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| 1 | Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-κB signaling pathway显示文摘The stiffness of the extracellular matrix(ECM)plays an important role in regulating the cellular programming.However,the mechanical characteristics of ECM affecting cell differentiation are still under investigated.Herein,we aimed to study the effect of ECM substrate stiffness on macrophage polarization.We prepared polyacrylamide hydrogels with different substrate stiffness,respectively.After the hydrogels were confirmed to have a good biocompatibility,the bone marrow-derived macrophages(BMMs)from mice were incubated on the hydrogels.With simulated by the low substrate stiffness,BMMs displayed an enhanced expression of CD86 on the cell surface and production of reactive oxygen species(ROS)in cells,and secreted more IL-1βand TNF-αin the supernatant.On the contrary,stressed by the medium stiffness,BMMs expressed more CD206,produced less ROS,and secreted more IL-4 and TGF-β.In vivo study by delivered the hydrogels subcutaneously in mice,more CD68+CD86+cells around the hydrogels with the low substrate stiffness were observed while more CD68+CD206+cells near by the middle stiffness hydrogels.In addition,the expressions of NIK,phosphorylated p65(pi-p65)and phosphorylated IκB(pi-IκB)were significantly increased after stimulation with low stiffness in BMMs.Taken together,these findings demonstrated that substrate stiffness could affect macrophages polarization.Low substrate stiffness promoted BMMs to shift to classically activated macrophages(M1)and the middle one to alternatively activated macrophages(M2),through modulating ROS-initiated NF-κB pathway.Therefore,we anticipated ECM-based substrate stiffness with immune modulation would be under consideration in the clinical applications if necessary. | Mimi Chen Yu Zhang Pinghui Zhou Xingzhi Liu Huan Zhao Xichao Zhou Qiaoli Gu Bin Li Xuesong Zhu Qin Shi | 2020 | Bioactive Materials2020，5，4： | 7 |
| 2 | Activation of Piezo1 contributes to matrix stiffness-induced angiogenesis in hepatocellular carcinoma显示文摘Background:Despite integrin being highlighted as a stiffness-sensor molecule in matrix stiffness-driven angiogenesis,other stiffness-sensor molecules and their mechanosensory pathways related to angiogenesis in hepatocellular carcinoma(HCC)remain obscure.Here,we explored the interplay between Piezo1 and integrinβ1 in the mechanosensory pathway and their effects on HCC angiogenesis to better understand matrix stiffness-induced angiogenesis.Methods:The role of Piezo1 in matrix stiffness-induced angiogenesis was investigated using orthotopic liver cancer SD rat models with high liver stiffness background,and its clinical significance was evaluated in human HCC tissues.Matrix stiffness-mediated Piezo1 upregulation and activation were assayed using an in vitro fibronectin(FN)-coated cell culture system with different stiffness,Western blotting and Ca^(2+)probe.The effects of shPiezo1-conditioned medium(CM)on angiogenesis were examined by tube formation assay,wound healing assay and angiogenesis array.The underlying mechanism by which Piezo1 participated in matrix stiffness-induced angiogenesis was analyzed by microRNA quantitative real-time polymerase chain reaction(qRT-PCR),matrix stiffness measurement,dual-luciferase reporter assay,ubiquitination assay and co-immunoprecipitation.Results:Increased matrix stiffness significantly upregulated Piezo1 expression at both cellular and tissue levels,and high expression of Piezo1 indicated an unfavorable prognosis.High matrix stiffness also noticeably enhanced the activation level of Piezo1,similar to its expression level.Piezo1 knockdown significantly suppressed tumor growth,angiogenesis,and lung metastasis of HCC rat models with high liver stiffness background.shPiezo1-CM from HCC cells attenuated tube formation and migration abilities of vascular endothelial cells remarkably,and analysis of differentially expressed pro-angiogenic factors revealed that Piezo1 promoted the expression and secretion of vascular endothelial growth factor(VEGF),CXC chemokine ligand 16(CXCL16)and insulin-like growth factor binding protein 2(IGFBP2).Matrix stiffness-caused Piezo1 upregulation/activation restrained hypoxia inducible factor-1α(HIF-1α)ubiquitination,subsequently enhanced the expression of downstream pro-angiogenic factors to accelerate HCC angiogenesis.Besides,collagen 1(COL1)-reinforced tissue stiffening resulted in more expression of Piezo1 via miR-625-5p.Conclusions:This study unravels a new mechanism by which the inte-grinβ1/Piezo1 activation/Ca2+influx/HIF-1αubiquitination/VEGF,CXCL16 and IGFBP2 pathway participates in matrix stiffness-driven HCC angiogenesis.Simultaneously,a positive feedback regulation loop as stiff matrix/integrinβ1/miR-625-5p/Piezo1 and COL1/stiffer matrix mediates matrix stiffness-caused Piezo1 upregulation. | Miao Li Xi Zhang Mimi Wang Yaohui Wang Jiali Qian Xiaoxia Xing Zhiming Wang Yang You Kun Guo Jie Chen Dongmei Gao Yan Zhao Lan Zhang Rongxin Chen Jiefeng Cui Zhenggang Ren | 2022 | Cancer Communications2022，42，11： | 3 |
| 3 | Tourism development of world heritage sites in China: a geographic perspective 显示文摘 | Mimi Li Bihu Wu Liping Cai | 2008 | Tourism Management2008，，1： | 1 |
| 4 | Tourism development of world heritage sites in China: a geographic perspective显示文摘 | Li Mimi Wu Bihu Cai Liping | 2008 | Tourism Management2008，，29： | 1 |
| 5 | Tourism development of World Heritage Sites in China:a geographic perspective显示文摘 | Mimi Li Bihu Wu Liping Cai | 2008 | Tourism Manage-ment2008，29，2： | 1 |
| 6 | GSH-induced chemotaxis nanomotors for cancer treatment by ferroptosis strategy显示文摘Overexpression of glutathione(GSH) in tumor cells greatly inhibits the therapy effect of traditional ferroptosis inducers;thus,control of the GSH level is an important way to improve the efficacy of ferroptosis.Herein,a kind of nanomotor based on metal organic framework material NH_(2)-MIL-101 is constructed,in which polyethylene glycol(PEG) and glutathione hydrolase γ-glutamyltransferase(GGT) are asymmetrically modified to obtain mPEG@MIL-101@GGT nanomotors(PMG NMs).The nanomotor proposed in this article can be induced by overexpressing GSH in tumors to form chemotactic effects through the specific affinity between enzymes and substrates.Results indicate that the tail structure provided by PEG and the affinity between GGT and GSH can enable the stable chemotaxis behavior of nanomotors in a complex environment,thus enriching and penetrating deeply at the tumor site.In addition,after loading the ferroptosis inducer Erastin,the system shows a highly effective induction effect of tumor ferroptosis.Erastin in the system can effectively inhibit the synthesis of GSH,and PMG NMS can react with GSH through Fe^(3+)and GGT to promote GSH depletion.The produced Fe^(2+)can generate excessive reactive oxygen species through Fenton reaction,which further promotes the death of tumor cells.Meantime,the chemotaxis behavior of the nanomotors based on the endogenous biochemical reaction of GGT-catalyzed GSH hydrolysis can endow nanomotors with the enhanced delivery and penetration ability in tumors,thus collaboratively enhancing the ferroptosis effect.This strategy designed according to the physiological characteristics of tumors has good biosafety and treatment effect,providing new perspectives for micro/nanomotor and tumor treatment. | Zhiyong Liu Ting Li Nan Li Yujing Wang Lin Chen Xueting Tang Mimi Wan Chun Mao | 2022 | Science China Chemistry2022，65，5： | 1 |
| 7 | Variability of Atlantic Meridional Overturning Circulation in FGOALS-g2显示文摘The variability of Atlantic Meridional Overturning Circulation(AMOC) in the pre-industrial control experiment of the Flexible Global Ocean–Atmosphere–Land System model, Grid-point Version 2(FGOALS-g2) was investigated using the model outputs with the most stable state in a 512-yr time window from the total 1500-yr period of the experiment. The period of AMOC in FGOALS-g2 is double peaked at 20 and 32 years according to the power spectrum, and 22 years according to an auto-correlation analysis, which shows very obvious decadal variability. Like many other coupled climate models, the decadal variability of AMOC in FGOALS-g2 is closely related to the convection that occurs in the Labrador Sea region. Deep convection in the Labrador Sea in FGOALS-g2 leads the AMOC maximum by 3–4 years. The contributions of thermal and haline effects to the variability of the convection in three different regions [the Labrador, Irminger and Greenland–Iceland– Norwegian(GIN) Seas] were analyzed for FGOALS-g2. The variability of convection in the Labrador and Irminger Seas is thermally dominant, while that in the colder GIN Seas can be mainly attributed to salinity changes due to the lower thermal expansion. By comparing the simulation results from FGOALS-g2 and 11 other models, it was found that AMOC variability can be attributed to salinity changes for longer periods(longer than 35 years) and to temperature changes for shorter periods. | HUANG Wenyu WANG Bin LI Lijuan DONG Li LIN Pengfei YU Yongqiang ZHOU Tianjun LIU Li XU Shiming XIA Kun PU Ye WANG Lu LIU Mimi SHEN Si HU Ning WANG Yong SUN Wenqi DONG Fang | 2014 | Advances in Atmospheric Sciences2014，31，1： | 1 |
| 8 | A model of community-based festivalimage显示文摘 | Huang J Z Li Mimi Cai L A | 2010 | International Journal of Hospitality Management2010，29，2： | 1 |
| 9 | Tourism development of Word Heritage Sites in China:a geographic perspective显示文摘 | Mimi Li Bihu Wu Liping Cai | | 0，，02： | 1 |
| 10 | Surface modification of POSS–polyimide hybrid films by atomic oxygen using ECR plasma显示文摘 | Shuwang Duo Huan Ke Tingzhi Liu Mimi Song Meishuan Li | 2012 | Nuclear Inst and Methods in Physics Research B2012，，： | 1 |
| 11 | Tourism development of World Heritage Sites in China: a geographic perspective 显示文摘 | Mimi Li Bihu Wu Liping Cai | 2008 | Tourism Management2008，29，2： | 1 |
| 12 | Novel CO2-capture derived from the basic ionic liquids orientated on mesoporous materials显示文摘 | WAN Mimi ZHU Haoyue LI Yanyan | 2014 | ACS Applied Materials and Interfaces2014，6，12： | 1 |
| 13 | A model of community-based festival image显示文摘 | Huang J Z Li Mimi Cai L P | 2010 | International Journal of Hospitality Management2010，29，2： | 1 |
| 14 | Tourism development of World Heritage Sites in China: A geographic perspective 显示文摘 | Li Mimi Wu Bihu Cai Liping | 2008 | Tourism Management2008，，29： | 1 |
| 15 | Improved refractory wound healing with administration of acidic fibroblast growth factor in diabetic rats显示文摘 | Liyun Xie Meiling Zhang Baijun Dong Mimi Guan Meifei Lu Zhifeng Huang Hongchang Gao Xiaokun Li | 2011 | Diabetes Research and Clinical Practice2011，，： | 1 |
| 16 | Tourism development of World Her- itage Sites in China: a geographic perspective显示文摘 | Mimi Li Bihu Wu Liping Cai | 2008 | Tourism Manage- ment2008，29，2： | 1 |
| 17 | Bound states in the continuum in all-dielectric metasurfaces with scaled lattice constants显示文摘Bound states in the continuum(BICs)have emerged as an efficient tool for trapping light at the nanoscale,promising several exciting applications in photonics.Breaking the structural symmetry has been proposed as an effective way of exciting quasiBICs(QBICs)and generating high-Q resonances.Herein,we demonstrate that QBICs can be excited in an all-dielectric metasurface by scaling the lattice of the metasurface,causing translational symmetry breaking.The corresponding BICs arise from band folding from the band edge to the Γ point in the first Brillouin zone.Multipole analysis reveals that the toroidal dipole dominates these QBICs.Furthermore,scaling the lattice along different directions provides additional freedom for tailoring QBICs,enabling polarization-dependent or-independent QBICs.In addition,this allows the realization of two QBICs at different wavelengths using plane-wave illumination with different polarizations on the metasurface.We experimentally demonstrated the existence of these BICs by fabricating silicon metasurfaces with scaled lattices and measuring their transmission spectra.The vanished resonant linewidth identifies BICs in the transmission spectrum,and the QBICs are characterized by highQ Fano resonances with the Q-factor reaching 2000.Our results have potential applications in enhancing light-matter interaction,such as laser,nonlinear harmonic generation,and strong coupling. | Mimi Zhou Shaojun You Lei Xu Menghui Fan Jing Huang Wenbin Ma Mingzhe Hu Shengyun Luo Mohsen Rahmani Ya Cheng Lin Li Chaobiao Zhou Lujun Huang Andrey E.Miroshnichenko | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，12： | 0 |
| 18 | Enhancing the electrocatalytic performance of nitrate reduction to ammonia by in-situ nitrogen leaching显示文摘Electrochemical nitrate reduction reaction (NITRR) is regarded as a “two birds-one stone” method for the treatment of nitrate contaminant in polluted water and the synthesis of valuable ammonia, which is retarded by the lack of highly reactive and selective electrocatalysts .Herein, for the first time, nickel foam supported Co_(4) N was designed as a high-performance NITRR catalyst by an in-situ nonmetal leaching-induced strategy.At the optimal potential, the Co_(4) N/NF catalyst achieves ultra-high Faraday efficiency and NH_(3) selectivity of 95.4% and 99.4%, respectively.Ex situ X-ray absorption spectroscopy (XAS), together with other experiments powerfully reveal that the nitrogen vacancies produced by nitrogen leaching are stable and play a key role in boosting nitrate reduction to ammonia.Theoretical calculations confirm that Co_(4) N with abundant nitrogen vacancies can optimize the adsorption energies of NO_(3)^(-) and intermediates, lower the free energy (Δ G ) of the potential-determining step (*NH_(3) to NH_(3) ) and inhibit the formation of N-containing byproducts.In addition, we also conclude that the nitrogen vacancies can stabilize the adsorbed hydrogen, making H_(2) quite difficult to produce, and lowering ΔG from *NO to *NOH, which facilitates the selective reduction of nitrate.This study reveals significant insights about the in-situ nonmetal leaching to enhance the NITRR activity. | Mimi Fu Yini Mao Hua Wang Wei Luo Yimin Jiang Wei Shen Ming Li Rongxing He | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 19 | Constructing crystalline homophase carbon nitride S-scheme heterojunctions for efficient photocatalytic hydrogen evolution显示文摘The number of photogenerated carriers involved in the photocatalytic reaction is one of the main factors influencing the photocatalytic activity,and constructing S-scheme heterojunctions can significantly en-hance the migration of photogenerated carriers,which is regarded as an effective method.In this study,Au nanoparticles(NPs)-supported crystallized heptazine/triazine-based carbon nitride(AHTCN)S-scheme heterojunction photocatalysts are successfully prepared by photoreduction methods.Except for the Au NPs function as an electron mediator,the experiment results and DFT calculations demonstrate that the Fermi energy level of crystallized heptazine/triazine-based heterojunction(HTCN)is pulled down after anchoring Au NPs,and thus the electron transfer path of HTCN changed from Type II-scheme to S-scheme.Owing to S-scheme heterojunction,the optimal AHTCN-2(2 wt.%Au loaded)exhibits the best photocat-alytic hydrogen evolution with a production rate of 715.2μmol h^(−1)g^(−1),which significantly outperforms that of the HTCN.This work delivers a new strategy for the construction of S-scheme heterojunctions. | Mimi Luo Guanjie Jiang Min Yu Yupeng Yan Zhangjie Qin Yang Li Qin Zhang | 2023 | Journal of Materials Science & Technology2023，，30： | 0 |
| 20 | Spatial Autocorrelation Analysis of Genetic Structure of Zelkova schneideriana in Mailing Town,Guangxi显示文摘We analyzed the fine-scale spatial genetic structure of the individuals of Zelkova schneideriana,which were classified by age using the spatial autocorrelation method,to quantify spatial patterns of genetic variation within the population and to explore potential mechanisms that determine genetic variation in population. The spatial autocorrelation coefficient( r) at 13 distance classes was determined on the basis of both geographical distance and genetic distance matrix which was derived from co-dominant SSR data using Gen Al Ex software. The results showed that all the individuals of Z. schneideriana exhibited significantly positive spatial genetic structure at distance less than 40 m( the X-intercept was 53. 568),indicating that the average length of the smallest genetic patch for the same genotype clustering of the Z. schneideriana Mailing population was about 50 m. Limited seed dispersal is the main factor that leads to the spatial genetic variation within populations. The individuals in age Class II showed significantly positive spatial genetic structure at distance less than 30 m( the X-intercept was 47. 882),while the individuals in age Class I and age Class III showed no significant spatial genetic structure in any of the spatial distance classes. Z. schneideriana is a long-lived perennial plant; the self-thinning resulted from the cohort competition between individuals in the growing process may lead to this certain spatial structure in age Class III of Z. schneideriana population. | Yufeng QIN Lingdan WANG Zihai QIN Ye ZHANG Mimi LI Bowen CHEN Riqing ZHANg Hailong LIU | 2018 | Agricultural Biotechnology2018，7，5： | 0 |
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