics exerts beneficial effects on animals’growth.However,limited studies have evaluated the efficacy of Bacillus spp.on weaned pigs and their effects on host gut health and microbiome,and systemic immunity using a disease challenge model.The objective of this experiment was to investigate the effects of two Bacillus spp.strains(Bacillus subtilis DSM 32540 and Bacillus pumilus DSM 32539)on growth performance,diarrhea,intestinal health,microbiome,and systemic immunity of weaned pigs experimentally infected with an enterotoxigenic Escherichia coli(ETEC).Results:Pigs in PRO1(Bacillus subtilis DSM 32540)had greater(P<0.05)body weight on d 7 and 14 PI,greater(P<0.05)ADG from d 0 to 7 and d 7 to 14 PI,compared with pigs in CON(Control).Pigs in PRO1 had milder(P<0.05)diarrhea on d 2 and 3 PI compared with pigs in CON.However,no differences were observed in growth performance and diarrhea score between PRO2(Bacillus pumilus DSM 32539)and CON groups.Supplementation of PRO1 decreased(P<0.05)lymphocyte counts on d 7 and 14 PI,compared with CON.Supplementation of PRO1 and PRO2 both reduced(P<0.05)total coliforms in mesenteric lymph nodes on d 21 PI.Pigs in PRO2 had greater(P<0.05)goblet cell number and sulfomucin percentage in duodenal villi and greater(P<0.05)sialomucin percentage in jejunal villi than pigs in CON.Supplementation of PRO1 up-regulated(P<0.05)MUC2 gene expression in jejunal mucosa and reduced(P<0.05)PTGS-2 and IL1B gene expression in ileal mucosa on d 21 PI,compared with CON.Pigs in PRO1 had reduced(P<0.05)relative abundance of families Lachnospiraceae,Peptostreptococcaceae and Pasteurellaceae in the ileum.Conclusions:Supplementation of Bacillus subtilis DSM 32540 improved growth performance,alleviated diarrhea severity,enhanced gut health,and reduced systemic inflammation of weaned pigs infected with ETEC F18.Although Bacillus pumilus DSM 32539 was able to alleviate systemic inflammation,it had limited impacts on growth performance and severity of diarrhea of ETEC F18 challenged weaned pigs. | Yijie He Cynthia Jinno Kwangwook Kim Zhaohai Wu Bie Tan Xunde Li Rose Whelan Yanhong Liu | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 2 |
| 8 | Agricultural cooperatives and the role of organisational models in new intelligent traceability systems and big data analysis显示文摘Traceability systems are key to assuring food safety,creating a benefit for food supply chain components.Currently,the appearance of new technologies such as IoT and Big Data Analysis leads to a new generation of more functional,but complex,traceability systems.Organisational models based on cooperation of multiple small/medium size agents,for example of small/family farming cooperatives,play an important role in high standard agricultural production and commercialization processes.These function as both social and economic networks,with high social and economic impact in the rural areas.The case of Almeria as an example of this model was used to analyze its cooperative model.The actual traceability systems in the Almeria model were studied,taking account of the different networked agents and their interrelation.This study includes two main parts:a)analysis of the net-chains that constitute the food supply chains and their different relationships,and b)actual traceability.The next step studied how the net-chain model,including many diverse agents,may be applied to develop a new generation of traceability systems based of IoT and Big Data.This implies extending the special and functional scope of the actual systems and defining clear rules of exchange of the results of the Big Data Analysis,taking account of the adequate Privacy Rules.This work analyses the current organisation as a base for a new generation of traceability systems considered in the European project IoF2020(Internet of the Food and Farm 2020).Some parallels between Almeria’s model and certain areas in China,mainly in the areas of Beijing-Tianjin-Hebei and Shandong were detected.Another of the objectives of this work is to deepen the understanding of these similarities and analyze the possible adaptation of the results from Almeria to China. | Cynthia Giagnocavo Fernando Bienvenido Li Ming Zhao Yurong Jorge Antonio Sanchez-Molina Yang Xinting | 2017 | International Journal of Agricultural and Biological Engineering2017，10，5： | 2 |
| 9 | Tensile Strain - Hardening Behavior of PVA - ECC 显示文摘 | Li Victor C Wang Shuxin Wu Cynthia | 2001 | ACI Journal of Materials2001，98，6： | 1 |
| 10 | Influence of reinforcing bars on shrinkage stresses in concrete slabs显示文摘 | Zhang Jun Li Victor C Wu Cynthia | 2000 | Journal of Engineering Mechanics2000，126，12： | 1 |
| 11 | Stimulation of cAMP production and cyclooxygenase-2 by prostaglandin E 2 and selective prostaglandin receptor agonists in murine osteoblastic cells显示文摘 | Yoko Sakuma Ziaodong Li Carol C Pilbeam Cynthia B Alander Daichi Chikazu Hiroshi Kawaguchi Lawrence G Raisz | 2003 | Bone2003，，5： | 1 |
| 12 | Analysis of nitrite and nitrate in biological samples using high-performance liquid chromatography显示文摘 | Wenjuan S. Jobgen Scott C. Jobgen Hui Li Cynthia J. Meininger Guoyao Wu | 2006 | Journal of Chromatography B2006，，1： | 1 |
| 13 | Tensile strain-hardening behavior of polyvinyl alcohol engineered cementitious composite(PVA-ECC)显示文摘 | Victor C Li Shuxin Wang Cynthia Wu | 2001 | ACI Materials Journal2001，98，6： | 1 |
| 14 | Randomised trial of eradication of Helicobacter pylori before non-steroidal anti-inflammatory drug therapy to prevent peptic ulcers显示文摘 | Francis KL Chan Joseph JY Sung SC Sydney Chung KF To MY Yung Vincent KS Leung YT Lee Cynthia SY Chan Edmund KM Li Jean Woo | 1997 | 1997 (9083)1997，，9083： | 1 |
| 15 | Estimating nutrient uptake requirements for wheat in China显示文摘 | Limin Chuan Ping He Jiyun Jin Shutian Li Cynthia Grant Xinpeng Xu Shaojun Qiu Shicheng Zhao Wei Zhou | 2013 | Field Crops Research2013，，： | 1 |
| 16 | Measuring and Modifying Interface Proferities of PVA Fibers in ECC Matrix显示文摘 | Carl Redon Victor C Li Cynthia Wu | 2001 | Journal of Materials in Civil Engineering2001，13，6： | 1 |
| 17 | Tensile Strain-Hardening Behavior of Polyvinyl Alcohol Engineered Cementitious Composite (PVA-ECC)显示文摘 | VICTOR C Li WANG Shu-xin CYNTHIA Wu | 2001 | ACI Materials Journal2001，98，6： | 1 |
| 18 | High fat feeding and dietary l-arginine supplementation differentially regulate gene expression in rat white adipose tissue显示文摘 | Wenjuan Jobgen Wenjiang J. Fu Haijun Gao Peng Li Cynthia J. Meininger Stephen B. Smith Thomas E. Spencer Guoyao Wu | 2009 | Amino Acids2009，，1： | 1 |
| 19 | Effect of Alcohol on miR‐212 Expression in Intestinal Epithelial Cells and Its Potential Role in Alcoholic Liver Disease显示文摘 | YuemingTang AliBanan Christopher B.Forsyth Jeremy Z.Fields Cynthia K.Lau Li JuanZhang AliKeshavarzian | 2007 | Alcoholism: Clinical and Experimental Research2007，，2： | 1 |
| 20 | Biocompatibility of boron nitride nanosheets显示文摘硼氮化物(BN ) 的性质和应用程序 nanosheets 对 graphene 的那些补足,与在化学、热的稳定性的优点。Biocompatibility 是为未来的一个重要性质生物医学的应用程序但是没试验性地被调查。我们学习了不同尺寸的 BN nanosheets 的 biocompatibility 并且在像造骨细胞的房间把它与 BN nanoparticles 的作比较(SaOS 2) 。我们的结果证明 BN nanomaterials 的 biocompatibility 取决于他们的尺寸,形状,结构,和表面化学药品性质。电子旋转回声测量表明在 nanosheet 边或在粒子表面上定位的不饱和的 B 原子为在新窗户中的房间 death.Open | Srikanth Mateti Cynthia S. Wong Zhen Liu Wenrong Yang Yuncang Li Lu Hua Li Ying Chen | 2018 | Nano Research2018，11，1： | 1 |
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